Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2106647772', 'doi': 'https://doi.org/10.5352/jls.2007.17.6.847', 'title': 'Endoplasmic Reticulum Signaling for Recombinant-protein Production', 'display_name': 'Endoplasmic Reticulum Signaling for Recombinant-protein Production', 'publication_year': 2007, 'publication_date': '2007-06-25', 'ids': {'openalex': 'https://openalex.org/W2106647772', 'doi': 'https://doi.org/10.5352/jls.2007.17.6.847', 'mag': '2106647772'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.5352/jls.2007.17.6.847', 'pdf_url': 'http://koreascience.or.kr:80/article/JAKO200724737573085.pdf', 'source': {'id': 'https://openalex.org/S4210184715', 'display_name': 'Journal of Life Science', 'issn_l': '1225-9918', 'issn': ['1225-9918', '2287-3406'], 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://koreascience.or.kr:80/article/JAKO200724737573085.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054942030', 'display_name': 'Tae‐Won Goo', 'orcid': 'https://orcid.org/0000-0001-8093-4089'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Tae-Won Goo', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009810500', 'display_name': 'Eun‐Young Yun', 'orcid': 'https://orcid.org/0000-0002-4518-6537'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Eun-Young Yun', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029715924', 'display_name': 'Seokwoo Kang', 'orcid': 'https://orcid.org/0000-0001-8264-8254'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Seok-Woo Kang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057635837', 'display_name': 'Kisang Kwon', 'orcid': 'https://orcid.org/0000-0001-5013-4478'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ki-Sang Kwon', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5031290671', 'display_name': 'O‐Yu Kwon', 'orcid': 'https://orcid.org/0000-0002-4236-6276'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'O-Yu Kwon', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.377908, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 63, 'max': 70}, 'biblio': {'volume': '17', 'issue': '6', 'first_page': '847', 'last_page': '858'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12856', 'display_name': 'Transgenic Plants and Applications', 'score': 0.9938, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11455', 'display_name': 'Microbial Inactivation Methods', 'score': 0.9791, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/secretory-protein', 'display_name': 'Secretory protein', 'score': 0.49628478}], 'concepts': [{'id': 'https://openalex.org/C139447449', 'wikidata': 'https://www.wikidata.org/wiki/Q14633900', 'display_name': 'Unfolded protein response', 'level': 3, 'score': 0.9565203}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.94068426}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.73602736}, {'id': 'https://openalex.org/C6492254', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretory pathway', 'level': 4, 'score': 0.6722825}, {'id': 'https://openalex.org/C119062480', 'wikidata': 'https://www.wikidata.org/wiki/Q83181', 'display_name': 'Golgi apparatus', 'level': 3, 'score': 0.6337087}, {'id': 'https://openalex.org/C204328495', 'wikidata': 'https://www.wikidata.org/wiki/Q847556', 'display_name': 'Protein folding', 'level': 2, 'score': 0.5360461}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.5292584}, {'id': 'https://openalex.org/C156399914', 'wikidata': 'https://www.wikidata.org/wiki/Q7444454', 'display_name': 'Secretory protein', 'level': 3, 'score': 0.49628478}, {'id': 'https://openalex.org/C24530287', 'wikidata': 'https://www.wikidata.org/wiki/Q424204', 'display_name': 'Transmembrane protein', 'level': 3, 'score': 0.41133046}, {'id': 'https://openalex.org/C49039625', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretion', 'level': 2, 'score': 