Publication Information

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55, 64, 80, 88, 200, 202, 206, 211, 225, 230, 247, 251, 260, 276, 284, 466, 478, 494, 555, 738, 829, 1037, 1108, 1125, 1229, 1236, 1456, 1463, 1534, 1572, 1578, 1609, 1957, 1973, 1978, 1989, 2185, 2317, 2348, 2370, 2466, 2476, 2511, 2711, 2890, 2898, 2927, 2949, 2999, 3016, 3040, 3094, 3100, 3104, 3250, 3287, 3343, 3383, 3434, 3480, 3490, 3532, 3541, 3553, 3718, 3759, 3768, 3802, 3817, 3827, 3846, 3867, 3883, 3924, 3936, 3949, 4000, 4159, 4391, 4457, 4467, 4483, 4520, 4558, 4742, 4761, 4786, 4844, 4925, 4951, 4985, 4988, 5013, 5066, 5317, 5329, 5366], 'localize': [5, 201], 'late': [7, 16, 35, 57, 89, 203, 212, 231, 253, 285, 1307, 1464, 1532, 1613, 1959, 1979, 1991, 2319, 2351, 2478, 2899, 2930, 3018, 3095, 3105, 3182, 3344, 3555, 3769, 3805, 3819, 3925, 3937, 4458, 4484, 4845, 4926, 4952, 4989, 5014, 5067], 'endosomes': [8, 36, 87, 204, 232, 283, 616, 1235, 1278, 1462, 1465, 2475, 3096, 3770, 4456, 4459, 4613, 5196], 'and': [9, 21, 77, 106, 150, 171, 205, 217, 273, 302, 346, 367, 398, 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3689, 3703, 3712, 3737, 3757, 3799, 3804, 3810, 3815, 3818, 3822, 3847, 3862, 3865, 3880, 3902, 3909, 3922, 3961, 3983, 3989, 4001, 4028, 4160, 4224, 4229, 4340, 4403, 4426, 4431, 4434, 4438, 4441, 4448, 4478, 4481, 4500, 4525, 4541, 4560, 4611, 4622, 4739, 4774, 4837, 4842, 4856, 4876, 4890, 4915, 4923, 4935, 4944, 4958, 5003, 5011, 5168, 5201, 5311, 5318, 5338, 5371, 5386, 5393, 5401], 'Xenopusoocyte.': [39, 235], 'Oocytes': [40, 236, 2171, 2909], 'were': [41, 49, 61, 71, 237, 245, 257, 267, 2009, 2025, 2035, 2044, 2064, 2105, 2119, 2125, 2145, 2172, 2199, 2208, 2239, 2291, 2303, 2323, 2337, 2356, 2381, 2395, 2403, 2409, 2433, 2445, 2459, 2720, 2730, 2910, 2922, 2937, 2957, 3082, 3285, 3381, 3835], 'pulsed': [42, 238, 2938], 'with': [43, 74, 239, 270, 560, 849, 1305, 2122, 2133, 2174, 2210, 2230, 2325, 2360, 2536, 2693, 2747, 2912, 2939, 2960, 3021, 3058, 3167, 3176, 3252, 3365, 3518, 3736, 3837, 4027, 4270, 4528, 4531, 4570, 4867, 4875, 5002, 5111], 'avidin': [44, 53, 240, 249, 2326, 2913, 3002], 'after': [45, 241, 2919, 3513], 'which': [46, 242, 2508, 2920, 3359, 3545, 4156, 5007], 'oocytes': [48, 60, 70, 244, 256, 266, 1914, 1953, 2144, 2198, 2207, 2238, 2322, 2336, 2386, 2394, 2402, 2408, 2744, 2781, 3056, 3662, 3834, 3941, 4234, 4529, 4866], 'incubated': [50, 78, 246, 274, 2209, 2324, 2341, 2359, 2397, 2923], 'allow': [52, 81, 248, 277], 'compartment.': [58, 254, 1961, 2353, 2375, 2954, 3424, 3807], 'The': [59, 69, 255, 265, 563, 1982, 2050, 2205, 2253, 2289, 2335, 2401, 2457, 2515, 2955, 3004, 3031, 3327, 3497, 3522, 3912, 3944, 3979, 4202, 4444, 4547, 4736, 4751], 'then': [62, 72, 258, 268, 2183, 2200, 2240, 2338, 2382, 2404, 2460, 2958, 3529, 3701, 3821, 4913], 'allowed': [63, 259, 2184], 'internalize': [65, 261], 'biotin-horseradish': [66, 262], 'peroxidase': [67, 263], '(HRP).': [68, 264], 'injected': [73, 269, 2173, 2206, 2383, 2731, 2959, 3057, 3730], 'test': [75, 271, 2175, 2379], 'proteins': [76, 272, 410, 463, 580, 734, 825, 1089, 1103, 1586, 2008, 2052, 2104, 2110, 2118, 2380, 2719, 2729, 4382], 'further': [79, 275, 1963, 2396], 'of': [83, 99, 103, 191, 279, 295, 299, 387, 404, 408, 438, 522, 541, 565, 576, 615, 742, 752, 823, 1040, 1114, 1562, 1569, 1574, 1584, 1893, 1920, 1949, 2017, 2180, 2245, 2307, 2378, 2390, 2414, 2426, 2486, 2495, 2501, 2518, 2532, 2544, 2772, 2809, 2858, 2945, 2970, 2974, 2986, 2997, 3014, 3034, 3051, 3070, 3169, 3493, 3505, 3525, 3698, 3716, 3864, 3904, 3947, 3985, 3991, 4065, 4163, 4226, 4231, 4237, 4256, 4429, 4543, 4565, 4621, 4697, 4738, 4797, 4839, 4858, 4892, 4917, 4940, 4946, 4957, 5094, 5203, 5302, 5313, 5320, 5337, 5352, 5388, 5395, 5403], 'biotin-HRP': [84, 280, 2034, 2361, 2940, 3015], 'endosomal/lysosomal': [90, 286], 'compartments.': [91, 287, 1981, 3326, 4928, 4954], 'Transport': [92, 288, 2471], 'was': [93, 120, 141, 167, 289, 316, 337, 363, 2222, 2255, 2480, 2490, 2509, 2522, 2823, 2977, 2990, 3025, 3038, 3046, 3062, 3072, 3248, 3634, 3843, 3857, 3927, 4259, 4465, 4551, 4983], 'quantified': [94, 290, 2292, 2481], 'by': [95, 122, 143, 169, 291, 318, 339, 365, 558, 573, 755, 1736, 1954, 2012, 2224, 2451, 2482, 2492, 2553, 2825, 3392, 3536, 3658, 3861, 3930, 4233, 4250, 4263, 4349, 4889, 4907, 4966, 5072, 5085, 5101, 5156, 5354], 'assessing': [96, 292], 'formation': [98, 294, 437, 2973], 'HRP-biotin-avidin': [100, 296], 'complexes.': [101, 297], 'Injection': [102, 298, 3697], 'Rab7:wild-type': [104, 300], '(WT)': [105, 301], 'Rab7:Q67L,': [107, 303, 2061, 2702, 2774, 3544, 4499], 'GTPase': [109, 305, 2541, 2699, 3548], 'defective': [110, 173, 306, 369, 2542, 2700], 'mutant,': [111, 307, 2701, 2707, 3353, 4503, 5305], 'stimulated': [112, 308, 2777, 3623, 4247, 5071], 'transport.': [113, 309, 530, 543, 3346, 3625, 3642, 3724, 3978, 4470, 4522, 5095, 5163], 'Rab5:WT': [114, 310, 2776, 4252, 4280, 4544], 'had': [115, 311, 2832, 3354, 4342], 'no': [116, 312, 3355, 4216, 4343], 'effect.': [117, 313, 3356], 'Rab7:WT-stimulated': [118, 136, 314, 332, 4883], 'inhibited': [121, 317, 2824, 2828, 3844, 4336, 4943], 'nocodazole,': [123, 319, 3840, 3931], 'suggesting': [124, 320, 841, 4509, 4614, 5087, 5103, 5349], 'role': [126, 322, 2847, 4916], 'for': [127, 157, 323, 353, 401, 1091, 1105, 1686, 1857, 2194, 2202, 2214, 2257, 2329, 2342, 2367, 2435, 2916, 2924, 2941, 2967, 3085, 3180, 3397, 3419, 3495, 3742, 3746, 3982, 3997, 4005, 4416, 4540, 4600, 4747, 4756, 4768, 4830, 4978, 5028, 5116, 5177, 5189, 5358, 5411, 5420], 'intact': [128, 324, 3777, 5079], 'microtubules.': [129, 325, 3890, 5080], 'Wortmannin,': [130, 326, 4147], 'phosphatidylinositol': [132, 154, 328, 350, 1740], '3-kinase': [133, 155, 329, 351], 'inhibitor,': [134, 330], 'blocked': [135, 168, 331, 364, 3929, 4262, 5084, 5100], 'transport,': [137, 333, 1966, 4602, 4605], 'but': [138, 334, 2528, 2831, 3174, 3404, 