Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4389025114', 'doi': 'https://doi.org/10.1096/fasebj.30.1_supplement.1264.6', 'title': 'Claudin‐5 Decreases Alveolar Barrier Function in Alcoholic Lung Syndrome by Displacing Claudin‐18 from Tight Junctions', 'display_name': 'Claudin‐5 Decreases Alveolar Barrier Function in Alcoholic Lung Syndrome by Displacing Claudin‐18 from Tight Junctions', 'publication_year': 2016, 'publication_date': '2016-04-01', 'ids': {'openalex': 'https://openalex.org/W4389025114', 'doi': 'https://doi.org/10.1096/fasebj.30.1_supplement.1264.6'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1096/fasebj.30.1_supplement.1264.6', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1096/fasebj.30.1_supplement.1264.6', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054678086', 'display_name': 'Barbara Schlingmann', 'orcid': 'https://orcid.org/0000-0002-1697-4235'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Barbara Lisa Schlingmann', 'raw_affiliation_strings': ['Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, School of Medicine, Atlanta, GA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, School of Medicine, Atlanta, GA', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061993900', 'display_name': 'StevenClaude Dorsainvil White', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'StevenClaude Dorsainvil White', 'raw_affiliation_strings': ['Emory University, School of Medicine, Atlanta, GA'], 'affiliations': [{'raw_affiliation_string': 'Emory University, School of Medicine, Atlanta, GA', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034037007', 'display_name': 'Samuel A. Molina', 'orcid': 'https://orcid.org/0000-0002-5861-3390'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Samuel Molina', 'raw_affiliation_strings': ['Emory University, School of Medicine, Atlanta, GA'], 'affiliations': [{'raw_affiliation_string': 'Emory University, School of Medicine, Atlanta, GA', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084995236', 'display_name': 'K. Sabrina Lynn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'K. Sabrina Lynn', 'raw_affiliation_strings': ['Emory University, School of Medicine, Atlanta, GA'], 'affiliations': [{'raw_affiliation_string': 'Emory University, School of Medicine, Atlanta, GA', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054260081', 'display_name': 'Christopher Capaldo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher T. Capaldo', 'raw_affiliation_strings': ['Emory University, School of Medicine, Atlanta, GA'], 'affiliations': [{'raw_affiliation_string': 'Emory University, School of Medicine, Atlanta, GA', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5082867899', 'display_name': 'Michael Koval', 'orcid': 'https://orcid.org/0000-0002-5422-5614'}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael Koval', 'raw_affiliation_strings': ['Department of Cell Biology, Emory University, Atlanta, GA', 'Emory University, School of Medicine, Atlanta, GA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Emory University, Atlanta, GA', 'institution_ids': ['https://openalex.org/I150468666']}, {'raw_affiliation_string': 'Emory University, School of Medicine, Atlanta, GA', 'institution_ids': ['https://openalex.org/I150468666']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': '30', 'issue': 'S1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11872', 'display_name': 'Barrier Structure and Function Studies', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11872', 'display_name': 'Barrier Structure and Function Studies', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10227', 'display_name': 'Acute Ischemic Stroke Management', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase-1 and Carbon Monoxide', 'score': 0.9915, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/claudin', 'display_name': 'Claudin', 'score': 0.98063827}, {'id': 'https://openalex.org/keywords/paracellular-transport', 'display_name': 'Paracellular transport', 'score': 0.6612689}, {'id': 'https://openalex.org/keywords/barrier-function', 'display_name': 'Barrier function', 'score': 0.6185111}], 'concepts': [{'id': 'https://openalex.org/C51872919', 'wikidata': 'https://www.wikidata.org/wiki/Q420863', 'display_name': 'Claudin', 'level': 3, 'score': 0.98063827}, {'id': 'https://openalex.org/C177779419', 'wikidata': 'https://www.wikidata.org/wiki/Q1053832', 'display_name': 'Tight junction', 'level': 2, 'score': 0.96541595}, {'id': 'https://openalex.org/C60903277', 'wikidata': 'https://www.wikidata.org/wiki/Q2051926', 'display_name': 'Paracellular transport', 'level': 4, 'score': 0.6612689}, {'id': 'https://openalex.org/C51911345', 'wikidata': 'https://www.wikidata.org/wiki/Q4863604', 'display_name': 'Barrier function', 'level': 2, 'score': 0.6185111}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.51183075}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5012944}, {'id': 'https://openalex.org/C2776348555', 'wikidata': 'https://www.wikidata.org/wiki/Q344873', 'display_name': 'ARDS', 'level': 3, 'score': 0.4979403}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.4784953}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.3475023}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2735892}, {'id': 'https://openalex.org/C2777714996', 'wikidata': 'https://www.wikidata.org/wiki/Q7886', 'display_name': 'Lung', 'level': 2, 'score': 0.25502735}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.20267537}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15126026}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.14321378}, {'id': 