Publication Information

{'id': 'https://openalex.org/W1974442900', 'doi': 'https://doi.org/10.1074/jbc.m300239200', 'title': 'Bikunin Target Genes in Ovarian Cancer Cells Identified by Microarray Analysis', 'display_name': 'Bikunin Target Genes in Ovarian Cancer Cells Identified by Microarray Analysis', 'publication_year': 2003, 'publication_date': '2003-04-01', 'ids': {'openalex': 'https://openalex.org/W1974442900', 'doi': 'https://doi.org/10.1074/jbc.m300239200', 'mag': '1974442900', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12571229'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m300239200', 'pdf_url': 'http://www.jbc.org/article/S0021925819302558/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819302558/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5059414258', 'display_name': 'Mika Suzuki', 'orcid': 'https://orcid.org/0000-0002-3861-0766'}, 'institutions': [{'id': 'https://openalex.org/I3123035732', 'display_name': 'Hamamatsu University School of Medicine', 'ror': 'https://ror.org/00ndx3g44', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I3123035732']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mika Suzuki', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka, 431-3192, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka, 431-3192, Japan', 'institution_ids': ['https://openalex.org/I3123035732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040233451', 'display_name': 'Hiroshi Kobayashi', 'orcid': 'https://orcid.org/0000-0002-8124-6269'}, 'institutions': [{'id': 'https://openalex.org/I3123035732', 'display_name': 'Hamamatsu University School of Medicine', 'ror': 'https://ror.org/00ndx3g44', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I3123035732']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Kobayashi', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka, 431-3192, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka, 431-3192, Japan', 'institution_ids': ['https://openalex.org/I3123035732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071820323', 'display_name': 'Yoshiko Tanaka', 'orcid': 'https://orcid.org/0000-0002-1503-2035'}, 'institutions': [{'id': 'https://openalex.org/I3123035732', 'display_name': 'Hamamatsu University School of Medicine', 'ror': 'https://ror.org/00ndx3g44', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I3123035732']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshiko Tanaka', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka, 431-3192, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka, 431-3192, Japan', 'institution_ids': ['https://openalex.org/I3123035732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004971708', 'display_name': 'Yasuyuki Hirashima', 'orcid': 'https://orcid.org/0000-0003-0269-9313'}, 'institutions': [{'id': 'https://openalex.org/I3123035732', 'display_name': 'Hamamatsu University School of Medicine', 'ror': 'https://ror.org/00ndx3g44', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I3123035732']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasuyuki Hirashima', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka, 431-3192, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka, 431-3192, Japan', 'institution_ids': ['https://openalex.org/I3123035732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103428302', 'display_name': 'Naohiro Kanayama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3123035732', 'display_name': 'Hamamatsu University School of Medicine', 'ror': 'https://ror.org/00ndx3g44', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I3123035732']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naohiro Kanayama', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka, 431-3192, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka, 431-3192, Japan', 'institution_ids': ['https://openalex.org/I3123035732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033422556', 'display_name': 'Yuji Takei', 'orcid': 'https://orcid.org/0000-0002-1744-5570'}, 'institutions': [{'id': 'https://openalex.org/I146500386', 'display_name': 'Jichi Medical University', 'ror': 'https://ror.org/010hz0g26', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146500386']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuji Takei', 'raw_affiliation_strings': ['¶Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi 329-0498, Japan'], 'affiliations': [{'raw_affiliation_string': '¶Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi 329-0498, Japan', 'institution_ids': ['https://openalex.org/I146500386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103483559', 'display_name': 'Yasushi Saga', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I146500386', 'display_name': 'Jichi Medical University', 'ror': 'https://ror.org/010hz0g26', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146500386']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasushi Saga', 'raw_affiliation_strings': ['¶Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi 329-0498, Japan'], 'affiliations': [{'raw_affiliation_string': '¶Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi 329-0498, Japan', 'institution_ids': ['https://openalex.org/I146500386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102946822', 'display_name': 'Mitsuaki Suzuki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I146500386', 'display_name': 'Jichi Medical University', 'ror': 'https://ror.org/010hz0g26', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146500386']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mitsuaki Suzuki', 'raw_affiliation_strings': ['¶Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi 329-0498, Japan'], 'affiliations': [{'raw_affiliation_string': '¶Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi 