Coordinate Regulation of Phospholipid Biosynthesis and Secretory Pathway Gene Expression in XBP-1(S)-induced Endoplasmic Reticulum Biogenesis

Name: Work Video:
Duration: 3 min 30 s
Rungtawan Sriburi; Hemamalini Bommiasamy; Gerald L. Buldak; Gregory R. Robbins; Matthew W. Frank; Suzanne Jackowski; Joseph W. Brewer
{'id': 'https://openalex.org/W1988988264', 'doi': 'https://doi.org/10.1074/jbc.m609490200', 'title': 'Coordinate Regulation of Phospholipid Biosynthesis and Secretory Pathway Gene Expression in XBP-1(S)-induced Endoplasmic Reticulum Biogenesis', 'display_name': 'Coordinate Regulation of Phospholipid Biosynthesis and Secretory Pathway Gene Expression in XBP-1(S)-induced Endoplasmic Reticulum Biogenesis', 'publication_year': 2007, 'publication_date': '2007-01-10', 'ids': {'openalex': 'https://openalex.org/W1988988264', 'doi': 'https://doi.org/10.1074/jbc.m609490200', 'mag': '1988988264', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17213183'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m609490200', 'pdf_url': 'http://www.jbc.org/article/S002192582063544X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S002192582063544X/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5025786939', 'display_name': 'Rungtawan Sriburi', 'orcid': 'https://orcid.org/0000-0002-8900-9233'}, 'institutions': [{'id': 'https://openalex.org/I1925986', 'display_name': 'Loyola University Chicago', 'ror': 'https://ror.org/04b6x2g63', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1925986']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rungtawan Sriburi', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153 and the'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153 and the', 'institution_ids': ['https://openalex.org/I1925986']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052119024', 'display_name': 'Hemamalini Bommiasamy', 'orcid': 'https://orcid.org/0000-0003-2960-9402'}, 'institutions': [{'id': 'https://openalex.org/I1925986', 'display_name': 'Loyola University Chicago', 'ror': 'https://ror.org/04b6x2g63', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1925986']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hemamalini Bommiasamy', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153 and the'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153 and the', 'institution_ids': ['https://openalex.org/I1925986']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010982462', 'display_name': 'Gerald L. Buldak', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1925986', 'display_name': 'Loyola University Chicago', 'ror': 'https://ror.org/04b6x2g63', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1925986']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gerald L. Buldak', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153 and the'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153 and the', 'institution_ids': ['https://openalex.org/I1925986']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034843394', 'display_name': 'Gregory R. Robbins', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1925986', 'display_name': 'Loyola University Chicago', 'ror': 'https://ror.org/04b6x2g63', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1925986']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gregory R. Robbins', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153 and the'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153 and the', 'institution_ids': ['https://openalex.org/I1925986']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040466202', 'display_name': 'Matthew W. Frank', 'orcid': 'https://orcid.org/0000-0002-4914-1440'}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew Frank', 'raw_affiliation_strings': ["Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105"], 'affiliations': [{'raw_affiliation_string': "Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105", 'institution_ids': ['https://openalex.org/I1313298211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090935512', 'display_name': 'Suzanne Jackowski', 'orcid': 'https://orcid.org/0000-0002-6855-1429'}, 'institutions': [{'id': 'https://openalex.org/I1313298211', 'display_name': "St. Jude Children's Research Hospital", 'ror': 'https://ror.org/02r3e0967', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313298211', 'https://openalex.org/I2802152183']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Suzanne Jackowski', 'raw_affiliation_strings': ["Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105"], 'affiliations': [{'raw_affiliation_string': "Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105", 'institution_ids': ['https://openalex.org/I1313298211']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103493861', 'display_name': 'Joseph W. Brewer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1925986', 'display_name': 'Loyola University Chicago', 'ror': 'https://ror.org/04b6x2g63', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1925986']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joseph W. Brewer', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153 and the'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153 and the', 'institution_ids': ['https://openalex.org/I1925986']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 7.649, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 254, 'citation_normalized_percentile': {'value': 0.99985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '282', 'issue': '10', 'first_page': '7024', 'last_page': '7034'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders Research', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9947, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/phosphocholine', 'display_name': 'Phosphocholine', 'score': 0.42889225}, {'id': 'https://openalex.org/keywords/secretory-protein', 'display_name': 'Secretory protein', 'score': 0.42021316}], 'concepts': [{'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.88980895}, {'id': 'https://openalex.org/C139447449', 'wikidata': 'https://www.wikidata.org/wiki/Q14633900', 'display_name': 'Unfolded protein response', 'level': 3, 'score': 0.6920254}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6473921}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45442936}, {'id': 'https://openalex.org/C6492254', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretory pathway', 'level': 4, 'score': 0.44248405}, {'id': 'https://openalex.org/C2776923060', 'wikidata': 'https://www.wikidata.org/wiki/Q576895', 'display_name': 'Phosphocholine', 'level': 5, 'score': 0.42889225}, {'id': 'https://openalex.org/C156399914', 'wikidata': 'https://www.wikidata.org/wiki/Q7444454', 'display_name': 'Secretory protein', 'level': 3, 'score': 0.42021316}, {'id': 'https://openalex.org/C131934819', 'wikidata': 'https://www.wikidata.org/wiki/Q135390', 'display_name': 'Biogenesis', 'level': 3, 'score': 