Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1496031212', 'doi': 'https://doi.org/10.1016/s0021-9258(18)81771-9', 'title': 'The role of autolysis in activity of the Ca2+-dependent proteinases (μ-calpain and m-calpain)', 'display_name': 'The role of autolysis in activity of the Ca2+-dependent proteinases (μ-calpain and m-calpain)', 'publication_year': 1989, 'publication_date': '1989-06-01', 'ids': {'openalex': 'https://openalex.org/W1496031212', 'doi': 'https://doi.org/10.1016/s0021-9258(18)81771-9', 'mag': '1496031212', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2542320'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(18)81771-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/s0021-9258(18)81771-9', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041191984', 'display_name': 'Jinyang Cong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}, {'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'J Cong', 'raw_affiliation_strings': ["Department of Chemical Engineering, Tsinghua University, Beijing, People's Republic of China.", 'From the Muscle Biology Group, Departments of Animal Sciences and Biochemistry, Uniuersity of Arizona, Tucson, Arizona 85721', 'Muscle Biology Group, University of Arizona, Tucson, AZ 85721. 10096'], 'affiliations': [{'raw_affiliation_string': 'From the Muscle Biology Group, Departments of Animal Sciences and Biochemistry, Uniuersity of Arizona, Tucson, Arizona 85721', 'institution_ids': ['https://openalex.org/I138006243']}, {'raw_affiliation_string': 'Muscle Biology Group, University of Arizona, Tucson, AZ 85721. 10096', 'institution_ids': ['https://openalex.org/I138006243']}, {'raw_affiliation_string': "Department of Chemical Engineering, Tsinghua University, Beijing, People's Republic of China.", 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012087403', 'display_name': 'Darrel E. Goll', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}, {'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'D E Goll', 'raw_affiliation_strings': ["Department of Chemical Engineering, Tsinghua University, Beijing, People's Republic of China.", 'From the Muscle Biology Group, Departments of Animal Sciences and Biochemistry, Uniuersity of Arizona, Tucson, Arizona 85721', 'Muscle Biology Group, University of Arizona, Tucson, AZ 85721. 10096'], 'affiliations': [{'raw_affiliation_string': 'From the Muscle Biology Group, Departments of Animal Sciences and Biochemistry, Uniuersity of Arizona, Tucson, Arizona 85721', 'institution_ids': ['https://openalex.org/I138006243']}, {'raw_affiliation_string': 'Muscle Biology Group, University of Arizona, Tucson, AZ 85721. 10096', 'institution_ids': ['https://openalex.org/I138006243']}, {'raw_affiliation_string': "Department of Chemical Engineering, Tsinghua University, Beijing, People's Republic of China.", 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111791816', 'display_name': 'Ann M. Peterson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}, {'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'A M Peterson', 'raw_affiliation_strings': ["Department of Chemical Engineering, Tsinghua University, Beijing, People's Republic of China.", 'From the Muscle Biology Group, Departments of Animal Sciences and Biochemistry, Uniuersity of Arizona, Tucson, Arizona 85721', 'Muscle Biology Group, University of Arizona, Tucson, AZ 85721. 10096'], 'affiliations': [{'raw_affiliation_string': 'From the Muscle Biology Group, Departments of Animal Sciences and Biochemistry, Uniuersity of Arizona, Tucson, Arizona 85721', 'institution_ids': ['https://openalex.org/I138006243']}, {'raw_affiliation_string': 'Muscle Biology Group, University of Arizona, Tucson, AZ 85721. 