329-0498, Japan', 'institution_ids': ['https://openalex.org/I146500386']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080521687', 'display_name': 'Hiroshi Itoh', 'orcid': 'https://orcid.org/0000-0002-6434-1184'}, 'institutions': [{'id': 'https://openalex.org/I118574687', 'display_name': 'University of Miyazaki', 'ror': 'https://ror.org/0447kww10', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I118574687']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Itoh', 'raw_affiliation_strings': ['‖Second Department of Pathology, Miyazaki University School of Medicine, Miyazaki 889-1692, Japan'], 'affiliations': [{'raw_affiliation_string': '‖Second Department of Pathology, Miyazaki University School of Medicine, Miyazaki 889-1692, Japan', 'institution_ids': ['https://openalex.org/I118574687']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111949628', 'display_name': 'Toshihiko Terao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3123035732', 'display_name': 'Hamamatsu University School of Medicine', 'ror': 'https://ror.org/00ndx3g44', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I3123035732']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshihiko Terao', 'raw_affiliation_strings': ['Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka, 431-3192, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Handayama 1-20-1, Hamamatsu, Shizuoka, 431-3192, Japan', 'institution_ids': ['https://openalex.org/I3123035732']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 3.399, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 60, 'citation_normalized_percentile': {'value': 0.816782, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '278', 'issue': '17', 'first_page': '14640', 'last_page': '14646'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11966', 'display_name': 'Silk-based biomaterials and applications', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Cell Adhesion Molecules Research', 'score': 0.9947, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6421678}, {'id': 'https://openalex.org/C8415881', 'wikidata': 'https://www.wikidata.org/wiki/Q6839217', 'display_name': 'Microarray analysis techniques', 'level': 4, 'score': 0.4961811}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.4050033}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.38294497}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.37404463}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.34498954}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.32820493}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.13136452}], 'mesh': [{'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D014360', 'descriptor_name': 'Trypsin Inhibitor, Kunitz Soybean', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011266', 'descriptor_name': 'Pregnancy-Associated Plasma Protein-A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011266', 'descriptor_name': 'Pregnancy-Associated Plasma Protein-A', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012697', 'descriptor_name': 'Serine Endopeptidases', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015842', 'descriptor_name': 'Serine Proteinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015842', 'descriptor_name': 'Serine Proteinase Inhibitors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015842', 'descriptor_name': 'Serine Proteinase Inhibitors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015842', 'descriptor_name': 'Serine Proteinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014357', 'descriptor_name': 'Trypsin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014357', 'descriptor_name': 'Trypsin', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m300239200', 'pdf_url': 'http://www.jbc.org/article/S0021925819302558/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12571229', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m300239200', 'pdf_url': 'http://www.jbc.org/article/S0021925819302558/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.8, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1506878337', 'https://openalex.org/W1604213476', 'https://openalex.org/W1615987657', 'https://openalex.org/W1773446223', 'https://openalex.org/W1947723185', 'https://openalex.org/W1965709276', 'https://openalex.org/W1969754678', 'https://openalex.org/W1971262237', 'https://openalex.org/W1971290197', 'https://openalex.org/W1991911689', 'https://openalex.org/W1992553937', 'https://openalex.org/W1998162329', 'https://openalex.org/W2014801535', 'https://openalex.org/W2015647756', 'https://openalex.org/W2025339373', 'https://openalex.org/W2034188105', 'https://openalex.org/W2036123452', 'https://openalex.org/W2036362928', 'https://openalex.org/W2039135880', 'https://openalex.org/W2040663639', 'https://openalex.org/W2042670053', 'https://openalex.org/W2044896610', 'https://openalex.org/W2055772435', 'https://openalex.org/W2059538895', 'https://openalex.org/W2061064073', 'https://openalex.org/W2061437879', 'https://openalex.org/W2063730519', 'https://openalex.org/W2067541328', 'https://openalex.org/W2069849774', 'https://openalex.org/W2075776658', 'https://openalex.org/W2082557543', 'https://openalex.org/W2087068775', 'https://openalex.org/W2095847870', 'https://openalex.org/W2106162263', 'https://openalex.org/W2113028019', 'https://openalex.org/W2116620357', 'https://openalex.org/W2118359991', 'https://openalex.org/W2119542456', 'https://openalex.org/W2144185179', 'https://openalex.org/W2150197018', 'https://openalex.org/W2156723896', 'https://openalex.org/W2248671072', 'https://openalex.org/W2311293739', 'https://openalex.org/W2401308315', 'https://openalex.org/W2410829021', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W3133147219', 