Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1976176203', 'doi': 'https://doi.org/10.1073/pnas.87.8.3018', 'title': 'Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.', 'display_name': 'Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.', 'publication_year': 1990, 'publication_date': '1990-04-01', 'ids': {'openalex': 'https://openalex.org/W1976176203', 'doi': 'https://doi.org/10.1073/pnas.87.8.3018', 'mag': '1976176203', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/PMC53825', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/53825'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.87.8.3018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1073/pnas.87.8.3018', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5048998643', 'display_name': 'David S. Peterson', 'orcid': 'https://orcid.org/0000-0003-4394-6181'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'D S Peterson', 'raw_affiliation_strings': ['Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.', 'institution_ids': ['https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077273005', 'display_name': 'Wilbur K. Milhous', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'W K Milhous', 'raw_affiliation_strings': ['Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.', 'institution_ids': ['https://openalex.org/I4210134534', 'https://openalex.org/I1299303238']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067549205', 'display_name': 'Thomas E. Wellems', 'orcid': 'https://orcid.org/0000-0003-3899-8454'}, 'institutions': [{'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'T E Wellems', 'raw_affiliation_strings': ['Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.', 'institution_ids': ['https://openalex.org/I4210134534', 'https://openalex.org/I1299303238']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 10.586, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 415, 'citation_normalized_percentile': {'value': 0.999883, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '87', 'issue': '8', 'first_page': '3018', 'last_page': '3022'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10091', 'display_name': 'Malaria', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10526', 'display_name': 'Efficacy and Safety of Antiretroviral Therapy for HIV', 'score': 0.9809, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Methods in Drug Discovery', 'score': 0.9807, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proguanil', 'display_name': 'Proguanil', 'score': 0.9648978}, {'id': 'https://openalex.org/keywords/dihydrofolate-reductase', 'display_name': 'Dihydrofolate reductase', 'score': 0.9158069}, {'id': 'https://openalex.org/keywords/antifolate', 'display_name': 'Antifolate', 'score': 0.7959571}, {'id': 'https://openalex.org/keywords/antimalarial-drugs', 'display_name': 'Antimalarial Drugs', 'score': 0.48327}], 'concepts': [{'id': 'https://openalex.org/C2779636613', 'wikidata': 'https://www.wikidata.org/wiki/Q420607', 'display_name': 'Proguanil', 'level': 4, 'score': 0.9648978}, {'id': 'https://openalex.org/C2781320022', 'wikidata': 'https://www.wikidata.org/wiki/Q417149', 'display_name': 'Dihydrofolate reductase', 'level': 3, 'score': 0.9158069}, {'id': 'https://openalex.org/C2777035104', 'wikidata': 'https://www.wikidata.org/wiki/Q421072', 'display_name': 'Pyrimethamine', 'level': 4, 'score': 0.9038989}, {'id': 'https://openalex.org/C2781382166', 'wikidata': 'https://www.wikidata.org/wiki/Q50573407', 'display_name': 'Antifolate', 'level': 4, 'score': 0.7959571}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.7764616}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.69482464}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.46923667}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.43085277}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.41728008}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.2140992}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.17003614}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.06780964}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.064606994}, {'id': 'https://openalex.org/C2778397455', 'wikidata': 'https://www.wikidata.org/wiki/Q50429865', 'display_name': 'Antimetabolite', 'level': 3, 'score': 0.05155328}], 'mesh': [{'descriptor_ui': 'D004351', 'descriptor_name': 'Drug Resistance', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011739', 'descriptor_name': 'Pyrimethamine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D014227', 'descriptor_name': 'Triazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004351', 'descriptor_name': 'Drug Resistance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': 'Q000469', 'qualifier_name': 'parasitology', 'is_major_topic': False}, {'descriptor_ui': 'D008288', 'descriptor_name': 'Malaria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008961', 'descriptor_name': 'Models, Structural', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000469', 'qualifier_name': 'parasitology', 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002727', 'descriptor_name': 'Proguanil', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011739', 'descriptor_name': 'Pyrimethamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013762', 'descriptor_name': 'Tetrahydrofolate Dehydrogenase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013762', 'descriptor_name': 'Tetrahydrofolate Dehydrogenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014227', 'descriptor_name': 'Triazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.87.8.3018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc53825', 'pdf_url': 'https://europepmc.org/articles/pmc53825?