Publication Information

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'https://openalex.org/W2071146869', 'https://openalex.org/W2049613194', 'https://openalex.org/W2006178640', 'https://openalex.org/W194800238'], 'abstract_inverted_index': {'Epidermal': [0, 241, 482], 'growth': [1, 107, 225, 242, 348, 466, 483, 492, 499, 569, 619, 904, 970, 1004, 1008, 1079, 4110, 4275], 'factor': [2, 243, 484, 500, 520, 620, 1005, 1009, 1080, 1379], '(EGF)': [3, 244, 485], 'is': [4, 30, 34, 245, 271, 275, 553, 675, 778, 858, 1272, 1546, 3596, 4147, 4380], 'a': [5, 165, 246, 406, 554, 628, 678, 714, 779, 1019, 1273, 1547, 1554, 1705, 2015, 2105, 2211, 2270, 2506, 2826, 2862, 2934, 2953, 2962, 3021, 3069, 3146, 3204, 3211, 3294, 3359, 3395, 3455, 3554, 3707, 3717, 3744, 4148, 4175, 4247, 4359, 4399, 4436], 'well': [6, 247, 3012, 3730, 4456], 'known': [7, 248, 855, 859], 'mitogen,': [8, 249, 781], 'but': [9, 90, 210, 250, 331, 451, 3432], 'it': [10, 191, 251, 432, 782, 2797, 3595, 3806, 3849, 4159], 'paradoxically': [11, 252, 783], 'induces': [12, 253, 784], 'apoptosis': [13, 29, 254, 270, 540, 785, 824, 862, 945, 973, 1111, 1172, 1326, 1383, 1449, 1497, 1529, 1970, 2033, 2061, 3120, 4164, 4384], 'in': [14, 148, 235, 255, 389, 476, 638, 677, 786, 814, 863, 905, 943, 1018, 1070, 1112, 1448, 1597, 1603, 1711, 1848, 2000, 2249, 2269, 2289, 2354, 2359, 2422, 2432, 2444, 2463, 2505, 2537, 2560, 2675, 2739, 2818, 2825, 2893, 2903, 2923, 2968, 2987, 3080, 3116, 3192, 3233, 3358, 3430, 3535, 3558, 3726, 3775, 3790, 3820, 3839, 3850, 3854, 3867, 3915, 3972, 4023, 4039, 4131, 4242, 4298, 4352, 4358, 4417, 4421, 4461, 4463, 4484], 'cells': [15, 42, 62, 133, 150, 171, 222, 256, 283, 303, 374, 391, 412, 463, 787, 819, 864, 907, 1022, 1117, 1494, 1703, 1893, 1965, 2006, 2055, 2243, 2283, 2356, 2437, 2494, 2534, 2713, 2898, 3056, 3075, 3094, 3142, 3182, 3541, 3656, 3669, 3686, 3695, 3733, 3780, 3792, 3824, 3852, 3870, 3893, 3952, 3974, 4003, 4041, 4119, 4180, 4213, 4220, 4278, 4284, 4326, 4343, 4357, 4366, 4467, 4477, 4493], 'that': [16, 26, 44, 257, 267, 285, 557, 788, 865, 1283, 1520, 1886, 1953, 2007, 2053, 3587, 3712, 3725, 3785, 3947, 4000, 4010, 4030, 4058, 4266, 4282, 4402, 4414, 4455, 4491], 'overexpress': [17, 45, 258, 286, 789, 866, 2008], 'its': [18, 259, 1390, 1683, 1721, 2066, 3678], 'receptor.': [19, 260], 'We': [20, 261, 4307], 'demonstrate': [21, 262], 'for': [22, 233, 263, 474, 718, 2118, 2237, 2482, 2502, 2603, 2718, 2849, 2909, 3020, 3089, 3221, 3253, 3264, 3386, 4152, 4223], 'the': [23, 27, 58, 78, 103, 106, 122, 129, 161, 218, 236, 264, 268, 299, 319, 344, 347, 363, 370, 402, 459, 477, 560, 617, 686, 809, 850, 868, 872, 1074, 1158, 1257, 1376, 1387, 1408, 1419, 1423, 1429, 1441, 1686, 1726, 1737, 1889, 1957, 2042, 2196, 2205, 2234, 2342, 2349, 2366, 2376, 2398, 2436, 2493, 2511, 2617, 2628, 2635, 2652, 2735, 2810, 2819, 2856, 2872, 2916, 2944, 2958, 2995, 3002, 3016, 3038, 3055, 3064, 3093, 3113, 3117, 3133, 3181, 3229, 3339, 3401, 3460, 3531, 3548, 3561, 3567, 3576, 3583, 3624, 3628, 3642, 3645, 3661, 3667, 3727, 3737, 3747, 3753, 3766, 3782, 3796, 3815, 3834, 3855, 3869, 3876, 3880, 3887, 3921, 3935, 3940, 3956, 4001, 4005, 4034, 4043, 4048, 4055, 4063, 4070, 4080, 4084, 4104, 4128, 4153, 4190, 4200, 4211, 4224, 4234, 4274, 4310, 4318, 4325, 4345, 4364, 4392, 4439, 4442, 4446, 4475, 4481, 4486], 'first': [24, 265], 'time': [25, 266], 'EGF-induced': [28, 139, 213, 239, 269, 380, 454, 480, 944, 1171, 2001, 2060, 3536, 4095, 4290, 4371, 4515], 'accelerated': [31, 272], 'if': [32, 273, 4189], 'NF-κB': [33, 116, 156, 234, 274, 357, 397, 475, 1518, 1545, 1596, 1676, 1733, 1776, 1844, 1879, 1961, 1996, 2807, 3426, 3534, 3593, 3602, 3816, 3835, 3866, 3882, 3923, 3936, 3957, 3971, 4012, 4019, 4035, 4045, 4074, 4114, 4496], 'inactivated.': [35, 276], 'To': [36, 277, 1993, 3529, 3760, 3873], 'inactivate': [37, 278, 2020, 3804], 'NF-κB,': [38, 279, 518, 3805, 4068], 'human': [39, 280, 681, 1782, 2811, 3436], 'epidermoid': [40, 281, 2226, 3437], 'carcinoma': [41, 282, 2227, 3438], '(A431)': [43, 284], 'EGF': [46, 67, 111, 141, 188, 287, 308, 352, 382, 429, 561, 777, 851, 964, 967, 1000, 1072, 1590, 2999, 3088, 3424, 3463, 3812, 3832, 3845, 3858, 3898, 4015, 4031, 4107, 4126, 4167, 4209, 4245, 4272, 4313, 4331, 4348, 4473, 4505], 'receptor': [47, 288, 621], 'were': [48, 63, 99, 289, 304, 340, 2088, 2112, 2130, 2150, 2187, 2244, 2264, 2284, 2372, 2438, 2461, 2535, 2546, 2558, 2606, 2649, 2654, 2668, 2714, 2869, 2875, 2907, 2950, 2990, 3040, 3057, 3078, 3095, 3135, 3143, 3188, 3231, 3261, 3276, 3314, 3422, 3687, 3860, 3899, 4120, 4267, 4295, 4367], 'stably': [49, 290, 2011, 3543], 'transfected': [50, 135, 291, 376, 2012, 2286, 3544, 3670], 'with': [51, 68, 136, 198, 292, 309, 377, 439, 713, 720, 965, 1389, 1435, 1704, 2014, 2255, 2287, 2357, 2363, 2497, 2515, 2552, 2616, 2627, 2670, 2798, 2933, 2957, 2992, 3035, 3042, 3053, 3059, 3085, 3097, 3101, 3137, 3184, 3210, 3278, 3286, 3345, 3400, 3546, 3671, 3684, 3706, 3724, 3895, 3901, 3928, 3953, 4181, 4214, 4233, 4426, 4431, 4470, 4494, 4507], 'an': [52, 200, 230, 293, 441, 471, 2938, 3931, 4422], 'IκB-α': [53, 294, 1714, 2145, 3570, 3581, 3709, 3721, 4009], 'double': [54, 295, 2805, 3555, 3577], 'mutant': [55, 296, 2016, 3556, 3578, 3646, 4006], 'construct.': [56, 297], 'Under': [57, 298], 'NF-κB-inactivated': [59, 300, 2063], 'condition,': [60, 301], 'A431': [61, 149, 302, 390, 793, 2005, 2054, 2230, 2355, 3540], 'more': [64, 305, 1263, 2057, 4287, 4368, 4460, 4498], 'sensitive': [65, 306, 2058, 4288, 4369, 4400], 'to': [66, 138, 223, 307, 379, 464, 559, 577, 822, 860, 969, 1261, 1325, 1415, 1594, 1675, 1685, 1725, 1734, 1736, 1850, 1888, 2019, 2025, 2031, 2059, 2109, 2137, 2162, 2181, 2348, 2440, 2523, 2716, 2792, 2897, 3010, 3266, 3458, 3573, 3589, 3599, 3640, 3803, 3809, 3903, 3968, 4082, 4094, 4122, 4256, 4269, 4289, 4327, 4335, 4338, 4370, 4386, 4500], 'decreased': [69, 310], 'cell': [70, 79, 311, 320, 579, 903, 1013, 1270, 1606, 1779, 1787, 1854, 2043, 2228, 2562, 2966, 3341, 3439, 3465, 4109, 4129, 4156, 4182, 4394, 4501], 'viability': [71, 209, 312, 450, 2967, 4130, 4191], 'and': [72, 