'https://openalex.org/W3032874291', 'https://openalex.org/W2803323662', 'https://openalex.org/W2415025170', 'https://openalex.org/W2388669904', 'https://openalex.org/W2363156284', 'https://openalex.org/W2120108543', 'https://openalex.org/W2114409792', 'https://openalex.org/W2024266978', 'https://openalex.org/W2005057264'], 'abstract_inverted_index': {'Bikunin,': [0, 212], 'a': [1, 22, 31, 46, 207, 213, 234, 243, 258, 419, 447, 460, 540, 558, 919, 1019, 1411, 1480, 1563, 1605, 1609, 1712, 1760, 1846, 1903, 1981, 2014, 2040, 2306, 2341, 2348, 2479, 2486, 2727, 2947, 3011, 3072, 3111, 3142, 3189, 3286, 3294, 3314, 3699, 3706, 3943, 4180], 'Kunitz-type': [2, 214, 541], 'protease': [3, 215, 431, 542, 1578], 'inhibitor,': [4, 216], 'could': [5, 186, 217, 398, 1246, 3524, 3767], 'potentially': [6, 218], 'suppress': [7, 219, 1247], 'tumor': [8, 160, 220, 372, 457, 476, 829, 1043, 1077, 1129, 1254, 1401, 1616, 2684, 3289, 4235], 'cell': [9, 26, 210, 221, 238, 422, 477, 567, 830, 975, 1364, 1402, 1415, 1542, 1544, 1649, 1684, 1781, 2685, 2918, 2933, 3032, 3047, 3119, 3175, 3239, 3290, 3320, 3535, 3693, 3702, 3971], 'invasion': [10, 222, 736, 964, 1041, 1130, 1211, 1365, 1650, 1654, 2891], 'and': [11, 34, 68, 83, 148, 171, 223, 246, 280, 295, 360, 383, 459, 469, 480, 496, 499, 549, 737, 791, 821, 971, 1025, 1033, 1206, 1251, 1256, 1274, 1295, 1490, 1523, 1554, 1569, 1580, 1707, 1757, 1876, 1892, 1919, 1954, 1964, 1978, 1999, 2131, 2381, 2462, 2498, 2629, 2697, 2773, 2787, 2818, 2884, 2917, 2944, 2970, 3040, 3177, 3180, 3247, 3316, 3527, 3710, 3720, 3853, 3869, 3905, 4005, 4010, 4025, 4033, 4041, 4077, 4081, 4179, 4234, 4238, 4277], 'metastasis.': [12, 224], 'Our': [13, 77, 225, 289], 'previous': [14, 226], 'study': [15, 227, 3203], 'revealed': [16, 228, 4019], 'that': [17, 166, 194, 229, 378, 406, 1014, 1031, 1071, 1153, 1343, 1376, 1463, 1513, 1524, 1811, 2018, 2038, 2073, 3522, 3940, 4003, 4020], 'overexpression': [18, 230, 3750], 'of': [19, 43, 63, 125, 182, 199, 231, 255, 275, 337, 394, 411, 484, 491, 547, 566, 603, 609, 661, 673, 724, 728, 735, 785, 816, 873, 962, 1042, 1127, 1193, 1203, 1209, 1258, 1262, 1291, 1298, 1351, 1359, 1362, 1380, 1385, 1400, 1433, 1437, 1448, 1461, 1485, 1533, 1566, 1576, 1594, 1763, 1780, 1854, 1889, 1942, 1952, 2023, 2114, 2160, 2176, 2253, 2287, 2305, 2427, 2609, 2642, 2660, 2677, 2775, 2779, 3013, 3030, 3043, 3106, 3113, 3162, 3201, 3288, 3306, 3362, 3532, 3708, 3743, 3751, 3867, 3872, 3883, 3889, 3893, 3901, 3908, 3918, 3923, 3952, 3956, 3978, 3992, 4055, 4066, 4201, 4268, 4283, 4299], 'bikunin': [20, 176, 195, 232, 388, 407, 535, 667, 729, 780, 826, 917, 1015, 1023, 1072, 1119, 1154, 1198, 1245, 1355, 1377, 1386, 1396, 1454, 1504, 1520, 1599, 1601, 1613, 1620, 1740, 1830, 1841, 1870, 2494, 2909, 3214, 3236, 3250, 3284, 3307, 3523, 3721, 3753, 3765, 3780, 3788, 3806, 3921, 4086], 'in': [21, 30, 158, 202, 209, 233, 242, 370, 414, 421, 563, 590, 606, 670, 721, 973, 1076, 1260, 1270, 1348, 1410, 1530, 1562, 1614, 1689, 1738, 1746, 1777, 1845, 1851, 1877, 1902, 2045, 2606, 2639, 2662, 2912, 2922, 2963, 3045, 3051, 3064, 3071, 3158, 3196, 3216, 3228, 3233, 3293, 3309, 3319, 3359, 3530, 3692, 3701, 3732, 3736, 3755, 3879, 3965, 3981, 3995, 4012, 4083, 4094, 4207], 'human': [23, 235, 1412, 1619, 2178, 2343, 2356, 2767, 3217], 'ovarian': [24, 236, 1253, 1413, 1595, 1682, 3218, 3533], 'cancer': [25, 237, 731, 1363, 1414, 1596, 1683, 3219, 3534], 'line,': [27, 239, 1416, 1685, 3033], 'HRA,': [28, 240, 1417, 1686], 'resulted': [29, 241], 'down-regulation': [32, 244, 3977], 'inuPA': [33, 245], 'uPAR': [35, 247, 1034, 1123, 1157, 2382, 3528, 3711], 'gene': [36, 200, 248, 412, 1199, 1602, 1842, 2056, 3230, 3308, 3712, 3722, 3754, 3966, 3979, 3993, 4068, 4205], 'expression.': [37, 249, 3713], 'For': [38, 250, 1117, 1735, 3946], 'identifying': [39, 251], 'the': [40, 197, 252, 409, 455, 482, 488, 564, 592, 601, 722, 828, 874, 915, 1022, 1040, 1128, 1161, 1197, 1287, 1289, 1292, 1296, 1349, 1430, 1446, 1459, 1472, 1503, 1531, 1577, 1771, 1778, 1786, 1840, 1855, 1869, 1896, 1939, 1943, 1949, 2019, 2049, 2079, 2177, 2291, 2298, 2303, 2416, 2425, 2431, 2458, 2499, 2542, 2607, 2640, 2674, 2678, 2766, 2776, 2810, 2873, 2885, 2979, 3001, 3028, 3041, 3128, 3159, 3163, 3210, 3358, 3363, 3733, 3740, 3749, 3752, 3786, 3790, 3798, 3804, 3857, 3870, 3873, 3884, 3891, 3894, 3899, 3902, 3906, 3913, 3924, 3949, 3969, 4063, 4072], 'full': [41, 253, 1431], 'repertoire': [42, 254, 1432], 'bikunin-regulated': [44, 64, 256, 276, 1408, 1434], 'genes,': [45, 103, 257, 315, 1522, 1538, 3773], 'cDNA': [47, 259, 1481, 1791, 1818, 1956, 2167, 2179, 2216, 2245, 2294, 2345, 2380, 2383, 2417, 3875], 'microarray': [48, 260, 1419, 1482, 1898, 2033, 3737, 3799, 4073], 'hybridization': [49, 261, 1483, 1906, 2083, 3928], 'screening': [50, 262], 'was': [51, 71, 263, 283, 536, 1266, 1621, 1632, 1687, 1741, 1857, 1872, 1880, 1899, 1994, 2034, 2084, 2148, 2868, 2996, 3019, 3049, 3062, 3108, 3125, 3134, 3148, 3204, 3241, 3695, 3841, 3896, 3937], 'conducted': [52, 264], 'using': [53, 265, 1418, 1479, 1509, 1770, 1822, 1980, 2142, 2358, 2478], 'mRNA': [54, 266, 2770, 3246, 3919, 4084, 4155, 4222, 4254, 4262], 'from': [55, 267, 1046, 1488, 1623, 1634, 1643, 1658, 1671, 1814, 1825, 2355, 2491, 2931, 3843, 3934, 3942], 'bikunin-treated': [56, 268, 1489], 'or': [57, 184, 269, 396, 504, 1466, 1600, 1837, 1863, 2042, 2070, 2135, 2991, 3730, 3769, 3781, 3850, 3910, 3916, 4031, 4047], 'bikunin-transfected': [58, 270, 1281], 'HRA': [59, 203, 271, 415, 1194, 1492, 1499, 2539, 2682, 2896, 3221, 3364, 3734, 3756, 3774, 4056], 'cells.': [60, 272, 1493, 3220, 3925, 3983, 3997], 'A': [61, 273, 814], 'number': [62, 274, 815, 3042], 'genes': [65, 82, 89, 127, 168, 277, 