0.41609162}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3582919}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2836789}, {'id': 'https://openalex.org/C2778918659', 'wikidata': 'https://www.wikidata.org/wiki/Q186915', 'display_name': 'Phospholipid', 'level': 3, 'score': 0.242223}, {'id': 'https://openalex.org/C2776330855', 'wikidata': 'https://www.wikidata.org/wiki/Q650187', 'display_name': 'Phosphatidylcholine', 'level': 4, 'score': 0.23823005}, {'id': 'https://openalex.org/C49039625', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretion', 'level': 2, 'score': 0.231008}, {'id': 'https://openalex.org/C119062480', 'wikidata': 'https://www.wikidata.org/wiki/Q83181', 'display_name': 'Golgi apparatus', 'level': 3, 'score': 0.16530883}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.13128307}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D010743', 'descriptor_name': 'Phospholipids', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019916', 'descriptor_name': 'Choline-Phosphate Cytidylyltransferase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019916', 'descriptor_name': 'Choline-Phosphate Cytidylyltransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002798', 'descriptor_name': 'Diacylglycerol Cholinephosphotransferase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002798', 'descriptor_name': 'Diacylglycerol Cholinephosphotransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D041681', 'descriptor_name': 'NIH 3T3 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010743', 'descriptor_name': 'Phospholipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071701', 'descriptor_name': 'Regulatory Factor X Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071717', 'descriptor_name': 'X-Box Binding Protein 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m609490200', 'pdf_url': 'http://www.jbc.org/article/S002192582063544X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17213183', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m609490200', 'pdf_url': 'http://www.jbc.org/article/S002192582063544X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W1487624404', 'https://openalex.org/W1545450687', 'https://openalex.org/W1672219033', 'https://openalex.org/W1965245606', 'https://openalex.org/W1965843055', 'https://openalex.org/W1966357496', 'https://openalex.org/W1967883750', 'https://openalex.org/W1970090817', 'https://openalex.org/W1974123109', 'https://openalex.org/W1974817754', 'https://openalex.org/W1982716938', 'https://openalex.org/W1986737010', 'https://openalex.org/W1999183503', 'https://openalex.org/W2005129842', 'https://openalex.org/W2006308545', 'https://openalex.org/W2010494349', 'https://openalex.org/W2018175015', 'https://openalex.org/W2022418117', 'https://openalex.org/W2025846979', 'https://openalex.org/W2028878583', 'https://openalex.org/W2028912233', 'https://openalex.org/W2034505413', 'https://openalex.org/W2035450414', 'https://openalex.org/W2048508221', 'https://openalex.org/W2050298719', 'https://openalex.org/W2050477788', 'https://openalex.org/W2054929946', 'https://openalex.org/W2057269327', 'https://openalex.org/W2059606380', 'https://openalex.org/W2063032509', 'https://openalex.org/W2068859969', 'https://openalex.org/W2072968094', 'https://openalex.org/W2076880493', 'https://openalex.org/W2088884715', 'https://openalex.org/W2096947423', 'https://openalex.org/W2102100103', 'https://openalex.org/W2102651270', 'https://openalex.org/W2112286580', 'https://openalex.org/W2112826932', 'https://openalex.org/W2113142075', 'https://openalex.org/W2116931062', 'https://openalex.org/W2127906377', 'https://openalex.org/W2128635872', 'https://openalex.org/W2132468746', 'https://openalex.org/W2143070830', 'https://openalex.org/W2143952529', 'https://openalex.org/W2147336345', 'https://openalex.org/W2147598606', 'https://openalex.org/W2148809997', 'https://openalex.org/W2148911704', 'https://openalex.org/W2152311269', 'https://openalex.org/W2154171026', 'https://openalex.org/W2155884826', 'https://openalex.org/W3175225512', 'https://openalex.org/W4293247451', 'https://openalex.org/W4562572'], 'related_works': ['https://openalex.org/W939715917', 'https://openalex.org/W4211044652', 'https://openalex.org/W2953355091', 'https://openalex.org/W2523520718', 'https://openalex.org/W2383393066', 'https://openalex.org/W2371834241', 'https://openalex.org/W2148528360', 'https://openalex.org/W2140327417', 'https://openalex.org/W2106647772', 'https://openalex.org/W2006943139'], 'abstract_inverted_index': {'Development': [0, 232], 'of': [1, 19, 30, 38, 54, 60, 67, 81, 92, 115, 134, 172, 186, 190, 220, 233, 251, 262, 270, 286, 292, 299, 313, 324, 347, 366, 404, 418, 422, 452, 485, 538, 576, 591, 682, 769, 808, 824, 944, 1024, 1030, 1038, 1046, 1058, 1143, 1188, 1302, 1309, 1334, 1338, 1467, 1487, 1499, 1562, 1575, 1593, 1688, 1715, 1737, 1752, 1788, 1801, 1814, 1837, 1858, 2041, 2099, 2158, 2259, 2268, 2345, 2383, 2560, 2601, 2610, 2730, 2825, 2829, 2845, 2934, 2978, 2987, 3031, 3050, 3112, 3131, 3179, 3275, 3287, 3346, 3410, 3420, 3430, 3435, 3461, 3522, 3543, 3578, 3629, 3646, 3654, 3661, 3668, 3677, 3724, 3744, 3763, 3768, 3775, 3825, 3838, 3847, 3855, 3860, 3867, 3893, 3925, 3935, 3949, 3980, 4010, 4015, 4024, 4070, 4160, 4165, 4204, 4236], 'the': [2, 57, 61, 68, 76, 88, 94, 98, 113, 132, 135, 198, 205, 218, 226, 234, 289, 293, 300, 308, 320, 326, 330, 345, 364, 367, 430, 437, 450, 458, 534, 543, 567, 661, 700, 732, 735, 739, 773, 785, 804, 809, 813, 816, 858, 1044, 1144, 1192, 1310, 1465, 1471, 1490, 1532, 1539, 1559, 1563, 1573, 1712, 1748, 1769, 1773, 1859, 2169, 2257, 2263, 2400, 2469, 2558, 2676, 2701, 2717, 2823, 3035, 3059, 3082, 3092, 3129, 3132, 3138, 3143, 3172, 3180, 3186, 3195, 3207, 3216, 3276, 3300, 3423, 3438, 3520, 3544, 3579, 3627, 3630, 3644, 3650, 3666, 3669, 3693, 3722, 3752, 3761, 3773, 3777, 3823, 3856, 3863, 3872, 3886, 3891, 3900, 3904, 3909, 3923, 3933, 3936, 3946, 3951, 3998, 4047, 4158, 4163, 4202, 4234], 'expansive': [3, 235], 'endoplasmic': [4, 236, 465, 473], 'reticulum': [5, 237, 466], '(ER)': [6, 238, 467], 'present': [7, 239, 3697, 3756], 'in': [8, 48, 75, 97, 103, 126, 157, 166, 197, 204, 240, 280, 307, 329, 335, 358, 389, 398, 429, 436, 667, 704, 1128, 1504, 1572, 1718, 1756, 1768, 1791, 1981, 2358, 2399, 2404, 2495, 2586, 2591, 2618, 2650, 2675, 2716, 2726, 2797, 2822, 3047, 3258, 3343, 3413, 3422, 3437, 3458, 3479, 3485, 3535, 3554, 3585, 3633, 3649, 3682, 3690, 3698, 3730, 3757, 3782, 3786, 3830, 3869, 3876, 3903, 3917, 3932, 3956, 3990, 3992, 4002, 4017, 4049, 4052, 4072, 4081, 4085, 4143, 4147, 4230], 'specialized': [9, 241, 669], 'secretory': [10, 173, 206, 242, 405, 438, 544, 670, 736, 1041, 1065], 'cell': [11, 243, 671, 1050, 2438, 2575, 3023, 3042, 4078, 4180], 'types': [12, 244, 672, 1051], 'requires': [13, 245], 'X-box-binding': [14, 246, 480, 486, 934], 'protein-1': [15, 247, 935], '(Xbp-1).': [16, 248], 'Enforced': [17, 249, 1300, 4013], 'expression': [18, 250, 823, 1057, 1301, 1333, 1813, 1836, 3542, 3837, 