Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2051086962', 'doi': 'https://doi.org/10.1538/expanim.55.57', 'title': 'Comparison of K-Cl Cotransport Expression in High and Low K Dog Erythrocytes', 'display_name': 'Comparison of K-Cl Cotransport Expression in High and Low K Dog Erythrocytes', 'publication_year': 2006, 'publication_date': '2006-01-01', 'ids': {'openalex': 'https://openalex.org/W2051086962', 'doi': 'https://doi.org/10.1538/expanim.55.57', 'mag': '2051086962', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16508213'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1538/expanim.55.57', 'pdf_url': 'https://www.jstage.jst.go.jp/article/expanim/55/1/55_1_57/_pdf', 'source': {'id': 'https://openalex.org/S4210168996', 'display_name': 'EXPERIMENTAL ANIMALS', 'issn_l': '0007-5124', 'issn': ['0007-5124', '1341-1357', '1881-7122', '1884-4162', '1884-4170'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.jstage.jst.go.jp/article/expanim/55/1/55_1_57/_pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5003829840', 'display_name': 'Hideharu Ochiai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I57361664', 'display_name': 'Azabu University', 'ror': 'https://ror.org/00wzjq897', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I57361664']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hideharu OCHIAI', 'raw_affiliation_strings': ['Research Institute of Biosciences, Azabu University'], 'affiliations': [{'raw_affiliation_string': 'Research Institute of Biosciences, Azabu University', 'institution_ids': ['https://openalex.org/I57361664']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018402506', 'display_name': 'Kazunari Higa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I57361664', 'display_name': 'Azabu University', 'ror': 'https://ror.org/00wzjq897', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I57361664']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazunari HIGA', 'raw_affiliation_strings': ['Laboratory of Pathobiochemistry, School of Veterinary Medicine, Azabu University'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Pathobiochemistry, School of Veterinary Medicine, Azabu University', 'institution_ids': ['https://openalex.org/I57361664']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001315657', 'display_name': 'S. Hisamatsu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I57361664', 'display_name': 'Azabu University', 'ror': 'https://ror.org/00wzjq897', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I57361664']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shin HISAMATSU', 'raw_affiliation_strings': ['Laboratory of Environmental Chemistry, College of Environmental Health, Azabu University'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Environmental Chemistry, College of Environmental Health, Azabu University', 'institution_ids': ['https://openalex.org/I57361664']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016340306', 'display_name': 'Hiroshi Fujise', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I57361664', 'display_name': 'Azabu University', 'ror': 'https://ror.org/00wzjq897', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I57361664']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroshi FUJISE', 'raw_affiliation_strings': ['Laboratory of Pathobiochemistry, School of Veterinary Medicine, Azabu University', 'Research Institute of Biosciences, Azabu University'], 'affiliations': [{'raw_affiliation_string': 'Research Institute of Biosciences, Azabu University', 'institution_ids': ['https://openalex.org/I57361664']}, {'raw_affiliation_string': 'Laboratory of Pathobiochemistry, School of Veterinary Medicine, Azabu University', 'institution_ids': ['https://openalex.org/I57361664']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 61}, 'biblio': {'volume': '55', 'issue': '1', 'first_page': '57', 'last_page': '63'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12286', 'display_name': 'Erythrocyte Function and Pathophysiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12286', 'display_name': 'Erythrocyte Function and Pathophysiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C188053792', 'wikidata': 'https://www.wikidata.org/wiki/Q3640664', 'display_name': 'Cotransporter', 'level': 3, 'score': 0.98379576}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.6561922}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.60545874}, {'id': 'https://openalex.org/C2776557347', 'wikidata': 'https://www.wikidata.org/wiki/Q37187', 'display_name': 'Red blood cell', 'level': 2, 'score': 0.4340801}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.36904013}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3616494}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.28670043}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.095982224}, {'id': 'https://openalex.org/C537181965', 'wikidata': 'https://www.wikidata.org/wiki/Q658', 'display_name': 'Sodium', 'level': 2, 'score': 0.08331913}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002712', 'descriptor_name': 'Chlorides', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D004912', 'descriptor_name': 'Erythrocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011188', 'descriptor_name': 'Potassium', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D027981', 'descriptor_name': 'Symporters', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048429', 'descriptor_name': 'Cell Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002712', 'descriptor_name': 'Chlorides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004285', 'descriptor_name': 'Dogs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004912', 'descriptor_name': 'Erythrocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004912', 'descriptor_name': 'Erythrocytes', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D004912', 'descriptor_name': 'Erythrocytes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000096922', 'descriptor_name': 'K Cl- Cotransporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010042', 'descriptor_name': 'Ouabain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010042', 'descriptor_name': 'Ouabain', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011188', 'descriptor_name': 'Potassium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012413', 'descriptor_name': 'Rubidium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012413', 'descriptor_name': 'Rubidium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012977', 'descriptor_name': 'Sodium Nitrite', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012977', 'descriptor_name': 'Sodium Nitrite', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D027981', 'descriptor_name': 'Symporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027981', 'descriptor_name': 'Symporters', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1538/expanim.55.57', 'pdf_url': 'https://www.jstage.jst.go.jp/article/expanim/55/1/55_1_57/_pdf', 'source': {'id': 'https://openalex.org/S4210168996', 'display_name': 'EXPERIMENTAL ANIMALS', 'issn_l': '0007-5124', 'issn': ['0007-5124', '1341-1357', '1881-7122', '1884-4162', '1884-4170'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16508213', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1538/expanim.55.57', 'pdf_url': 'https://www.jstage.jst.go.jp/article/expanim/55/1/55_1_57/_pdf', 'source': {'id': 'https://openalex.org/S4210168996', 'display_name': 'EXPERIMENTAL ANIMALS', 'issn_l': '0007-5124', 'issn': ['0007-5124', '1341-1357', '1881-7122', '1884-4162', '1884-4170'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.59, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1538247717', 'https://openalex.org/W1601097851', 'https://openalex.org/W1965283125', 'https://openalex.org/W1995823402', 'https://openalex.org/W2003269536', 'https://openalex.org/W2022004687', 'https://openalex.org/W2049286220', 'https://openalex.org/W2066054126', 'https://openalex.org/W2094131991', 'https://openalex.org/W2123361823', 'https://openalex.org/W2158173502', 'https://openalex.org/W2170185329', 'https://openalex.org/W2184793333', 'https://openalex.org/W2216732349', 'https://openalex.org/W2256733819', 'https://openalex.org/W2303146437', 'https://openalex.org/W2416578807', 'https://openalex.org/W2417000186', 'https://openalex.org/W2471770510', 'https://openalex.org/W4249863577', 'https://openalex.org/W4255573251'], 'related_works': ['https://openalex.org/W2414211301', 'https://openalex.org/W2395684592', 'https://openalex.org/W2264338901', 'https://openalex.org/W2261587121', 'https://openalex.org/W2176632303', 'https://openalex.org/W2070882743', 'https://openalex.org/W2059389639', 'https://openalex.org/W2051086962', 'https://openalex.org/W2041386649', 'https://openalex.org/W1965128339'], 'abstract_inverted_index': {'K-Cl': [0, 12, 35, 64, 74, 101], 'cotransport': [1, 13, 36, 92, 102], 'plays': [2], 'a': [3, 106], 'crucial': [4], 'role': [5], 'in': [6, 15, 38, 91, 108], 'regulatory': [7], 'volume': [8], 'decrease': [9], 'of': [10, 53, 73, 100], 'erythrocytes.': [11, 84], 'activities': [14], 'dog': [16], 'erythrocytes': [17, 28], 'with': [18], 'an': [19], 'inherited': [20], 'high': [21], 'Na-K': [22], 'pump': [23], 'activity': [24, 37, 93], '(HK)': [25], 'and': [26, 46, 58, 69, 82], 'normal': [27], '(LK)': [29], 'were': [30], 'compared.': [31], 'Nitrite': [32], '(NO2)': [33], 'stimulated': [34], 'HK': [39, 81], 'cells': [40], 'around': [41], '14-fold': [42], 'at': [43], '2.4': [44], 'mM,': [45], 'it': [47], 'also': [48], 'increased': [49], 'the': [50, 71, 89, 98, 109], 'Km': [51], 'value': [52], 'this': [54], 'cotransporter.': [55], 'Real-time': [56], 'PCR': [57], 'western': [59], 'blot': [60], 'analysis': [61], 'revealed': [62], 'that': [63, 70, 88], 'cotransporter': [65, 75], '1': [66, 76], 'was': [67, 78, 94], 'dominant,': [68], 'quantity': [72], 'protein': [77, 103], 'comparable': [79], 'between': [80], 'LK': [83], 'These': [85], 'results': [86], 'suggest': [87], 'difference': [90, 107], 'not': [95], 'caused': [96], 'by': [97, 105], 'amount': [99], 'but': [104], 'regulation': [110], 'system,': [111], 'which': [112], 'is': [113], 'susceptible': [114], 'to': [115], 'oxidant.': [116]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2051086962', 'counts_by_year': [], 'updated_date': '2024-12-24T15:01:24.375238', 'created_date': '2016-06-24'}