83, 88, 118, 121, 158, 160, 183, 187, 313, 324, 329, 359, 362, 399, 401, 424, 428, 574, 626, 689, 693, 722, 961, 972, 1006, 1016, 1069, 1157, 1162, 1265, 1280, 1293, 1321, 1405, 1431, 1440, 1507, 1512, 1525, 1565, 1569, 1602, 1681, 1718, 1728, 1739, 1785, 1793, 2010, 2047, 2072, 2084, 2104, 2124, 2147, 2172, 2183, 2185, 2195, 2224, 2260, 2276, 2280, 2417, 2455, 2474, 2477, 2500, 2509, 2520, 2543, 2549, 2593, 2610, 2620, 2625, 2651, 2673, 2708, 2732, 2734, 2773, 2846, 2855, 2871, 2900, 2912, 3000, 3015, 3037, 3050, 3063, 3083, 3099, 3107, 3139, 3150, 3190, 3201, 3219, 3250, 3284, 3291, 3302, 3403, 3408, 3449, 3542, 3564, 3746, 3758, 3778, 3781, 3822, 3853, 3885, 3907, 3960, 4013, 4042, 4051, 4078, 4097, 4117, 4127, 4165, 4171, 4186, 4217, 4228, 4252, 4259, 4292, 4341, 4355, 4362, 4385, 4438], 'increased': [73, 314, 709, 1882], 'externalization': [74, 315, 2037], 'of': [75, 85, 95, 105, 110, 115, 125, 131, 146, 155, 163, 168, 175, 180, 185, 202, 212, 215, 238, 316, 326, 336, 346, 351, 356, 366, 372, 387, 396, 404, 409, 416, 421, 426, 443, 453, 456, 479, 539, 563, 630, 680, 685, 811, 849, 871, 938, 963, 1021, 1077, 1150, 1160, 1295, 1375, 1386, 1425, 1509, 1514, 1549, 1557, 1673, 1702, 1708, 1713, 1730, 1775, 1781, 1884, 1891, 1897, 1956, 1960, 2038, 2049, 2208, 2219, 2273, 2400, 2405, 2412, 2420, 2425, 2453, 2458, 2466, 2600, 2678, 2725, 2742, 2782, 2801, 2821, 2888, 2915, 2931, 2975, 2979, 2998, 3004, 3024, 3214, 3299, 3308, 3350, 3362, 3365, 3406, 3413, 3420, 3462, 3533, 3569, 3580, 3635, 3644, 3654, 3663, 3693, 3720, 3752, 3768, 3799, 3857, 3865, 3930, 3950, 4008, 4062, 4066, 4072, 4087, 4106, 4113, 4125, 4155, 4184, 4192, 4202, 4219, 4226, 4249, 4276, 4302, 4312, 4320, 4330, 4373, 4383, 4405, 4441, 4448], 'phosphatidylserine': [76, 317, 2039], 'on': [77, 318, 1715, 2041, 3203, 3464, 4108, 4178, 4314], 'surface,': [80, 321, 2044], 'DNA': [81, 152, 322, 393, 1291, 2045, 2454, 3427, 3817, 3836, 4020, 4036, 4075, 4098, 4315, 4350, 4374, 4378, 4406, 4409, 4428, 4449], 'fragmentation,': [82, 323, 1292, 2046], 'activation': [84, 325, 1149, 1294, 2048, 2067], 'caspases': [86, 327, 1297, 2050], '(3': [87, 328], '8': [89, 330, 2164], 'not': [91, 206, 332, 447, 3676, 3847, 4017, 4161, 4305, 4479], '9),': [92, 333], 'typical': [93, 334], 'features': [94, 335, 1282], 'apoptosis.': [96, 140, 240, 337, 381, 481, 1416], 'These': [97, 338, 3997, 4488], 'results': [98, 228, 339, 469, 1710, 3748, 3783, 3998, 4027, 4056, 4294, 4489], 'further': [100, 341], 'supported': [101, 342], 'by': [102, 112, 128, 343, 353, 369, 1277, 1384, 1498, 1553, 1789, 2375, 2408, 2608, 2788, 2795, 2877, 3592, 3658, 3827, 3965, 4141, 4317, 4344, 4504], 'potentiation': [104, 345], 'inhibitory': [108, 349, 4255, 4337], 'effects': [109, 350, 3461, 4105], 'chemical': [113, 354], 'inhibitors': [114, 355, 1896], '(curcumin': [117, 358], 'sodium': [119, 360, 2093, 2596, 2920], 'salicylate)': [120, 361], 'protective': [123, 364], 'role': [124, 232, 365, 473, 1999, 3532], 'RelA': [126, 147, 367, 388, 1958, 2023, 2140, 3904], 'evidenced': [127, 368], 'resistance': [130, 371], 'A431-RelA': [132, 170, 221, 373, 411, 462], '(stably': [134, 375], 'RelA)': [137, 159, 378, 400], 'treatment': [142, 189, 383, 430, 4168], 'or': [143, 384, 817, 1268, 1517, 2022, 2365, 2370, 2993, 3086, 3185, 3311, 3354, 3552, 3905], 'ectopic': [144, 385, 1954], 'expression': [145, 162, 386, 403, 711, 813, 1883, 1955, 3679, 3722], 'induced': [151, 392, 4469, 4503], 'binding': [153, 394, 566, 576, 2827, 3818, 3837, 3937, 4021, 4037, 4076], 'activity': [154, 395, 1777, 3819, 3838, 4022, 4038], '(p50': [157, 398], 'c-IAP1,': [164, 405], 'downstream': [166, 178, 407, 419], 'target': [167, 179, 408, 420], 'NF-κB.': [169, 410], 'exhibited': [172, 413], 'spontaneous': [173, 414], 'phosphorylation': [174, 197, 214, 415, 438, 455, 1712], 'Akt': [176, 196, 216, 417, 437, 457, 2182], '(a': [177, 418], 'phosphatidylinositol': [181, 203, 422, 444, 543], '3-kinase': [182, 423], 'regulator': [184, 425], 'NF-κB)': [186, 427, 2021], 'stimulated': [190, 431, 3894], 'further.': [192, 433], 'Blocking': [193, 434], 'this': [194, 435], 'basal': [195, 436], 'LY294002,': [199, 440], 'inhibitor': [201, 442, 510, 538], '3-kinase,': [204, 445], 'did': [205, 446, 3675, 4478], 'affect': [207, 448], 'their': [208, 449], 'blocking': [211, 452], 'sensitized': [217, 458, 1846], 'otherwise': [219, 460], 'resistant': [220, 461], 'EGF-mediated': [224, 465], 'inhibition.': [226, 467], 'Our': [227, 468], 'favor': [229, 470], 'anti-apoptotic': [231, 472, 1501], 'regulation': [237, 478], '1The': [486], 'abbreviations': [487], 'used': [488, 2004, 2650, 2791, 3453, 3539, 3639, 3742, 3964, 4391], 'are:': [489], 'EGF,': [490, 567, 1560], 'epidermal': [491, 498, 618], 'factor;': [493, 536], 'ECL,': [494], 'enhanced': [495, 1073, 2629, 3833], 'chemiluminescence;': [496], 'EGFR,': [497, 3769], 'receptor;': [501], 'EMSA,': [502], 'electrophoretic': [503], 'mobility': [504], 'shift': [505], 'assay;': [506], 'HA,': [507], 'hemagglutinin;': [508], 'IκB,': [509], 'κB;': [511, 521], 'IKK,': [512], 'IκB': [513, 1674, 2017, 3647], 'kinase;': [514], 'MTT,': [515], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [516], 'bromide;': [517], 'nuclear': [519, 1678, 2743, 2778, 3888], 'PARP,': [522], 'poly-(ADP-ribose)': [523], 'polymerase;': [524], 'PBS,': [525, 3036], 'phosphate-buffered': [526], 'saline;': [527], 'PI,': [528], 'propidium': [529, 3108], 'iodide;': [530], 'PS,': [531], 'phosphatidylserine;': [532], 'TNF,': [533], 'tumor': [534, 1377, 1892], 'necrosis': [535, 1378], 'IAP,': [537], 'protein;': [541], 'PI-3K,': [542], '3-kinase;': [544], 'AFC,': [545], '7-amino-4-trifluromethyl': [546], 'coumarin;': [547], 'DTT,': [548, 2582, 2697, 2762, 2842], 'dithiothreitol;': [549], 'CHAPS,': [550, 3376], '3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic': [551], 'acid.': [552, 3045], 'polypeptide': [555], '(6-kDa)': [556], 'belongs': [558], 'family': [562, 874, 1548], 'ligands': [564], '(heparin': [565], 'transforming': [568], 'factor-α,': [570], 'amphiregulin,': [571], 'β-cellulin,': [572], 'epiregulin,': [573], 'neuregulins)': [575], 'specific': [578], 