'https://openalex.org/C120882062', 'wikidata': 'https://www.wikidata.org/wiki/Q28352', 'display_name': 'Permeability (electromagnetism)', 'level': 3, 'score': 0.07191345}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.066639215}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1096/fasebj.30.1_supplement.1264.6', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1096/fasebj.30.1_supplement.1264.6', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.86, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320320875', 'funder_display_name': 'Deutscher Akademischer Austauschdienst', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2898469163', 'https://openalex.org/W28798147', 'https://openalex.org/W2780935698', 'https://openalex.org/W2223893340', 'https://openalex.org/W2161141468', 'https://openalex.org/W2103690626', 'https://openalex.org/W2094468216', 'https://openalex.org/W2075536490', 'https://openalex.org/W190197617', 'https://openalex.org/W1729818254'], 'abstract_inverted_index': {'We': [0, 46, 74], 'found': [1, 75], 'that': [2, 76, 115, 143, 165, 204, 256, 302, 326, 345], 'alcohol': [3, 53, 67, 79, 122, 144, 161, 191, 232, 257, 331], 'abuse': [4], 'increases': [5, 145], 'the': [6, 40, 64, 173, 188, 228, 280, 303], 'susceptibility': [7], 'to': [8, 62, 95, 260, 312, 353], 'develop': [9], 'Acute': [10], 'Respiratory': [11], 'Distress': [12], 'Syndrome': [13], '(ARDS)': [14], 'by': [15, 101, 127, 192], 'impairing': [16], 'alveolar': [17, 58], 'epithelial': [18, 59], 'cell': [19, 200], 'tight': [20, 24, 69, 84, 97, 108, 130, 236, 322, 339], 'junctions.': [21, 323], 'Understanding': [22], 'how': [23], 'junction': [25, 70, 85, 109, 131, 237, 340], 'proteins': [26], 'are': [27, 207], 'regulated': [28], 'on': [29, 68], 'a': [30, 48, 105, 246, 274, 294, 350], 'molecular': [31, 229], 'level': [32], 'may': [33, 348], 'identify': [34], 'potential': [35], 'new': [36], 'therapeutic': [37, 351], 'targets': [38], 'for': [39], 'treatment': [41], 'and': [42, 55, 72, 87, 148, 171, 196, 213, 266, 279, 299, 307, 337], 'prevention': [43], 'of': [44, 51, 66, 104, 119, 129, 137, 175, 190, 231, 248, 319], 'ARDS.': [45, 358], 'used': [47], 'rodent': [49], 'model': [50], 'chronic': [52], 'ingestion': [54, 258], 'cultured': [56], 'primary': [57], 'cells': [60, 138, 176], '(AEC)': [61], 'investigate': [63], 'influence': [65], 'formation': [71, 147], 'function.': [73, 225], 'AECs': [77, 120, 163, 186, 291, 333], 'from': [78, 121], 'fed': [80, 123], 'rats': [81, 124], 'had': [82], 'disrupted': [83], 'morphology': [86], 'were': [88, 99], 'leakier': [89], 'than': [90], 'control': [91, 185], 'AECs.': [92], 'Alcohol‐induced': [93], 'changes': [94, 234], 'AEC': [96], 'junctions': [98], 'accompanied': [100, 126], 'increased': [102, 154, 262, 334], 'expression': [103, 183], 'claudin': [106, 217], 'family': [107], 'protein,': [110], 'claudin‐5.': [111], 'Immunofluorescence': [112], 'analysis': [113], 'showed': [114, 142, 164], 'impaired': [116], 'barrier': [117, 169, 224, 335, 355], 'function': [118, 170, 329, 336, 356], 'was': [125, 150, 220, 271, 287, 293], 'disruption': [128], 'morphology,': [132], 'spikes,': [133], 'containing': [134, 139, 177], 'claudin‐18.': [135], 'Quantification': [136], 'claudin‐18': [140, 178, 194, 205, 265, 278, 298, 308, 320], 'spikes': [141, 195, 206], 'spike': [146], 'this': [149], 'also': [151], 'associated': [152, 221, 272], 'with': [153, 222, 273, 314], 'claudin‐5': [155, 167, 182, 267, 286, 306, 328, 347], 'expression.': [156], 'Claudin‐5': [157], 'knockdown': [158], 'experiments': [159, 202], 'in': [160, 184, 235, 269, 289, 321, 330, 357], 'exposed': [162, 332], 'decreasing': [166], 'improved': [168], 'reduced': [172], 'number': [174], 'spikes.': [179], 'Conversely,': [180], 'increasing': [181, 193], 'mimicked': [187], 'effects': [189], 'paracellular': [197], 'leak.': [198], 'Live': [199], 'imaging': [201], 'revealed': [203, 255], 'sites': [208], 'where': [209], 'claudin‐containing': [210], 'vesicles': [211], 'fuse': [212], 'form': [214, 247], 'reflecting': [215], 'enhanced': [216], 'turnover': [218], 'which': [219, 268], 'decreased': [223, 275, 295], 'To': [226], 'elucidate': [227], 'mechanisms': [230], 'dependent': [233], 'proteins,': [238], 'we': [239], 'performed': [240], 'Stochastic': [241], 'optical': [242], 'reconstruction': [243], 'microscopy': [244], '(STORM),': [245], 'super': [249], 'resolution': [250], 'immunofluorescence': [251], 'microscopy.': [252], 'The': [253, 342], 'data': [254, 343], 'lead': [259], 'an': [261], 'colocalization': [263, 276], 'between': [264, 277, 297, 305], 'turn': [270], 'scaffold': [281], 'protein': [282], 'ZO‐1.': [283], 'When': [284], 'YFP‐tagged': [285], 'expressed': [288], 'normal': [290], 'there': [292], 'co‐localization': [296], 'ZO‐1': [300], 'suggesting': [301], 'interaction': [304], 'impairs': [309], 'its': [310], 'ability': [311], 'interact': [313], 'ZO‐1,': [315], 'thus': [316], 'destabilizing': [317], 'incorporation': [318], 'Moreover,': [324], 'agents': [325], 'inhibit': [327], 'stabilized': [338], 'morphology.': [341], 'suggest': [344], 'targeting': [346], 'provide': [349], 'strategy': [352], 'improve': [354], 'Support': [359], 'or': [360], 'Funding': [361], 'Information': [362], 'Support:': [363], 'Emory': [364], 'URC,': [365], 'NIH‐NIAAA,': [366], 'NIH‐NHLBI.': [367], 'DAAD': [368]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4389025114', 'counts_by_year': [], 'updated_date': '2024-12-13T09:52:43.283367', 'created_date': '2023-11-27'}