0.39675432}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39124852}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34326735}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18561026}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.10633719}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.5352/jls.2007.17.6.847', 'pdf_url': 'http://koreascience.or.kr:80/article/JAKO200724737573085.pdf', 'source': {'id': 'https://openalex.org/S4210184715', 'display_name': 'Journal of Life Science', 'issn_l': '1225-9918', 'issn': ['1225-9918', '2287-3406'], 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.5352/jls.2007.17.6.847', 'pdf_url': 'http://koreascience.or.kr:80/article/JAKO200724737573085.pdf', 'source': {'id': 'https://openalex.org/S4210184715', 'display_name': 'Journal of Life Science', 'issn_l': '1225-9918', 'issn': ['1225-9918', '2287-3406'], 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 77, 'referenced_works': ['https://openalex.org/W1546139069', 'https://openalex.org/W1575156763', 'https://openalex.org/W1863131315', 'https://openalex.org/W1963909878', 'https://openalex.org/W1965843055', 'https://openalex.org/W1967912613', 'https://openalex.org/W1970090817', 'https://openalex.org/W1971058161', 'https://openalex.org/W1971837853', 'https://openalex.org/W1975280295', 'https://openalex.org/W1978092165', 'https://openalex.org/W1983041786', 'https://openalex.org/W1983398917', 'https://openalex.org/W1986737010', 'https://openalex.org/W1991999080', 'https://openalex.org/W1992630084', 'https://openalex.org/W1994185551', 'https://openalex.org/W1996786950', 'https://openalex.org/W1997581772', 'https://openalex.org/W2002725367', 'https://openalex.org/W2014664217', 'https://openalex.org/W2014720377', 'https://openalex.org/W2017956920', 'https://openalex.org/W2018727351', 'https://openalex.org/W2020437934', 'https://openalex.org/W2025073674', 'https://openalex.org/W2025170604', 'https://openalex.org/W2025960504', 'https://openalex.org/W2029642537', 'https://openalex.org/W2030837323', 'https://openalex.org/W2034213169', 'https://openalex.org/W2035859053', 'https://openalex.org/W2040076847', 'https://openalex.org/W2040895935', 'https://openalex.org/W2051793369', 'https://openalex.org/W2060545673', 'https://openalex.org/W2061903251', 'https://openalex.org/W2064776807', 'https://openalex.org/W2066868766', 'https://openalex.org/W2069359746', 'https://openalex.org/W2069924169', 'https://openalex.org/W2071700771', 'https://openalex.org/W2077520734', 'https://openalex.org/W2080901528', 'https://openalex.org/W2081294646', 'https://openalex.org/W2081448012', 'https://openalex.org/W2082257591', 'https://openalex.org/W2082840689', 'https://openalex.org/W2083855141', 'https://openalex.org/W2087022377', 'https://openalex.org/W2087662274', 'https://openalex.org/W2098201181', 'https://openalex.org/W2103483160', 'https://openalex.org/W2115732428', 'https://openalex.org/W2117573196', 'https://openalex.org/W2120736516', 'https://openalex.org/W2124691447', 'https://openalex.org/W2127639686', 'https://openalex.org/W2128761336', 'https://openalex.org/W2133425838', 'https://openalex.org/W2133589858', 'https://openalex.org/W2134575216', 'https://openalex.org/W2136781721', 'https://openalex.org/W2137755719', 'https://openalex.org/W2139132159', 'https://openalex.org/W2140798038', 'https://openalex.org/W2143116542', 'https://openalex.org/W2147336345', 'https://openalex.org/W2152708819', 'https://openalex.org/W2157766920', 'https://openalex.org/W2162076197', 'https://openalex.org/W2164322102', 'https://openalex.org/W2171729220', 'https://openalex.org/W2178113031', 'https://openalex.org/W2197083763', 'https://openalex.org/W23481714', 'https://openalex.org/W4295677776'], 'related_works': ['https://openalex.org/W4303986677', 'https://openalex.org/W4288858752', 'https://openalex.org/W2158535876', 'https://openalex.org/W2062180917', 'https://openalex.org/W1972670322', 'https://openalex.org/W1965514223', 