4339, 4758, 4895], 'Rab7:Q67L-stimulated': [139, 335, 5096], 'unaffected': [142, 338], 'drug.': [145, 341], 'Rab7:Q67L': [146, 342, 3247, 3340, 3622, 4245], 'is': [147, 343, 399, 517, 846, 1035, 1632, 1674, 1734, 1898, 1997, 3092, 3320, 3363, 3394, 3406, 3417, 3432, 3488, 3528, 3644, 3686, 3692, 3727, 3749, 3886, 3896, 3942, 4151, 4204, 4538, 4598, 4617, 4688, 4745, 4754, 4764, 4825, 4886, 5008, 5070, 5083, 5098, 5106, 5158, 5172, 5182, 5187, 5341, 5356, 5385], 'constitutively': [148, 344, 4501], 'activated': [149, 345, 4399, 4502], 'may': [151, 193, 347, 389, 617, 3958, 3972, 5326], 'not': [152, 348, 1682, 2805, 3165, 3371, 3395, 3635, 3639, 3710, 3851, 3870, 3887, 4505, 4765, 4887, 4910, 4995, 5099], 'require': [153, 349, 1683, 4383, 4506], 'activity': [156, 164, 352, 360, 4034, 4170, 4462, 4537, 4564], 'activation.': [158, 354], 'Rab7-stimulated': [159, 355, 1995, 2829, 3023, 3841, 4920, 5162], 'requiresN-ethylmaleimide-sensitive': [161, 357], 'factor': [162, 358, 4556, 5175], '(NSF)': [163, 359], 'as': [165, 361, 434, 2107, 2147, 2265, 2305, 2428, 2715, 2722, 2905, 3256, 3258, 3763, 4071, 4073, 4463, 4554, 4606, 4608, 4961, 4963, 5091, 5114], 'N-ethylmaleimide': [170, 366], 'ATPase': [172, 368], 'NSF': [174, 370, 1856, 2003, 4597, 4616, 4687, 4769, 4798, 4824, 4840, 4852, 4859, 4877, 4918, 4941, 4968, 5157, 5171], 'mutants.': [175, 371, 4853, 4878], 'Our': [176, 372, 4879], 'results': [177, 373, 1983, 2840, 3005, 3328, 3913, 4267, 4880, 4998, 5062, 5149], 'indicate': [178, 374, 1270, 4062], 'that': [179, 375, 525, 842, 1117, 1271, 1905, 1916, 1985, 1994, 2739, 2842, 3010, 3162, 3336, 3408, 3429, 3473, 3487, 3650, 3688, 3729, 3751, 3772, 3877, 3918, 3933, 3954, 3966, 4063, 4419, 4452, 4475, 4510, 4535, 4615, 4823, 4882, 4896, 4971, 5005, 5064, 5075, 5088, 5104, 5151, 5170, 5185, 5198, 5325, 5350, 5379], 'sequentially': [180, 376], 'acting': [181, 377, 2856], 'endocytic': [182, 378, 832, 844, 1665, 1960, 2352, 2374, 2851, 2900, 2931, 2953, 3172, 3183, 3325, 3368, 3624, 5323, 5372], 'Rab': [183, 379, 626, 733, 824, 2962, 3430, 4381, 5391, 5399], 'GTPases': [184, 380, 627, 3284], 'utilize': [185, 381], 'similar': [186, 382, 2526], 'factors': [187, 383, 1738, 1888, 3508, 3744], 'although': [188, 384], 'their': [189, 385, 553, 3969], 'modes': [190, 386], 'action': [192, 388], 'be': [194, 390, 1038, 2512, 3041, 3288, 3384, 3825, 5327, 5381], 'different.': [195, 391], 'Endocytosis': [392], 'occurs': [393, 3512], 'all': [395, 1886, 4246], 'eukaryotic': [396], 'essential': [400, 3996], 'uptake': [403, 1912, 2221, 2309, 2779, 2822, 2830, 3361, 3842, 3856, 4249, 4258, 4905, 4960], 'nutrients,': [405], 'turnover': [407], 'membranes': [409], '(1Trowbridge': [411], 'I.S.': [412], 'Collawn': [413], 'J.F.': [414], 'Hopkins': [415], 'C.R.': [416], 'Annu.': [417, 3783, 5289], 'Rev.': [418, 3784, 5290], 'Cell': [419, 505, 585, 723, 794, 1000, 1021, 1053, 1217, 1290, 1366, 1381, 1473, 1522, 1622, 2609, 2680, 3115, 3192, 3239, 3271, 3564, 3611], 'Biol.': [420, 506, 586, 686, 706, 724, 795, 903, 923, 1001, 1022, 1054, 1180, 1200, 1218, 1291, 1382, 1406, 1474, 1498, 1700, 1846, 1875, 1938, 2072, 2092, 2165, 2587, 2610, 2681, 2765, 2798, 2876, 3116, 3140, 3193, 3217, 3307, 3565, 3589, 3679, 3786, 4014, 4119, 4138, 4191, 4328, 4672, 4727, 4813, 5232, 5252, 5292], '1993;': [421, 688, 725, 905, 1002, 1182, 1219, 1345, 1368, 1552, 1624, 2074, 2589, 4048, 4193, 5234], '9:': [422], '129-161Crossref': [423], 'PubMed': [424, 452, 510, 590, 604, 656, 676, 694, 714, 728, 778, 799, 816, 873, 893, 911, 931, 950, 978, 1005, 1026, 1058, 1074, 1150, 1170, 1188, 1208, 1222, 1262, 1295, 1327, 1348, 1371, 1386, 1416, 1445, 1478, 1508, 1555, 1600, 1627, 1658, 1708, 1728, 1818, 2080, 2100, 2284, 2577, 2595, 2614, 2642, 2664, 2685, 3120, 3150, 3197, 3227, 3315, 3450, 3467, 3569, 3599, 3790, 4018, 4051, 4099, 4127, 4142, 4199, 4307, 4375, 4592, 4639, 4658, 4682, 4731, 4817, 5045, 5142, 5222, 5240, 5260, 5280, 5296], 'Scopus': [425, 453, 511, 591, 605, 657, 677, 729, 779, 800, 817, 874, 894, 951, 979, 1006, 1027, 1059, 1151, 1171, 1223, 1263, 1296, 1328, 1349, 1387, 1417, 1446, 1479, 1509, 1556, 1601, 1659, 1729, 1819, 2285, 2578, 2615, 2643, 2665, 2686, 3121, 3151, 3198, 3228, 3451, 3468, 3570, 3600, 3791, 4019, 4052, 4100, 4143, 4308, 4376, 4593, 4640, 4659, 4683, 4732, 4818, 5046, 5143, 5223, 5281, 5297], '(701)': [426], 'Google': [427, 455, 513, 593, 607, 659, 679, 695, 715, 731, 781, 802, 819, 876, 896, 912, 932, 953, 981, 1008, 1029, 1061, 1075, 1153, 1173, 1189, 1209, 1225, 1265, 1298, 1330, 1351, 1372, 1389, 1419, 1448, 1481, 1511, 1527, 1558, 1603, 1628, 1661, 1709, 1731, 1821, 2081, 2101, 2287, 2580, 2596, 2617, 2645, 2667, 2688, 3123, 3153, 3200, 3230, 3244, 3276, 3316, 3453, 3470, 3572, 3602, 3616, 3793, 4021, 4054, 4102, 4128, 4145, 4200, 4310, 4378, 4595, 4642, 4661, 4685, 4734, 4820, 5048, 5145, 5225, 5241, 5261, 5283, 5299], 'Scholar)': [428, 1512, 1528, 1822, 2803, 3471], 'and,': [429], 'some': [431, 4518], 'such': [433], 'oocytes,': [435, 2695], 'yolk': [439], 'platelets': [440], '(2Opresko': [441], 'L.': [442, 1590, 2272, 3297], 'Karpf': [443], 'R.A.': [444], 'Cell.': [445, 649, 669, 771, 866, 886, 943, 1069, 1143, 1163, 1320, 1593, 1874, 1937, 2164, 2570, 2764, 2797, 2875, 3678, 3785, 4013, 4137, 4726, 4812, 5036, 5215, 5291], '1987;': [446], '51:': [447], '557-568Abstract': [448], 'Full': [449, 653, 673, 691, 711, 775, 870, 890, 908, 928, 947, 1147, 1167, 1185, 1205, 1324, 1411, 1413, 1503, 1505, 1597, 1705, 2077, 2097, 2574, 2592, 3145, 3147, 3222, 3224, 3312, 3594, 3596, 4124, 4196, 4677, 4679, 5040, 5042, 5219, 5237, 5257], 'Text': [450, 654, 674, 692, 712, 776, 871, 891, 909, 929, 948, 1148, 1168, 1186, 1206, 1325, 1412, 1414, 1504, 1506, 1598, 1706, 2078, 2098, 2575, 2593, 3146, 3148, 3223, 3225, 3313, 3595, 3597, 4125, 4197, 4678, 4680, 5041, 5043, 5220, 5238, 5258], 'PDF': [451, 655, 675, 693, 713, 777, 872, 892, 910, 930, 949, 1149, 1169, 1187, 