'surface': [580], 'receptors': [581], '(1Grant': [582, 642], 'S.': [583, 643, 752, 828, 1032, 1047, 1059, 1084, 1096, 1611, 1649, 1918, 2323], 'Qiao': [584, 644], 'L.': [585, 645, 1301, 1660, 1906], 'Dent': [586, 646], 'P.': [587, 647, 750], 'Front.': [588, 648], 'Biosci.': [589, 649], '2002;': [590, 650, 1337, 1457, 1537, 1582, 1753], '7:': [591, 651, 1141, 3492], '376-389Crossref': [592, 652], 'PubMed': [593, 611, 653, 669, 703, 734, 771, 802, 842, 893, 958, 991, 1039, 1064, 1101, 1143, 1185, 1216, 1251, 1310, 1340, 1368, 1460, 1488, 1540, 1585, 1631, 1654, 1667, 1696, 1756, 1769, 1803, 1823, 1839, 1923, 1943, 1988, 2309, 2338, 3175, 3333, 3475, 3511, 3524, 3618, 3992], 'Scopus': [594, 654, 670, 704, 735, 772, 803, 843, 894, 992, 1040, 1065, 1102, 1144, 1217, 1252, 1311, 1341, 1369, 1461, 1489, 1541, 1586, 1632, 1655, 1668, 1697, 1757, 1770, 1804, 1824, 1840, 1924, 1989, 2310, 3176, 3334, 3476, 3512, 3525, 3619, 3993], '(171)': [595, 655], 'Google': [596, 612, 656, 672, 706, 737, 774, 805, 845, 896, 935, 959, 994, 1042, 1067, 1104, 1146, 1186, 1219, 1233, 1254, 1313, 1343, 1371, 1463, 1491, 1543, 1588, 1634, 1657, 1670, 1699, 1759, 1772, 1806, 1826, 1842, 1877, 1926, 1944, 1991, 2312, 2339, 3178, 3336, 3478, 3494, 3514, 3527, 3621, 3995], 'Scholar,': [597, 657, 738, 1043, 1187, 1220, 1234, 1344, 1464, 1635, 1658, 1760, 1807, 1827, 1927, 2313, 3479, 3495, 3515], '2Yarden': [598], 'Y.': [599, 953, 1180, 1574, 1745, 3324, 3326], 'Eur.': [600], 'J.': [601, 659, 766, 796, 980, 1205, 1228, 1350, 1357, 1470, 1477, 1868, 1977, 2298, 2321, 3469, 3497, 3981], 'Cancer.': [602, 767, 1336, 1456, 1536, 1581, 1752], '2001;': [603, 839, 1874], '37:': [604], 'S3-S8Abstract': [605], 'Full': [606, 608, 664, 666, 986, 988, 1211, 1213, 1363, 1365, 1483, 1485, 1983, 1985, 2304, 2306, 3987, 3989], 'Text': [607, 609, 665, 667, 987, 989, 1212, 1214, 1364, 1366, 1484, 1486, 1984, 1986, 2305, 2307, 3988, 3990], 'PDF': [610, 668, 990, 1215, 1367, 1487, 1987, 2308, 3991], 'Scholar).': [613, 673, 707, 775, 806, 846, 897, 936, 995, 1105, 1147, 1314, 1372, 1492, 1544, 1589, 1671, 1700, 1773, 1843, 1878, 1945, 1992, 2396, 3179, 3337, 3528, 3622, 3996], 'Upon': [614], 'ligand': [615, 848, 1388], 'binding,': [616], '(EGFR)': [622], 'dimerizes,': [623], 'autophosphorylates': [624], 'itself,': [625], 'recruits': [627, 1395], 'cascade': [629], 'signaling': [631], 'molecules': [632], 'before': [633], 'transmitting': [634], 'potent': [635, 780], 'mitogenic': [636], 'signals': [637, 1680], 'many': [639], 'cellular': [640], 'systems': [641], '3Schlessinger': [658], 'Cell.': [660, 1246, 1938, 2333], '2000;': [661, 932, 1140, 1307, 1651, 1980, 2301, 3984], '103:': [662], '211-225Abstract': [663], '(3538)': [671], 'EGFR': [674, 710, 790, 812, 873, 1151, 2009, 2199, 2209, 3786], 'overexpressed': [676], 'number': [679, 1556, 2122, 2128, 4462], 'malignancies': [682], 'including': [683, 1559], 'cancers': [684, 724], 'lung,': [687], 'head': [688], 'neck,': [690], 'brain,': [691], 'bladder,': [692], 'breast': [694, 721, 1783], '(4Gullick': [695], 'W.J.': [696], 'Br.': [697, 765], 'Med.': [698], 'Bull.': [699], '1991;': [700], '47:': [701], '87-98Crossref': [702], '(452)': [705], 'Furthermore,': [708], 'correlates': [712], 'poorer': [715], 'clinical': [716], 'outcome': [717], 'patients': [719], 'ovarian': [723], '(5Harris': [725], 'A.L.': [726, 1191], 'Breast': [727], 'Cancer': [728, 1872], 'Res.': [729, 1626, 1873, 3171, 3506], 'Treat.': [730], '1994;': [731], '29:': [732], '1-2Crossref': [733], '(21)': [736], '6Bartlett': [739], 'J.M.': [740, 876], 'Langdon': [741], 'S.P.': [742], 'Simpson': [743], 'B.J.': [744], 'Stewart': [745], 'M.': [746, 947, 1126, 1174, 1238, 1348, 1468, 1572, 1621, 1743, 1862, 1929], 'Katsaros': [747], 'D.': [748, 1798, 1976, 2297, 3980], 'Sismondi': [749], 'Love': [751], 'Scott': [753], 'W.N.': [754], 'Williams': [755], 'A.R.': [756], 'Lessells': [757], 'A.M.': [758, 880], 'Macleod': [759], 'K.G.': [760], 'Smyth': [761], 'J.F.': [762], 'Miller': [763], 'W.R.': [764], '1996;': [768, 1628, 1800, 1820, 1836, 3491, 3615], '73:': [769], '301-306Crossref': [770], '(184)': [773], 'Whereas': [776, 3829], 'such': [791, 1001, 1503, 1562, 1894, 2034], 'as': [792, 856, 1002, 1168, 1504, 1563, 1895, 2035, 2246, 2633, 2661, 2961, 2972, 3111, 3159, 3454, 3729, 3731, 3743, 4197], '(7Barnes': [794, 3467], 'D.W.': [795, 1912, 3468], 'Cell': [797, 1137, 2190, 2222, 2238, 3170, 3470, 3488], 'Biol.': [798, 981, 1206, 1247, 1358, 1478, 1939, 1978, 2299, 2334, 3471, 3982], '1982;': [799, 3472], '93:': [800, 3473], '1-4Crossref': [801, 3474], '(235)': [804, 3477], 'Experimentally': [807], 'increasing': [808], 'level': [810, 3719, 3767], 'epithelial,': [815], 'mesenchymal,': [816], 'glial': [818], 'also': [820, 901, 1011, 3945, 4028, 4296, 4308], 'leads': [821, 968, 1724], 'ligand-dependent': [823], '(8Hognason': [825], 'T.': [826, 830, 1026, 1617, 1814, 3320, 3609], 'Chatterjee': [827], 'Vartanian': [829], 'Ratan': [831], 'R.R.': [832, 3166], 'Ernewein': [833], 'K.M.': [834], 'Habib': [835], 'A.A.': [836, 1796], 'FEBS': [837], 'Lett.': [838], '491:': [840], '9-15Crossref': [841], '(36)': [844], 'Another': [847], 'family,': [852], 'heregulin': [853], '(also': [854], 'neuregulin),': [857], 'induce': [861, 1382, 3848, 4033], 'ErbB2,': [867], 'second': [869], 'member': [870], '(9Daly': [875], 'Olayioye': [877], 'M.A.': [878], 'Wong': [879], 'Neve': [881], 'R.': [882, 975, 1860, 1933, 2327, 3501], 'Lane': [883], 'H.A.': [884], 'Maurer': [885], 'F.G.': [886], 'Hynes': [887], 'N.E.': [888, 1198], 'Oncogene.': [889, 1663, 1692, 1765], '1999;': [890, 983, 1036, 1208, 1230, 1360, 1480, 1693, 1766, 3330], '18:': [891, 1694, 1767], '3440-3451Crossref': [892], '(85)': [895], 'In': [898, 1417, 4053, 4207], 'addition,': [899, 1071, 4054], 'epiregulin': [900], 'inhibited': [902, 4210, 4273, 4349], 'EGFR-overexpressing': [906, 1605], '(10Xi': [908], 'Q.S.': [909], 'Pan': [910], 'W.': [911], 'Zhang': [912], 'Q.': [913], 'Qian': [914], 'X.G.': [915], 'Li': [916, 928, 1048, 1085, 1577, 1748], 'Z.P.': [917], 'Gan': [918], 'R.B.': [919], 'Sheng': [920, 925], 'Wu': [921, 926, 927], 'Hua': [922], 