294, 301, 339, 380, 1074, 1121, 1375, 1409, 1439, 1528, 1928, 3207, 3728, 4007, 4090, 4191], 'were': [66, 173, 278, 385, 1283, 1300, 1582, 1641, 1656, 1669, 1678, 1744, 1750, 1768, 1783, 1805, 1820, 1917, 1929, 1969, 2005, 2010, 2052, 2061, 2065, 2074, 2119, 2169, 2384, 2413, 2460, 2473, 2536, 2604, 2622, 2632, 2636, 2653, 2692, 2724, 2771, 2801, 2813, 2875, 2887, 2910, 2920, 2935, 2955, 2976, 3038, 3068, 3165, 3171, 3184, 3194, 3223, 3724, 3776, 3795, 3877, 4008, 4027, 4043], 'identified,': [67, 279], 'their': [69, 281], 'regulation': [70, 282, 565, 1350, 1532], 'confirmed': [72, 165, 284, 377, 2693], 'by': [73, 175, 177, 285, 387, 389, 502, 965, 1159, 1453, 1468, 1585, 1785, 1922, 1933, 2012, 2121, 2153, 2475, 2541, 2694, 2881, 2937, 2951, 2998, 3021, 3213, 3920, 4029, 4045, 4071], 'Northern': [74, 162, 286, 374, 1934, 2081], 'blot': [75, 163, 287, 375, 1935, 2082, 2699], 'analysis.': [76, 288], 'screen': [78, 122, 290, 334], 'identified': [79, 88, 123, 291, 300, 335, 538, 1516], '11': [80, 292], 'bikunin-stimulated': [81, 293], '29': [84, 296], 'bikunin-repressed': [85, 297], 'genes.': [86, 298, 1435], 'The': [87, 299, 779, 1382, 1557, 1664, 1681, 1790, 1989, 2007, 2036, 2165, 2493, 2602, 2634, 2648, 3103, 3118, 3131, 3155, 3192, 3198, 3238, 3926], 'can': [90, 302], 'indeed': [91, 303], 'be': [92, 304, 588, 1390], 'classified': [93, 305], 'into': [94, 306, 1286, 2297, 2538], 'distinct': [95, 307], 'subsets.': [96, 308], 'These': [97, 191, 309, 403, 465, 1339], 'include': [98, 310, 467, 1527], 'transcriptional': [99, 311, 3211], 'regulators,': [100, 312], 'oncogenes/tumor': [101, 313, 1536], 'suppressor': [102, 314, 1537, 4190], 'signaling': [104, 316, 1450, 1570, 3215], 'molecules,': [105, 317], 'growth/cell': [106, 318], 'cycle,': [107, 319, 1545], 'invasion/metastasis,': [108, 320, 1547], 'cytokines,': [109, 321], 'apoptosis,': [110, 322, 1548], 'ion': [111, 323, 1549], 'channels,': [112, 324, 1550], 'extracellular': [113, 325, 424, 1551], 'matrix': [114, 326, 425, 471, 1552], 'proteins,': [115, 327, 1553], 'as': [116, 118, 129, 328, 330, 341, 494, 539, 1018, 2087, 2171, 2386, 2568, 2726, 2893, 2903, 2905, 3075, 3141, 4069], 'well': [117, 329, 2904], 'some': [119, 331, 1853, 1867, 3531], 'proteases.': [120, 332, 1556], 'This': [121, 333, 2995], 'suppression': [124, 336, 734, 1208, 2286, 3287, 3707], 'several': [126, 167, 338, 379, 607, 671, 1047, 1555], 'such': [128, 340, 493], 'CDC-like': [130, 342], 'kinase,': [131, 144, 343, 356], 'LIM': [132, 344, 4182], 'domain': [133, 136, 345, 348, 2242, 4119, 4160, 4225], 'binding,': [134, 346], 'Ets': [135, 347], 'transcription': [137, 349, 1534, 4116, 4124, 4147, 4161], 'factor,': [138, 350, 4113, 4125], 'Rho': [139, 351], 'GTPase-activating': [140, 352], 'protein,': [141, 146, 353, 358], 'tyrosine': [142, 354], 'phosphorylation-regulated': [143, 355], 'hyaluronan-binding': [145, 357, 875], 'matriptase,': [147, 359, 4288], 'pregnancy-associated': [149, 361, 434], 'plasma': [150, 362, 435], 'protein-A': [151, 363, 436], '(PAPP-A),': [152, 364], 'which': [153, 365, 474, 1739, 1852, 3139], 'have': [154, 366, 1035, 1068, 1515], 'previously': [155, 367, 1069, 2089, 2388, 2570], 'been': [156, 368, 597, 1029, 1036, 1424], 'implicated': [157, 369], 'enhancing': [159, 371], 'promotion.': [161, 373], 'analysis': [164, 376, 1484, 2700, 3800, 4054, 4074], 'including': [169, 381], 'matriptase': [170, 183, 382, 395], 'PAPP-A': [172, 185, 384, 397, 2344, 2769, 2878], 'down-regulated': [174, 386, 4011], '∼9-fold.': [178, 390], 'Further,': [179, 391, 1191, 4016], 'genetic': [180, 392], 'inhibition': [181, 393, 546, 961, 1202, 1361], 'lead': [187, 399], 'to': [188, 206, 400, 418, 556, 599, 730, 788, 1038, 1389, 1406, 1427, 1598, 1829, 1895, 2054, 2157, 2422, 2655, 2664, 2765, 2816, 2946, 3056, 3127, 3205, 3235, 3244, 3698, 3726, 3747, 3856, 3898, 3939], 'diminished': [189, 401], 'invasion.': [190, 211, 402, 423], 'results': [192, 404], 'show': [193, 405], 'alters': [196, 408], 'pattern': [198, 410], 'expression': [201, 413, 1158, 1205, 1257, 2495, 2691, 2880, 3231, 3529, 3807, 3967, 3980, 3994], 'cells': [204, 416, 458, 610, 732, 1044, 1195, 1282, 1307, 1500, 1597, 1743, 1826, 2540, 2603, 2635, 2817, 2874, 2886, 2897, 3037, 3044, 3157, 3222, 3302, 3311, 3365, 3735, 3757, 3775, 3794, 3936], 'leading': [205, 417], 'block': [208, 420], 'glyceraldehyde-3-phosphate': [426, 2419], 'dehydrogenase': [427, 2420], 'membrane': [428, 2950], 'type': [429, 3176], 'serine': [430, 497], '1': [432, 443, 2958, 3016, 3792, 3957, 4143, 4220, 4252, 4260, 4306], 'luciferase': [433, 2534, 3782], 'insulin-like': [437], 'growth': [438, 500, 506, 2861, 3361, 4280], 'factor': [439, 2016, 2209, 4117, 4148, 4157, 4200, 4308], 'cartilage': [440, 868], 'link': [441, 869], 'protein': [442, 870, 923, 1788, 2690, 2879, 3248, 4111, 4123, 4188, 4213, 4231, 4242, 4245, 4259, 4274, 4291], 'Cancer': [444], 'metastasis': [445, 738, 1250], 'is': [446, 552, 1012, 1016, 1345, 1357, 1366, 1378, 1440], 'complex': [448], 'multistep': [449], 'process': [450], 'involving': [451], 'sequential': [452], 'interactions': [453, 466], 'between': [454, 2048, 3968], 'disseminating': [456], 'continuously': [461], 'changing': [462], 'host': [463], 'microenvironment.': [464], 'cell-cell': [468], 'cell-extracellular': [470], '(ECM)1': [472], 'communication,': [473], 'regulate': [475], 'attachment,': [478], 'spreading,': [479], 'migration,': [481], 'dissolution': [483], 'tissue': [485], 'barriers': [486], 'through': [487, 2123], 'degradative': [489], 'activity': [490], 'enzymes': [492], 'metallo': [495], 'proteinases,': [498], 'modulation': [501], 'autocrine': [503], 'paracrine': [505], 'factors': [507, 4101], '(1Brodt': [508], 'P.': [509, 2218, 2516], 'Fallavollita': [510], 