1207, 1326, 1415, 1507, 1599, 1707, 2079, 2099, 2576, 2594, 3149, 3226, 3314, 3598, 4126, 4198, 4681, 5044, 5221, 5239, 5259], '(68)': [454], 'Scholar).': [456, 514, 608, 732, 820, 1030, 1076, 1226, 1299, 1449, 1604, 1629, 1662, 1732, 1852, 1880, 1943, 2102, 2170, 2288, 2689, 2770, 2881, 3154, 3245, 3277, 3317, 3617, 3684, 3794, 4022, 4055, 4146, 4201, 4334, 4379, 4596, 4686, 4735, 4821, 5058, 5146, 5300], 'After': [457], 'internalization,': [458], 'endocytosed': [459, 3752], 'solute': [460], 'receptor-bound': [462], 'are': [464, 474, 571, 735, 1098, 1303, 3754, 3797, 4268, 4694, 4784, 4976, 4999], 'delivered': [465], 'common': [468], 'endosomal': [470, 527, 1033, 1308, 3106, 3345, 3402, 3806, 4927, 4953, 5068], 'compartment': [471, 498, 845, 1034, 1309, 1992, 3019, 3173, 3184, 3535, 3556, 3926, 3938], 'where': [472, 746, 1087, 3097], 'they': [473, 747, 2921, 3764], 'sorted': [475, 1099], 'targeted': [477, 1104], 'other': [479, 1824, 2042, 3955, 4219], 'intracellular': [480, 629, 744, 1894, 5405], 'destinations,': [481], 'including': [482, 834, 1739, 1828, 2057, 2933], 'putative': [484], 'recycling': [485, 1106, 1232, 1274, 3431], 'compartment,': [486, 2321, 2932, 3369, 3403], 'trans': [488, 1095], 'Golgi': [489, 1096, 4566], 'network': [490, 1097, 1536], 'pathway': [491, 833, 3691, 5373], 'diversion': [493], 'lysosomal': [496, 3260, 3292], 'degradative/storage': [497], '(3Gruenberg': [499, 1047], 'J.': [500, 668, 685, 705, 793, 811, 885, 902, 922, 999, 1020, 1048, 1068, 1162, 1179, 1199, 1289, 1344, 1365, 1380, 1405, 1441, 1472, 1497, 1521, 1551, 1621, 1654, 1699, 1720, 1724, 1838, 1845, 1873, 1936, 2071, 2091, 2163, 2274, 2277, 2586, 2608, 2656, 2660, 2674, 2676, 2679, 2763, 2796, 2874, 3114, 3139, 3191, 3216, 3238, 3270, 3299, 3301, 3305, 3306, 3563, 3588, 3610, 3677, 3780, 4118, 4136, 4190, 4320, 4327, 4671, 4725, 4811, 5054, 5214, 5231, 5251, 5272, 5276, 5286], 'Maxfield': [501, 1049, 1066], 'F.': [502, 1050, 1618], 'Curr.': [503, 583, 721, 1051, 1215], 'Opin.': [504, 584, 722, 1052, 1216], '1995;': [507, 1055, 1383, 1475, 1524, 1655, 1815, 3117, 3194, 3241, 3273, 3566, 3613, 4096, 4304, 4372, 5139], '7:': [508, 1056], '552-563Crossref': [509, 1057], '(551)': [512, 1060], 'Currently,': [515], 'there': [516], 'only': [518], 'rudimentary': [520], 'understanding': [521, 540], 'mechanisms': [524], 'sorting': [528, 1085], 'Nevertheless,': [531], 'much': [532, 3720, 3858], 'progress': [533, 3765], 'made': [536, 4695], 'toward': [537, 5374], 'general': [539, 4619], 'vesicular': [542, 753, 3977, 4832], 'Vesicles': [544], 'containing': [545, 2234, 2247, 2416], 'cargo': [546], 'bud': [547], 'donor': [549, 3482, 3534], 'compartments': [550, 557, 745, 2479, 2901, 3483, 3820, 4485], 'deliver': [552], 'contents': [554], 'acceptor': [556, 3520], 'fusion': [559, 570, 760, 1638, 1690, 2051, 2109, 2117, 2725, 3507, 3517, 4549, 4609, 4623, 5206, 5330], 'latter.': [562], 'processes': [564], 'vesicle': [566, 757, 3514], 'budding,': [567], 'docking,': [568], 'regulated': [572, 1735], 'series': [575], 'generic': [577, 5174], 'compartment-specific': [579], '(4Pfeffer': [581], 'S.R.': [582, 1342, 1549, 3462], '1994;': [587, 601, 708, 925, 1071, 1202, 1702, 1725, 2094, 2661, 2682, 3309, 3447, 3464, 4121, 4728, 4814, 5254, 5277], '6:': [588], '522-526Crossref': [589], '(296)': [592], 'Scholar,': [594, 660, 680, 696, 716, 782, 803, 877, 897, 913, 954, 982, 1009, 1154, 1174, 1190, 1210, 1352, 1373, 1390, 1420, 1482, 1710, 2082, 2581, 2597, 2618, 2646, 2668, 3124, 3201, 3231, 3454, 3573, 3603, 4103, 4129, 4311, 4643, 4662, 5226, 5242, 5262, 5284], '5Rothman': [595], 'J.E.': [596, 4581, 4632, 4651, 4724, 4810], 'Nature': [597], '(': [598], 'Lond': [599], '.).': [600], '372:': [602], '55-63Crossref': [603], '(2001)': [606], 'Sorting': [609], 'at': [612, 1041, 2191, 2217, 2293, 2332, 2345, 2364, 2398, 2453, 2462, 2503, 3027, 3075, 3088, 4171, 4208], 'level': [614], 'involve': [618], 'budding': [619], 'or': [620, 623, 1093, 1513, 4516, 4873, 5108], 'tubule': [621], 'formation,': [622], 'both.': [624], 'Ras-related': [625], 'regulate': [628, 748, 1457, 1610], 'trafficking': [630, 1895], 'during': [631, 1896], 'endocytosis': [632, 1897, 2742, 3656, 4070, 4230, 4347, 4884, 5314], 'secretion': [634], '(6Bucci': [635, 852, 1129, 2556], 'C.': [636, 853, 1130, 1404, 1426, 1439, 1496, 1797, 2557, 2670, 3138, 3215, 3443, 3587, 4078, 4286, 4354, 5121], 'Parton': [637, 763, 854, 935, 987, 1018, 1131, 1287, 1312, 1713, 2558, 2649, 5265], 'R.G.': [638, 764, 855, 936, 988, 1019, 1132, 1288, 1313, 1714, 2559, 2650, 5266], 'Mather': [639, 856, 1133, 2560], 'I.H.': [640, 857, 1134, 2561], 'Stunnenberg': [641, 858, 1135, 2562], 'H.': [642, 720, 859, 1136, 1214, 1588, 1620, 1712, 2563, 2648, 3441, 4175, 5264], 'Simons': [643, 767, 860, 939, 1137, 1316, 1363, 2564], 'K.': [644, 768, 861, 940, 1138, 1317, 1364, 2565, 4038, 4107, 4179, 4716, 4802], 'Hoflack': [645, 862, 1139, 2566], 'B.': [646, 805, 863, 965, 1140, 1249, 1377, 1424, 1469, 2567, 2629, 3111, 3188, 3560], 'Zerial': [647, 665, 769, 864, 882, 941, 997, 1016, 1141, 1159, 1285, 1318, 1339, 1361, 1436, 1546, 1721, 2568, 2657, 3444, 5211, 5273], 'M.': [648, 666, 718, 770, 865, 883, 942, 998, 1017, 1142, 1160, 1212, 1286, 1319, 1340, 1362, 1394, 1398, 1400, 1429, 1437, 1486, 1490, 1492, 1547, 1722, 1835, 2569, 2658, 3128, 3132, 3134, 3205, 3209, 3211, 3445, 3577, 3581, 3583, 4117, 4317, 4666, 4720, 4806, 5212, 5274], '1992;': [650, 796, 867, 1144, 1594, 2571, 2611], '70:': [651, 868, 1145, 2572], '715-728Abstract': [652, 869, 1146, 2573], '(1116)': [658, 875, 1152, 2579], '7Grovel': [661, 878, 1155], 'J.P.': [662, 879, 1156, 1518, 3235, 3267, 3607, 5208], 'Chavrier': [663, 880, 989, 1157, 1519, 3236, 3268, 3608, 5209], 'P.': [664, 762, 881, 934, 990, 1158, 1311, 1356, 1520, 1842, 1870, 1933, 2160, 2760, 2793, 2871, 3237, 3269, 3609, 3674, 4324, 4412, 4492, 5210], 'Gruenberg': [667, 884, 1161, 1719, 2655, 5213, 5271], '1991;': [670, 