'https://openalex.org/W191643612', 'https://openalex.org/W1577299974', 'https://openalex.org/W1433191198', 'https://openalex.org/W1120756646'], 'abstract_inverted_index': {'ER-Golgi': [0], '분비': [1], '경로를': [2], '통해서': [3], '정확한': [4], '구조를': [5], '가지면서': [6], 'post-translational': [7], 'modification': [8], '과정을': [9], '거친': [10], '재조합': [11, 31], '단백질의': [12, 32, 122], '발현을': [13], '최대화하는': [14], '것은': [15], 'ER': [16, 28, 42, 73, 88, 110, 148, 163, 175, 199, 214, 239, 253], 'stress반응에': [17], '대한': [18], '연구의': [19], '중요한': [20], '계기가': [21], '된다.': [22, 41], '세포가': [23], '스트레스를': [24], '받지': [25], '않는': [26], '상태라도': [27], 'stress': [29, 43, 74, 111, 178], 'signaling은': [30], '생산량을': [33, 106], '제한하고': [34], '품질을': [35], '떨어뜨리는': [36], '여러': [37, 46], '가지': [38, 47], '조건을': [39], '만들게': [40], 'signaling을': [44], '막는': [45], '방법들이': [48], '제시되고': [49], '있으며': [50], '표': [51], '2는': [52], '이러한': [53], '방법들': [54], '중': [55], '일부를': [56], '나타내고': [57], '있다.': [58], '일반적으로는': [59], 'pro-survival': [60], '경로에': [61], '관련되어': [62, 67], '있는': [63, 68], '인자를': [64, 69, 92], '촉진하고': [65], 'pro-apoptosis에': [66], '억제하는': [70], '것들이다.': [71], '그러나': [72], '반응은': [75], '매우': [76], '복잡하고': [77], '적응과': [78], '사멸': [79, 119], '기작(adaptation': [80], 'and': [81, 138, 144, 164, 171, 198, 221], 'elimination': [82], 'mechanism)의': [83], '중간': [84], '역할을': [85], '하기': [86], '때문에': [87], 'stress에': [89], '관련된': [90], '주요': [91], '산업적으로': [93], '응용하기': [94], '위해선': [95], '이들의': [96], '기능에': [97], '대해': [98], '보다': [99], '깊은': [100], '연구가': [101], '이루어져야': [102], '한다.': [103], '현재까지': [104], '재조합단백질의': [105], '최대한으로': [107], '높이는': [108], '방법은': [109], '반응이': [112], '생기지': [113], '않도록': [114], 'fed-batch': [115], 'process를': [116], '개선하고': [117], '세포': [118], '기작을': [120], '조절하며': [121], 'glycosylation': [123], '처리를': [124], '하는': [125], '것이다.': [126], 'The': [127, 147, 174], 'endoplasmic': [128], 'reticulum': [129], '(ER)': [130], 'is': [131, 215], 'an': [132, 217], 'important': [133, 218], 'intracellular': [134], 'organelle': [135], 'for': [136, 211], 'folding': [137], 'maturation': [139], 'of': [140, 193, 224, 231, 237, 251, 262, 266], 'newly': [141], 'synthesized': [142], 'transmembrane': [143], 'secretory': [145, 240], 'proteins.': [146], 'provides': [149], 'stringent': [150], 'quality': [151], 'control': [152], 'systems': [153], 'to': [154, 188, 209, 260], 'ensure': [155], 'that': [156], 'only': [157], 'correctly': [158], 'folded': [159], 'proteins': [160, 168, 197], 'exit': [161], 'the': [162, 183, 191, 238, 252, 257, 263], 'unfolded': [165, 184, 194], 'or': [166, 195], 'misfolded': [167, 196], 'are': [169], 'retained': [170], 'ultimately': [172], 'degraded.': [173], 'has': [176], 'evolved': [177], 'response': [179, 186, 201], 'both': [180], 'signaling': [181, 219, 254], 'pathways': [182], 'protein': [185, 212], '(UPR)': [187], 'cope': [189], 'with': [190], 'accmulation': [192], 'overload': [200], '(EOR).': [202], 'Accumulating': [203], 'evidence': [204], 'suggests': [205], 'that,': [206], 'in': [207, 242, 256], 'addition': [208], 'responsibility': [210], 'processing,': [213], 'also': [216], 'compartment': [220], 'a': [222], 'sensor': [223], 'cellular': [225], 'stress.': [226], 'In': [227], 'this': [228], 'respect,': [229], 'production': [230], 'bio-functional': [232], 'recombinant-proteins': [233], 'requires': [234], 'efficient': [235], 'functioning': [236], 'pathway': [241], 'host': [243], 'cells.': [244, 268], 'This': [245], 'review': [246], 'briefly': [247], 'summarizes': [248], 'our': [249], 'understanding': [250], 'developed': [255], 'recent': [258], 'years': [259], 'help': [261], 'secretion': [264], 'capacities': [265], 'recombinant': [267]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2106647772', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2025-01-09T19:09:37.465555', 'created_date': '2016-06-24'}