'L.': [511], 'Khatib': [512], 'A.M.': [513, 572, 614], 'Samani': [514], 'A.A.': [515], 'Zhang': [516], 'D.': [517, 2324], 'J.': [518, 574, 616, 752, 772, 850, 895, 942, 995, 1089, 1175, 1233, 1329, 1728, 2103, 2192, 2222, 2224, 2325, 2402, 2446, 2592, 2750, 3087, 3272, 3343, 3379, 3399, 3445, 3471, 3508, 3550, 3570, 3616, 3642, 3679, 3829], 'Biol.': [519, 577, 619, 773, 851, 896, 943, 996, 1090, 1176, 1729, 2193, 2231, 2326, 3088, 3400, 3446, 3472, 3571, 3617, 3643], 'Chem.': [520, 774, 852, 897, 944, 997, 1091, 1177, 1730, 2194, 2327, 3089, 3401, 3447, 3473, 3572, 3618, 3644], '2001;': [521, 806, 853, 898, 945, 998, 1109, 1178, 2328, 3090, 3419, 3448, 3474, 3590, 3619, 3645], '276:': [522, 854, 899, 946, 999, 1179, 2329, 3091, 3449, 3475, 3620, 3646], '33608-33615Abstract': [523], 'Full': [524, 526, 856, 858, 901, 903, 948, 950, 1001, 1003, 1181, 1183, 2198, 2200, 2331, 2333, 2560, 3093, 3095, 3451, 3453, 3477, 3479, 3622, 3624, 3648, 3650], 'Text': [525, 527, 857, 859, 902, 904, 949, 951, 1002, 1004, 1182, 1184, 2199, 2201, 2332, 2334, 2561, 3094, 3096, 3452, 3454, 3478, 3480, 3623, 3625, 3649, 3651], 'PDF': [528, 860, 905, 952, 1005, 1185, 2202, 2335, 2562, 3097, 3455, 3481, 3626, 3652], 'PubMed': [529, 581, 623, 653, 700, 757, 809, 861, 906, 953, 1006, 1062, 1112, 1145, 1186, 1238, 1334, 2108, 2203, 2235, 2281, 2336, 2407, 2451, 2528, 2563, 2597, 2717, 2755, 2851, 3098, 3277, 3348, 3384, 3422, 3456, 3482, 3513, 3555, 3593, 3627, 3653, 3684, 3834], 'Scopus': [530, 582, 624, 654, 701, 758, 810, 862, 907, 954, 1007, 1063, 1113, 1146, 1187, 1239, 1335, 2109, 2204, 2236, 2282, 2337, 2408, 2452, 2529, 2564, 2598, 2718, 2756, 2852, 3099, 3278, 3349, 3385, 3423, 3457, 3483, 3514, 3556, 3594, 3628, 3654, 3685, 3835], '(85)': [531], 'Google': [532, 584, 626, 656, 703, 718, 760, 812, 864, 909, 956, 1009, 1065, 1115, 1148, 1189, 1241, 1337, 2111, 2206, 2238, 2284, 2339, 2410, 2454, 2531, 2566, 2600, 2720, 2758, 2854, 3101, 3280, 3351, 3387, 3425, 3459, 3485, 3516, 3558, 3596, 3630, 3656, 3687, 3837], 'Scholar).': [533, 585, 657, 719, 778, 813, 865, 910, 957, 1010, 1066, 1116, 1149, 1190, 1242, 1338, 1734, 2112, 2411, 2455, 2601, 2721, 2759, 2855, 3102, 3281, 3352, 3517, 3688, 3838], 'Although': [534], 'originally': [537], 'inhibitor': [543], 'essential': [544], 'for': [545, 560, 825, 1444, 1457, 1612, 1817, 1908, 1931, 1946, 1996, 2418, 2424, 2803, 2877, 2889, 2957, 3015, 3152, 3173, 3225, 3249, 3797], 'trypsin': [548, 790], 'plasmin,': [550], 'there': [551, 1371], 'now': [553], 'increasing': [554], 'evidence': [555, 1152], 'indicate': [557, 3958, 3976, 3989, 4062], 'role': [559, 1611], 'this': [561, 1469, 1477, 3202, 3690, 3999], 'glycoprotein': [562], 'biology': [568], '(2Fries': [569, 611], 'E.': [570, 612], 'Blom': [571, 613], 'Int.': [573, 615, 646, 693, 1232, 1328, 2591, 2749, 3271, 3342, 3507, 3678, 3828], 'Biochem.': [575, 617, 753, 2104, 2403, 2447, 3380, 3551], 'Cell': [576, 618], '2000;': [578, 620, 1059, 1142], '32:': [579, 621], '125-137Crossref': [580, 622], '(152)': [583, 625], 'Bikunin': [586, 911, 958, 3353], 'may': [587, 959], 'important': [589], 'inhibiting': [591, 1160], 'inflammatory': [593, 662], 'response:': [594], 'it': [595, 1879, 3802], 'has': [596, 782, 1028, 1422, 3520], 'shown': [598, 1037, 3521], 'inhibit': [600, 789], 'induction': [602, 3915, 4065], 'pro-inflammatory': [604], 'cytokines': [605], 'types': [608, 976], 'Scholar,': [627, 704, 761, 1095, 3388, 3405, 3426, 3460, 3486, 3559, 3576, 3597, 3631, 3657], '3Nakamura': [628], 'H.': [629, 639, 643, 645, 676, 686, 690, 692, 740, 763, 796, 835, 880, 927, 980, 1080, 1099, 1166, 1215, 1229, 1275, 1311, 1325, 1719, 2091, 2390, 2434, 2574, 2588, 2732, 2746, 3078, 3254, 3268, 3325, 3339, 3367, 3390, 3409, 3430, 3462, 3490, 3504, 3538, 3561, 3580, 3601, 3633, 3661, 3675, 3811, 3825], 'Abe': [630, 677], 'S.': [631, 637, 678, 684, 708, 2264, 2276, 2553, 2712, 2846], 'Shibata': [632, 679], 'Y.': [633, 680, 706, 712, 767, 798, 800, 833, 839, 878, 884, 925, 931, 978, 984, 1084, 1101, 1103, 1170, 1172, 1217, 1219, 1223, 1225, 1313, 1315, 1319, 1321, 1723, 2183, 2220, 2506, 2508, 2576, 2578, 2582, 2584, 2734, 2736, 2740, 2742, 3082, 3084, 3256, 3258, 3262, 3264, 3327, 3329, 3333, 3335, 3394, 3411, 3413, 3428, 3434, 3466, 3468, 3492, 3494, 3498, 3500, 3565, 3582, 3584, 3599, 3605, 3637, 3639, 3663, 3665, 3669, 3671, 3813, 3815, 3819, 3821], 'Sata': [634, 681], 'M.': [635, 682, 742, 748, 765, 794, 837, 843, 847, 882, 888, 892, 929, 935, 939, 982, 988, 992, 1082, 1097, 1168, 1213, 1227, 1309, 1323, 1721, 2093, 2099, 2266, 2270, 2392, 2398, 2436, 2442, 2504, 2549, 2572, 2586, 2730, 2744, 2828, 2834, 2840, 3080, 3252, 3266, 3323, 3337, 3369, 3375, 3392, 3407, 3432, 3438, 3442, 3464, 3488, 3502, 3540, 3546, 3563, 3578, 3603, 3609, 3613, 3635, 3659, 3673, 3809, 3823], 'Kato': [636, 683], 'Saito': [638, 685], 'Hino': [640, 687], 'T.': [641, 688, 746, 750, 771, 802, 845, 849, 890, 894, 937, 941, 990, 994, 1088, 1105, 1174, 1231, 1327, 1727, 2097, 2101, 2396, 2400, 2440, 2444, 2510, 2590, 2748, 3086, 3270, 3341, 3373, 3377, 3398, 3415, 3440, 3444, 3470, 3506, 3544, 3548, 3569, 3586, 3611, 3615, 3641, 3677, 3827], 'Takahashi': [642, 689], 'Tomoike': [644, 691], 'Arch.': [647, 694], 'Allergy': [648, 695], 'Immunol.': [649, 696], '1997;': [650, 697, 2525], '112:': [651, 698], '157-162Crossref': [652, 699, 2527], '(24)': [655, 702], 'In': [658, 1471, 1494, 1866, 3739, 3984], 'animal': [659], 'models': [660], 'status,': [663], 'mice': [664, 1265, 1666], 'treated': [665], 'with': [666, 914, 968, 1021, 1196, 1304, 1502, 1591, 1698, 1715, 1753, 1807, 1839, 1859, 1874, 1882, 1884, 1972, 2026, 2071, 2151, 2415, 2485, 2687, 2798, 2821, 2900, 2908, 2978, 3000, 3110, 3136, 3167, 3300, 3779, 3847], 