887, 975, 1164, 1259, 2639, 5216], '64:': [671, 888, 1165, 5217], '915-925Abstract': [672, 889, 1166, 5218], '(856)': [678, 895, 1172, 5224], '8Li': [681, 898, 1175, 2582, 5227], 'G.': [682, 698, 899, 915, 1176, 1192, 1692, 1795, 2068, 2084, 2270, 2583, 4076, 4284, 4352, 5119, 5228, 5244], 'Stahl': [683, 703, 900, 920, 1177, 1197, 1697, 1806, 2069, 2089, 2584, 4087, 4295, 4363, 4652, 4669, 5130, 5229, 5249], 'P.D.': [684, 704, 901, 921, 1178, 1198, 1698, 1807, 2070, 2090, 2585, 4088, 4296, 4364, 4653, 4670, 5131, 5230, 5250], 'Chem.': [687, 707, 904, 924, 1181, 1201, 1407, 1499, 1701, 1847, 2073, 2093, 2588, 3141, 3218, 3308, 3590, 4120, 4192, 4329, 4673, 5233, 5253], '268:': [689, 906, 1183, 2075, 2590, 4194, 5235], '24475-24480Abstract': [690, 907, 1184, 2076, 2591, 5236], '9Li': [697, 914, 1191, 2083, 5243], 'Barbieri': [699, 916, 1193, 1693, 1798, 2085, 4079, 4287, 4355, 5122, 5245, 5419], 'A.': [700, 807, 809, 917, 961, 963, 974, 984, 992, 1194, 1245, 1247, 1258, 1360, 1379, 1471, 1644, 1694, 1718, 1803, 1814, 1862, 1925, 2086, 2152, 2276, 2625, 2627, 2638, 2654, 2752, 2785, 2863, 3113, 3190, 3562, 3666, 4084, 4095, 4292, 4303, 4360, 4371, 4409, 4588, 5031, 5035, 5050, 5127, 5138, 5246, 5270], 'Colombo': [701, 918, 1195, 1695, 2087, 5247, 5416], 'M.I.': [702, 919, 1196, 1696, 2088, 4664, 5248], '269:': [709, 926, 1203, 1703, 2095, 3310, 4122, 5255], '14631-14635Abstract': [710, 927, 1204, 1704, 2096, 5256], '10Zerial': [717, 1211], 'Stenmark': [719, 1213], '5:': [726, 1220, 3788, 5294], '613-620Crossref': [727, 1221], '(343)': [730, 1224], 'specifically': [736], 'localized': [737, 828, 3093, 3289], 'cytoplasmic': [740], 'surface': [741], 'specific': [743, 4206], 'individual': [750], 'steps': [751], 'controlling': [756], 'docking': [758, 1688, 3515], '(11Chavrier': [761, 1310], 'Hauri': [765, 937, 1314], 'H.P.': [766, 938, 1315], '1990;': [772, 813, 944, 1321, 4015], '62:': [773, 945, 1322], '317-329Abstract': [774, 946, 1323], '(882)': [780, 952, 1329], '12Tisdale': [783, 2598], 'E.J.': [784, 2599], 'Bourne': [785, 2600], 'J.R.': [786, 2601], 'Khosravi-Far': [787, 2602], 'R.': [788, 1013, 1282, 1392, 1433, 1435, 1484, 2603, 3126, 3203, 3575, 4645, 4722, 4808], 'Der': [789, 2604], 'C.J.': [790, 2605], 'Balch': [791, 2606, 2677, 4633], 'W.E.': [792, 2607, 2678, 4634], '119:': [797, 2612], '749-761Crossref': [798, 2613], '(418)': [801, 2616], '13Goud': [804], 'Zahraoui': [806, 960, 1244, 2624], 'Tavitian': [808, 962, 1246, 2626], 'Saraste': [810], 'Nature.': [812, 3446, 3463, 4635, 4654], '345:': [814], '553-556Crossref': [815], '(252)': [818], 'A': [821, 1111, 2294, 3334, 3425, 5376], 'number': [822], 'have': [826, 1453, 1903, 2548, 2737, 3719, 4472], 'Rab4,': [835], 'Rab5,': [836, 3358, 4430], 'Rab11,': [837], 'Rab18,': [838], 'Rab20,': [840], 'highly': [847, 4205], 'complex': [848, 5404], 'multiple': [850, 1737, 4831, 5178], 'functions': [851, 1918, 5090], 'Scholar,11Chavrier': [933], '14van': [955, 2619], 'der': [956, 1240, 2620], 'Sluijs': [957, 1241, 2621], 'Hull': [958, 1242, 2622], 'P.M.': [959, 1243, 2623], 'Goud': [964, 1248, 2628], 'Mellman': [966, 1250, 2630], 'I.': [967, 1251, 1358, 2631], 'Proc.': [968, 1252, 1808, 2632, 4089, 4297, 4365, 4582, 5132], 'Natl.': [969, 1253, 1809, 2633, 4090, 4298, 4366, 4583, 5133], 'Sci.': [970, 1070, 1254, 1367, 1523, 1623, 1811, 2634, 3240, 3272, 3612, 4092, 4300, 4368, 4585, 5135], 'Acad.': [971, 1255, 1810, 2635, 4091, 4299, 4367, 4584, 5134], 'U.': [972, 1256, 1812, 2636, 4093, 4301, 4369, 4586, 5136], 'S.': [973, 986, 1015, 1257, 1284, 1516, 1813, 2637, 3233, 3265, 3605, 4094, 4177, 4302, 4370, 4587, 5137], '88:': [976, 1260, 2640], '6313-6317Crossref': [977, 1261, 2641], '(220)': [980, 1264, 2644], '15Lutcke': [983], 'Jansson': [985], 'Valencia': [991], 'Huber': [993], 'L.A.': [994], 'Lehtonen': [995], 'E.': [996, 1422], '121:': [1003], '553-564Crossref': [1004], '(116)': [1007], '16Ullrich': [1010], 'O.': [1011, 1280, 1716, 2652, 3439, 4115, 5268], 'Sigrid': [1012, 1281], 'Urbe': [1014, 1283], '1996;': [1023, 1292, 4139, 4674, 5037, 5055], '135:': [1024, 1293, 4140], '913-924Crossref': [1025, 1294], '(1075)': [1028, 1297], 'Morphologically,': [1031], 'thought': [1036], 'comprised': [1039], 'least': [1042, 2463], 'two': [1043, 4705], 'functionally': [1044], 'distinct': [1045, 4699], 'sub-compartments': [1046], 'Scholar,17Ghosh': [1062], 'R.N.': [1063], 'Gelman': [1064], 'D.L.': [1065], 'F.R.': [1067], '107:': [1072], '2177-2189Crossref': [1073], 'Internalized': [1077], 'receptor': [1078], 'ligand': [1080, 1970, 2520, 2903], 'first': [1081, 3980, 4222, 4775], 'enter': [1082], 'peripheral': [1084, 3758], 'endosome': [1086, 1128, 1533, 1614, 3885, 5205, 5340], 'membrane': [1088, 1102, 1124, 1238, 3293, 3882, 4567, 4749, 5193], 'destined': [1090], 'degradation': [1092], 'away': [1100], 'back': [1107, 3531], 'plasma': [1109, 1123, 1237, 3881, 5192], 'membrane.': [1110, 3521], 'substantial': [1112], 'body': [1113], 'evidence': [1115, 3981], 'indicates': [1116, 3965, 4418, 4970], 'Rab5': [1118, 1667, 1673, 1733, 1853, 1907, 1921, 2545, 2748, 2810, 2859, 3393, 3416, 5117, 5186, 5355, 5362], 'regulates': [1119, 1273, 2741, 5200], 'Rab4': [1227], 'appears': [1228, 3099], 'control': [1230, 3059, 3848], '(14van': [1239], 'Scholar),': [1266, 1559], 'recent': [1268], 'studies': [1269, 3990, 4057], 'Rab11': [1272], 'through': [1275, 4517], 'perinuclear': [1277, 3761], '(16Ullrich': [1279], 'Rab9': [1302, 1452], 'associated': [1304, 3364, 5110], 'Scholar,18Lombardi': [1331], 'D.': [1332, 1396, 1488, 1539, 1592, 1646, 1650, 1843, 1871, 1934, 2161, 2761, 2794, 2872, 3130, 3207, 3579, 3675, 4325, 4413, 4493], 'Soldati': [1333, 1540], 'T.': [1334, 1541, 1648, 3456, 4111, 4113], 'Riederer': [1335, 1542], 'M.A.': [1336, 1543, 1799, 4080, 4288, 4356, 5123], 'Goda': [1337, 1544], 'Y.': [1338, 1375, 1467, 1545, 3109, 3186, 3558, 4109, 4183, 4185, 4187, 4189], 'Pfeffer': [1341, 1548, 3461], 