Publication Information

{'id': 'https://openalex.org/W2147461325', 'doi': 'https://doi.org/10.1002/jcp.1041560310', 'title': 'Epidermal growth factor induces terminal differentiation in human epidermoid carcinoma cells', 'display_name': 'Epidermal growth factor induces terminal differentiation in human epidermoid carcinoma cells', 'publication_year': 1993, 'publication_date': '1993-09-01', 'ids': {'openalex': 'https://openalex.org/W2147461325', 'doi': 'https://doi.org/10.1002/jcp.1041560310', 'mag': '2147461325', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8103053'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcp.1041560310', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S43643205', 'display_name': 'Journal of Cellular Physiology', 'issn_l': '0021-9541', 'issn': ['0021-9541', '1097-4652'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5028890075', 'display_name': 'Raymond L. Konger', 'orcid': 'https://orcid.org/0000-0002-4923-2406'}, 'institutions': [{'id': 'https://openalex.org/I219193219', 'display_name': 'Purdue University West Lafayette', 'ror': 'https://ror.org/02dqehb95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I219193219']}, {'id': 'https://openalex.org/I592451', 'display_name': 'Indiana University', 'ror': 'https://ror.org/01kg8sb98', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I592451']}, {'id': 'https://openalex.org/I4394709130', 'display_name': 'Indiana University School of Medicine', 'ror': 'https://ror.org/02ets8c94', 'country_code': None, 'type': 'education', 'lineage': ['https://openalex.org/I4394709130', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Raymond L. Konger', 'raw_affiliation_strings': ['Department of Physiology and Pharmacology, School of Veterinary Medicine, and the Lafayette Center for Medical Education, Indiana University School of Medicine, Purdue University, West Lafayette, Indiana 47907'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Pharmacology, School of Veterinary Medicine, and the Lafayette Center for Medical Education, Indiana University School of Medicine, Purdue University, West Lafayette, Indiana 47907', 'institution_ids': ['https://openalex.org/I219193219', 'https://openalex.org/I592451', 'https://openalex.org/I4394709130']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057399487', 'display_name': 'Thomas Chan', 'orcid': 'https://orcid.org/0000-0001-6025-3796'}, 'institutions': [{'id': 'https://openalex.org/I219193219', 'display_name': 'Purdue University West Lafayette', 'ror': 'https://ror.org/02dqehb95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I219193219']}, {'id': 'https://openalex.org/I592451', 'display_name': 'Indiana University', 'ror': 'https://ror.org/01kg8sb98', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I592451']}, {'id': 'https://openalex.org/I4394709130', 'display_name': 'Indiana University School of Medicine', 'ror': 'https://ror.org/02ets8c94', 'country_code': None, 'type': 'education', 'lineage': ['https://openalex.org/I4394709130', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas C. K. Chan', 'raw_affiliation_strings': ['Department of Physiology and Pharmacology, School of Veterinary Medicine, and the Lafayette Center for Medical Education, Indiana University School of Medicine, Purdue University, West Lafayette, Indiana 47907'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Pharmacology, School of Veterinary Medicine, and the Lafayette Center for Medical Education, Indiana University School of Medicine, Purdue University, West Lafayette, Indiana 47907', 'institution_ids': ['https://openalex.org/I219193219', 'https://openalex.org/I592451', 'https://openalex.org/I4394709130']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4940, 'currency': 'USD', 'value_usd': 4940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.287, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 15, 'citation_normalized_percentile': {'value': 0.624902, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 81, 'max': 82}, 'biblio': {'volume': '156', 'issue': '3', 'first_page': '515', 