'exhibit': [668], 'decreases': [669], 'indices': [672], 'inflammation': [674], '(3Nakamura': [675], '4Futamura': [705], 'Kajikawa': [707], 'Kaga': [709], 'N.': [710, 744, 769, 841, 886, 933, 986, 1086, 1221, 1317, 1725, 2095, 2394, 2438, 2512, 2580, 2738, 3260, 3331, 3371, 3396, 3436, 3496, 3542, 3567, 3607, 3667, 3817], 'Shibutani': [711], 'Obstet.': [713], 'Gynecol.': [714], '1999;': [715], '93:': [716, 2279], '100-108PubMed': [717], 'Interestingly,': [720, 1572], 'case': [723], 'neoplastic': [725], 'cells,': [726, 4014], 'exposure': [727, 1593, 3719], 'induces': [733, 3313], '(5Kobayashi': [739, 2090, 2389, 2433, 3366, 3537], 'Suzuki': [741, 764, 836, 881, 928, 981, 1081, 1167, 1226, 1273, 1322, 1720, 2092, 2391, 2435, 2585, 2743, 3079, 3265, 3336, 3368, 3391, 3431, 3463, 3501, 3539, 3562, 3602, 3634, 3672, 3822], 'Kanayama': [743, 768, 840, 885, 932, 985, 1085, 1220, 1316, 1724, 2094, 2393, 2437, 2579, 2737, 3259, 3330, 3370, 3395, 3435, 3495, 3541, 3566, 3606, 3666, 3816], 'Nishida': [745, 844, 889, 936, 989, 2096, 2395, 2439, 3372, 3439, 3543, 3610], 'Takigawa': [747, 846, 891, 938, 991, 2098, 2397, 2441, 3374, 3441, 3545, 3612], 'Terao': [749, 770, 801, 848, 893, 940, 993, 1087, 1104, 1173, 1230, 1326, 1726, 2100, 2399, 2443, 2589, 2747, 3085, 3269, 3340, 3376, 3397, 3414, 3443, 3469, 3505, 3547, 3568, 3585, 3614, 3640, 3676, 3826], 'Eur.': [751, 2102, 2401, 2445, 3378, 3549], '2002;': [754, 775, 1092, 1731, 2105, 2404, 2448, 3381, 3402, 3552, 3573], '269:': [755, 2106, 2405, 2449, 3382, 3553], '3945-3957Crossref': [756, 2107, 2406, 2450, 3383, 3554], '(38)': [759, 2110, 2409, 2453, 3386, 3557], '6Kobayashi': [762, 3389, 3560], 'Tanaka': [766, 797, 838, 883, 930, 983, 1083, 1100, 1169, 1216, 1312, 1722, 2575, 2733, 3081, 3255, 3326, 3393, 3410, 3433, 3465, 3491, 3564, 3581, 3604, 3636, 3662, 3812], '(PMID:': [776, 1093, 1732, 3403, 3574], '12496270)Google': [777, 1094, 1733, 3404, 3575], 'molecule': [781], 'effects': [783, 3356], 'independent': [784], 'its': [786, 969, 3226], 'ability': [787, 3292], 'plasmin': [792], '(7Suzuki': [793], 'Kobayashi': [795, 834, 879, 926, 979, 1098, 1214, 1310, 2573, 2731, 3253, 3324, 3408, 3429, 3489, 3579, 3600, 3660, 3810], 'Hirashima': [799, 1102, 1171, 1218, 1314, 2577, 2735, 3083, 3257, 3328, 3412, 3467, 3493, 3583, 3638, 3664, 3814], 'Biochim.': [803, 1106, 3416, 3587], 'Biophys.': [804, 1107, 3417, 3588], 'Acta.': [805, 1108, 3418, 3589], '1547:': [807, 1110, 3420, 3591], '26-36Crossref': [808, 1111, 3421, 3592], '(32)': [811, 1114, 2530, 3424, 3595], 'high': [817], 'affinity': [818], 'specific': [819, 2158, 3315], 'receptors': [820], 'binding': [822, 4120, 4258], 'proteins': [823, 876, 1462, 1559], 'exist': [824], 'on': [827, 1958, 2002, 2031, 2464, 2941, 3357], 'surface': [831, 3105], '(8Hirashima': [832, 877, 924, 977], 'Fujie': [842, 887, 934, 987, 3437, 3608], '13650-13656Abstract': [855, 900, 947, 1000, 3450, 3621], '(27)': [863, 908, 955, 1008, 3458, 3629], 'It': [866, 1011, 1027], 'binds': [867], '(Crtl1),': [871], 'one': [872, 4097], 'also': [912, 1301, 1456, 3312], 'interacts': [913], '45-kDa': [916], 'receptor,': [918], 'putative': [920], 'CD44': [921], 'accessory': [922], 'cause': [960], 'ECM': [963, 1210, 2890], 'interacting': [966], 'both': [967, 1890], 'receptor': [970, 1024, 4137], 'Crtl1': [972], 'various': [974], 'possible': [1013], 'associated': [1017], 'heterotrimer': [1020], 'Crtl1.': [1026], 'established': [1030], 'uPA': [1032, 1204, 1259, 1299, 1344, 2379, 3526, 3709], 'modulate': [1039], 'derived': [1045], 'organs': [1048], '(9Andreasen': [1049, 1132], 'P.A.': [1050, 1133], 'Egelund': [1051, 1134], 'R.': [1052, 1135, 2555, 2830], 'Petersen': [1053, 1136], 'H.H.': [1054, 1137], 'Cell.': [1055, 1138, 2230, 2556], 'Mol.': [1056, 1139, 2229], 'Life': [1057, 1140], 'Sci.': [1058, 1141, 2274, 2710, 2844], '57:': [1060, 1143], '25-40Crossref': [1061, 1144], '(845)': [1064, 1147], 'We': [1067, 1150, 1587], 'reported': [1070], 'down-regulates': [1073], 'involved': [1075, 1347, 1529, 1561], 'aggressiveness': [1078], '(6Kobayashi': [1079, 1718], '7Suzuki': [1096, 3406, 3577], 'example,': [1118], 'target': [1120, 1374, 1521, 3772], 'uPAand': [1122, 1156], 'are': [1124, 1372, 1464, 1560, 1812, 4079, 4092], 'central': [1125], 'components': [1126], 'program': [1131], 'provide': [1151], 'repressed': [1155, 1467, 1584, 3731, 4044], 'MAP': [1162], 'kinase': [1163, 4103, 4176, 4305], 'pathway': [1164], '(10Kobayashi': [1165, 3077], '2015-2022Abstract': [1180, 3092, 3476, 3647], '(71)': [1188, 3100, 3484, 3655], 'transfection': [1192, 1603, 3305, 3766, 3922], 'caused': [1200], 'pronounced': [1201], 'drastic': [1207], '(11Suzuki': [1212, 1308, 2571, 2729, 3251, 3322, 3808], 'Takei': [1222, 1318, 2581, 2739, 3261, 3332, 3497, 3668, 3818], 'Saga': [1224, 1320, 2583, 2741, 3263, 3334, 3499, 3670, 3820], 'Itoh': [1228, 1324, 2587, 2745, 3267, 3338, 3503, 3674, 3824], 'Cancer.': [1234, 1330, 2593, 2751, 3273, 3344, 3509, 3680, 3830], '2003;': [1235, 1331, 2594, 2752, 3274, 3345, 3510, 3681, 3831], '104:': [1236, 1332, 2595, 2753, 3275, 3346, 3511, 3682, 3832], '289-302Crossref': [1237, 1333, 2596, 2754, 3276, 3347, 3512, 3683, 3833], '(57)': [1240, 1336, 2599, 2757, 3279, 3350, 3515, 3686, 3836], 'Exogenously': [1243, 3282], 'added': [1244, 2815, 3126, 3283], 'peritoneal': [1248], 'disseminated': [1249], 'intraperitoneal': [1252, 1293], 'growth,': [1255, 1543], 'tumors': [1261, 1294], 'bikunin-injected': [1263], 'nude': [1264, 1665], 'significantly': [1267], 'lower': [1268, 3132, 3160], 'than': [1269, 4096], 'controls.': [1271], '2M.': [1272], 'Kobayashi,': [1276], 'unpublished': [1277], 'data.': [1278], 'Similarly,': [1279], 'when': [1280], 'intraperitoneally': [1284], 'injected': [1285], 