'Xue': [923, 929], 'Yu': [924], 'Bao': [930], '(Shanghai).': [931], '32:': [933], '601-604PubMed': [934], 'Induction': [937], 'amphiregulin': [939], 'mRNA': [940], 'was': [941, 2210, 2231, 2427, 2490, 2513, 2729, 2737, 2790, 2859, 2895, 2927, 2970, 3008, 3018, 3030, 3048, 3066, 3155, 3343, 3392, 3638, 3741, 3772, 3802, 3807, 3910, 3963, 4136, 4195, 4254], 'observed': [942, 3292], '(11Silvy': [946, 1173], 'Martin': [948, 1175, 1811, 3606], 'P.M.': [949, 1176], 'Chajry': [950, 1177], 'N.': [951, 1130, 1178, 1613], 'Berthois': [952, 1179], 'Endocrinology.': [954, 1181], '1998;': [955, 1182, 1664], '139:': [956, 1183], '2382-2391Crossref': [957, 1184], 'Scholar)': [960, 1068, 1255, 2340], 'interaction': [962, 1385], 'pro-heparin-binding': [966], 'inhibition': [971, 1845, 4372], '(12Iwamoto': [974], 'Handa': [976], 'K.': [977, 1240, 1864, 2319, 2329, 2382, 2384], 'Mekada': [978], 'E.': [979, 1641], 'Chem.': [982, 1207, 1359, 1479, 1979, 2300, 3983], '274:': [984, 1209, 1361, 1481, 1801, 1821, 1837, 3616], '25906-25912Abstract': [985], '(92)': [993], 'Growth': [996, 3489], 'factors': [997, 1551], 'other': [998, 4300], 'than': [999, 4465], 'platelet-derived': [1003, 1078], 'hepatocyte': [1007], 'can': [1010, 4032, 4239], 'trigger': [1012], 'cycle': [1014], 'arrest': [1015], 'death': [1017, 1271, 1391, 1398, 1401, 4157, 4502], 'variety': [1020], '(13Conner': [1023], 'E.A.': [1024], 'Teramoto': [1025], 'Wirth': [1027], 'P.J.': [1028, 1866], 'Kiss': [1029], 'A.': [1030, 1060, 1097, 1132, 1299, 1650, 1919, 3318, 3322], 'Garfield': [1031], 'Thorgeirsson': [1033], 'S.S.': [1034], 'Carcinogenesis.': [1035], '20:': [1037], '583-590Crossref': [1038], '(41)': [1041], '14Kim': [1044], 'H.R.': [1045, 1082, 1936], 'Upadhyay': [1046, 1083], 'G.': [1049, 1086, 1662], 'Palmer': [1050, 1087, 3482], 'K.C.': [1051, 1088, 3483], 'Deuel': [1052, 1089], 'T.F.': [1053, 1090], 'Proc.': [1054, 1091, 1644, 1913], 'Natl.': [1055, 1092, 1645, 1914], 'Acad.': [1056, 1093, 1646, 1915], 'Sci.': [1057, 1094, 1647, 1916], 'U.': [1058, 1095, 1648, 1917, 2331], '1995;': [1061, 1098], '92:': [1062, 1099], '9500-9504Crossref': [1063, 1100], '(58)': [1066, 1103], 'apoptotic': [1075, 1898, 3141], 'effect': [1076, 4086, 4177, 4311], '(14Kim': [1081], 'An': [1106], 'EGF-related': [1107], 'protein,': [1108], 'Cripto-1,': [1109], 'promotes': [1110], 'HC-11': [1113], 'mouse': [1114, 2077, 2106, 2197], 'mammary': [1115], 'epithelial': [1116], '(15De': [1118], 'Santis': [1119], 'M.L.': [1120], 'Martinez-Lacaci': [1121], 'I.': [1122], 'Bianco': [1123], 'C.': [1124, 1134, 1691, 1764], 'Seno': [1125], 'Wallace-Jones': [1127], 'B.': [1128, 1689, 1762], 'Kim': [1129], 'Ebert': [1131], 'Wechselberger': [1133], 'Salomon': [1135], 'D.S.': [1136], 'Death': [1138], 'Differ.': [1139, 3490], '189-196Crossref': [1142], '(11)': [1145], 'Anoikis,': [1148], 'tyrosine': [1152], 'kinase,': [1153], 'Ras-MAP': [1154], 'kinase': [1155], 'signaling,': [1156], 'elevation': [1159], 'Stat1': [1161], 'p21': [1163], 'levels': [1164, 3787], 'have': [1165, 1327, 1950, 4390], 'been': [1166, 1328, 1592, 3451], 'advocated': [1167], 'mechanisms': [1169], 'driving': [1170], '16Kottke': [1188], 'T.J.': [1189], 'Blajeski': [1190], 'Martins': [1192], 'L.M.': [1193], 'Mesner': [1194], 'Jr.,': [1195, 1833, 1857, 1870, 1935], 'P.W.': [1196], 'Davidson': [1197], 'Earnshaw': [1199], 'W.C.': [1200], 'Armstrong': [1201], 'D.K.': [1202, 1637], 'Kaufmann': [1203], 'S.H.': [1204], '15927-15936Abstract': [1210], '(80)': [1218], '17Reddy': [1221], 'K.B.': [1222, 3487], 'Keshamouni': [1223], 'V.G.': [1224], 'Chen': [1225, 3484], 'Y.Q.': [1226, 3485], 'Int.': [1227], 'Oncol.': [1229], '15:': [1231], '301-306PubMed': [1232], '18Chin': [1235], 'Y.E.': [1236], 'Kitagawa': [1237], 'Kuida': [1239], 'Flavell': [1241], 'R.A.': [1242], 'Fu': [1243], 'X.Y.': [1244], 'Mol.': [1245, 1937, 2332], '1997;': [1248, 1920, 1940], '17:': [1249, 1941], '5328-5337Crossref': [1250], '(469)': [1253], 'but,': [1256], 'actual': [1258], 'mechanism': [1259], 'appears': [1260], 'be': [1262, 3590, 4240, 4336], 'elusive': [1264], 'complicated.': [1266], 'Apoptosis': [1267], 'programmed': [1269], 'physiological': [1274], 'process': [1275], 'characterized': [1276], 'distinct': [1278], 'morphological': [1279], 'biochemical': [1281], 'include': [1284], 'membrane': [1285], 'blebbing,': [1286], 'chromatin': [1287], 'condensation,': [1288], 'cytoplasmic': [1289], 'shrinking,': [1290], 'different': [1296, 1317, 4328], '(19Strasser': [1298], "O'Connor": [1300], 'Dixit': [1302], 'V.M.': [1303], 'Annu.': [1304], 'Rev.': [1305, 1335, 1455, 1535, 1580, 1751], 'Biochem.': [1306, 1624, 3504], '69:': [1308], '217-245Crossref': [1309], '(1383)': [1312], 'Typically': [1315], 'two': [1316], 'pathways,': [1318], 'extrinsic': [1319], 'receptor-mediated': [1320], 'intrinsic': [1322], 'mitochondria-mediated,': [1323], 'leading': [1324, 1414], 'identified': [1329], '(20Igney': [1330, 1450, 1530], 'F.H.': [1331, 1451, 1531], 'Krammer': [1332, 1452, 1532], 'P.H.': [1333, 1453, 1533], 'Nat.': [1334, 1454, 1534, 1579, 1750], '2:': [1338, 1458, 1538, 1583, 1754], '277-288Crossref': [1339, 1459, 1539], '(1649)': [1342, 1462, 1542], '21Sun': [1345, 1465], 'X.M.': [1346, 1466], 'MacFarlane': [1347, 1467], 'Zhuang': [1349, 1469], 'Wolf': [1351, 1471], 'B.B.': [1352, 1472], 'Green': [1353, 1473, 1815, 3610], 'D.R.': [1354, 1474, 1816, 3611], 'Cohen': [1355, 1475], 'G.M.': [1356, 1476], '5053-5060Abstract': [1362, 1482], '(780)': [1370, 1490], 'Mostly': [1373], 'cytokines': [1374], '(TNF)': [1380], 'superfamily': [1381], 'receptor,': [1392], 'which': [1393, 2722, 3559], 'sequentially': [1394], 'TNF': [1396], 'receptor-associated': [1397], 'domain,': [1399, 1402], 'Fas-associated': [1400], 'caspase': [1403, 1406, 1438, 1445, 2119, 2125, 2163, 3309, 3312, 3351, 3355], '8,': [1404], '3,': [1407, 1446], 'last': [1409], 'then': [1410, 1443, 2510, 3031, 3262, 3908], 'cleaves': [1411], 'various': [1412, 4123], 'substrates': [1413, 2117, 3349], 'contrast,': [1418, 4208], 'mitochondria-mediated': [1420], 'pathway': [1421, 2174], 'involves': [1422], 'release': [1424], 'cytochrome': [1426, 1432], 