'last_page': '521'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11650', 'display_name': 'Skin and Cellular Biology Research', 'score': 0.99, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11650', 'display_name': 'Skin and Cellular Biology Research', 'score': 0.99, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 0.9858, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9805, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/a431-cells', 'display_name': 'A431 cells', 'score': 0.93891656}, {'id': 'https://openalex.org/keywords/epidermoid-carcinoma', 'display_name': 'Epidermoid carcinoma', 'score': 0.7357757}, {'id': 'https://openalex.org/keywords/squamous-carcinoma', 'display_name': 'Squamous carcinoma', 'score': 0.4749708}], 'concepts': [{'id': 'https://openalex.org/C47170353', 'wikidata': 'https://www.wikidata.org/wiki/Q4649310', 'display_name': 'A431 cells', 'level': 5, 'score': 0.93891656}, {'id': 'https://openalex.org/C2776362946', 'wikidata': 'https://www.wikidata.org/wiki/Q424374', 'display_name': 'Epidermal growth factor', 'level': 3, 'score': 0.8857031}, {'id': 'https://openalex.org/C2994460389', 'wikidata': 'https://www.wikidata.org/wiki/Q681817', 'display_name': 'Epidermoid carcinoma', 'level': 3, 'score': 0.7357757}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.6328062}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6042368}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.50371116}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.49977303}, {'id': 'https://openalex.org/C2994491419', 'wikidata': 'https://www.wikidata.org/wiki/Q681817', 'display_name': 'Squamous carcinoma', 'level': 3, 'score': 0.4749708}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4668532}, {'id': 'https://openalex.org/C148738053', 'wikidata': 'https://www.wikidata.org/wiki/Q210861', 'display_name': 'Cellular differentiation', 'level': 3, 'score': 0.43109062}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.37785518}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.35468602}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3414148}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.33705693}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.27672854}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19544017}, {'id': 'https://openalex.org/C2777546739', 'wikidata': 'https://www.wikidata.org/wiki/Q33525', 'display_name': 'Carcinoma', 'level': 2, 'score': 0.16773322}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.1532279}, {'id': 'https://openalex.org/C2781018059', 'wikidata': 'https://www.wikidata.org/wiki/Q207609', 'display_name': 'Oncogene', 'level': 4, 'score': 0.08647075}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.06794569}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D002294', 'descriptor_name': 'Carcinoma, Squamous Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011503', 'descriptor_name': 'Transglutaminases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011503', 'descriptor_name': 'Transglutaminases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcp.1041560310', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S43643205', 'display_name': 'Journal of Cellular Physiology', 'issn_l': '0021-9541', 'issn': ['0021-9541', '1097-4652'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8103053', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.57, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1548966243', 'https://openalex.org/W1608647261', 'https://openalex.org/W1894641937', 'https://openalex.org/W1963804483', 'https://openalex.org/W1965568245', 'https://openalex.org/W1974027176', 'https://openalex.org/W1979580749', 'https://openalex.org/W1983649348', 'https://openalex.org/W1994737139', 'https://openalex.org/W2000490940', 'https://openalex.org/W2000710512', 'https://openalex.org/W2004408045', 'https://openalex.org/W2009300543', 'https://openalex.org/W2010640454', 'https://openalex.org/W2012046594', 'https://openalex.org/W2013405071', 'https://openalex.org/W2016568386', 'https://openalex.org/W2020475637', 'https://openalex.org/W2031933070', 