4014, 4069], 'XBP-1(S),': [20, 252, 482, 1208], 'a': [21, 152, 163, 187, 253, 384, 395, 419, 529, 779, 855, 1119, 1140, 1199, 1202, 1211, 1335, 1496, 1653, 1798, 1850, 1854, 1909, 1936, 1960, 2072, 2105, 2301, 2524, 2727, 3048, 3110, 3357, 3404, 3471, 3986, 4058, 4075, 4138], 'transcriptional': [22, 254], 'activator': [23, 255], 'generated': [24, 256, 1870, 1906, 1933, 1957], 'by': [25, 184, 215, 257, 416, 447, 819, 1118, 1124, 1473, 1531, 1624, 1776, 1830, 1871, 1907, 1934, 1958, 2068, 2176, 2180, 2287, 2508, 2597, 2710, 2722, 2742, 2752, 2946, 3156, 3427, 3493, 3514, 3741, 3911, 4057], 'unfolded': [26, 258, 476, 774], 'protein': [27, 259, 477, 514, 518, 522, 775, 805, 1408, 2156, 2171, 2443, 2458, 3363, 4145], 'response-mediated': [28, 260], 'splicing': [29, 261, 1121, 1873], 'Xbp-1': [31, 263, 1047, 1114, 1189], 'mRNA,': [32, 264], 'is': [33, 101, 120, 265, 333, 352, 528, 664, 702, 728, 772, 811, 937, 1116, 1304, 1460, 1502, 1528, 1595, 1622, 1730, 1739, 1754, 1772, 1794, 3548, 3871, 3915, 4055], 'sufficient': [34, 121, 266, 353, 1305, 1463, 1740, 1795, 3549], 'to': [35, 122, 151, 155, 267, 354, 383, 387, 542, 571, 595, 731, 1197, 1306, 1570, 1598, 2272, 2437, 2574, 3065, 3069, 3148, 3171, 3185, 3205, 3251, 3441, 3550, 3771, 4156], 'induce': [36, 268, 4021], 'proliferation': [37, 269], 'rough': [39, 167, 271, 399, 592, 662, 1031, 1311, 1802], 'ER.': [40, 272, 1803], 'We': [41, 208, 273, 440, 1678, 1782, 3920, 4184], 'previously': [42, 274, 1679, 2184, 2763, 2851, 2904, 2950, 3002, 3538], 'showed': [43, 275, 1680, 4066], 'that': [44, 87, 111, 129, 156, 194, 210, 276, 319, 343, 361, 388, 426, 442, 678, 741, 1137, 1209, 1656, 1681, 1747, 1764, 1785, 1825, 3278, 3540, 3751, 3822, 3897, 3922, 4067, 4171, 4225], 'XBP-1(S)-induced': [45, 179, 277, 411, 1719], 'ER': [46, 62, 168, 180, 199, 213, 224, 230, 278, 294, 400, 412, 431, 445, 456, 462, 568, 593, 663, 701, 725, 743, 770, 786, 810, 825, 861, 1032, 1060, 1134, 1312, 1339, 1500, 1723, 1742, 1816, 1820, 1828, 1838, 2994, 2998, 3857], 'biogenesis': [47, 279, 744, 1466, 1829], 'fibroblasts': [49, 104, 145, 281, 336, 377, 1505, 1682, 1757, 1807, 1972, 2043, 3556, 3788, 4004, 4018], 'correlates': [50, 282, 4005], 'with': [51, 283, 1853, 2063, 2256, 2351, 2376, 2392, 2442, 2448, 2457, 2462, 2476, 2644, 2744, 3299, 3308, 3506, 3516, 3640, 3692, 3818, 4006, 4193], 'increased': [52, 284, 574, 1735, 1786, 1809, 3728, 3828, 4008, 4022, 4228], 'production': [53, 285, 598, 2609, 3743, 3767], 'phosphatidylcholine': [55, 287], '(PtdCho),': [56, 288, 1489], 'primary': [58, 290, 1774], 'phospholipid': [59, 291, 1494, 1833, 3781, 3853, 3875], 'membrane,': [63, 295], 'and': [64, 72, 90, 169, 223, 296, 304, 322, 401, 455, 536, 827, 830, 860, 942, 1001, 1062, 1191, 1406, 1462, 1495, 1661, 1690, 1722, 1750, 1818, 1835, 1904, 1931, 1955, 1969, 1973, 2014, 2163, 2178, 2282, 2331, 2343, 2355, 2363, 2378, 2396, 2440, 2500, 2517, 2521, 2527, 2563, 2577, 2595, 2605, 2613, 2648, 2700, 2714, 2748, 2831, 2938, 2944, 2982, 2989, 2997, 3063, 3097, 3107, 3142, 3151, 3177, 3200, 3215, 3282, 3306, 3321, 3328, 3341, 3356, 3417, 3432, 3446, 3453, 3476, 3482, 3502, 3519, 3599, 3642, 3664, 3671, 3685, 3735, 3820, 3849, 3865, 3890, 4190, 4195, 4200, 4214], 'enhanced': [65, 297, 1686, 1765, 3595, 3753, 3999], 'activities': [66, 298, 1687], 'choline': [69, 301, 498, 501, 1565, 2619, 3592], 'cytidylyltransferase': [70, 302, 1566], '(CCT)': [71, 303, 1567], 'cholinephosphotransferase': [73, 305, 1626], 'enzymes': [74, 306, 684], 'cytidine': [77, 309, 495, 1533], 'diphosphocholine': [78, 310, 1534], '(CDP-choline)': [79, 311], 'pathway': [80, 137, 174, 312, 369, 406, 545, 1541, 1771, 3581, 3632], 'PtdCho': [82, 124, 149, 314, 356, 381, 1527, 1602, 1660, 1738, 1780, 1789, 1810, 2674, 2758, 2826, 3552, 3583, 3745, 3848, 3894], 'biosynthesis.': [83, 315, 3895], 'Here,': [84, 316, 1744], 'we': [85, 317, 1745, 1823, 3636, 3813, 3880, 3907, 3943, 4136, 4169], 'report': [86, 318, 1746], 'level': [89, 153, 321, 385, 1036, 1749, 3676, 3723, 3774, 3934, 3948, 4164], 'synthesis': [91, 150, 323, 382, 1037, 1751, 1787, 2759, 3679, 3726, 3824, 3846, 4146, 4227], 'CCT,': [93, 116, 325, 348, 497, 3598], 'rate-limiting': [95, 327, 1560, 3901], 'enzyme': [96, 328, 1655, 4051], 'CDP-choline': [99, 136, 331, 368, 1571, 1594, 1770, 2715, 3580, 3631, 3725, 3764, 3905], 'pathway,': [100, 332, 778, 1564, 3906], 'elevated': [102, 334, 1812, 3601, 3742], 'overexpressing': [105, 146, 337, 378, 1506, 1683, 1758], 'XBP-1(S).': [106, 338, 1759], 'Furthermore,': [107, 339, 1760, 3576], 'overexpression': [108, 340, 3291], 'experiments': [109, 341, 3115, 3123, 3277, 4223], 'demonstrated': [110, 342, 3539], 'raising': [112, 344], 'activity': [114, 346, 1066, 1767, 2848, 2899, 3590, 3596, 3602, 3696, 3755, 3914, 3927, 4001], 'but': [117, 160, 349, 392, 1711, 4140], 'not': [118, 350, 1482, 1726, 4020], 'cholinephosphotransferase,': [119, 351], 'augment': [123, 355, 1407], 'biosynthesis': [125, 357, 1409, 1721, 1834, 3553, 3584], 'fibroblasts,': [127, 359], 'indicating': [128, 360], 'XBP-1(S)': [130, 211, 362, 443, 1303, 1459, 1507, 1684, 1778, 1826, 3288, 3547, 3839, 3861, 3889, 4016, 4071, 4161], 'increases': [131, 363, 3760], 'output': [133, 365, 3645], 'primarily': [138, 370, 1529], 'via': [139, 371], 'its': [140, 372, 3913], 'effects': [141, 373, 1480], 'on': [142, 374, 734, 2402, 2582, 3270, 3339, 3862, 3884, 3945, 4162], 'CCT.': [143, 375], 'Finally,': [144, 376], 'CCT': [147, 379, 1689, 1753, 1766, 2830, 2846, 3754, 3898, 3926, 3937, 3953, 4000], 'up-regulated': [148, 380, 1503, 1755], 'similar': [154, 386, 3681, 3694], 'XBP-1(S)-transduced': [158, 390, 1806, 3108, 3536, 3586, 3634, 3686, 3731, 3758, 3787, 3831, 3918, 3993, 4003, 4148, 4191, 4231], 'cells': [159, 391, 677, 946, 1004, 1793, 1975, 2017, 2101, 2138, 2388, 2571, 2615, 2641, 2788, 2836, 2925, 2984, 3587, 3639, 3687, 3732, 3759, 3832, 3958, 3994, 4150, 4192], 'exhibited': [161, 393], 'only': [162, 394, 1797], 'small': [164, 396], 'increase': [165, 397, 1332, 3931, 3989, 4084, 4142], 'no': [170, 402], 'induction': [171, 185, 403, 417], 'genes.': [175, 407], 'The': [176, 408, 464, 930, 1590, 2208, 2250, 2311, 2738, 3040, 3190, 3265, 3284, 3351, 3448, 3675], 'more': [177, 409], 'robust': [178, 410, 1819], 'expansion': [181, 413, 1308, 1724, 1800], 'was': [182, 414, 1905, 1932, 1956, 2226, 2254, 2300, 2679, 2704, 2760, 2819, 2900, 3025, 3045, 3056, 3076, 3116, 3135, 3146, 3163, 3203, 3292, 3323, 3354, 3360, 3451, 3468, 3526, 3680, 3727, 3739, 3827], 'accompanied': [183, 415, 3740], 'wide': [188, 420], 'array': [189, 421, 3253], 'genes': [191, 423], 'encoding': [192, 424, 1201], 'proteins': [193, 425, 540, 1340, 4217], 'function': [195, 427, 943], 'either': [196, 428, 1625], 'or': [200, 432, 1650, 3089, 3289, 3348, 4060], 'at': [201, 433, 2636, 2794, 2985, 3091, 3168, 3304, 3330], 'other': [202, 434, 668], 'steps': [203, 435], 'pathway.': [207, 439, 737, 3651], 'propose': [209, 441, 1824], 'regulates': [212, 