'c': [1427, 1433], 'from': [1428, 1947, 1968, 2075, 2090, 2114, 2132, 2152, 2189, 2213, 2233, 2472, 2647, 2809, 3125, 3891], 'mitochondria,': [1430], 'together': [1434], 'Apaf1': [1436], 'activates': [1437, 1444], '9,': [1439], 'latter': [1442], 'resulting': [1447], 'Tumor': [1493], 'often': [1495], 'evade': [1496], 'expressing': [1499], 'several': [1500, 1604, 2029], 'proteins': [1502, 1885, 1899, 3039], 'Bcl-2,': [1505], 'down-regulation': [1506], 'mutation': [1508], 'pro-apoptotic': [1510], 'genes': [1511], 'alterations': [1513], 'p53,': [1515], 'PI-3K/Akt,': [1516], 'pathways': [1519], 'give': [1521], 'them': [1522, 1967, 2013, 3545], 'survival': [1523, 1890], 'advantage': [1524], 'thereby': [1526], 'resist': [1527], 'therapy-induced': [1528], 'transcription': [1550, 1741], 'activated': [1552], 'diverse': [1555, 1706], 'stimuli': [1558, 1709], 'cytokines,': [1561], 'TNF-α': [1564], 'interleukin-1,': [1566], 'UV': [1567], 'irradiation,': [1568], 'lipopolysaccharides': [1570], '(22Karin': [1571, 1742], 'Cao': [1573, 1744], 'Greten': [1575, 1746], 'F.R.': [1576, 1747], 'Z.W.': [1578, 1749], '301-310Crossref': [1584, 1755], '(2258)': [1587, 1758], 'has': [1591, 3450, 4079], 'reported': [1593], 'activate': [1595, 1740, 2026, 3970], 'smooth': [1598], 'muscle': [1599], 'cells,': [1600, 3841, 4271], 'fibroblasts,': [1601], 'lines': [1607, 1788], '(23Obata': [1608], 'H.': [1609, 1615, 1619, 1623], 'Biro': [1610], 'Arima': [1612], 'Kaieda': [1614], 'Kihara': [1616], 'Eto': [1618], 'Miyata': [1620], 'Tanaka': [1622], 'Biophys.': [1625, 3328, 3505], 'Commun.': [1627, 3507], '224:': [1629], '27-32Crossref': [1630], '(78)': [1633], '24Biswas': [1636], 'Cruz': [1638, 2154, 3127], 'A.P.': [1639], 'Gansberger': [1640], 'Pardee': [1642], 'A.B.': [1643], '97:': [1652], '8542-8547Crossref': [1653], '(317)': [1656], '25Sun': [1659], 'Carpenter': [1661], '16:': [1665], '2095-2102Crossref': [1666], '(113)': [1669], 'Binding': [1672, 3428], 'masks': [1677], 'localization': [1679], 'prevents': [1682], 'translocation': [1684], 'nucleus': [1687, 1738], '(26Rayet': [1688], 'Gelinas': [1690, 1763], '6938-6947Crossref': [1695, 1768], '(1009)': [1698, 1771], 'Stimulation': [1701], 'array': [1707], 'serines': [1716, 3562], '32': [1717], '36': [1719], 'at': [1720, 2266, 2479, 2852, 2941, 2947, 3001, 3198, 3224, 3256, 3269, 3383, 3566, 4169, 4199, 4246, 4264], 'NH2-terminal.': [1722], 'This': [1723], 'ubiquitination': [1727], 'degradation': [1729], 'IκB-α,': [1731], 'allowing': [1732], 'translocate': [1735], '26Rayet': [1761], 'Inhibition': [1774], 'potentiates': [1778], 'killing': [1780, 1855], 'cancer': [1784], 'fibrosarcoma': [1786, 1964], 'TNF-α,': [1790], 'ionizing': [1791], 'radiation,': [1792], 'daunorubicin': [1794], '(27Beg': [1795], 'Baltimore': [1797], 'Science.': [1799, 1819, 1835, 3614], '782-784Crossref': [1802], '(2935)': [1805], '28Van': [1808], 'Antwerp': [1809, 3604], 'D.J.': [1810, 3605], 'S.J.': [1812, 3607], 'Kafri': [1813, 3608], 'Verma': [1817, 3612], 'I.M.': [1818, 3613], '787-789Crossref': [1822, 3617], '(2449)': [1825, 3620], '29Wang': [1828], 'C.Y.': [1829], 'Mayo': [1830], 'M.W.': [1831], 'Baldwin': [1832, 1869], 'A.S.': [1834, 1871], '784-787Crossref': [1838], '(2512)': [1841], 'tumors': [1847], 'mice': [1849], 'chemotherapeutic': [1851], 'compound': [1852], 'CPT-11-mediated': [1853], '(30Cusack': [1856], 'J.C.': [1858], 'Liu': [1859, 1905], 'Houston': [1861], 'Abendroth': [1863], 'Elliott': [1865], 'Adams': [1867], '61:': [1875], '3535-3540PubMed': [1876], 'directly': [1880], 'causes': [1881], 'contribute': [1887], '(IAPs)': [1900], '(31Chu': [1901], 'Z.L.': [1902], 'McKinsey': [1903], 'T.A.': [1904], 'Gentry': [1907], 'J.J.': [1908], 'Malim': [1909], 'M.H.': [1910], 'Ballard': [1911], '94:': [1921], '10057-10062Crossref': [1922], '(825)': [1925], '32You': [1928], 'Ku': [1930], 'P.T.': [1931], 'Hrdlickova': [1932], 'Bose': [1934], '7328-7341Crossref': [1942], 'Results': [1946], 'our': [1948], 'laboratory': [1949], 'shown': [1951, 3914], 'earlier': [1952, 3967], 'subunit': [1959], 'into': [1962, 2429], 'murine': [1963], 'protects': [1966], 'curcumin-induced': [1969], '(33Anto': [1971, 2292, 3975], 'R.J.': [1972, 2293, 3976], 'Maliekal': [1973, 2294, 3977], 'T.T.': [1974, 2295, 3978], 'Karunagaran': [1975, 2296, 3979], '275:': [1981, 2302, 3985], '15601-15604Abstract': [1982, 2303, 3986], '(66)': [1990, 2311, 3994], 'understand': [1994], 'whether': [1995, 3762, 3811, 3875], 'plays': [1997], 'any': [1998], 'apoptosis,': [2002, 3537], 'we': [2003, 2051, 3538, 4389], '(known': [2018, 2024], 'NF-κB).': [2027], 'Using': [2028], 'parameters': [2030], 'assess': [2032], 'viability,': [2036], '(PS)': [2040], 'report': [2052], 'are': [2056, 3571, 4285, 4459, 4497], 'under': [2062, 3293, 4111], 'conditions': [2064, 4112], 'whereas': [2065, 3666, 3926], 'confers': [2068], 'resistance.': [2069], 'Reagents,': [2070], 'Chemicals,': [2071], 'Antibodies—EGF': [2073], '(isolated': [2074], 'male': [2076], 'submaxillary': [2078], 'glands),': [2079], "Dulbecco's": [2080, 2250, 2467], 'minimum': [2081, 2468], 'essential': [2082, 2469], 'medium,': [2083], 'fetal': [2085, 2257, 2517, 2525], 'bovine': [2086, 2258, 2518, 2526], 'serum': [2087, 2259, 2473, 2519, 2527], 'procured': [2089, 2151], 'Invitrogen.': [2091], 'Curcumin,': [2092], 'salicylate,': [2094], 'MTT': [2095, 2882, 2884, 2889, 2932, 4142, 4145, 4346], '(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [2096], 'bromide),': [2097], 'nitro': [2098, 2657], 'blue': [2099, 2658], 'tetrazolium/5-bromo-4-chloro-3-indolyl': [2100, 2659], 'phosphate': [2101, 2660], 'substrate': [2102], 'mixture,': [2103], 'monoclonal': [2107, 2160, 2198], 'antibody': [2108, 2161, 2169, 2200, 3710], 'β-actin': [2110, 3740], '(A-5441)': [2111], 'purchased': [2113, 2188], 'Sigma.': [2115], 'Fluorimetric': [2116], '3': [2120, 3301, 3310, 3352], '(Ac-DEVD-AFC': [2121], '264157)': [2123], '9': [2126, 3304, 3313, 3356], '(Ac-LEHD-AFC': [2127], '218765)': [2129], 'obtained': [2131, 2232], 'Calbiochem.': [2133], 'Rabbit': [2134], 'polyclonal': [2135, 2167, 3708], 'antibodies': [2136, 2180, 2619, 2646, 3902, 3919], 