Abstract: Proximal tubular reabsorption of inorganic phosphate (Pi) is a major determinant of the extracellular concentration of phosphate. The net proximal reabsorption of phosphate largely depends on the rate of apical sodium-dependent transport of Pi (Na/Pi cotransport), which is controlled by various hormonal and nonhormonal factors. Renal Na/Pi cotransport systems that represent proximal apical Na/Pi cotransport systems have recently been identified. Molecular knowledge of proximal tubular Na/Pi cotransport will lead to a new understanding of the cellular mechanisms of the physiologic control of proximal Pi reabsorption and to elucidation of the pathophysiologic mechanisms impairing Pi homeostasis.
Publication Year: 1994
Publication Date: 1994-09-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 56
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