444], 'abundance': [214, 446, 862], 'coordinately': [216, 448, 1831], 'increasing': [217, 449, 822, 4198], 'supply': [219, 451, 1736, 3762], 'membrane': [221, 453, 787], 'phospholipids': [222, 454], 'proteins,': [225, 457, 1061, 1817, 2566], 'key': [227, 459, 767, 3852], 'ingredients': [228, 460], 'for': [229, 461, 533, 939, 1034, 1464, 1741, 1796, 2038, 2366, 2373, 2502, 2633, 2706, 2750, 2791, 2843, 2993, 3078, 3095, 3165, 3362, 3531, 3582, 3591, 3597, 3603, 3659, 3765, 3843, 4197], 'biogenesis.': [231, 463, 1743], '3The': [468], 'abbreviations': [469], 'used': [470, 2037, 2842, 3204, 3250], 'are:': [471], 'ER,': [472, 1055, 1469], 'reticulum;': [474], 'UPR,': [475], 'response;': [478], 'XBP-1,': [479], 'protein-1;': [481, 487], 'spliced': [483], 'form': [484], 'IRE1,': [488], 'inositol': [489, 1130], 'requiring': [490, 1131], '1;': [491], 'PtdCho,': [492, 2604, 2614, 3772], 'phosphatidylcholine;': [493], 'CDP-choline,': [494, 2603, 2612, 3665], 'diphosphocholine;': [496], 'cytidylyltransferase;': [499], 'CK,': [500], 'kinase;': [502], 'DAG,': [503], 'diacylglycerol;': [504], 'CPT1,': [505], 'cholinephosphotransferase;': [506], 'CEPT1,': [507], 'choline/ethanolaminephosphotransferase;': [508], 'PtdEtn,': [509, 3776, 3850], 'phosphatidylethanolamine;': [510], 'BiP,': [511], 'immunoglobulin-binding': [512], 'protein/glucose-regulated': [513], '78;': [515], 'GRP94,': [516, 2280], 'glucose-regulated': [517], '94;': [519], 'TRAPα,': [520], 'translocon-associated': [521], 'α;': [523], 'GFP,': [524], 'green': [525], 'fluorescent': [526], 'protein.': [527], 'multifunctional': [530], 'organelle': [531], 'responsible': [532], 'folding': [535, 806, 828], 'assembly': [537], 'all': [539, 1023, 3274], 'targeted': [541], '(1Anken': [546], 'E.': [547, 551, 886, 956, 1076, 1364, 1433, 4110], 'Braakman': [548], 'I.': [549, 2855], 'Craig': [550], 'Crit.': [552], 'Rev.': [553, 793, 839], 'Biochem.': [554, 650, 794, 840, 1668, 2145, 2240, 2663, 2909, 3368], 'Mol.': [555, 1395, 1550, 1611, 2026], 'Biol.': [556, 630, 689, 757, 921, 1323, 1397, 1518, 1551, 1612, 1635, 1702, 1884, 1993, 2088, 2118, 2193, 2215, 2541, 2691, 2775, 2859, 2883, 2962, 3013, 3394, 3567, 3615, 3711, 3799, 3969, 4037], '2005;': [557, 758, 795, 841, 1015, 1106], '40:': [558], '191-228Crossref': [559], 'PubMed': [560, 611, 634, 655, 693, 722, 761, 798, 844, 906, 925, 971, 993, 1018, 1091, 1109, 1157, 1179, 1235, 1271, 1295, 1327, 1384, 1401, 1453, 1522, 1555, 1585, 1616, 1645, 1673, 1706, 1888, 2003, 2031, 2058, 2092, 2128, 2150, 2203, 2223, 2245, 2551, 2668, 2695, 2779, 2869, 2893, 2914, 2966, 3017, 3244, 3372, 3398, 3571, 3619, 3715, 3803, 3973, 4041, 4130], 'Scopus': [561, 612, 635, 656, 694, 762, 799, 845, 907, 926, 972, 994, 1019, 1092, 1110, 1158, 1180, 1236, 1272, 1296, 1328, 1385, 1402, 1454, 1523, 1586, 1646, 1674, 1707, 1889, 2004, 2032, 2059, 2093, 2129, 2151, 2204, 2246, 2552, 2669, 2696, 2780, 2870, 2894, 2915, 2967, 3018, 3245, 3373, 3399, 3572, 3620, 3716, 3804, 3974, 4042, 4131], '(173)': [562], 'Google': [563, 614, 637, 658, 696, 723, 764, 801, 847, 909, 928, 974, 996, 1021, 1094, 1112, 1160, 1182, 1238, 1274, 1298, 1330, 1387, 1404, 1456, 1525, 1556, 1588, 1617, 1648, 1676, 1709, 1891, 2006, 2034, 2061, 2095, 2131, 2153, 2206, 2224, 2248, 2554, 2671, 2698, 2782, 2872, 2896, 2917, 2969, 3020, 3247, 3375, 3401, 3574, 3622, 3718, 3806, 3976, 4044, 4133], 'Scholar).': [564, 659, 697, 724, 765, 802, 848, 929, 1113, 1183, 1299, 1457, 1526, 1557, 1589, 1618, 1677, 1892, 2007, 2096, 2132, 2154, 2207, 2249, 2555, 2783, 2897, 2970, 3021, 3376, 3575, 3623, 3719, 3807, 3977, 4134], 'As': [565], 'such,': [566], 'can': [569, 1657], 'adapt': [570], 'accommodate': [572], 'an': [573, 588, 1133, 1734, 3497, 3930, 4007, 4082], 'load': [575], 'nascent': [577], 'polypeptides.': [578], 'For': [579, 3104, 3118], 'example,': [580], 'when': [581], 'B-lymphocytes': [582], 'differentiate': [583], 'into': [584, 1919, 1946, 1965, 2565, 2816, 4206, 4215], 'antibody-secreting': [585], 'plasma': [586, 945], 'cells,': [587, 706, 1000, 3109, 3120, 3635, 4074], 'elaborate': [589], 'network': [590], 'develops': [594], 'facilitate': [596], 'immunoglobulin': [597], '(2Shohat': [599], 'M.': [600, 623, 789, 835, 866, 1171, 1216, 1344, 1413, 3227, 3387, 4090], 'Janossy': [601], 'G.': [602, 1631, 1842, 1977, 3221], 'Dourmashkin': [603], 'R.R.': [604], 'Eur.': [605], 'J.': [606, 628, 687, 716, 919, 952, 1014, 1072, 1105, 1175, 1321, 1516, 1634, 1669, 1700, 1882, 1992, 2086, 2117, 2146, 2192, 2214, 2540, 2662, 2689, 2773, 2858, 2877, 2882, 2910, 2960, 3011, 3229, 3392, 3565, 3613, 3709, 3797, 3967, 4035], 'Immunol.': [607, 989, 2027], '1973;': [608], '3:': [609], '680-687Crossref': [610], '(33)': [613], 'Scholar,': [615, 638, 910, 975, 1095, 1161, 1239, 1275, 1388, 2873], '3Wiest': [616], 'D.L.': [617, 3381], 'Burkhardt': [618, 3382], 'J.K.': [619, 3383], 'Hester': [620, 3384], 'S.': [621, 914, 1316, 1511, 1545, 1606, 1695, 1877, 2053, 2081, 2213, 2238, 2684, 2768, 2857, 2881, 2955, 3006, 3233, 3385, 3560, 3608, 3704, 3792, 3962, 4030], 'Hortsch': [622, 3386], 'Meyer': [624, 3388], 'D.I.': [625, 3389], 'Argon': [626, 3390], 'Y.': [627, 1167, 3391], 'Cell': [629, 688, 717, 756, 920, 1322, 1517, 1701, 1883, 1967, 2087, 2690, 2774, 2939, 2961, 3012, 3335, 3393, 3566, 3614, 3710, 3798, 3968, 4036], '1990;': [631, 3395], '110:': [632, 3396], '1501-1511Crossref': [633, 3397], '(190)': [636, 3400], '4Rush': [639], 'J.S.': [640], 'Sweitzer': [641], 'T.': [642, 1279, 1283], 'Kent': [643], 'C.': [644, 1578], 'Decker': [645], 'G.L.': [646], 'Waechter': [647], 'C.J.': [648], 'Arch.': [649, 2239], 'Biophys.': [651, 1580, 2241], '1991;': [652], '284:': [653], '63-70Crossref': [654], '(34)': [657], 'Likewise,': [660], 'highly': [665], 'developed': [666, 1054, 3477, 3484], 'such': [673, 707], 'as': [674, 708, 1139, 1538, 2066, 2139, 2183, 2532, 2762, 2821, 2849, 2902, 2949, 3000, 3736], 'pancreatic': [675, 998], 'acinar': [676, 999], 'secrete': [679], 'copious': [680], 'amounts': [681, 2579], 'digestive': [683], '(5Bolender': [685], 'R.P.': [686], '1974;': [690], '61:': [691], '269-287Crossref': [692], '(211)': [695], 'In': [698, 849, 1043, 1558, 1804, 2466, 2755, 3126, 3720, 3939], 'contrast,': [699, 1805, 3721], 'sparse': [703], 'non-secretory': [705], 'reticulocytes': [709], '(6Grasso': [710], 'J.A.': [711, 2047], 'Sullivan': [712], 'A.L.': [713, 864, 1342, 1411, 1629, 1665, 2142, 2906, 4088], 'Chan': [714], 'S.C.': [715], 'Sci.': [718, 2051], '1978;': [719], '31:': [720, 3242], '165-178Crossref': [721], 'abundance,': [726], 'therefore,': [727, 4046], 'regulated': [729], 'according': [730, 3184], 'demands': [733], 'However,': [738], 'mechanisms': [740, 1472], 'regulate': [742], 'are': [745, 1195], 'incompletely': [746], 'defined': [747], '(7Federovitch': [748], 'C.M.': [749], 'Ron': [750, 1172, 1229], 'D.': [751, 960, 1080, 1173, 1230, 3235], 'Hampton': [752], 'R.Y.': [753], 'Curr.': [754], 'Opin.': [755], '17:': [759, 