'p50': [2138, 3884, 3906, 4050], '(sc-7178),': [2139], '(sc-109),': [2141], 'hemagglutinin': [2142, 3629], '(HA)': [2143], '(sc-7392),': [2144], '(sc-271),': [2146], 'c-IAP1': [2148], '(sc-7943)': [2149], 'Santa': [2153, 3126], 'Biotechnology': [2155], '(Santa': [2156], 'Cruz,': [2157], 'CA).': [2158], 'Mouse': [2159], '(1C12),': [2165], 'rabbit': [2166], 'PARP': [2168], '(number': [2170, 2177], '9542),': [2171], 'phospho-Akt': [2173], 'sampler': [2175], 'kit': [2176, 2345, 3122], '9916': [2178], 'containing': [2179, 3934], 'phospho-Akt,': [2184], 'LY294002)': [2186], 'Signaling': [2191], 'Technology': [2192], '(Beverly,': [2193], 'MA),': [2194], '(clone': [2201, 3825], '111)': [2202], 'raised': [2203], 'against': [2204], 'extracellular': [2206], 'domain': [2207], 'gift': [2212], 'Dr.': [2214], 'Yosef': [2215], 'Yarden,': [2216], 'Weizmann': [2217], 'Institute': [2218], 'Science,': [2220, 2239], 'Israel.': [2221], 'Lines': [2223], 'Culture—Human': [2225], 'line': [2229], 'National': [2235], 'Center': [2236], 'Pune,': [2240], 'India.': [2241], 'The': [2242, 2485, 2712, 2777, 2867, 2964, 3027, 3046, 3259, 3272, 3389, 4026, 4144], 'grown': [2245, 2536, 2986], 'monolayer': [2247], 'cultures': [2248], 'modified': [2251], "Eagle's": [2252], 'medium': [2253, 2470, 2499, 2512, 2539, 3029], 'supplemented': [2254], '10%': [2256, 2524, 2726, 3251, 3373], 'antibiotics': [2261], '(Invitrogen).': [2262], 'Cells': [2263, 2906, 4090, 4425, 4513], 'incubated': [2265, 2478, 2908, 3344, 3900], '37': [2267, 2853, 2942, 3199, 3384], '°C': [2268, 2854, 3200, 3385], 'humidified': [2271], 'atmosphere': [2272], '5%': [2274, 2847, 3043], 'CO2': [2275, 2507], '95%': [2277], 'air.': [2278], 'Transient': [2279], 'Stable': [2281, 2352], 'Transfections—A431-IκB-α': [2282], 'transiently': [2285], 'relA': [2288, 2358, 3954, 3961], 'pMT2T': [2290, 2360], 'vector': [2291, 2361, 2368, 3550, 3673], '34Bours': [2314], 'V.': [2315, 3271], 'Burd': [2316], 'P.R.': [2317], 'Brown': [2318], 'Villalobos': [2320], 'Park': [2322], 'Ryseck': [2324], 'R.P.': [2325], 'Bravo': [2326], 'Kelly': [2328], 'Siebenlist': [2330], '1992;': [2335], '12:': [2336], '685-695Crossref': [2337], 'using': [2341, 2656, 2861, 2952, 3068, 3145, 3394, 3689], 'calcium-phosphate': [2343], 'transfection': [2344, 3763, 3801, 3949, 3962], '(Invitrogen)': [2346], 'according': [2347], "manufacturer's": [2350, 2636], 'protocol.': [2351], 'transfections': [2353], '(co-transfected': [2362], 'pcDNA3)': [2364], 'empty': [2367, 3549], 'pcDNA3': [2369], 'pcDNA3-IκB-α': [2371], 'carried': [2373, 3156, 3773, 3911], 'out': [2374, 3157, 3774], 'LipofectAMINE': [2377], 'method': [2378, 2632, 4319], '(35Taylor': [2379], 'N.A.': [2380], 'Docherty': [2381, 2383], 'Gene': [2385], 'Transcription:': [2386], 'RNA': [2387], 'Analysis.': [2388], 'John': [2389], 'Wiley': [2390], '&': [2391], 'Sons': [2392], 'Ltd.,': [2393], 'London1996:': [2394], '96-97Google': [2395], 'For': [2397, 2434, 2448, 2640, 3736], 'preparation': [2399], 'liposome': [2401, 2459, 2486], 'solution,': [2402], '20': [2403, 3265], 'μmol/ml': [2404], 'stock': [2406], '(prepared': [2407], 'mixing': [2409], '6.6': [2410], 'μmol': [2411, 2419], 'dimethyl': [2413, 2925], 'dioctadecyl': [2414], 'ammonium': [2415], 'bromide': [2416, 3288, 4433], '13.4': [2418], 'dioleyl-l-phosphatidylethanolamine': [2421], '1': [2423, 2430, 2580, 2695, 2754, 2757, 2760, 2763, 2822, 3254, 3387, 4250], 'ml': [2424, 2914], 'ethanol)': [2426], 'diluted': [2428], 'nmol/μl': [2431], 'water.': [2433], 'transfection,': [2435], 'seeded': [2439, 3079], 'attain': [2441], '70%': [2442], 'confluence': [2443], '35-mm': [2445], 'Petri': [2446], 'dishes.': [2447], 'each': [2449, 2604, 3011], 'dish,': [2450], '2': [2451, 2573, 2702, 2705, 2767, 2770, 2910, 3377, 3380, 3445, 4299], 'μg': [2452, 2781], '24': [2456, 2529, 3025], 'μl': [2457, 2465, 2677, 2724, 2741, 2887, 3364], 'solution': [2460, 2487, 2890, 3235], 'mixed': [2462], '500': [2464, 3363], 'free': [2471], 'antibiotics,': [2475], 'vortexed,': [2476, 2731], 'room': [2480], 'temperature': [2481], '30': [2483, 2719, 2786, 2850, 3267], 'min.': [2484], '(1': [2488, 3289], 'ml)': [2489], 'layered': [2491, 3202], 'over': [2492, 4133], 'previously': [2495, 3208], 'rinsed': [2496], 'serum-free': [2498], 'left': [2501], '4': [2503, 2594, 3225, 3257], 'h': [2504, 2911, 3255, 4140, 4204], 'incubator': [2508], 'replenished': [2514], '20%': [2516], 'reverted': [2521], 'back': [2522], 'after': [2528, 2721, 2785, 2929, 3051, 3274, 4138, 4323], 'h.': [2530, 3026, 3091, 3388], 'After': [2531, 2937, 3129, 3227], '72': [2532, 4139, 4203], 'h,': [2533, 3006], 'selection': [2538], '(400': [2540], 'μg/ml': [2541, 2554, 2584, 2587, 2703, 2706, 2768, 2771, 2823], 'G418)': [2542, 3659], 'clones': [2544, 3653, 4301], 'formed': [2545, 4457], 'picked': [2547], 'up': [2548], 'maintained': [2550], 'separately': [2551], '100': [2553, 3239, 3843], 'G418.': [2555], 'Western': [2556, 3633, 3704, 3738, 3770], 'Blotting—Cells': [2557], 'lysed': [2559], 'whole': [2561, 3340], 'lysis': [2563, 2679], 'buffer': [2564, 2680, 2745, 2828, 2918, 2960, 3367], '(20': [2565, 2746], 'mm': [2566, 2571, 2574, 2581, 2590, 2595, 2682, 2687, 2690, 2693, 2696, 2699, 2747, 2755, 2758, 2761, 2764, 2830, 2835, 2838, 2841, 3240, 3243, 3369, 3378, 3381], 'Tris,': [2567, 3244], 'pH': [2568, 2749, 3245, 3371], '7.4,': [2569], '250': [2570], 'NaCl,': [2572, 2753, 2836, 3238], 'EDTA,': [2575, 2691, 2756, 2839, 3241, 3379], '0.1%': [2576, 3375], 'Triton': [2577, 3248], 'X': [2578], '100,': [2579], '5': [2583, 2586, 3222, 4471], 'aprotinin,': [2585, 2707, 2772], 'leupeptin,': [2588, 2704, 2769], '0.5': [2589, 2698, 2709, 2774, 2837, 2840], 'phenylmethylsulfonyl': [2591, 2700, 2765], 'fluoride,': [2592, 2701, 2766], 'orthovanadate).': [2597], 'Equal': [2598], 'amounts': [2599], 'total': [2601, 3022, 3360], 'protein': [2602, 3421, 3637, 3665], 'sample': [2605], 'separated': [2607], 'SDS-PAGE': [2609], 'electrotransferred': [2611], 'onto': [2612], 'nitrocellulose': [2613], 'filters,': [2614], 'probed': [2615], 'primary': [2618], 'appropriate': [2621], 'peroxidase-conjugated': [2622], 'secondary': [2623, 