'https://openalex.org/W2040246951', 'https://openalex.org/W2045503469', 'https://openalex.org/W2046980821', 'https://openalex.org/W2049613194', 'https://openalex.org/W2051874884', 'https://openalex.org/W2065394892', 'https://openalex.org/W2070799389', 'https://openalex.org/W2077996184', 'https://openalex.org/W2080087599', 'https://openalex.org/W2091633447', 'https://openalex.org/W2108709388', 'https://openalex.org/W2116168546', 'https://openalex.org/W2127757892', 'https://openalex.org/W2146447599', 'https://openalex.org/W2159195088', 'https://openalex.org/W2161229567', 'https://openalex.org/W26780815'], 'related_works': ['https://openalex.org/W913811057', 'https://openalex.org/W2399443058', 'https://openalex.org/W2147461325', 'https://openalex.org/W2093269773', 'https://openalex.org/W2091633447', 'https://openalex.org/W2049613194', 'https://openalex.org/W2010702270', 'https://openalex.org/W1992132675', 'https://openalex.org/W1967509742', 'https://openalex.org/W194800238'], 'abstract_inverted_index': {'Abstract': [0], 'Previous': [1], 'studies': [2], 'have': [3, 50, 218], 'reported': [4], 'that': [5, 128, 169, 215], 'the': [6, 52, 62, 70, 93, 187, 191, 196, 203, 219], 'proliferation': [7, 239], 'of': [8, 54, 59, 66, 72, 86, 95, 105, 131, 141, 155, 184, 190, 198, 237], 'A431': [9, 67, 76, 137, 156, 167, 205, 216], 'cells,': [10], 'a': [11, 79, 114, 235], 'human': [12, 40], 'squamous': [13], 'cell': [14, 16], 'carcinoma': [15], 'line,': [17], 'was': [18, 107], 'stimulated': [19], 'by': [20, 28, 179], 'picomolar': [21], 'epidermal': [22, 124], 'growth': [23, 63, 83, 101, 172, 188], 'factor': [24], '(EGF)': [25], 'but': [26], 'inhibited': [27], 'nanomolar': [29, 44], 'EGF.': [30, 96, 182], 'This': [31], 'biphasic': [32, 206], 'dose‐response': [33], 'phenomenon': [34], 'is': [35, 46], 'not': [36], 'observed': [37], 'in': [38, 82, 92, 118, 123, 136, 165, 195, 229, 234], 'normal': [39], 'epithelial': [41], 'cells': [42, 77, 90, 157, 193, 200, 217], 'where': [43], 'EGF': [45, 60, 109, 132, 142, 163, 185, 228], 'usually': [47], 'mitogenic.': [48], 'We': [49], 'examined': [51], 'effects': [53], 'inhibitory': [55], 'and': [56, 64, 122, 240], 'stimulatory': [57], 'concentrations': [58, 130, 140], 'on': [61, 149], 'differentiation': [65, 135, 151], 'cells.': [68, 138], 'In': [69], 'presence': [71], '100': [73], 'pM': [74], 'EGF,': [75, 100], 'showed': [78], 'mild': [80], 'increase': [81, 116], 'rate': [84], '(129%': [85], 'control)': [87], 'compared': [88], 'to': [89, 103, 158, 176, 202, 221, 227, 231], 'grown': [91], 'absence': [94], 'At': [97], '10': [98, 111, 180], 'nM': [99, 112, 162, 181], 'inhibition': [102], '63%': [104], 'control': [106], 'observed.': [108], 'at': [110], 'stimulates': [113], 'twofold': [115], 'both': [117], 'cornified': [119], 'envelope': [120], 'formation': [121], 'transglutaminase': [125], 'activity,': [126], 'suggesting': [127], 'high': [129], 'induce': [133], 'terminal': [134, 243], 'Mitogenic': [139], '(100': [143], 'pM)': [144], 'had': [145], 'no': [146], 'significant': [147], 'effect': [148], 'these': [150, 199], 'markers.': [152], 'Chronic': [153], 'exposure': [154], '20': [159], 'or': [160], '50': [161], 'resulted': [164, 194], 'EGF‐resistant': [166, 192], 'variants': [168], 'are': [170], 'neither': [171], 'arrested': [173], 'nor': [174], 'induced': [175], 'terminally': [177], 'differentiate': [178], 'Removal': [183], 'from': [186, 242], 'medium': [189], 'reversion': [197], 'back': [201], 'wild‐type': [204], 'response': [207, 225], 'pattern': [208, 226], 'within': [209], '2': [210], 'weeks.': [211], 'Our': [212], 'results': [213], 'suggest': [214], 'capacity': [220], 'non‐mutatively': [222], 'alter': [223], 'their': [224], 'vitro': [230], 'maintain': [232], 'themselves': [233], 'state': [236], 'optimum': [238], 'away': [241], 'differentiation.': [244], '©': [245], '1993': [246], 'Wiley‐Liss,': [247], 'Inc.': [248]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2147461325', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-15T04:52:10.236298', 'created_date': '2016-06-24'}