1177], '409-414Crossref': [760], '(90)': [763], 'A': [766, 3465, 4063], 'regulator': [768], 'homeostasis': [771], 'response': [776], '(UPR)': [777], 'complex': [780], 'signaling': [781], 'system': [782, 2729, 4054], 'emanating': [783], 'from': [784, 1912, 1939, 1963, 2136, 2303, 2568, 2922, 3027, 3209, 3273, 3403, 4178], '(8Schroder': [788, 834], 'Kaufman': [790, 836, 1150, 1260], 'R.J.': [791, 837, 1151, 1261], 'Annu.': [792, 838], '74:': [796, 842], '739-789Crossref': [797, 843], '(2513)': [800, 846], 'When': [803], 'capacity': [807, 3842], 'challenged,': [812], 'UPR': [814, 859, 1145], 'relieves': [815], 'resulting': [817, 1193], 'stress': [818], 'repressing': [820], 'translation,': [821], 'chaperones': [826], 'enzymes,': [829], 'enhancing': [831], 'ER-associated': [832], 'degradation': [833], 'addition,': [850], 'recent': [851], 'studies': [852, 3817, 3883], 'have': [853, 1481], 'uncovered': [854], 'connection': [856, 3887], 'between': [857, 3888], '(9Shaffer': [863, 1341, 1410, 4087], 'Shapiro-Shelef': [865, 1343, 1412, 4089], 'Iwakoshi': [867, 949, 1009, 1069, 1100, 1345, 1391, 1414, 4091], 'N.N.': [868, 950, 977, 1010, 1070, 1101, 1346, 1392, 1415, 4092], 'Lee': [869, 978, 1244, 1347, 1416, 4093], 'A.H.': [870, 979, 1006, 1097, 1348, 1390, 1417, 4094], 'Quian': [871, 1349, 1418, 4095], 'S.B.': [872, 1350, 1419, 4096], 'Zhao': [873, 1351, 1420, 4097], 'H.': [874, 1218, 1253, 1277, 1352, 1421, 4098], 'Yu': [875, 1353, 1422, 4099], 'X.': [876, 1241, 1354, 1423, 4100], 'Yang': [877, 1248, 1355, 1424, 4101], 'L.': [878, 1356, 1425, 4102], 'Tan': [879, 1357, 1426, 4103], 'B.K.': [880, 1358, 1427, 4104], 'Rosenwald': [881, 1359, 1428, 4105], 'A.': [882, 1251, 1281, 1360, 1429, 1543, 1604, 2054, 2853, 2875, 4106], 'Hurt': [883, 1361, 1430, 4107], 'E.M.': [884, 958, 1078, 1169, 1362, 1431, 4108], 'Petroulakis': [885, 1363, 1432, 4109], 'Sonenberg': [887, 1365, 1434, 4111], 'N.': [888, 1366, 1435, 4112], 'Yewdell': [889, 1367, 1436, 4113], 'J.W.': [890, 918, 1320, 1368, 1437, 1515, 1699, 1881, 1991, 2025, 2045, 2085, 2116, 2191, 2539, 2688, 2772, 2959, 3010, 3564, 3612, 3708, 3796, 3966, 4034, 4114], 'Calame': [891, 1369, 1438, 4115], 'K.': [892, 916, 985, 1245, 1249, 1259, 1285, 1318, 1370, 1439, 1513, 1697, 1879, 2023, 2083, 2686, 2770, 2957, 3008, 3562, 3610, 3706, 3794, 3964, 4032, 4116], 'Glimcher': [893, 965, 986, 1011, 1085, 1102, 1371, 1393, 1440, 4117], 'L.H.': [894, 966, 987, 1012, 1086, 1103, 1372, 1394, 1441, 4118], 'Staudt': [895, 1373, 1442, 4119], 'L.M.': [896, 1374, 1443, 4120], 'Immunity.': [897, 1375, 1444, 4121], '2004;': [898, 922, 1324, 1376, 1445, 1519, 1703, 1885, 2028, 2089, 2692, 2776, 2963, 3014, 3568, 3616, 3712, 3800, 3970, 4038, 4122], '21:': [899, 1377, 1446, 4123], '81-93Abstract': [900, 1378, 1447, 4124], 'Full': [901, 903, 1266, 1268, 1290, 1292, 1379, 1381, 1448, 1450, 1640, 1642, 1998, 2000, 2123, 2125, 2198, 2200, 2220, 2546, 2548, 2864, 2866, 2888, 2890, 4125, 4127], 'Text': [902, 904, 1267, 1269, 1291, 1293, 1380, 1382, 1449, 1451, 1641, 1643, 1999, 2001, 2124, 2126, 2199, 2201, 2221, 2547, 2549, 2865, 2867, 2889, 2891, 4126, 4128], 'PDF': [905, 1270, 1294, 1383, 1452, 1644, 2002, 2127, 2202, 2222, 2550, 2868, 2892, 4129], '(798)': [908, 1386, 1455, 4132], '10Sriburi': [911], 'R.': [912, 1243, 1255, 1314, 1509, 1693, 1875, 2079, 2682, 2766, 2953, 3004, 3225, 3558, 3606, 3702, 3790, 3960, 4028], 'Jackowski': [913, 1315, 1510, 1544, 1605, 1694, 1876, 2080, 2237, 2683, 2767, 2856, 2880, 2954, 3005, 3559, 3607, 3703, 3791, 3961, 4029], 'Mori': [915, 1258, 1284, 1317, 1512, 1696, 1878, 2022, 2082, 2685, 2769, 2956, 3007, 3561, 3609, 3705, 3793, 3963, 4031], 'Brewer': [917, 1319, 1514, 1698, 1880, 1990, 2024, 2084, 2115, 2190, 2538, 2687, 2771, 2958, 3009, 3563, 3611, 3707, 3795, 3965, 4033], '167:': [923, 1325, 1520, 1704, 1886, 2090, 2693, 2777, 2964, 3015, 3569, 3617, 3713, 3801, 3971, 4039], '35-41Crossref': [924, 1326, 1521, 1705, 1887, 2091, 2694, 2778, 2965, 3016, 3570, 3618, 3714, 3802, 3972, 4040], '(532)': [927, 1329, 1524, 1708, 1890, 2094, 2697, 2781, 2968, 3019, 3573, 3621, 3717, 3805, 3975, 4043], 'UPR-regulated': [931], 'transcription': [932, 1476, 3545], 'factor': [933, 1477, 3546], '(XBP-1)': [936], 'required': [938], 'proper': [940], 'development': [941], '(11Reimold': [947, 1067], 'A.M.': [948, 1068], 'Manis': [951, 1071], 'Vallabhajosyula': [953, 980, 1073], 'P.': [954, 981, 1074], 'Szomolanyi-Tsuda': [955, 1075], 'Gravallese': [957, 1077], 'Friend': [959, 1079], 'Grusby': [961, 1081], 'M.J.': [962, 1082], 'Alt': [963, 1083], 'F.': [964, 1084, 1220], 'Nature.': [967, 1087, 1231], '2001;': [968, 1088, 1263, 1287, 1552, 1613, 2885], '412:': [969, 1089], '300-307Crossref': [970, 1090], '(1066)': [973, 1093], '12Iwakoshi': [976], 'Otipoby': [982], 'K.L.': [983], 'Rajewsky': [984], 'Nat.': [988], '2003;': [990, 1398, 3241], '4:': [991], '321-329Crossref': [992], '(721)': [995], 'Scholar),': [997, 1022, 1331, 1405, 1710, 2035, 2672, 2699], 'salivary': [1002], 'gland': [1003], '(13Lee': [1005], 'Chu': [1007, 1098], 'G.C.': [1008, 1099], 'EMBO': [1013, 1104, 1174], '24:': [1016, 1107], '4368-4380Crossref': [1017, 1108], '(363)': [1020, 1111], 'which': [1025, 1474, 1777, 3912], 'normally': [1026], 'contain': [1027], 'large': [1028, 1336], 'quantities': [1029], 'necessary': [1033, 1461], 'high': [1035], 'their': [1039], 'respective': [1040], 'cargoes.': [1042], 'absence': [1045], 'expression,': [1048], 'these': [1049, 1479, 1716], 'exhibit': [1052, 1685, 1808], 'poorly': [1053], 'reduced': [1056], 'many': [1059, 1815], 'severely': [1063], 'compromised': [1064], '13Lee': [1096], 'mRNA': [1115, 1190, 1852], 'modified': [1117, 1983, 2799], 'novel': [1120], 'mechanism': [1122, 3910], 'initiated': [1123], 'IRE1': [1125, 1184], '(first': [1126], 'identified': [1127, 2741, 3513], 'yeast,': [1129], 'mutant),': [1132], 'transmembrane': [1135], 'kinase/endoribonuclease': [1136], 'serves': [1138], 'proximal': [1141], 'transducer': [1142], '(14Tirasophon': [1146], 'W.': [1147], 'Welihinda': [1148], 'A.A.': [1149], 'Genes': [1152], 'Dev.': [1153], '1998;': [1154, 1176], '12:': [1155], '1812-1824Crossref': [1156], '(765)': [1159], '15Wang': [1162], 'X.Z.': [1163], 'Harding': [1164, 1225], 'H.P.': [1165, 1226], 'Zhang': [1166], 'Jolicoeur': [1168], 'Kuroda': [1170], '5708-5717Crossref': [1178], '(668)': [1181], 'executes': [1185], 'site-specific': [1186], 'cleavage': [1187], 'fragments': [1194], 'ligated': [1196], 'yield': [1198, 3442], 'transcript': [1200], 'basic': [1203], 'leucine': [1204], 'zipper': [1205], 'protein,': [1206], 'termed': [1207], 'bears': [1210], 'strong': [1212], 'transactivating': [1213], 'domain': [1214], '(16Calfon': [1215], 'Zeng': [1217], 'Urano': [1219], 'Till': [1221], 'J.H.': [1222], 'Hubbard': [1223], 'S.R.': [1224], 'Clark': [1227], 'S.G.': [1228], '2002;': [1232, 1995, 2120, 2195, 2543], '415:': [1233], '92-96Crossref': [1234], '(2210)': [1237], '17Shen': [1240], 'Ellis': [1242], 'Liu': [1246], 'C.