Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1983386882', 'doi': 'https://doi.org/10.1007/bf01874568', 'title': 'Reductive cleavage and regeneration of the disulfide bonds inStreptomyces subtilisin inhibitor (SSI) as studied by the carbonyl13C NMR resonances of cysteinyl residues', 'display_name': 'Reductive cleavage and regeneration of the disulfide bonds inStreptomyces subtilisin inhibitor (SSI) as studied by the carbonyl13C NMR resonances of cysteinyl residues', 'publication_year': 1991, 'publication_date': '1991-05-01', 'ids': {'openalex': 'https://openalex.org/W1983386882', 'doi': 'https://doi.org/10.1007/bf01874568', 'mag': '1983386882', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/1841689'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/bf01874568', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S181390377', 'display_name': 'Journal of Biomolecular NMR', 'issn_l': '0925-2738', 'issn': ['0925-2738', '1573-5001'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102988693', 'display_name': 'Kenichi Uchida', 'orcid': 'https://orcid.org/0000-0003-4791-0186'}, 'institutions': [{'id': 'https://openalex.org/I69740276', 'display_name': 'Tokyo Metropolitan University', 'ror': 'https://ror.org/00ws30h19', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I69740276']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenichi Uchida', 'raw_affiliation_strings': ['Department of Chemistry, Faculty of Science, Tokyo Metropolitan University, Hachioji-shi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Faculty of Science, Tokyo Metropolitan University, Hachioji-shi, Japan', 'institution_ids': ['https://openalex.org/I69740276']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111649330', 'display_name': 'Yoko Miyake', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I69740276', 'display_name': 'Tokyo Metropolitan University', 'ror': 'https://ror.org/00ws30h19', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I69740276']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoko Miyake', 'raw_affiliation_strings': ['Department of Chemistry, Faculty of Science, Tokyo Metropolitan University, Hachioji-shi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Faculty of Science, Tokyo Metropolitan University, Hachioji-shi, Japan', 'institution_ids': ['https://openalex.org/I69740276']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076485810', 'display_name': 'Masatsune Kainosho', 'orcid': 'https://orcid.org/0000-0002-5229-7251'}, 'institutions': [{'id': 'https://openalex.org/I69740276', 'display_name': 'Tokyo Metropolitan University', 'ror': 'https://ror.org/00ws30h19', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I69740276']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masatsune Kainosho', 'raw_affiliation_strings': ['Department of Chemistry, Faculty of Science, Tokyo Metropolitan University, Hachioji-shi, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Faculty of Science, Tokyo Metropolitan University, Hachioji-shi, Japan', 'institution_ids': ['https://openalex.org/I69740276']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2590, 'currency': 'EUR', 'value_usd': 3280, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.408, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 9, 'citation_normalized_percentile': {'value': 0.529147, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 78}, 'biblio': {'volume': '1', 'issue': '1', 'first_page': '49', 'last_page': '64'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11124', 'display_name': 'Protein purification and stability', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11124', 'display_name': 'Protein purification and stability', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure and Dynamics', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/subtilisin', 'display_name': 'Subtilisin', 'score': 0.8373674}, {'id': 'https://openalex.org/keywords/dithiothreitol', 'display_name': 'Dithiothreitol', 'score': 0.77810705}, {'id': 'https://openalex.org/keywords/guanidine', 'display_name': 'Guanidine', 'score': 0.7577063}, {'id': 'https://openalex.org/keywords/scissile-bond', 'display_name': 'Scissile bond', 'score': 0.69289875}, {'id': 'https://openalex.org/keywords/bond-cleavage', 'display_name': 'Bond cleavage', 'score': 0.44059548}], 'concepts': [{'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.9167558}, {'id': 'https://openalex.org/C2779811187', 'wikidata': 'https://www.wikidata.org/wiki/Q423655', 'display_name': 'Subtilisin', 'level': 3, 'score': 0.8373674}, {'id': 'https://openalex.org/C2777824588', 'wikidata': 'https://www.wikidata.org/wiki/Q414783', 'display_name': 'Dithiothreitol', 'level': 3, 'score': 0.77810705}, {'id': 'https://openalex.org/C2779463914', 'wikidata': 'https://www.wikidata.org/wiki/Q183309', 'display_name': 'Guanidine', 'level': 2, 'score': 0.7577063}, {'id': 'https://openalex.org/C87282627', 'wikidata': 'https://www.wikidata.org/wiki/Q3623657', 'display_name': 'Scissile bond', 'level': 4, 'score': 0.69289875}, {'id': 