'EMBO': [1343, 1440, 1550, 1653, 1723, 2659, 5053, 5275], '12:': [1346, 1553], '677-682Crossref': [1347, 1554], '(436)': [1350, 1557], '19Olkkonen': [1353], 'V.M.': [1354], 'Dupree': [1355], 'Killisch': [1357], 'Lutcke': [1359, 1717, 2653, 5269], '106:': [1369, 1625], '1249-1261Crossref': [1370], '20Feng': [1374], 'Press': [1376, 1468, 3110, 3187, 3559], 'Wandinger-Ness': [1378, 1470, 3112, 3189, 3561], '131:': [1384, 1476, 3118, 3195, 3567], '1435-1452Crossref': [1385, 1477, 3119, 3196, 3568], '(532)': [1388, 1480, 3122, 3199, 3571], '21Vitelli': [1391, 1483, 3125, 3202, 3574], 'Santillo': [1393, 1485, 3127, 3204, 3576], 'Lattero': [1395, 1487, 3129, 3206, 3578], 'Chiariello': [1397, 1489, 3131, 3208, 3580], 'Bifulco': [1399, 1491, 3133, 3210, 3582], 'Bruni': [1401, 1493, 3135, 3212, 3584], 'C.B.': [1402, 1494, 3136, 3213, 3585], 'Bucci': [1403, 1425, 1495, 3137, 3214, 3442, 3586], '1997;': [1408, 1442, 1500, 3142, 3219, 3591], '272:': [1409, 1501, 3143, 3220, 3592], '4391-4397Abstract': [1410, 1502, 3144, 3221, 3593], '(249)': [1418, 1510, 3152, 3229, 3452, 3601, 3792, 5298], '22Papini': [1421], 'Satin': [1423], 'de': [1427], 'Bernard': [1428], 'Telford': [1430], 'J.L.': [1431], 'Manetti': [1432], 'Rappuoli': [1434], 'Montecucco': [1438], '16:': [1443], '15-24Crossref': [1444], '(193)': [1447], 'traffic': [1459], '(20Feng': [1466, 3108, 3185, 3557], 'lysosomes': [1514], '(23Meresse': [1515, 3264], 'Grovel': [1517, 3234, 3266, 3606], '108:': [1525, 3242, 3274, 3614], '3349-3358PubMed': [1526, 3243, 3275, 3615], 'trans-Golgi': [1535], '(TGN)': [1537], '(18Lombardi': [1538], 'respectively.': [1560], 'Deletion': [1561], 'YPT7': [1564], 'gene,': [1565], 'yeast': [1567, 1642, 3994, 4002], 'homologue': [1568], 'Rab7,': [1570], 'leads': [1571, 5316], 'fragmentation': [1573], 'vacuole': [1576, 1616, 4003, 4006], 'delay': [1580], 'processing': [1583], 'vacuolar': [1585], '(24Wichmann': [1587], 'Hengst': [1589], 'Gallwitz': [1591, 1649], '71:': [1595], '1131-1142Abstract': [1596], '(202)': [1602], 'Ypt7': [1605, 1631], 'between': [1612, 1639, 4610, 5191, 5331], '(25Schimmoller': [1617], 'Riezman': [1619], '823-830Crossref': [1626], 'Moreover,': [1630, 1944, 2807, 3246, 4498], 'also': [1633, 1854, 4061, 4473, 5000, 5019, 5159, 5166], 'involved': [1634, 5009], 'homotypic': [1637], 'vacuoles': [1640], '(26Hass': [1643], 'Scheglmann': [1645], 'Lazar': [1647], 'Wickner': [1651, 5032, 5051], 'W.': [1652, 2014, 5033, 5052], '14:': [1656], '5258-5270Crossref': [1657], '(232)': [1660], 'Among': [1663], 'Rabs,': [1666], 'most': [1670], 'extensively': [1671], 'studied.': [1672], 'active': [1675, 3636], 'GTP': [1678, 1684, 3390, 3409, 3498, 3510, 4393, 5303, 5353], 'form': [1679, 3524, 4436], 'does': [1681, 3164, 4504], 'hydrolysis': [1685, 3391, 3410, 3511, 4975, 5155, 5351], 'mediating': [1687], '(9Li': [1691], '27Stenmark': [1711, 2647, 5263], 'Steele-Mortimer': [1715, 2651, 5267], '13:': [1726, 2662, 5278], '1287-1296Crossref': [1727, 2663, 5279], '(768)': [1730, 2666, 5282], '(PI)-3-kinase': [1741], '1The': [1742, 1768], 'abbreviations': [1743, 1769], 'used': [1744, 1770, 2053], 'are:': [1745, 1771], 'PI,': [1746, 1772], 'phosphatidylinositol;': [1747, 1773], 'GST,': [1748, 1774], 'glutathione': [1749, 1775, 2723], 'S-transferase;': [1750, 1776], 'HRP,': [1751, 1777], 'horseradish': [1752, 1778], 'peroxidase;': [1753, 1779], 'NEM,': [1754, 1780], 'N-ethylmaleimide;': [1755, 1781], 'NSF,': [1756, 1782], 'NEM-sensitive': [1757, 1783, 4548], 'factor;': [1758, 1784], 'WT,': [1759, 1785], 'wildtype;': [1760, 1786], 'PBS,': [1761, 1787, 2391], 'phosphate-buffered': [1762, 1788], 'saline;': [1763, 1789], 'BSA,': [1764, 1790], 'bovine': [1765, 1791], 'serum': [1766, 1792], 'albumin.': [1767, 1793], '(28Li': [1794, 4075, 4283, 4351, 5118], "D'Souza-Schorey": [1796, 4077, 4285, 4353, 5120], 'Roberts': [1800, 4081, 4289, 4357, 5124], 'R.L.': [1801, 4082, 4290, 4358, 5125], 'Klippel': [1802, 4083, 4291, 4359, 5126], 'Williams': [1804, 4085, 4293, 4361, 5128], 'L.T.': [1805, 4086, 4294, 4362, 5129], '92:': [1816, 4097, 4305, 4373, 5140], '10207-10211Crossref': [1817, 4098, 4306, 4374, 5141], '(246)': [1820, 4101, 4309, 4377, 5144], 'signal': [1825, 3045], 'transducing': [1826], 'elements': [1827], 'RAS': [1829], '(29Li,': [1830], 'G.,': [1831, 4313], "D'Souza-Schorey,": [1832, 4314], 'C.,': [1833, 4315], 'Barbieri,': [1834, 1861, 1924, 2151, 2751, 2784, 2862, 3665, 4316, 4410], 'A.,': [1836, 1839, 1860, 1923, 2150, 2750, 2783, 2861, 3664, 4318, 4321], 'Cooper,': [1837, 4319], 'Stahl,': [1841, 1869, 1932, 2159, 2759, 2792, 2870, 3673, 4323, 4414, 4494], '(1997)': [1844, 1872, 1935, 2162, 2762, 2795, 2873, 3676, 4326], ',': [1848, 1876, 1939, 2166, 2766, 2799, 2877, 3680, 4330], '272,': [1849, 1877, 1940, 2167, 2767, 2800, 2878, 3681, 4331], 'press.Google': [1851, 1879, 1942, 2169, 2769, 2802, 2880, 3683, 4333], 'requires': [1855, 4460, 5020, 5078], 'function': [1858, 3101, 5029], '(30Mukhopadhyay,': [1859, 1922, 2149, 2749, 2782, 2860, 3663], 'M.,': [1863, 1926, 2153, 2753, 2786, 2864, 3667], 'Funato,': [1864, 1927, 2154, 2754, 2787, 2865, 3668, 4490], 'K.,': [1865, 1928, 2155, 2755, 2788, 2866, 3669], 'Roberts,': [1866, 1929, 2156, 2756, 2789, 2867, 3670], 'R.,': [1867, 1930, 2157, 2757, 2790, 2868, 3671], 'However,': [1881, 5334], 'exact': [1883], 'relationship': [1884], 'among': [1885], 'these': [1887, 3706, 4209], 'overall': [1891], 'mechanism': [1892], 'largely': [1899], 'unknown.': [1900], 'Recently,': [1901, 2735], 'we': [1902, 1967, 2696, 2736, 2886, 3647, 3900, 4835, 4864], 'both': [1906, 3337, 3619, 4420, 4934, 4967, 4979], 'stimulate': [1910, 3341, 3551, 4521], 'HRP': [1911, 1951, 2203, 2211, 2220, 2258, 2308, 2496, 2778, 2818, 2821, 2837, 4232, 4248, 4257, 4862, 4885, 4904, 4948, 4959], 'downstream': [1919, 2857], 'stimulates': [1946, 1987, 3012, 3360], 'inactivation/degradation': [1948], 'preloaded': [1950, 2911], 'enhancing': [1955], 'To': [1962, 2312, 