-Y.': [1247], 'Solomon': [1250], 'Yoshida': [1252], 'Morimoto': [1254], 'Kurnit': [1256], 'D.M.': [1257], 'Cell.': [1262, 1286, 1396], '107:': [1264, 1288], '893-903Abstract': [1265], '(569)': [1273], '18Yoshida': [1276], 'Matsui': [1278], 'Yamamoto': [1280], 'Okada': [1282], '881-891Abstract': [1289], '(3099)': [1297], 'drive': [1307], '(10Sriburi': [1313, 1508, 1692, 1874, 2078, 2681, 2765, 2952, 3003, 3557, 3605, 3701, 3789, 3959, 4027], 'number': [1337, 1902], '19Lee': [1389], '23:': [1399], '7448-7459Crossref': [1400], '(1677)': [1403], 'Therefore,': [1458, 3835], 'functional': [1468], 'yet': [1470], 'this': [1475, 3738, 3811, 3941, 4053], 'mediates': [1478], 'been': [1483, 1727], 'fully': [1484], 'delineated.': [1485], 'Synthesis': [1486, 3866], 'phophatidylcholine': [1488], 'most': [1491, 3779, 3873], 'abundant': [1492, 3780, 3874], 'cellular': [1493, 3656, 3783, 3841, 3877], 'major': [1497], 'component': [1498], 'membranes,': [1501, 3784], 'produced': [1530, 2010], '(CDP-choline),': [1535], 'also': [1536, 1783], 'known': [1537], 'Kennedy': [1540], '(20Lykidis': [1542, 1603], 'Prog.': [1546, 1607], 'Nucleic': [1547, 1608, 3238], 'Acid': [1548, 1609], 'Res.': [1549, 1610, 3240], '65:': [1553, 1614], '361-393Crossref': [1554, 1615], 'step': [1561, 1621, 3425, 3440, 3648, 3902], 'converts': [1568], 'phosphocholine': [1569, 1591, 3663, 3678], 'presence': [1574], 'CTP': [1576], '(21Kent': [1577], 'Biochim.': [1579], 'Acta.': [1581], '1997;': [1582], '1348:': [1583], '79-90Crossref': [1584], '(192)': [1587], 'moiety': [1592], 'then': [1596, 2356, 2371, 2397, 2455, 2472, 3483, 4185], 'transferred': [1597], 'diacylglycerol': [1599], '(DAG),': [1600], 'yielding': [1601], 'This': [1619, 4153], 'final': [1620], 'catalyzed': [1623], '(CPT1)': [1627], '(22Henneberry': [1628], 'Wistow': [1630], 'McMaster': [1632, 1666, 2143, 2907], 'C.R.': [1633, 1667, 2144, 2908], 'Chem.': [1636, 1994, 2119, 2194, 2216, 2542, 2860, 2884], '2000;': [1637, 2055], '275:': [1638], '29808-29815Abstract': [1639], '(92)': [1647], 'Scholar)': [1649, 2062, 2225, 2918, 3248, 3402], 'choline/ethanolaminephosphotransferase': [1651], '(CEPT1),': [1652], 'bifunctional': [1654], 'synthesize': [1658], 'both': [1659, 3662, 3699], 'phosphatidylethanolamine': [1662], '(PtdEtn)': [1663], '(23Henneberry': [1664, 2141, 2905], '1999;': [1670, 2147, 2861, 2911], '339:': [1671, 2148, 2912], '291-298Crossref': [1672, 2149, 2913], '(103)': [1675, 2152, 2916], 'CPT1/CEPT1': [1691], 'relative': [1713], 'role': [1714], 'alterations': [1717], 'Ptd-Cho': [1720], 'has': [1725], 'clarified.': [1728], 'Neither': [1729], 'it': [1731], 'clear': [1732], 'whether': [1733], 'our': [1761, 3882], 'data': [1762, 3208, 3271, 3307, 3749], 'indicate': [1763, 3750], 'means': [1775], 'up-regulates': [1779], 'production.': [1781], 'demonstrate': [1784], 'alone': [1790], 'CCT-transduced': [1792], 'meager': [1799], 'synthesis,': [1811, 2787], 'expansion.': [1821], 'Thus,': [1822, 3997], 'orchestrates': [1827], 'regulating': [1832], 'proteins.': [1839], 'Plasmids—pBMN-I-GFP': [1840], '(Dr.': [1841, 1976], 'Nolan,': [1843], 'Stanford': [1844], 'University,': [1845, 2308], 'Palo': [1846], 'Alto,': [1847], 'CA)': [1848], 'encodes': [1849, 1866, 1894, 1922, 1949], 'bicistronic': [1851], 'GFP': [1855, 2069], 'cassette': [1856], '3′': [1857], 'internal': [1860], 'ribosomal': [1861], 'entry': [1862], 'site': [1863], '(I).': [1864], 'pBMN-hXBP-1(S)-I-GFP': [1865], 'full-length': [1867, 1895, 1923, 1950, 2229], 'human': [1868, 1924, 4076], 'XBP-1': [1869, 2269], 'UPR-mediated': [1872], 'pBMN-mCEPT1-I-GFP': [1893], 'mouse': [1896, 1951, 2320, 3085], 'CEPT1': [1897], '(nucleotides': [1898, 1926, 1953], '1–2050;': [1899], 'GenBank™': [1900], 'accession': [1901, 1929], 'BC023783)': [1903], 'subcloning': [1908, 1935, 1959], 'NotI-StuI': [1910, 1937], 'insert': [1911, 1938, 1962], 'pCMV-Sport6-mCEPT1': [1913], '(American': [1914, 1941], 'Type': [1915, 1942], 'Culture': [1916, 1943, 1968], 'Collection': [1917, 1944], '#7062235)': [1918], 'pBMN-I-GFP.': [1920, 1947, 1966], 'pBMN-hCPT1-I-GFP': [1921], 'CPT1': [1925], '1–1579;': [1927], 'GenBank': [1928], '#BC050429)': [1930], 'pCMV-Sport6-hCPT1': [1940], '#9271995)': [1945], 'pBMN-mCCTα-I-GFP': [1948], 'CCTα': [1952, 2232, 2346, 3290, 3868, 3991, 4011, 4025, 4050, 4166, 4173, 4209, 4226], '47–1150)': [1954], 'XhoI-HindIII': [1961], 'pPJ37-CT': [1964], 'Retroviral': [1970], 'Transduction—NIH-3T3': [1971], 'Phoenix-Eco': [1974, 2015], 'Nolan)': [1978], 'were': [1979, 2036, 2102, 2134, 2166, 2174, 2284, 2339, 2348, 2370, 2389, 2434, 2454, 2471, 2506, 2515, 2519, 2572, 2580, 2589, 2616, 2642, 2655, 2720, 2740, 2789, 2841, 2942, 2991, 3124, 3182, 3192, 3249, 3256, 3268, 3279, 3312, 3319, 3326, 3337, 3378, 3456, 3491, 3504, 3512], 'maintained': [1980], "Dulbecco's": [1982, 2798], "Eagle's": [1984, 2800], 'medium': [1985, 2623, 2801], '(24Gass': [1986, 2111, 2186, 2534], 'J.N.': [1987, 2112, 2187, 2535], 'Gifford': [1988, 2020, 2113, 2188, 2536], 'N.M.': [1989, 2021, 2114, 2189, 2537], '277:': [1996, 2121, 2196, 2544], '49047-49054Abstract': [1997, 2122, 2197, 2545], '(256)': [2005, 2130, 2205, 2553], 'Ecotropic': [2008], 'retroviruses,': [2009], 'using': [2011, 2071, 2104, 2168, 2380, 2510, 2523, 2919, 3034, 3058, 3081, 3137, 3153, 3194, 3294, 3407, 3496, 3528], 'pBMN': [2012], 'plasmids': [2013], 'packaging': [2016], '(25Gunn': [2018], 'K.E.': [2019], '41:': [2029], '919-927Crossref': [2030], '(41)': [2033], 'retroviral': [2039], 'transduction': [2040], 'NIH-3T3': [2042, 3555, 3957, 4149, 4179], '(26Brewer': [2044], 'Diehl': [2046], 'Proc.': [2048], 'Natl.': [2049], 'Acad.': [2050], 'U.': [2052], '97:': [2056], '12625-12630Crossref': [2057], '(372)': [2060], '≥95%': [2064], 'efficiency,': [2065], 'measured': [2067, 2761], 'fluorescence': [2070], 'FACSCalibur': [2073], 'flow': [2074], 'cytometer': [2075], '(BD': [2076], 'Biosciences)': [2077, 2531, 2632], 'Immunoblotting—Cell': [2097], 'lysates': [2098, 2162, 2453, 2567, 4181], 'pelleted': [2100, 2137, 2923, 3320], 'prepared': [2103, 2135, 2921], '1%': [2106], 'Nonidet': [2107, 2160, 2409, 2481, 3981], 'P-40': [2108, 2161, 3982], 'lysis': [2109], 'buffer': [2110, 2407, 2479], 'Microsomes': [2133], 'described': [2140, 2185, 2533, 2764, 2850, 2903, 2951, 3001], 'Total': [2155], 'concentrations': [2157], 'clarified': [2159], 'microsomal': [2164], 'preparations': [2165], 'determined': [2167, 2820, 3026, 3046, 3136, 3293], 'Bio-Rad': [2170], 'assay.': [2172], 'Proteins': [2173], 'resolved': [2175, 2507], 'SDS-PAGE': [2177, 2497, 2509], 'analyzed': [2179, 2596, 2992, 3193], 'chemiluminescent': [2181], 'immunoblotting': [2182], 'rabbit': [2209, 2251, 2276, 2312, 2450, 2463], 'anti-CCTα': [2210, 2464], 'antibody': [2211, 2253, 2317], '(27Jackowski': [2212], '1994;': [2217], '269:': [2218], '3858-3867Abstract': [2219], 'raised': [2227, 2255], 'against': [2228, 2262, 2278], 'recombinant': [2230], 'rodent': [2231], '(28Luche': [2233], 'M.M.': [2234, 