'https://openalex.org/C19472624', 'wikidata': 'https://www.wikidata.org/wiki/Q583851', 'display_name': 'Native state', 'level': 2, 'score': 0.49594554}, {'id': 'https://openalex.org/C163111631', 'wikidata': 'https://www.wikidata.org/wiki/Q1952454', 'display_name': 'Carbon-13 NMR', 'level': 2, 'score': 0.4777288}, {'id': 'https://openalex.org/C5098756', 'wikidata': 'https://www.wikidata.org/wiki/Q1641611', 'display_name': 'Protein disulfide-isomerase', 'level': 3, 'score': 0.46554267}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.46328965}, {'id': 'https://openalex.org/C3044715', 'wikidata': 'https://www.wikidata.org/wiki/Q3952437', 'display_name': 'Bond cleavage', 'level': 3, 'score': 0.44059548}, {'id': 'https://openalex.org/C27256138', 'wikidata': 'https://www.wikidata.org/wiki/Q1230226', 'display_name': 'Disulfide bond', 'level': 2, 'score': 0.33337265}, {'id': 'https://openalex.org/C41183919', 'wikidata': 'https://www.wikidata.org/wiki/Q423026', 'display_name': 'Active site', 'level': 3, 'score': 0.30400133}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.25921994}, {'id': 'https://openalex.org/C8010536', 'wikidata': 'https://www.wikidata.org/wiki/Q160398', 'display_name': 'Crystallography', 'level': 1, 'score': 0.20023876}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.16734022}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15988919}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003545', 'descriptor_name': 'Cysteine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003553', 'descriptor_name': 'Cystine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009682', 'descriptor_name': 'Magnetic Resonance Spectroscopy', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D015842', 'descriptor_name': 'Serine Proteinase Inhibitors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013381', 'descriptor_name': 'Subtilisins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002247', 'descriptor_name': 'Carbon Isotopes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003545', 'descriptor_name': 'Cysteine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003553', 'descriptor_name': 'Cystine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004229', 'descriptor_name': 'Dithiothreitol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004229', 'descriptor_name': 'Dithiothreitol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009682', 'descriptor_name': 'Magnetic Resonance Spectroscopy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016297', 'descriptor_name': 'Mutagenesis, Site-Directed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011392', 'descriptor_name': 'Proline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015842', 'descriptor_name': 'Serine Proteinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015842', 'descriptor_name': 'Serine Proteinase Inhibitors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013302', 'descriptor_name': 'Streptomyces', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013302', 'descriptor_name': 'Streptomyces', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013302', 'descriptor_name': 'Streptomyces', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013381', 'descriptor_name': 'Subtilisins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/bf01874568', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S181390377', 'display_name': 'Journal of Biomolecular NMR', 'issn_l': '0925-2738', 'issn': ['0925-2738', '1573-5001'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/1841689', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'score': 0.52, 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 23, 'referenced_works': ['https://openalex.org/W1565549300', 'https://openalex.org/W1765698972', 'https://openalex.org/W1782484459', 'https://openalex.org/W1872778842', 'https://openalex.org/W1965878271', 'https://openalex.org/W1968463373', 'https://openalex.org/W1969339600', 'https://openalex.org/W1971959062', 'https://openalex.org/W1973057925', 'https://openalex.org/W1980927085', 'https://openalex.org/W1997254631', 'https://openalex.org/W2006370393', 'https://openalex.org/W2061831461', 'https://openalex.org/W2072667995', 'https://openalex.org/W2081230077', 'https://openalex.org/W2090338919', 'https://openalex.org/W2093064306', 'https://openalex.org/W2128954946', 'https://openalex.org/W2167792804', 'https://openalex.org/W2203044109', 'https://openalex.org/W2315638565', 'https://openalex.org/W268238884', 'https://openalex.org/W2798586839'], 'related_works': ['https://openalex.org/W2565465727', 'https://openalex.org/W2076568372', 'https://openalex.org/W2069861579', 'https://openalex.org/W2037318322', 'https://openalex.org/W2033131456', 'https://openalex.org/W2016842935', 'https://openalex.org/W1993636042', 'https://openalex.org/W1990788160', 'https://openalex.org/W1983386882', 'https://openalex.org/W1951949336'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1983386882', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-12T17:30:56.881268', 'created_date': '2016-06-24'}