3891, 4854], 'characterize': [1964], 'Rab7-mediated': [1965, 2315, 2820, 3035, 3894, 3919, 4861], 'mixing': [1971, 2521, 2904], 'measure': [1974], 'demonstrate': [1984, 2841, 5063], 'NSF-,': [1998], 'microtubule-,': [1999], 'PI-3-kinase-dependent.': [2001], 'Recombinant': [2002, 2103], 'wild': [2004], 'type': [2005], 'mutant': [2007, 3633, 3654, 3715], 'generously': [2010], 'provided': [2011], 'Sidney': [2013], 'Whiteheart': [2015, 4667], '(University': [2016], 'Kentucky,': [2018], 'Lexington,': [2019], 'KY).': [2020], 'Adult': [2021], 'female': [2022, 2129], 'Xenopus': [2023, 2694], 'laevis': [2024, 2131], 'purchased': [2026], 'Nasco,': [2028], 'Fort': [2029], 'Atkinson,': [2030], 'WI.': [2031], 'Avidin': [2032], 'obtained': [2036], 'Pierce': [2038], '(Rockford,': [2039], 'IL).': [2040], 'All': [2041, 2717, 3078], 'reagents': [2043], 'Sigma': [2046], '(St.': [2047], 'Louis,': [2048], 'MO).': [2049], 'this': [2055, 3542, 3651, 3773, 4469, 5076], 'study,': [2056, 2885], 'Rab5:Q79L,': [2058, 5306], 'Rab5:S34N,': [2059], 'Rab7:WT,': [2060, 2773, 4239, 4243], 'Rab7:T22N,': [2063, 2708, 3349, 3629], 'described': [2065, 2148], 'previously': [2066], '(8Li': [2067], 'expressed': [2106, 2304], 'glutathioneS-transferase': [2108], 'Escherichia': [2112], 'colistrain': [2113], 'JM': [2114], '101.': [2115], 'GST': [2116], 'affinity': [2120], 'purified': [2121, 2728], 'glutathione-Sepharose.': [2123], 'Ovaries': [2124], 'dissected': [2126], 'adult': [2128], 'X.': [2130], 'anesthetized': [2132], '3-aminobenzoic': [2134], 'acid': [2135], 'ethyl': [2136], 'ester': [2137], '(1': [2138, 2362], 'g/liter)': [2139], 'ice': [2141], 'water,': [2142], 'prepared': [2146, 2550, 2721], 'molecules': [2176], '50': [2178, 2388, 3838, 3905], 'nl': [2179, 2389], 'PBS': [2181, 2246, 2415], 'recover': [2186], 'modified': [2188, 2231], "Barth's": [2189, 2232], 'saline': [2190, 2233], '18': [2192, 2218, 2333, 2346, 2365, 2399, 3089], '°C': [2193, 2347, 2366, 2455], '2': [2195, 2215, 3333, 3388], 'h.': [2196], 'Healthy': [2197], 'selected': [2201], 'uptake.': [2204, 2819, 2838], '(2': [2212, 2327, 2914], 'mg/ml)': [2213, 2328, 2363], 'h': [2216, 2331, 2344, 2926], '°C.': [2219, 2334, 2400, 3090], 'stopped': [2223], 'washing': [2225], '3': [2228, 4450], 'times': [2229, 2465], '5%': [2235], 'BSA.': [2236], 'Individual': [2237], 'lysed': [2241, 2410], '200': [2243], 'μl': [2244, 2413], '0.1%': [2248], 'Triton': [2249, 2418], 'X-100': [2250], 'centrifuged.': [2252], 'lysate': [2254], 'assayed': [2256], '96-well': [2260], 'plates': [2261, 2450, 2458], '(Costar': [2262], 'Corp.)': [2263], 'usingo-phenylenediamine': [2264], 'chromogenic': [2267], 'substrate': [2268], '(31Wolters': [2269], 'Kuijpers': [2271], 'Kacaki': [2273], 'Schuurs': [2275], 'Clin.': [2278], 'Pathol.': [2279], '(Lond.).': [2280], '1976;': [2281], '29:': [2282], '873-879Crossref': [2283], '(153)': [2286], 'products': [2290, 3971], '490': [2295], 'nm': [2296], 'Bio-Rad': [2299], 'microplate': [2300], 'reader.': [2301], 'Results': [2302], 'nanograms': [2306], 'per': [2310], 'oocyte.': [2311, 3962], 'monitor': [2313], 'endosome/prelysosome': [2320], '5': [2330, 2464, 2917], 'washed': [2339, 2357, 2461], '16': [2343, 2925], 'label': [2349, 2928], 'Subsequently,': [2354, 2935], '30': [2368, 2436], 'min': [2369, 3087], 'mark': [2371, 2950], 'Indicated': [2376], 'amounts': [2377], 'into': [2384, 2733, 2780, 3399, 3661], 'washed,': [2405], 'three': [2407, 4698], '100': [2412], '0.3%': [2417], 'X-100,': [2419], '0.2%': [2420], 'methylbenzethorium': [2421], 'chloride,': [2422], '400': [2424], 'μg/ml': [2425], 'BSA-biotin': [2427], 'scavenger.': [2429, 2533], 'Finally,': [2430], 'lysates': [2432], 'centrifuged': [2434], 's': [2437], 'microfuge,': [2440], 'avidin-biotin': [2443], 'complexes': [2444, 2976, 2989], 'immunoprecipitated': [2446, 2487, 2497], 'anti-avidin': [2448], 'antibody-coated': [2449], 'incubation': [2452, 2966], '4': [2454], 'overnight.': [2456], 'remove': [2467], 'unbound': [2469], 'proteins.': [2470], 'measuring': [2483], 'amount': [2485, 2494, 2517], 'HRP.': [2488], 'Background': [2489], 'determined': [2491, 2978, 3047], 'presence': [2500, 2996, 4891], 'scavenger': [2502, 3053], '0': [2505], 'time': [2506, 2946], 'point,': [2507], 'found': [2510, 3249, 3286, 3322, 3382, 4466, 4474, 4984], 'very': [2513, 5321], 'low.': [2514], 'total': [2516], 'possible': [2519, 3407, 3687, 3728], 'measured': [2523], 'way': [2527], 'absence': [2531, 3050], 'By': [2534], 'analogy': [2535], 'RAS,': [2537], 'dominant': [2538, 2705, 3351, 3631, 3652, 3713], 'negative': [2539, 2706, 3352, 3632, 3653, 3714], 'mutants': [2543, 4400, 4939, 4969], 'characterized': [2552], 'several': [2554], 'laboratories': [2555], '32Nuoffer': [2669], 'Davidson': [2671], 'H.W.': [2672], 'Matteson': [2673], 'Meinkoth': [2675], '125:': [2683], '225-237Crossref': [2684], '(192)': [2687], 'For': [2690], 'microinjection': [2691, 4236], 'experiments': [2692], 'generated': [2697], 'addition': [2710], 'wild-type': [2713, 4871], 'protein': [2714, 3500, 3527, 3995, 3998, 4550, 4828, 4872, 4894], 'described.': [2716], 'S-transferase': [2724], 'proteins,': [2726], 'directly': [2732, 4515, 5107], 'oocytes.': [2734, 3696], 'concert': [2746], 'Microinjection': [2771], '(data': [2804, 3850, 3869, 4909, 4994], 'shown).': [2806, 3852, 3871, 4911], 'co-injection': [2808], 'produced': [2813, 4348], 'an': [2814, 2888, 4384, 4701, 4826, 5396], 'additive': [2815], 'effect': [2816, 2834, 3721, 3903, 4217, 4225, 4344, 4838], 'on': [2817, 2835, 3290, 3323, 3415, 3722, 3776, 3889, 3898, 4218, 4228, 4345, 5392], 'Rab5:S34N.': [2826], 'Rab7:T22N': [2827, 3643], 'little': [2833], 'Rab5-stimulated': [2836], 'These': [2839, 3872, 4266, 4997, 5164], 'plays': [2844], 'crucial': [2846], 'process': [2852, 3774, 3823], 'oocyte': [2855], 'In': [2882, 3055, 3347, 3376, 3853, 4523, 5059], 'present': [2884, 4526], 'detect': [2891], 'biochemical': [2907], 'readout.': [2908], 