'mice,': [1288], 'size': [1290], 'levels': [1297], 'suppressed': [1302], 'compared': [1303, 3299], 'luciferase-transfected': [1305], 'control': [1306, 2304, 2500, 2728, 3301, 3783, 3944], 'data': [1340], 'strongly': [1341], 'support': [1342], 'mechanistically': [1346], 'these': [1352, 1438, 3310, 3844], 'processes.': [1353], 'Why': [1354], 'treatment': [1356], 'capable': [1358, 1379], 'inducing': [1360], 'not': [1367, 1423, 1442, 2075, 3243, 3696], 'fully': [1368], 'known.': [1369], 'Presumably,': [1370], 'select': [1373], 'regulating.': [1381], 'physiological': [1383], 'function': [1384], 'still': [1387], 'remains': [1388], 'established.': [1391], 'To': [1392, 1937, 3026, 3144, 3762], 'understand': [1393], 'better': [1394], 'how': [1395], 'regulates': [1397], 'different': [1398, 1511, 1574, 3716], 'facets': [1399], 'biology,': [1403], 'we': [1404, 1475, 1497, 1507, 1514, 3745, 4001], 'sought': [1405], 'identify': [1407, 3206, 3727], 'technology.': [1420], 'There': [1421], 'any': [1425], 'attempt': [1426], 'systematically': [1428], 'define': [1429], 'Identification': [1436], 'required': [1441], 'only': [1443], 'revealing': [1445], 'nature': [1447], 'all': [1449, 1736, 2024, 3931], 'pathways': [1451], 'used': [1452, 1498, 2053, 2170, 2725, 2888, 3172, 3725], 'but': [1455, 3704], 'defining': [1458], 'set': [1460, 3742], 'induced': [1465, 3285, 3729, 4028], 'inhibitor.': [1470], 'current': [1473], 'study,': [1474], 'started': [1476], 'investigation': [1478], 'RNA': [1486, 1766, 1824, 2116, 2428, 3840, 4106], 'isolated': [1487], 'untreated': [1491], 'other': [1495, 1676], 'experiments,': [1496, 1868, 3744], 'transfected': [1501, 1838, 2537, 2899, 2907, 3778], 'gene.': [1505], 'Here': [1506], 'show,': [1508], 'two': [1510, 1573, 1944, 2050, 2658, 3715, 3874, 3887, 3970], 'approaches,': [1512], 'at': [1517, 1759, 1912, 1924, 1960, 2469, 2656, 2806, 2960, 2984, 3010, 3149, 3209], 'least': [1518, 2657], '40': [1519], 'bikunin-selective': [1525], 'targets': [1526], 'factors,': [1535], 'signal': [1539, 3895], 'transduction': [1540], 'modifiers,': [1541], 'inflammation,': [1546], 'encoded': [1558], 'broad': [1564], 'range': [1565], 'cellular': [1567], 'functions': [1568], 'pathways.': [1571], 'members': [1575], '(matriptase': [1579], 'PAPP-A)': [1581], 'markedly': [1583], 'bikunin.': [1586], 'confirm': [1588], 'that,': [1589], 'consistent': [1590], 'this,': [1592], 'suppresses': [1604], 'matriptase/PAPP-A-dependent': [1606], 'invasion,': [1607, 3146], 'suggesting': [1608], 'potential': [1610, 3771], 'modulating': [1615], 'biology.': [1617], 'Purified': [1618], 'obtained': [1622, 1642, 1657, 1670, 2623, 3941], 'Mochida': [1624], 'Pharmaceutical': [1625], 'Co.': [1626, 2616], '(Gotenba,': [1627], 'Japan).': [1628, 1647, 1674, 2619], 'LipofectAMINE': [1629], 'Plus': [1630], 'reagent': [1631, 1773, 2800], 'purchased': [1633], 'Invitrogen.': [1635], 'Mouse': [1636], 'monoclonal': [1637, 2992], 'anti-PAPP-A': [1638, 2993], 'antibodies': [1639, 2982], '(IgG2b)': [1640], 'CosmoBio': [1644], 'Inc.': [1645], '(Tokyo,': [1646], 'Boyden-type': [1648], 'chambers': [1651], '(BioCoat': [1652], 'MatrigelTM': [1653], 'chambers)': [1655], 'Collaborative': [1659], 'Biomedical': [1660], '(Franklin': [1661], 'Lakes,': [1662], 'NJ).': [1663], '(Balb-c,': [1667], 'nu/nu)': [1668], 'SLC': [1672], '(Hamamatsu,': [1673], 'All': [1675], 'chemicals': [1677], 'analytical': [1679], 'grade.': [1680], 'grown': [1688], "Dulbecco's": [1690], 'modified': [1691, 3295], "Eagle's": [1692], 'medium': [1693, 2822, 2862], '(Sigma': [1694], 'Chemical': [1695], 'Co.)': [1696], 'supplemented': [1697], '10%': [1699, 2864], 'fetal': [1700, 2865], 'bovine': [1701, 2866, 2972], 'serum': [1702, 2867, 2973], '(Invitrogen),': [1703], 'penicillin': [1704], '(100': [1705, 1709], 'units/ml),': [1706], 'streptomycin': [1708], 'μg/ml)': [1710], 'under': [1711, 2302, 3188], '5%': [1713], 'CO2atmosphere': [1714], 'constant': [1716], 'humidity': [1717], 'experiments': [1737, 2892, 3193], 'added,': [1742], 'incubated': [1745, 2802], 'serum-free': [1747], 'medium.': [1748], 'Cells': [1749], 'disaggregated': [1751], 'routinely': [1752], '0.1%': [1754, 2967], 'trypsin/EDTA': [1755], 'solution': [1756], 'replated': [1758], 'split': [1761], 'ratio': [1762, 1992, 2022, 3951], '1:10.': [1764], 'Total': [1765, 3839], 'isolations': [1767], 'performed': [1769], 'Trizol': [1772], '(Invitrogen).': [1774], 'Protein': [1775], 'concentrations': [1776], 'supernatants': [1779], 'extracts': [1782], 'measured': [1784], 'Bio-Rad': [1787, 2480], 'assay.': [1789], 'microarrays': [1792, 1819], '(TaKaRa': [1793, 1986], 'Human': [1794, 3859], '3K': [1795, 3860], 'CHIP': [1796], 'Ver.': [1797, 1984], '3.0;': [1798], 'TaKaRa': [1799, 3858], 'Bio': [1800, 1987], 'Inc.,': [1801], 'Otsu,': [1802], 'Japan;': [1803], 'www.takara-bio.co.jp)': [1804], 'spotted': [1806], '3,126': [1808], 'sequence-verified': [1809], 'clones': [1810, 2621, 2668, 2686], 'available': [1813], 'GenBankTM(www.ncbi.nlm.nih.gov/Genbank/index.html).': [1815], 'Probes': [1816], 'generated': [1821, 2354], 'total': [1823, 2115], 'either': [1827, 1860, 2901, 3848], 'exposed': [1828, 2463], '(1': [1831, 3121], 'μm,': [1832], '6': [1833], 'h;': [1834], 'Exp.': [1835, 4051], '1)': [1836, 4271], '(Exp.': [1843, 3758], '2)': [1844], 'standard': [1847, 2143, 2543], 'reverse': [1848], 'transcriptase': [1849], 'reaction': [1850], 'dTTP': [1856], 'replaced': [1858], 'Cy3-labeled': [1861], 'dUTP': [1862], 'Cy5-labeled': [1864, 1893], 'dUTP.': [1865], 'sample': [1871], 'labeled': [1873, 1881, 3846], 'Cy3;': [1875], 'others,': [1878], 'Cy5,': [1883], 'essentially': [1885], 'identical': [1886], 'results.': [1887], 'Hybridization': [1888, 2147], 'Cy3-': [1891, 1953], 'probes': [1894, 3876], 