2645], 'antibodies,': [2624], 'visualized': [2626, 2876], 'chemiluminescence': [2630], '(ECL)': [2631], 'per': [2634, 3112, 3418], 'protocol': [2637, 3114], '(Amersham': [2638], 'Biosciences).': [2639], 'some': [2641], 'experiments,': [2642], 'alkaline': [2643], 'phosphatase-conjugated': [2644], 'Sigma': [2648], 'bands': [2653, 2874], 'detected': [2655], 'substrate.': [2662], 'Electrophoretic': [2663], 'Mobility': [2664], 'Shift': [2665], 'Assay': [2666], '(EMSA)—Cells': [2667], 'washed': [2669, 3033, 3096, 3136, 3277], 'cold': [2671], 'PBS': [2672, 2935, 3098, 3138], 'suspended': [2674, 2738], '150': [2676], '(10': [2681], 'HEPES': [2683, 2831], '(pH': [2684, 2832, 3282], '7.9),': [2685, 2833], '10': [2686, 3130, 3242], 'KCl,': [2688], '0.1': [2689, 2692, 2913, 4172, 4229], 'EGTA,': [2694, 2759], 'mg/ml': [2710, 2775, 2892], 'benzamidine).': [2711, 2776], 'allowed': [2715], 'swell': [2717], 'min,': [2720, 3132], '4.5': [2723], 'Nonidet': [2727, 2844], 'P-40': [2728], 'added,': [2730], 'centrifuged,': [2733], 'pellet': [2736], '25': [2740, 2886, 3270], 'extraction': [2744, 2917, 2959], 'HEPES,': [2748], '7.9,': [2750], '0.4': [2751, 3279], 'm': [2752, 3237, 3280], 'extract': [2779], '(8': [2780], 'protein)': [2783], 'collected': [2784], 'min': [2787, 2851, 3223, 3268], 'centrifugation': [2789], 'perform': [2793], 'EMSA': [2794, 3909], 'incubating': [2796], '16': [2799, 3090], 'fmol': [2800], '32P-end': [2802], 'labeled': [2803], '45-mer': [2804], 'stranded': [2806], 'oligonucleotide': [2808, 3933], 'immunodeficiency': [2812], 'virus-1': [2813], 'long': [2814], 'terminal': [2815], 'repeat': [2816], '(5′-TTGTTACAAGGGACTTTCCGCTGGGGACTTTCCAGGGAGGCGTGG-3′)': [2817], 'presence': [2820, 3643, 3662], 'poly(dI-dC)': [2824], '(25': [2829], '50': [2834, 3346, 3830, 3896], '1%': [2843, 3247], 'P-40,': [2845], 'glycerol)': [2848], 'DNA-protein': [2857], 'complex': [2858, 3878, 3924, 4046], 'resolved': [2860], '6.6%': [2863], 'native': [2864], 'polyacrylamide': [2865], 'gel.': [2866], 'gels': [2868, 4419], 'dried': [2870], 'radioactive': [2873], 'phosphorimaging': [2878], '(Bio-Rad': [2879], 'Personal': [2880], 'FX).': [2881], 'Assay—For': [2883], 'assay,': [2885], '(5': [2891], 'PBS)': [2894], 'added': [2896, 2928, 3009], '(untreated': [2899], 'treated)': [2901], 'cultured': [2902], '96-well': [2904, 2988], 'plates.': [2905], '(20%': [2919], 'dodecyl': [2921], 'sulfate': [2922], '50%': [2924], 'formamide)': [2926], 'removal': [2930], 'wash.': [2936], 'overnight': [2939], 'incubation': [2940, 3017, 3927], '°C,': [2943], 'optical': [2945], 'densities': [2946], '570': [2948, 2974, 2978], 'nm': [2949], 'measured': [2951], 'plate': [2954], 'reader': [2955], '(Bio-Rad),': [2956], 'blank.': [2963], 'relative': [2965, 3414], 'percentage': [2969, 4132], 'calculated': [2971], '(A': [2973], 'treated': [2976, 2991, 3084, 3100], 'samples/A': [2977], 'untreated': [2980, 4134, 4193, 4476], 'samples)': [2981], '×': [2982, 3446], '100.': [2983], '[3H]Thymidine': [2984], 'Incorporation—Cells': [2985], 'plates': [2989, 3082], 'without': [2994, 3087, 3186], 'indicated': [2996], 'concentrations': [2997, 4124, 4225, 4265, 4329], 'end': [3003, 4201], '18': [3005], '[3H]thymidine': [3007], '(0.5': [3013], 'μCi/well)': [3014], 'continued': [3019], 'period': [3023], 'culture': [3028], 'removed,': [3032], 'twice': [3034], 'precipitated': [3041], 'trichloroacetic': [3044], 'supernatant': [3047], 'removed': [3049, 3939], 'washing': [3052], 'ethanol,': [3054], 'solubilized': [3058], '0.2': [3060], 'n': [3061], 'NaOH,': [3062], 'radioactivity': [3065], 'counted': [3067], 'liquid': [3070], 'scintillation': [3071], 'counter.': [3072], 'Annexin-PI': [3073], 'Staining—The': [3074], '(104': [3076], 'cells/well)': [3077], '48-well': [3081], 'Then': [3092], '1×': [3102], 'assay': [3103, 3154, 4146, 4151], 'buffer,': [3104], 'annexin-fluorescein': [3105], 'isothiocyanate': [3106], 'iodide': [3109], '(PI)': [3110], 'described': [3115, 3160], 'annexin': [3118], 'V': [3119], 'detection': [3121, 4404], '(sc-4252': [3123], 'AK)': [3124], 'Biotechnology.': [3128], '–20': [3131], 'wells': [3134], 'greenish': [3140], 'viewed': [3144], 'Nikon': [3147, 3295], 'fluorescent': [3148, 3296], 'microscope': [3149, 3206], 'photographed.': [3151], 'Comet': [3152], 'Assay—Comet': [3153], 'essentially': [3158], '(36Singh': [3161], 'N.P.': [3162], 'McCoy': [3163], 'M.T.': [3164], 'Tice': [3165], 'Schneider': [3167], 'E.L.': [3168], 'Exp.': [3169], '1988;': [3172], '175:': [3173], '184-191Crossref': [3174], '(9058)': [3177], 'Briefly,': [3180, 3338], '(treated': [3183], 'EGF)': [3187], 'pelleted': [3189], 'resuspended': [3191], '0.5%': [3193, 3215], 'low': [3194], 'melting': [3195, 3217], 'point': [3196], 'agarose': [3197, 3218, 4418], 'frosted': [3205], 'slide': [3207], 'coated': [3209], 'thin': [3212], 'layer': [3213], 'normal': [3216], 'kept': [3220], '°C.': [3226, 3258], 'solidification,': [3228], 'slides': [3230, 3260, 3273], 'immersed': [3232], 'lysing': [3234], '(2.5': [3236], '10.5,': [3246], 'X-100,': [3249], 'Me2SO)': [3252], 'electrophoresed': [3263], 'electrophoresis': [3275, 4396], 'Tris': [3281], '7.5)': [3283], 'stained': [3285, 4430], 'ethidium': [3287, 4432], 'μg/ml)': [3290], 'microscope.': [3297], 'Assays': [3298], 'Caspase': [3300, 3303], '—The': [3305], 'enzymatic': [3306], 'activities': [3307], 'assayed': [3315], 'spectrofluorimetrically': [3316], '(37Ito': [3317], 'Uehara': [3319], 'Tokumitsu': [3321], 'Okuma': [3323], 'Nomura': [3325], 'Biochim.': [3327], 'Acta.': [3329], '1452:': [3331], '263-274Crossref': [3332], '(63)': [3335], 'lysate': [3342], 'μm': [3347], 'fluorimetric': [3348], '(Ac-DEVD-AFC)': [3353], '(Ac-LEHD-AFC)': [3357], 'volume': [3361], 'reaction': [3366], '(50': [3368], 'HEPES-KOH,': [3370], '7.0,': [3372], 'glycerol,': [3374], 'DTT)': [3382], 'released': [3390, 3417], 'AFC': [3391], 'quantitated': [3393], 'spectrofluorimeter': [3396], '(PerkinElmer': [3397], 'LS-50': [3398], 'B)': [3399], 'excitation': [3402], 'emission': [3404], 'wavelengths': [3405], '380': [3407], '460': [3409], 'nm,': [3410], 'respectively.': [3411], 'Values': [3412], 'fluorescence': [3415], 