'mg/ml': [2915], 'h)': [2918], 'lysosomes.': [2934, 5375], 'short': [2943], 'period': [2944], '(30': [2947], 'min)': [2948], 'different': [2961], 'preparations,': [2963], 'following': [2965, 4235], 'various': [2968], 'periods': [2969], 'time,': [2971], 'avidin-biotin-HRP': [2975, 2987], 'cell': [2980], 'lysates.': [2981], 'Oocyte': [2982], 'lysis': [2983], 'preparation': [2985], 'immune': [2988], 'routinely': [2991], 'carried': [2992, 3083], 'out': [2993, 3084, 5336], 'biotin-BSA': [2998], 'scavenge': [3000], 'unoccupied': [3001], 'molecules.': [3003], 'presented': [3006, 3329, 3914, 4446], 'Fig.1': [3008], 'show': [3009, 3335, 4451, 4881, 5150], 'Rab7:WT': [3011, 3163, 3338, 3620, 4254, 4513, 4868, 4874, 4908, 5081], 'prelabeled': [3020], 'avidin.': [3022], 'maximal': [3026, 3032], 'about': [3028, 3042, 3073], '90': [3029, 3065, 3076], 'min.': [3030, 3077], 'efficiency': [3033, 3037, 3069], 'calculated': [3039], '80%': [3043], '(total': [3044], 'biotin-BSA).': [3054], 'buffer,': [3060], 'linear': [3063], 'over': [3064], 'min,': [3066], '20%': [3074], 'subsequent': [3079, 5359], 'assays': [3081], '60': [3086], 'it': [3098, 3405, 3726, 5199], 'It': [3155, 3685, 3748, 5181], 'Hela': [3160], 'colocalize': [3166], 'markers': [3168, 3800], 'colocalizes': [3175], 'MPR,': [3177], 'marker': [3179], '23Meresse': [3232, 3604], 'co-localize': [3251], 'LAMP1': [3253], 'LAMP2': [3255], 'well': [3257, 4072, 4607, 4962, 5183], 'enzyme': [3261], 'cathepsin': [3262], 'D': [3263], 'Using': [3278], 'subcellular': [3279], 'fractionation,': [3280], 'Rab7-': [3281], 'Rab4-like': [3283], 'inDictyostelium': [3294], 'discoideum': [3295], '(33Temesvari': [3296], 'Rodriguez-Paris': [3298], 'Bush': [3300], 'Steck': [3302], 'T.L.': [3303], 'Cardelli': [3304], '25719-25727Abstract': [3311], 'Thus,': [3318, 3808], 'commonly': [3321], 'terminal': [3324], 'Fig.': [3332, 3916, 4449, 4932], 'contrast,': [3348, 3854], 'Furthermore,': [3357, 5147], 'did': [3370, 3638], 'affect': [3372, 4425, 4787], '(Fig.2': [3374], 'B).': [3375, 3389], 'fact,': [3377], 'Rab5:Q79L': [3378, 4282, 4350], 'Rab5:S34N': [3380], 'slightly': [3385], 'inhibitory': [3386], '(Fig.': [3387], 'required': [3396, 3418, 4539, 4557, 4599, 4746, 4755, 4767, 4829, 4977, 5160, 5176, 5188, 5357], 'entrance': [3398], 'guanine': [3412, 3435, 4388], 'nucleotide': [3413, 3436, 4389, 4427, 5112], 'cycling': [3414], 'exit': [3420], 'current': [3426], 'model': [3427], 'suggests': [3428, 3953], 'coupled': [3433, 3489], 'exchange': [3437, 3492, 5113], '(34Ullrich': [3438], 'Horiuchi': [3440], '368:': [3448], '157-160Crossref': [3449], '35Soldati': [3455], 'Shapiro': [3457], 'A.D.': [3458], 'Svejstrup': [3459], 'A.B.': [3460], '369:': [3465], '18-19Crossref': [3466], '(151)': [3469], 'GDP': [3474, 3494, 3523, 3537], 'dissociation': [3475, 3538], 'inhibitor': [3476, 4155], 'delivers': [3477], 'cytosolic': [3478], 'Rabs': [3479], 'appropriate': [3481, 3506], 'reaction': [3486], 'GTP.': [3496], 'bound': [3499, 4394, 5304], 'assists': [3501], 'recruitment': [3504], 'recycled': [3530], 'inhibitor.': [3539], 'According': [3540], 'model,': [3543], 'reduced': [3547], 'activity,': [3549, 4508], 'should': [3550, 3824], 'Indeed,': [3618], 'As': [3626, 4929], 'indicated': [3627], 'above,': [3628], 'substantially': [3640], 'inhibit': [3641, 4468, 4903, 4986], '"functional"': [3645], 'since': [3646, 4207], 'demonstrated': [3648], 'earlier': [3649, 3875, 4532], 'blocks': [3655], 'induced': [3657], 'injection': [3660], 'Rab7-dependent': [3690], 'relatively': [3693], 'inactive': [3694, 4795], 'would': [3700, 3709], 'activate': [3702], 'pathway.': [3704], 'Under': [3705], 'conditions,': [3707], 'one': [3708], 'expect': [3711], 'normal': [3723], 'Alternatively,': [3725], 'recombinant': [3731, 4423], 'competes': [3734], 'poorly': [3735], 'endogenous': [3738], 'equivalent': [3739], 'frog': [3740], 'accessory': [3743], 'necessary': [3745], 'function.': [3747, 4770], 'known': [3750, 4785], 'materials': [3753], 'transported': [3755], 'location': [3762], 'depends': [3775], 'microtubules': [3778, 3796], '(36Gruenberg': [3779], 'Howell': [3781, 5287], 'K.E.': [3782, 5288], '1989;': [3787, 4636, 4655, 5293], '453-481Crossref': [3789, 5295], 'When': [3795, 3833], 'depolymerized,': [3798], 'failed': [3801], 'reach': [3803], 'if': [3809], 'mediates': [3812], 'sensitive': [3826], 'microtubule': [3828], 'depolymerizing': [3829], 'agents': [3830], 'like': [3831], 'nocodazole.': [3832], 'preincubated': [3836], 'μm': [3839, 3906], 'almost': [3845], 'levels': [3849, 3952], 'Rab5-mediated': [3855], 'less': [3859], 'affected': [3860, 4888], 'exposure': [3863], 'nocodazole': [3868, 3907], 'data': [3873, 4445, 4527, 4533], 'confirm': [3874, 4855], 'observations': [3876], 'dependent': [3888, 3897], 'determine': [3892], 'whether': [3893], 'microtubules,': [3899], 'tested': [3901, 4836], 'assay.': [3911], '3show': [3917], 'totally': [3928], 'indicating': [3932], 'Rab7stimulated': [3934], 'microtubule-dependent.': [3943], 'complete': [3945], 'inhibition': [3946, 4203, 4965], 'essentially': [3950], 'basal': [3951], 'microtubule-sensitive': [3956], 'pathways': [3957], 'exist': [3959], 'Recent': [3963, 4406], 'work': [3964, 4407], 'PI-3-kinases': [3967], 'lipid': [3970], 'play': [3973], 'key': [3974, 5377], 'roles': [3975], 'involvement': [3984], 'PI-3-kinase': [3986, 4030, 4033, 4066, 4154, 4164, 4424, 4461, 4507, 4511, 4536, 5089, 5105], 'came': [3987], 'VPS34p,': [3992], 'targeting': [3999], 'morphogenesis': [4007], '(37Herman': [4008], 'P.K.': [4009], 'Emr': [4010, 4045], 'S.D.': [4011, 4046], 'Mol.': [4012], '10:': [4016], '6742-6754Crossref': [4017], '(354)': [4020], 'VPS34p': [4023], 'shows': [4024], 'sequence': [4025, 5369], 'homology': [4026], 'exhibits': [4032], '(38Schu': [4035], 'P.V.': [4036], 'Takegawa': [4037], 'Fry': [4039], 'M.J.': [4040], 'Stack': [4041], 'J.H.': [4042], 'Waterfield': [4043], 'M.D.': [4044], 'Science.': [4047], '260:': [4049], '88-91Crossref': [4050], '(803)': [4053], 