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC53825', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2183222', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.87.8.3018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.86, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1489847725', 'https://openalex.org/W1511899162', 'https://openalex.org/W1601844248', 'https://openalex.org/W1936514055', 'https://openalex.org/W1969503178', 'https://openalex.org/W1980752431', 'https://openalex.org/W1982050558', 'https://openalex.org/W2016203598', 'https://openalex.org/W2017060738', 'https://openalex.org/W2033314986', 'https://openalex.org/W2034930879', 'https://openalex.org/W2042526641', 'https://openalex.org/W2049748137', 'https://openalex.org/W2050341196', 'https://openalex.org/W2051220419', 'https://openalex.org/W2055009933', 'https://openalex.org/W2079451231', 'https://openalex.org/W2081729133', 'https://openalex.org/W2086386648', 'https://openalex.org/W2090000377', 'https://openalex.org/W2091398130', 'https://openalex.org/W2095458479', 'https://openalex.org/W2139767135', 'https://openalex.org/W2149921398', 'https://openalex.org/W2263666754', 'https://openalex.org/W2297814434', 'https://openalex.org/W2307452791', 'https://openalex.org/W2417592803', 'https://openalex.org/W2989410471', 'https://openalex.org/W99143111'], 'related_works': ['https://openalex.org/W2344075384', 'https://openalex.org/W2111990435', 'https://openalex.org/W2099941316', 'https://openalex.org/W2089765100', 'https://openalex.org/W2088791835', 'https://openalex.org/W2031134843', 'https://openalex.org/W2004547182', 'https://openalex.org/W2002869829', 'https://openalex.org/W1976176203', 'https://openalex.org/W1970017265'], 'abstract_inverted_index': {'Proguanil': [0], 'and': [1, 17, 25, 41, 77, 129, 139, 141], 'pyrimethamine': [2, 106, 138], 'are': [3, 11, 82], 'antifolate': [4, 64], 'drugs': [5, 120], 'with': [6, 39, 107], 'distinct': [7, 135], 'chemical': [8], 'structures': [9, 136], 'that': [10, 30, 126], 'used': [12, 156], 'commonly': [13], 'in': [14, 112, 122, 145, 159], 'the': [15, 46, 56, 100, 134, 148], 'prophylaxis': [16], 'treatment': [18], 'of': [19, 45, 70, 89, 137, 152, 167], 'Plasmodium': [20], 'falciparum': [21, 48], 'malaria.': [22, 171], 'Clinical': [23], 'reports': [24], 'field': [26], 'studies': [27], 'have': [28], 'suggested': [29], 'some': [31, 165], 'parasites': [32, 54, 123], 'refractory': [33], 'to': [34, 62, 75, 80, 84, 93, 105, 114, 118], 'proguanil': [35], 'can': [36], 'be': [37, 162], 'treated': [38], 'pyrimethamine,': [40], 'vice': [42], 'versa.': [43], 'Analysis': [44], 'P.': [47], 'dihydrofolate': [49], 'reductase': [50], '(DHFR)': [51], 'from': [52, 73, 78], 'different': [53], 'reveals': [55], 'structural': [57], 'basis': [58], 'for': [59], 'differential': [60], 'susceptibility': [61, 113], 'these': [63], 'drugs.': [65], 'Parasites': [66], 'harboring': [67], 'a': [68, 109], 'pair': [69], 'point': [71], 'mutations': [72, 125], 'Ala-16': [74], 'Val-16': [76], 'Ser-108': [79], 'Thr-108': [81], 'resistant': [83], 'cycloguanil': [85, 140], '(the': [86], 'active': [87, 149], 'metabolite': [88], 'proguanil)': [90], 'but': [91], 'not': [92], 'pyrimethamine.': [94], 'A': [95], 'single': [96], 'Asn-108': [97], 'mutation,': [98], 'on': [99], 'other': [101], 'hand,': [102], 'confers': [103], 'resistance': [104], 'only': [108], 'moderate': [110], 'decrease': [111], 'cycloguanil.': [115], 'Significant': [116], 'cross-resistance': [117], 'both': [119], 'occurs': [121], 'having': [124], 'include': [127], 'Ser-108----Asn-108': [128], 'Ile-164----Leu-164.': [130], 'These': [131], 'results': [132], 'reflect': [133], 'suggest': [142], 'fine': [143], 'differences': [144], 'binding': [146], 'within': [147], 'site': [150], 'cavity': [151], 'DHFR.': [153], 'Alternative': [154], 'inhibitors,': [155], 'alone': [157], 'or': [158, 169], 'combination,': [160], 'may': [161], 'effective': [163], 'against': [164], 'strains': [166], 'cycloguanil-': [168], 'pyrimethamine-resistant': [170]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1976176203', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-09-24T00:45:47.821168', 'created_date': '2016-06-24'}