10096', 'institution_ids': ['https://openalex.org/I138006243']}, {'raw_affiliation_string': "Department of Chemical Engineering, Tsinghua University, Beijing, People's Republic of China.", 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005219513', 'display_name': 'Hans‐Peter Kapprell', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}, {'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'H P Kapprell', 'raw_affiliation_strings': ["Department of Chemical Engineering, Tsinghua University, Beijing, People's Republic of China.", 'From the Muscle Biology Group, Departments of Animal Sciences and Biochemistry, Uniuersity of Arizona, Tucson, Arizona 85721', 'Muscle Biology Group, University of Arizona, Tucson, AZ 85721. 10096'], 'affiliations': [{'raw_affiliation_string': 'From the Muscle Biology Group, Departments of Animal Sciences and Biochemistry, Uniuersity of Arizona, Tucson, Arizona 85721', 'institution_ids': ['https://openalex.org/I138006243']}, {'raw_affiliation_string': 'Muscle Biology Group, University of Arizona, Tucson, AZ 85721. 10096', 'institution_ids': ['https://openalex.org/I138006243']}, {'raw_affiliation_string': "Department of Chemical Engineering, Tsinghua University, Beijing, People's Republic of China.", 'institution_ids': ['https://openalex.org/I99065089']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 3.706, 'has_fulltext': False, 'cited_by_count': 216, 'citation_normalized_percentile': {'value': 0.999721, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '264', 'issue': '17', 'first_page': '10096', 'last_page': '10103'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13637', 'display_name': 'Calpain Protease Function and Regulation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13637', 'display_name': 'Calpain Protease Function and Regulation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11353', 'display_name': 'Venomous Animal Envenomation and Studies', 'score': 0.9876, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9595, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/autolysis', 'display_name': 'Autolysis (biology)', 'score': 0.97818005}, {'id': 'https://openalex.org/keywords/proteolysis', 'display_name': 'Proteolysis', 'score': 0.8454045}], 'concepts': [{'id': 'https://openalex.org/C104810894', 'wikidata': 'https://www.wikidata.org/wiki/Q787099', 'display_name': 'Autolysis (biology)', 'level': 3, 'score': 0.97818005}, {'id': 'https://openalex.org/C56928146', 'wikidata': 'https://www.wikidata.org/wiki/Q2934402', 'display_name': 'Calpain', 'level': 3, 'score': 0.96606153}, {'id': 'https://openalex.org/C2780610907', 'wikidata': 'https://www.wikidata.org/wiki/Q2273248', 'display_name': 'Phosphatidylinositol', 'level': 3, 'score': 0.8987853}, {'id': 'https://openalex.org/C2781307694', 'wikidata': 'https://www.wikidata.org/wiki/Q33123', 'display_name': 'Proteolysis', 'level': 3, 'score': 0.8454045}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.620174}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42392027}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3683704}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.3603853}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.0901753}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(18)81771-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0021-9258(18)81771-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1441986670', 'https://openalex.org/W1487644812', 'https://openalex.org/W1527067333', 'https://openalex.org/W1554324315', 'https://openalex.org/W1603766333', 'https://openalex.org/W1615094203', 'https://openalex.org/W1617349725', 'https://openalex.org/W1626297236', 'https://openalex.org/W1890122215', 'https://openalex.org/W1903793818', 'https://openalex.org/W1970219999', 'https://openalex.org/W1993622301', 'https://openalex.org/W1997876679', 'https://openalex.org/W2002560793', 'https://openalex.org/W2006823088', 'https://openalex.org/W2012461075', 'https://openalex.org/W2018400133', 'https://openalex.org/W2040745689', 'https://openalex.org/W2046894421', 'https://openalex.org/W2049615473', 'https://openalex.org/W2050372824', 'https://openalex.org/W2063968553', 'https://openalex.org/W2070589373', 'https://openalex.org/W2073994544', 'https://openalex.org/W2088233139', 'https://openalex.org/W2092359857', 'https://openalex.org/W2097267045', 'https://openalex.org/W2100837269', 