'Several': [4056], 'inhibitors': [4064], 'block': [4067], 'fluid': [4068], 'phase': [4069], 'phagocytosis': [4074], '39Ninomiya': [4104], 'N.': [4105, 4131, 4181], 'Hazeki': [4106, 4114], 'Fukui': [4108, 4184], 'Seya': [4110], 'Okada': [4112], 'Ui': [4116], '22732-22737Abstract': [4123], '40Araki': [4130], 'Johnson': [4132], 'M.T.': [4133], 'Swanson': [4134], 'J.A.': [4135], '1249-1260Crossref': [4141], '(780)': [4144], 'fungal': [4149], 'metabolite,': [4150], 'potent': [4153], 'binds': [4157], 'covalently': [4158], 'catalytic': [4161], 'subunit': [4162], '(p110)': [4165], 'irreversibly': [4167], 'inhibits': [4168, 4477], 'enzymatic': [4169], 'nanomolar': [4172], 'concentrations': [4173, 4211], '(41Yano': [4174], 'Nakanishi': [4176], 'Kimura': [4178], 'Hanai': [4180], 'Saitoh': [4182], 'Nonomura': [4186], 'Matsuda': [4188], '25846-25856Abstract': [4195], 'low': [4210], '(50–100': [4212], 'nm),': [4213], 'wortmannin': [4214, 4227, 4264, 4421, 4464, 4476], 'kinases.': [4220], 'examined': [4223], 'Rab5:WT,': [4238, 4242], 'Rab7:Q67L.': [4241], '2–2.5-fold.': [4251], 'stimulation': [4255, 4956, 5082], 'nearly': [4260], 'completely': [4261], 'treatment.': [4265], 'consistent': [4269, 5001], 'previous': [4271], 'findings': [4272, 5165], 'baby': [4274], 'hamster': [4275], 'kidney': [4276], 'transiently': [4278], 'expressing': [4279], '29Li,': [4312], 'Wortmannin': [4335], 'Rab5-enhanced': [4337], 'uptake,': [4338], 'drug': [4341], 'enhanced': [4346], 'Wild-type': [4380], 'activation': [4385, 4404, 4542, 5394], 'step': [4386], '(e.g.': [4387], 'exchange)': [4390], 'become': [4392], 'biologically': [4396], 'active.': [4397], 'Constitutively': [4398], 'presumably': [4401], 'bypass': [4402], 'step.': [4405], '2M.': [4408], 'submitted': [4415], 'publication.': [4417], 'status': [4428], 'former': [4432], 'favoring': [4433, 4440], 'GDP-bound': [4435], 'latter': [4439], 'GTP-bound': [4442], 'form.': [4443], 'cells.': [4488], '3K.': [4489], 'manuscript': [4495, 5346], 'preparation.': [4497, 5348], 'activates': [4512], 'either': [4514], 'intermediate': [4519], 'sum,': [4524], 'along': [4530, 5370], 'suggest': [4534], 'Rab7:WT.': [4546], 'originally': [4552], 'identified': [4553], 'restore': [4559], 'vitro': [4562], 'fractions': [4568], 'treated': [4569], 'NEM': [4571, 4982], '(42Block': [4572], 'M.R.': [4573, 4628], 'Glick': [4574, 4629], 'B.S.': [4575, 4630], 'Wilcox': [4576], 'C.A.': [4577], 'Wieland': [4578], 'F.T.': [4579], 'Rothman': [4580, 4631, 4650, 4723, 4809], '1988;': [4589], '85:': [4590, 5038], '7852-7856Crossref': [4591], '(396)': [4594], 'intra-Golgi': [4601], 'endoplasmic': [4603], 'reticulum-Golgi': [4604], 'component': [4620], 'machinery': [4624], '(43Beckers': [4625], 'C.J.M.': [4626], 'Bloch': [4627], '339:': [4637, 4656], '397-398Crossref': [4638], '(188)': [4641], '44Diaz': [4644], 'Mayorga': [4646], 'L.S.': [4647], 'Weideman': [4648], 'P.J.': [4649], '398-400Crossref': [4657], '(157)': [4660], '45Colombo': [4663], 'Taddese': [4665], 'S.W.': [4668, 4714, 4800], '271:': [4675], '18810-18816Abstract': [4676], '(49)': [4684], 'heterotrimer': [4690], 'whose': [4691], 'polypeptide': [4692], 'subunits': [4693], 'up': [4696], 'domains,': [4700], 'amino-terminal': [4702], 'domain': [4703, 4741, 4753], 'homologous': [4706], 'ATP': [4707, 4744, 4763, 4776, 4788, 4972, 5152], '(D1': [4708], 'D2)': [4710], 'binding': [4711, 4777, 4789, 4973, 5153], 'domains': [4712], '(46Whiteheart': [4713, 4799], 'Rossnagel': [4715, 4801], 'Buhrow': [4717, 4803], 'S.A.': [4718, 4804], 'Brunner': [4719, 4805], 'Aenicke': [4721, 4807], '126:': [4729, 4815], '945-954Crossref': [4730, 4816], '(340)': [4733, 4819], 'ability': [4737, 4760], 'D1': [4740], 'hydrolyze': [4743, 4762], 'NSF-mediated': [4748], 'fusion.': [4750], 'D2': [4752], 'trimerization,': [4757], 'its': [4759], 'absolutely': [4766], 'Two': [4771], 'mutations': [4772], 'site': [4778], '(D1),': [4779], 'i.e.': [4780], 'D1-K266A': [4781, 4901], 'D1-E329Q,': [4783], 'hydrolysis,': [4791], 'respectively,': [4792], 'resulting': [4793], 'forms': [4796], 'Given': [4822], 'ubiquitous': [4827], 'events,': [4834], 'anti-NSF': [4849], 'antibodies': [4850], 'participation': [4857], 'endocytosis,': [4863], 'co-injected': [4865], 'His6NSF': [4870], 'NSF:WT': [4893], 'His6': [4897, 4900], 'D1-E329Q': [4898], 'significantly': [4902, 4942], 'mediated': [4906], 'explored': [4914], '4,': [4933], 'DIEQ': [4936], 'DIKA': [4938], 'biotin': [4947], 'processes.': [4980], '(Moreover,': [4981], 'shown).)': [4996], 'finding': [5004], 'YPT7,': [5006], 'events': [5016], 'yeast,': [5018], 'Sec17p': [5021], '(yeast': [5022, 5026], 'α-snap)': [5023], 'Sec18p': [5025], 'NSF)': [5027], '(47Mayer': [5030], 'Hass': [5034], '83-94Abstract': [5039], '(479)': [5047], 'Scholar,48Hass': [5049], '15:': [5056], '296-3305Google': [5057], 'summary,': [5060], 'our': [5061, 5148], 'wortmannin,': [5086, 5102], 'regulator': [5093], 'indirectly': [5109], 'suggested': [5115], 'support': [5167], 'notion': [5169], 'events.': [5180, 5361], 'documented': [5184], 'dynamics': [5202], '(7Grovel': [5207], '36Gruenberg': [5285], 'Overexpression': [5301], 'cultured': [5308], 'increases': [5310], 'rate': [5312], 'appearance': [5319], 'large': [5322, 5339], 'vesicles': [5324], 'due': [5328], 'endosomes.': [5333], 'delayed,': [5342], '4Funato': [5343], 'et': [5344], 'al.,': [5345], 'appear': [5365], 'act': [5367], 'question': [5378], 'must': [5380], 'framed': [5382], 'resolved': [5384], 'influence': [5387], 'proximal': [5390], 'immediately': [5397], 'distal': [5398], 'regulation': [5402], 'pathways.': [5406], 'thank': [5408], 'Rita': [5409], 'Boshans': [5410], 'technical': [5412], 'assistance': [5413], 'Marisa': [5415], 'Alejandro': [5418], 'advice.': [5421]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1983853999', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-13T07:49:42.120403', 'created_date': '2016-06-24'}