3366], 'Rock': [2235], 'C.O.': [2236], '1993;': [2242], '301:': [2243], '114-118Crossref': [2244], '(28)': [2247], 'anti-XBP-1': [2252], 'assistance': [2258], 'Rockland': [2260], 'Immunochemicals': [2261], 'N-terminal': [2264], '81': [2265], 'amino': [2266], 'acids': [2267], 'fused': [2270], 'in-frame': [2271], 'glutathione': [2273], 'S-transferase.': [2274], 'Polyclonal': [2275], 'antisera': [2277], 'BiP/GRP78,': [2279], 'ERdj3,': [2281], 'calnexin': [2283], 'generously': [2285], 'provided': [2286], 'Dr.': [2288, 2304], 'Linda': [2289], 'Hendershot': [2290], '(St.': [2291, 3260], 'Jude': [2292, 3100, 3261], "Children's": [2293, 3101, 3262], 'Research': [2294, 3102, 3263], 'Hospital,': [2295], 'Memphis,': [2296], 'TN).': [2297], 'Rabbit': [2298], 'anti-TRAPα': [2299], 'gift': [2302], 'Chris': [2305], 'Nicchitta': [2306], '(Duke': [2307], 'Durham,': [2309], 'NC).': [2310], 'anti-protein': [2313], 'disulfide': [2314], 'isomerase': [2315], 'polyclonal': [2316], '(Stressgen': [2318], 'Bioreagents),': [2319], 'anti-β-actin': [2321], 'monoclonal': [2322], 'antibody,': [2323], 'clone': [2324], 'AC-15': [2325], '(Sigma),': [2326], 'peroxidase-conjugated': [2327, 2332], 'donkey': [2328, 2333], 'anti-mouse': [2329], 'IgG,': [2330], 'anti-rabbit': [2334], 'IgG': [2335], '(Jackson': [2336], 'ImmunoResearch': [2337], 'Laboratories)': [2338], 'purchased.': [2340], 'Metabolic': [2341], 'Labeling': [2342], 'Analysis': [2344, 2600, 2828, 3218], 'Synthesis—Cells': [2347], 'washed': [2349, 2390, 2473, 2643], 'twice': [2350, 2391], 'warm': [2352, 2359], 'phosphate-buffered': [2353, 2394, 2646, 3349], 'saline': [2354, 2395, 2647], 'cultured': [2357, 2617, 2790], 'media': [2360], 'lacking': [2361], 'methionine': [2362, 2562], 'cysteine': [2364, 2564], '(Invitrogen)': [2365], '20': [2367, 2422], 'min.': [2368, 2504], 'Cells': [2369, 3325], 'labeled': [2372, 2570, 3159, 3638, 4187], 'various': [2374], 'intervals': [2375, 3302, 4199], '[35S]methionine': [2377, 4194], '[35S]cysteine': [2379, 4196], '100': [2381, 2428, 3459], 'μCi/ml': [2382, 2626, 2804], 'Tran35S-label': [2384], '(MB': [2385], 'Biomedicals).': [2386], 'Labeled': [2387], 'cold': [2393, 2405, 2477, 2645], 'solubilized': [2398], 'dish': [2401], 'ice': [2403, 3340], 'lysing': [2406], '(0.5%': [2408, 2480], 'P-40,': [2410, 2482], '0.5%': [2411, 2483], 'sodium': [2412, 2484], 'deoxycholate,': [2413, 2485], '150': [2414], 'mm': [2415, 2418, 2487, 2490], 'NaCl,': [2416, 2488, 2733], '50': [2417, 2489, 3169], 'Tris-HCL,': [2419], 'pH': [2420, 2492], '7.5,': [2421], 'μg/ml': [2423, 2426, 2429], 'leupeptin,': [2424], '40': [2425], 'aprotinin,': [2427], 'phenylmethylsulfonyl': [2430], 'fluoride).': [2431], 'Post-nuclear': [2432], 'supernatants': [2433], 'prepared,': [2435], 'normalized': [2436, 2573], 'number,': [2439, 2576], 'pre-cleared': [2441], 'A-Sepharose': [2444, 2459], 'beads': [2445, 2460, 2470], '(Sigma)': [2446], 'pre-coated': [2447, 2461], 'normal': [2449], 'sera.': [2451], 'Pre-cleared': [2452], 'incubated': [2456], 'antibodies.': [2465], 'each': [2467, 3079, 3127, 3523, 3647], 'case,': [2468], '4': [2474], 'times': [2475], 'washing': [2478], '400': [2486], 'Tris-HCl,': [2491], '7.5),': [2493], 'resuspended': [2494, 3342, 3457], 'reducing': [2496], 'sample': [2498, 3080, 3145], 'buffer,': [2499], 'boiled': [2501, 2590], '5': [2503], 'Samples': [2505], '10%': [2511, 2592], 'polyacrylamide': [2512], 'gels.': [2513], 'Gels': [2514], 'processed,': [2516], 'signals': [2518], 'visualized': [2520], 'quantified': [2522], 'Typhoon': [2525], 'PhosphorImager': [2526], 'ImageQuant': [2528], 'software': [2529, 3508], '(Amersham': [2530], 'To': [2556, 2784, 3624, 3808], 'measure': [2557], 'incorporation': [2559, 4203], 'radiolabeled': [2561, 2673, 4172], 'metabolically': [2569, 3637, 4186], 'equivalent': [2578], 'spotted': [2581], 'Whatman': [2583], 'filter': [2584], 'paper': [2585], 'triplicate.': [2587], 'Filters': [2588], 'trichloroacetic': [2593], 'acid': [2594, 3412], 'scintillation': [2598, 2753], 'spectroscopy.': [2599, 2754], 'Phosphocholine,': [2602], 'PtdEtn': [2606, 2786, 3826], 'Synthesis—To': [2607], 'assess': [2608, 2785, 4157], 'phosphocholine,': [2611, 2713], 'chloride-free': [2620], 'RPMI': [2621], '1640': [2622], 'containing': [2624, 2802, 2975], '2': [2625, 2634, 2792, 2803], '[methyl-3H]choline': [2627], 'chloride': [2628], '(81': [2629], 'Ci/mmol;': [2630, 2808], 'Amersham': [2631], 'h': [2635, 2793, 3167], '37': [2637, 2795], '°C.': [2638], 'After': [2639, 2708, 2812, 3174], 'labeling,': [2640, 2813], 'scraped': [2649], 'methanol/water': [2651], '(2:0.8,': [2652], 'v/v).': [2653, 2737, 3464], 'Lipids': [2654, 3377, 3455, 3490], 'extracted': [2656, 3379], '(29Bligh': [2657], 'E.G.': [2658], 'Dyer': [2659], 'W.J.': [2660], 'Can.': [2661], 'Physiol.': [2664], '1959;': [2665], '37:': [2666], '911-917Crossref': [2667], '(44282)': [2670], 'lipid': [2677, 3524], 'fraction': [2678], 'assessed': [2680, 2749, 2901, 4201], 'aqueous': [2702, 2718], 'phase': [2703, 2719, 3450], 'saved': [2705], 'analysis.': [2707, 3334], 'drying': [2709], 'vacuum,': [2711], 'choline,': [2712], 'separated': [2721], 'thin': [2723], 'layer': [2724], 'chromatography': [2725], 'solvent': [2728], 'methanol,': [2731], '0.78%': [2732], 'ammonium': [2734], 'hydroxide': [2735], '(50:50:5,': [2736], 'spots': [2739], 'co-migration': [2743], 'authentic': [2745, 3517], 'standards,': [2746, 3518], 'scraped,': [2747], 'radioactivity': [2751], 'some': [2756], 'experiments,': [2757], '°C': [2796, 3170, 3332], '[1-3H]ethanolamine': [2805], 'hydrochloride': [2806], '(60': [2807], 'American': [2809], 'Radiolabeled': [2810], 'Chemical).': [2811], 'radiolabel': [2814, 4205], 'incorporated': [2815], 'chloroform-soluble': [2817], 'metabolites': [2818], 'analysis': [2824, 3030, 3075, 3577, 3653, 3660, 3979], 'synthesis.': [2827], 'CPT': [2832, 2898, 3604], 'Enzymatic': [2833], 'Activity—Pelleted': [2834], 'frozen': [2835, 2924], '(2': [2837, 2926, 3316], '×': [2838, 2927, 3317], '107': [2839, 2928], 'cells)': [2840], 'assays': [2844], 'enzymatic': [2847], '(30Lykidis': [2852], 'Baburina': [2854], '274:': [2862], '26992-27001Abstract': [2863], '(134)': [2871], '31Lykidis': [2874], 'Wang': [2876], 'Karim': [2878], 'M.A.': [2879, 3237], '276:': [2886], '2174-2179Abstract': [2887], '(83)': [2895], 'microsomes': [2920], 'cells).': [2929], 'Electron': [2930], 'Microscopy,': [2931], 'Stereological': [2932], 'Measurements': [2933], 'Rough': [2935], 'Endoplasmic': [2936], 'Reticulum,': [2937], 'Size': [2940], 'Determinations—Cells': [2941], 'processed': [2943, 3281], 'examined': [2945], 'electron': [2947, 2976], 'microscopy': [2948, 3029], 'Two': [2971], 'independent': [2972], 'stereological': [2973], 'sets': [2974, 3272], 'micrographs': [2977], 'empty': [2979, 3105, 3683, 4188], 'vector-,': [2980], 'XBP-1(S)-,': [2981], 'CCTα-transduced': [2983, 3119], 'magnifications': [2986], '8,000': [2988], '20,000': [2990], 'surface': [2995], 'area': [2996, 3043], 