'https://openalex.org/W2122704155', 'https://openalex.org/W2176903450', 'https://openalex.org/W4232534952', 'https://openalex.org/W4297865974'], 'related_works': ['https://openalex.org/W2475317774', 'https://openalex.org/W2395261377', 'https://openalex.org/W2084589572', 'https://openalex.org/W2064475469', 'https://openalex.org/W2062125039', 'https://openalex.org/W2046968011', 'https://openalex.org/W2020739220', 'https://openalex.org/W1991719291', 'https://openalex.org/W1986586932', 'https://openalex.org/W1971997211'], 'abstract_inverted_index': {'A': [0], 'recent': [1], 'hypothesis': [2], 'suggests': [3], 'that': [4, 197, 210], 'proteolytic': [5, 62, 79], 'activity': [6, 80, 238, 245], 'of': [7, 14, 40, 81, 91, 104, 106, 119, 133, 159, 161, 174, 188, 225, 229, 239, 243, 249, 255, 275, 298], 'the': [8, 15, 34, 41, 46, 57, 71, 82, 86, 89, 117, 131, 172, 186, 195, 205, 222, 226, 236, 247, 252, 256, 271, 296, 317], 'micromolar': [9], 'and': [10, 19, 52, 77, 88, 123, 141, 178, 262, 282, 313], 'millimolar': [11], 'Ca2+-requiring': [12], 'forms': [13, 228, 254], 'Ca2+-dependent': [16], 'proteinases': [17], '(mu-': [18], 'm-calpain,': [20, 259, 261], 'respectively)': [21], 'is': [22, 137, 213], 'regulated': [23], 'in': [24, 54, 85, 116, 130, 171, 185, 200, 246, 295, 308], 'vivo': [25], 'by': [26, 38], 'their': [27], 'association': [28, 44, 312], 'with': [29, 194], 'a': [30, 107, 162, 303], 'phosphatidylinositol-containing': [31], 'site': [32], 'on': [33, 221], 'plasma': [35], 'membrane': [36, 311], 'followed': [37], 'autolysis': [39, 76, 115, 129, 145, 170, 184, 289, 314], 'proteinases.': [42], 'Phosphatidylinositol': [43], 'lowers': [45, 56], 'Ca2+': [47, 58, 72, 100, 112, 126, 155, 167, 181, 223, 273, 292], 'concentration': [48, 59], 'needed': [49, 60, 74], 'for': [50, 61, 75, 78, 101, 113, 127, 146, 156, 168, 182], 'autolysis,': [51, 53], 'turn,': [55], 'activity.': [63], 'To': [64], 'test': [65], 'this': [66], 'hypothesis,': [67], 'we': [68], 'have': [69], 'compared': [70], 'concentrations': [73, 274], 'calpains': [83], 'both': [84], 'presence': [87, 118, 173, 297], 'absence': [90, 132, 187, 248], 'phosphatidylinositol.': [92, 134, 189, 250, 299], 'Bovine': [93, 148], 'skeletal': [94, 149], 'muscle': [95, 150], 'mu-calpain': [96, 136, 240, 264], 'required': [97, 152], '40-50': [98], 'microM': [99, 111, 121, 125, 154, 166, 176, 180, 216], 'half-maximal': [102, 114, 128, 157, 169, 183], 'rate': [103, 158], 'proteolysis': [105, 160], 'casein': [108, 163], 'substrate,': [109, 164], '140-150': [110], '80': [120, 175, 215], 'phosphatidylinositol,': [122, 177], '190-210': [124], 'Consequently,': [135], 'an': [138], 'active': [139, 269], 'proteinase': [140], 'does': [142], 'not': [143, 208, 266], 'require': [144], 'activation.': [147], 'm-calpain': [151, 198, 212, 233, 286], '700-740': [153], '370-400': [165], '740-780': [179], 'These': [190], 'results': [191, 206], 'are': [192], 'consistent': [193], 'idea': [196], 'functions': [199], 'its': [201, 244], 'autolyzed': [202, 227, 260], 'form,': [203], 'but': [204, 234], 'do': [207], 'demonstrate': [209], 'unautolyzed': [211, 258, 263], 'inactive.': [214], 'phosphatidylinositol': [217], 'had': [218], 'no': [219], 'effect': [220], 'requirement': [224], 'either': [230], 'mu-': [231, 284], 'or': [232, 307], 'lowered': [235], 'specific': [237], 'to': [241, 310, 315], '20%': [242], 'Of': [251], 'four': [253], 'calpains,': [257], 'would': [265, 287], 'be': [267], 'proteolytically': [268], 'at': [270, 290], 'free': [272], '300-1200': [276], 'nM': [277], 'present': [278], 'inside': [279], 'normal': [280], 'cells,': [281], 'neither': [283], 'nor': [285], 'undergo': [288], 'these': [291], 'concentrations,': [293], 'even': [294], 'Cells': [300], 'must': [301], 'contain': [302], 'mechanism': [304], 'other': [305], 'than': [306], 'addition': [309], 'activate': [316], 'calpains.': [318]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1496031212', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 15}], 'updated_date': '2024-12-10T02:20:35.075161', 'created_date': '2016-06-24'}