Abstract: NeuroD is a basic helix-loop-helix (bHLH) transcription factor cloned from a two hybrid screen designed to search for new bHLH proteins. In our previous studies, we showed that NeuroD could convert <i>Xenopus</i> ectoderm into fully differentiated neurons and that it could prematurely differentiate neural precursor cells in the nervous system. Recently, an insulin transcription activator, Beta-2, was cloned from a hamster insulinoma cell line by Naya et al. [Genes Dev (1995)9:1009–1019]. Sequence analysis revealed that Beta-2 is the hamster homologue of NeuroD. We are currently investigating the role that Neu-roD/Beta-2 plays in vertebrate neurogenesis and pancreatic development.
Publication Year: 1997
Publication Date: 1997-01-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 82
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