'volume': [2999, 3353], 'Average': [3022], 'size': [3024], 'light': [3028], 'thick': [3032], 'sections': [3033], 'Scion': [3036], 'image': [3037], 'program': [3038], '(Scion).': [3039], 'mean': [3041], '(μm2)': [3044], 'minimum': [3049], '10': [3051], 'fields.': [3052], 'Microarray': [3053, 3074], 'Analysis—Total': [3054], 'RNA': [3055, 3134, 3144], 'isolated': [3057], 'RNeasy': [3060], 'kit': [3061], '(Qiagen)': [3062], 'subjected': [3064], 'DNase': [3066], 'I': [3067], 'digestion': [3068], 'remove': [3070], 'contaminating': [3071], 'genomic': [3072], 'DNA.': [3073], 'performed': [3077, 3183, 3269, 3814], 'Affymetrix': [3083], 'GeneChip®': [3084, 3196], 'genome': [3086], 'arrays': [3087, 3181, 3191], 'MOE430A': [3088], 'MOE430V2': [3090], 'Hartwell': [3093], 'Center': [3094, 3219], 'Bioinformatics': [3096], 'Biotechnology,': [3098], 'St.': [3099], 'Hospital.': [3103], 'vector-': [3106, 3684, 4189], 'total': [3111, 3133, 3352, 4144, 4216], 'four': [3113], 'separate': [3114, 3122], 'performed.': [3117, 3125], 'two': [3121, 3443, 3851], 'experiment,': [3128], 'integrity': [3130], 'Agilent': [3139], 'Bioanalyzer': [3140], 'Lab-on-a-Chip,': [3141], 'converted': [3147], 'cDNA,': [3149], 'labeled,': [3150], 'fragmented': [3152], 'procedures': [3154], 'recommended': [3155], 'Affymetrix.': [3157], 'Fragmented': [3158], 'cDNA': [3160], '(4.0': [3161], 'μg)': [3162], 'hybridized': [3164, 3257], '16': [3166], 'array.': [3173], 'washing,': [3175], 'staining': [3176], 'scanning': [3178], "manufacturer's": [3187], 'protocol': [3188], '(Affymetrix).': [3189], 'Operating': [3197], 'Software': [3198], '(GCOS),': [3199], 'global': [3201], 'scaling': [3202], 'normalize': [3206], 'different': [3210], 'arrays.': [3211], 'Spotfire®': [3212], 'DecisionSite®': [3213], '8.2.1': [3214], 'NetAffx™': [3217], '(32Liu': [3220], 'Loraine': [3222], 'A.E.': [3223], 'Shigeta': [3224], 'Cline': [3226], 'Cheng': [3228], 'Valmeekam': [3230], 'V.': [3231], 'Sun': [3232], 'Kulp': [3234], 'Siani-Rose': [3236], 'Acids': [3239], '82-86Crossref': [3243], '(421)': [3246], 'analyze': [3252], 'results.': [3254], 'Genechips': [3255], 'duplicate': [3259], 'Hospital).': [3264], 'statistical': [3266, 3285], 'analyses': [3267], 'independently': [3280], 'hybridized.': [3283], 'significance': [3286], 'two-tailed': [3295], 'unpaired': [3296], 't': [3297], 'test': [3298], 'confidence': [3301], 'set': [3303], '95%': [3305], 'p': [3309], 'values': [3310], '≤0.05': [3311], 'significant.': [3313], 'Phospholipid': [3314, 3533], 'Analysis—Cells': [3315], '107)': [3318], 'supernatant': [3322], 'removed.': [3324], 'flash-frozen': [3327], 'stored': [3329], '–80': [3331], 'until': [3333], 'pellets': [3336], 'thawed': [3338], '1': [3344, 3418], 'ml': [3345, 3409, 3419, 3429, 3434], 'water': [3347, 3436], 'saline.': [3350], 'measured,': [3355], '100-μl': [3358], 'aliquot': [3359, 3406, 3467], 'removed': [3361], 'determination': [3364], '(33Bradford': [3365], 'Anal.': [3367], '1976;': [3369], '72:': [3370], '248-254Crossref': [3371], '(223028)': [3374], '(3Wiest': [3380], '900-μl': [3405], '2.4': [3408], 'acetic': [3411], 'methanol': [3414], '(2%,': [3415], 'v/v)': [3416], 'chloroform': [3421, 3431], 'first': [3424, 3478], 'followed': [3426], '1.5': [3428], '1.2': [3433], 'second': [3439, 3778], 'phases,': [3444], 'organic': [3445, 3449], 'aqueous.': [3447], 'collected': [3452], 'dried.': [3454], 'μl': [3460], 'chloroform/methanol': [3462], '(2:1,': [3463], '1-μl': [3466], 'loaded': [3469], 'onto': [3470], 'thin-layer': [3472], 'silica': [3473], 'gel': [3474], 'rod': [3475], 'ether,': [3480], 'dried,': [3481], 'chloroform/methanol/acetic': [3486], 'acid/water': [3487], '(50:25:8:2,': [3488], 'v/v/v/v).': [3489], 'detected': [3492], 'flame': [3494], 'ionization': [3495], 'Iatroscan': [3498], 'instrument': [3499], '(Iatron': [3500], 'Laboratories),': [3501], 'peaks': [3503], 'integrated': [3505], 'PEAKSIMPLE': [3507], '(SRI': [3509], 'Instruments).': [3510], 'Peaks': [3511], 'comigration': [3515], 'amount': [3521], 'species': [3525], 'calculated': [3527], 'standard': [3529], 'curves': [3530], 'each.': [3532], 'Biosynthesis': [3534], 'Fibroblasts—We': [3537], 'enforced': [3541, 3836, 4068], 'up-regulate': [3551], 'revealed': [3588, 3985, 4224], 'basal': [3589], 'kinase': [3593], '(CK),': [3594], 'markedly': [3600], 'further': [3625, 3809], 'investigate': [3626], 'status': [3628], '[3H]choline': [3641], 'monitored': [3643], 'Chromatographic': [3652], 'soluble': [3655, 3983], 'material': [3657, 3984], 'allowed': [3658], 'products': [3667], 'CK-': [3670], 'CCT-catalyzed': [3672], 'steps,': [3673], 'respectively.': [3674], '(Fig.': [3688, 3733, 3746, 3833, 3995, 4151, 4182, 4210, 4218], '1A),': [3689], 'keeping': [3691], 'CK': [3695], 'populations': [3700], '∼2-fold': [3729, 3829], '1B),': [3734], 'expected,': [3737], '1C).': [3747], 'These': [3748, 4222], 'CPT-catalyzed': [3766], 'PtdCho.': [3769], 'Similar': [3770], 'elevates': [3785], 'explore': [3810], 'observation,': [3812], 'metabolic': [3815], 'labeling': [3816], '[3H]ethanolamine': [3819], 'found': [3821], '1D).': [3834], 'augments': [3840], 'de': [3844], 'novo': [3845], 'components': [3854], 'membrane.': [3858], 'Effect': [3859], 'Level': [3864], 'Fibroblasts—PtdCho': [3870], 'membranes;': [3878], 'thus,': [3879], 'focused': [3881, 3944], 'delineating': [3885], 'regulation': [3892], 'Given': [3896], 'catalyzes': [3899], 'investigated': [3908], 'augmented': [3916], 'cells.': [3919, 4232], 'reasoned': [3921], 'elevation': [3924], 'might': [3928], 'involve': [3929], 'enzyme.': [3938, 4012], 'testing': [3940], 'hypothesis,': [3942], 'steady-state': [3947], 'CCTα,': [3950], 'predominant': [3952], 'isoform': [3954], 'expressed': [3955], 'Immunoblot': [3978], 'nearly': [3987], '50%': [3988], '2).': [3996], 'pool': [4009], 'does': [4019], 'levels': [4023], 'transcripts': [4026], 'Scholar);': [4045], 'rise': [4048], 'mediated': [4056], 'post-transcriptional': [4059], 'post-translational': [4061], 'mechanism.': [4062], 'previous': [4064], 'study': [4065], 'Raji': [4073], 'B': [4077], 'line,': [4079], 'resulted': [4080], 'overall': [4083], 'translation': [4086], 'Similarly,': [4135], 'observed': [4137], 'modest,': [4139], 'measurable,': [4141], '3A).': [4152], 'led': [4154], 'us': [4155], 'effect': [4159, 4235], 'translation.': [4167], 'First,': [4168], 'verified': [4170], 'could': [4174], 'be': [4175], 'specifically': [4176], 'immunoprecipitated': [4177], '3B).': [4183], 'newly': [4207], 'synthesized': [4208], '3C,': [4211, 4219], 'upper': [4212], 'panel)': [4213], 'middle': [4220], 'panel).': [4221], '∼60%': [4229], 'Importantly,': [4233], 'XBP-1(': [4237]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1988988264', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 20}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 18}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2025-01-05T07:46:06.063568', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