'units': [3416], 'mg': [3419], 'calculated.': [3423], 'Induces': [3425], 'Activity': [3429], 'A431-Neo': [3431, 3668, 3732, 3821, 3840, 3892, 4040, 4101, 4116, 4179, 4258, 4270, 4340, 4354, 4466, 4508], 'Not': [3433], 'A431-IκB-α': [3434, 3655, 3694, 3779, 3823, 3851, 3951, 4002, 4089, 4118, 4212, 4260, 4277, 4283, 4303, 4342, 4356, 4365, 4464, 4492, 4512], 'Cells—The': [3435], 'line,': [3440], 'A431,': [3441], 'overexpresses': [3442], 'EGFRs': [3443], '(about': [3444], '106': [3447], 'EGFRs/cell)': [3448], 'extensively': [3452], 'model': [3456], 'system': [3457], 'study': [3459, 3530, 4103], 'proliferation': [3466], '38Gulli': [3480], 'L.F.': [3481], 'Reddy': [3486], '173-178PubMed': [3493], '39Filmus': [3496], 'Pollak': [3498], 'M.N.': [3499], 'Cailleau': [3500], 'Buick': [3502], 'R.N.': [3503], '1985;': [3508], '128:': [3509], '898-905Crossref': [3510], '(283)': [3513], '40Gill': [3516], 'G.N.': [3517], 'Lazar': [3518], 'C.S.': [3519], 'Nature.': [3520], '1981;': [3521], '293:': [3522], '305-307Crossref': [3523], '(323)': [3526], 'either': [3547], '(pcDNA3)': [3551, 3674], 'pcDNA3-IκB-α,': [3553, 3626], 'construct': [3557], 'both': [3560, 3868, 3918, 4257, 4339, 4353, 4485], '(32': [3563], '36)': [3565], 'amino-terminal': [3568], 'mutated': [3572], 'alanine.': [3574], 'Because': [3575, 3795], 'form': [3579, 4007], 'lacks': [3582], 'crucial': [3584], 'serine': [3585], 'residues': [3586], 'need': [3588], 'phosphorylated': [3591], 'activators,': [3594], 'popularly': [3597], 'employed': [3598], 'strongly': [3600], 'inhibit': [3601], '(28Van': [3603], 'As': [3623, 3649, 3913, 4238], 'construct,': [3625], 'contains': [3627, 3879, 4047], 'tag': [3630], '(HA': [3631], 'tag),': [3632], 'blotting': [3634, 3705, 3771], 'HA': [3636, 3664, 3699], 'ascertain': [3641], 'protein.': [3648], 'expected,': [3650], 'all': [3651], 'six': [3652], '(selected': [3657], 'showed': [3660], 'control': [3672, 3745, 4135, 4194, 4235], 'show': [3677, 4057], '(Fig.': [3680, 3734, 3755, 3793, 3871, 4205, 4236, 4279, 4376], '1A).': [3681], 'Further': [3682], 'experiments': [3683], 'IκB-transfected': [3685], 'done': [3688], 'only': [3690, 4215], 'clone': [3691, 3713], '6': [3692, 3714], '(showing': [3696], 'very': [3697, 3797], 'high': [3698], 'expression)': [3700], 'unless': [3701], 'stated': [3702], 'otherwise.': [3703], 'confirmed': [3711, 3784, 4297], 'had': [3715, 4174], 'indeed': [3716], 'higher': [3718], 'compared': [3723, 4232, 4506], 'parental': [3728], '1B).': [3735], 'blots,': [3739], 'confirm': [3749, 3874, 3999], 'equal': [3750], 'loading': [3751], 'samples': [3754], '1,': [3756], 'A': [3757], 'B).': [3759], 'see': [3761], 'procedures': [3764], 'affected': [3765], 'parental,': [3776], 'A431-Neo,': [3777], 'remained': [3788], 'unaffected': [3789], 'these': [3791, 4024, 4293], '1C).': [3794], 'purpose': [3798], 'stable': [3800], 'logical': [3808], 'check': [3810], 'could': [3813, 3846, 4016], 'stimulate': [3814, 4018], '6)': [3826], 'EMSA.': [3828], 'ng/ml': [3831, 3844, 3897, 4173, 4251, 4472], 'even': [3842, 4263], 'absence': [3856], 'there': [3859], 'no': [3861], 'active': [3862, 3877, 3922, 3941, 3958, 4044, 4067, 4073], 'DNA-binding': [3863], 'complexes': [3864, 4077], '1D).': [3872], 'classical': [3881], 'partners,': [3883], 'RelA,': [3886, 4059], 'extracts': [3889], 'prepared': [3890], 'out.': [3912], 'Fig.': [3916, 3943, 4243, 4451], '1E,': [3917], 'shifted': [3920], '(supershift)': [3925], 'excess': [3929], 'unlabeled': [3932], 'site': [3938], 'complex.': [3942], '1E': [3944], 'shows': [3946], 'transient': [3948], 'restored': [3955], 'complex,': [3959], 'us': [3966], 'constitutively': [3969], 'L-929': [3973], 'express': [4004], 'inactivated': [4011, 4495], 'hence,': [4014], 'cells.': [4025, 4261, 4487, 4509], 'indicate': [4029], 'heterodimers,': [4049], 'RelA.': [4052], 'being': [4060, 4221], 'one': [4061], 'heterodimeric': [4064], 'partners': [4065], 'favors': [4069], 'formation': [4071], 'potential': [4081], 'reverse': [4083], 'NF-κB-inactivating': [4085], 'IκB.': [4088], 'Are': [4091], 'More': [4092, 4511], 'Sensitive': [4093], 'Cytotoxicity': [4096], 'Fragmentation': [4099], 'Than': [4100], 'Cells—To': [4102], 'inactivation,': [4115], 'exposed': [4121], 'determined': [4137], 'assay.': [4143, 4347], 'convenient': [4149], 'screening': [4150], 'measurement': [4154], 'while': [4158, 4474], 'does': [4160], 'discriminate': [4162], 'between': [4163], 'necrosis.': [4166], '0.01': [4170, 4227], 'stimulatory': [4176, 4268], 'viabilities': [4183], '130': [4185], '110%,': [4187], 'respectively,': [4188, 4231], 'taken': [4196], '100%': [4198], '2A).': [4206, 4237], '81': [4216], '67%': [4218], 'alive': [4222], 'ng/ml,': [4230], 'seen': [4241], '2A,': [4244], 'concentration': [4248], 'above': [4253], 'Thus,': [4262], '2A)': [4280], 'suggesting': [4281], 'much': [4286], 'cytotoxicity': [4291], '(data': [4304], 'shown).': [4306], 'examined': [4309], 'synthesis': [4316, 4351, 4375], 'thymidine': [4321], 'incorporation': [4322], 'exposing': [4324], '(1–10': [4332], 'ng/ml)': [4333], 'found': [4334], 'dose-dependent': [4360], 'manner': [4361], 'again': [4363], '2B).': [4377], 'fragmentation': [4379], 'another': [4381], 'hallmark': [4382], 'detect': [4387], 'this,': [4388], 'single': [4393], 'gel': [4395], '(Comet': [4397], 'assay),': [4398], 'technique': [4401], 'allows': [4403], 'strand': [4407, 4410], 'breaks.': [4408], 'breaks': [4411], 'create': [4412], 'fragments': [4413], 'when': [4415, 4429, 4468], 'embedded': [4416], 'migrate': [4420], 'electric': [4423], 'field.': [4424], 'damaged': [4427], 'appear': [4434], 'like': [4435], 'comet': [4437, 4443, 4482], 'length': [4440], 'tail': [4444], 'represents': [4445], 'extent': [4447], 'damage.': [4450], '2C': [4452], 'clearly': [4453], 'indicates': [4454], 'comets': [4458], 'exhibit': [4480], 'morphology': [4483], 'suggest': [4490], 'susceptible': [4499], 'Relatively': [4510], 'Undergo': [4514], 'Exter': [4516]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1990000902', 'counts_by_year': [{'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-13T11:45:27.095308', 'created_date': '2016-06-24'}