'same': [1897], 'carried': [1900, 2085, 2149, 3069], 'out': [1901, 2086, 2150, 3070], 'sealed,': [1904], 'humid': [1905], 'cassette': [1907], 'about': [1909], '14': [1910, 2289, 4285], 'h': [1911, 2959, 3055], '65': [1913], '°C.': [1914, 2471], 'Microarrays': [1915], 'slides': [1916], 'washed': [1918, 2461, 2819], 'then': [1920, 2814, 3854], 'dried': [1921], 'centrifugation': [1923], 'room': [1925, 2807, 2961], 'temperature.': [1926, 2808], 'Nine': [1927], 'tested': [1930], 'confirmation': [1932], 'hybridization.': [1936], 'determine': [1938], 'fluorescent': [1940], 'intensities': [1941, 2009, 2047, 3960], 'dyes': [1945, 2051], 'each': [1947, 1997, 2003, 2032, 2932, 3031, 3046, 3174, 3947, 4067], 'spot,': [1948, 1998], 'fluorescence': [1950, 2008, 2021, 2046], 'signals': [1951, 2028, 3885], 'Cy5-tagged': [1955], 'spots': [1957, 2001, 2025, 2037, 2060], 'arrays': [1959], '532': [1961], 'nm': [1962, 1966], '(Cy3)': [1963], '635': [1965], '(Cy5)': [1967], 'simultaneously': [1968], 'scanned': [1970], 'immediately': [1971], 'an': [1973, 3990], 'Affymetrix': [1974], '428': [1975], 'Array': [1976], 'Scanner': [1977], 'quantitated': [1979, 2474], 'BioDiscovery': [1982], 'ImaGene': [1983], '4.2': [1985], 'Inc.).': [1988], 'background-subtracted': [1990], 'median': [1991, 2020], 'value': [1993], 'calculated': [1995], 'replicate': [2000], 'slide': [2004, 3863], 'averaged.': [2006], 'normalized': [2011, 3938], 'applying': [2013], 'scaling': [2015], 'so': [2017], 'detectable': [2027], 'above': [2029, 3987], 'background': [2030], '1.0.': [2035], 'displayed': [2039], '2-fold': [2041], 'greater': [2043], 'difference': [2044], 'generate': [2055], 'clusters.': [2057], 'Poor': [2058], 'quality': [2059], 'removed': [2062], 'if': [2063], 'they': [2064], 'very': [2066], 'small,': [2067], 'irregularly': [2068], 'shaped,': [2069], 'pixels': [2072], 'uniformly': [2076], 'distributed': [2077], 'throughout': [2078], 'spot.': [2080], 'described': [2088, 2387, 2569, 2894, 3076], 'Samples': [2113], '(10': [2117], 'μg)': [2118, 2930], 'separated': [2120], 'electrophoresis': [2122, 2940], 'denaturing': [2124], '1.2%': [2125], 'agarose': [2126], 'gels': [2127, 2943], 'containing': [2128, 2863, 2966], '1%': [2129], 'formaldehyde': [2130], 'transferred': [2132, 2945], 'onto': [2133, 2430], 'nylon': [2134], 'nitrocellulose': [2136], 'membranes': [2137, 2459], '(Hybond': [2138], 'N+,': [2139], 'Amersham': [2140], 'Biosciences)': [2141], 'molecular': [2144], 'biological': [2145], 'techniques.': [2146], '[α-32P]dCTP': [2152], 'random': [2154, 3182], 'oligonucleotide': [2155], 'priming': [2156], 'activities': [2159], '0.4–0.9': [2161], '×': [2162, 3035, 3122], '109': [2163], 'cpm/μg.': [2164], 'following': [2166, 2980], 'sequences': [2168, 2778], 'probes:': [2172], 'DYRK2,': [2173], 'bp': [2174, 2252], '1344–2154': [2175], '(12Becker': [2180], 'W.': [2181], 'Weber': [2182], 'Wetzel': [2184], 'K.': [2185, 2187, 2262, 2520, 2522], 'Eirmbter': [2186], 'Tejedor': [2188], 'F.J.': [2189], 'Joost': [2190], 'H.G.': [2191], '1998;': [2195], '273:': [2196], '25893-25902Abstract': [2197], '(241)': [2205], 'Scholar);': [2207, 2239, 2285, 2340], 'E74-like': [2208], '2': [2210, 4121, 4158, 4171, 4177, 4246, 4264, 4309], '(new': [2211], 'Ets-related': [2212], 'factor;': [2213], 'NERF),': [2214], 'NERF': [2215], '(13Oettgen': [2217], 'Akbarali': [2219], 'Boltax': [2221], 'Best': [2223], 'Kunsch': [2225], 'C.': [2226, 2260, 2314, 2320, 2704], 'Libermann': [2227], 'T.A.': [2228], '1996;': [2232, 2278], '16:': [2233], '5091-5106Crossref': [2234], '(73)': [2237], 'triple': [2240], 'functional': [2241, 4224], '(PTPRF-interacting),': [2243], 'Trio': [2244], '(encoding': [2246], 'amino': [2247], 'acids': [2248], '2249–2861': [2249], 'plus': [2250], '140': [2251], '3′': [2254], 'nontranslated': [2255], 'sequence)': [2256], '(14Debant': [2257], 'A.': [2258, 2277, 2514, 2551, 2713, 2847], 'Serra-Pages': [2259], 'Seipel': [2261], "O'Brien": [2263], 'Tang': [2265], 'Park': [2267, 2323], 'S.H.': [2268], 'Streuli': [2269], 'Proc.': [2271, 2707, 2841], 'Natl.': [2272, 2708, 2842], 'Acad.': [2273, 2709, 2843], 'U.': [2275, 2711, 2845], '5466-5471Crossref': [2280], '(399)': [2283], 'tumorigenicity': [2288, 4284], '(MT-SP1[matriptase]),': [2290], 'full-length': [2292], 'MT-SP1': [2293], '(pcDNA3/MT-SP1)': [2295], 'ligated': [2296], 'pcDNA3': [2299], 'vector': [2300, 2496, 2501], '(Invitrogen)': [2301], 'cytomegalovirus': [2307], 'promoter': [2308], '(15Cho': [2309], 'E.G.': [2310], 'Kim': [2311, 2313, 2315], 'M.G.': [2312], 'S.R.': [2316], 'Seong': [2317], 'I.S.': [2318], 'Chung': [2319], 'Schwartz': [2321], 'R.H.': [2322], '44581-44589Abstract': [2330], '(74)': [2338], 'partial': [2342], '(553': [2346], 'bp),': [2347], 'PCR': [2349], 'product': [2350], '(GenBankTMU28727;': [2351], 'nucleotides': [2352], '5593–6145)': [2353], 'ovaries': [2357], 'PAPP-A-specific': [2359], 'primers': [2360], '(F:': [2361], '5′-TGA': [2362], 'GTC': [2363], 'TCT': [2364], 'GAC': [2365], 'CAT': [2366], 'TTG': [2367], 'GGT': [2368], 'GAC-3′,': [2369], 'B:': [2370], '5′-TTG': [2371], 'GCT': [2372], 'GCA': [2373, 2377], 'GAA': [2374], 'AAG': [2375], 'GGA': [2376], 'G-3′).': [2378], 'prepared': [2385], 'Filters': [2412, 2472], 'reprobed': [2414], '(GAPDH)': [2421], 'correct': [2423, 2675], 'amount': [2426], 'loaded': [2429], 'filters': [2432, 3170], 'After': [2456, 2856], 'hybridization,': [2457], 'Kodak': [2465], 'BioMax': [2466], 'MS-1': [2467], 'film': [2468], '−70': [2470], 'scanning': [2476], 'densitometry': [2477], 'model': [2481], '620': [2482], 'Video': [2483], 'Densitometer': [2484], '1-d': [2487], 'Analyst': [2488], 'software': [2489], 'package': [2490], 'Macintosh.': [2492], 'pCMV-bikunin-IRES-bsr': [2497], 'pCMV-luciferase-IRES-bsr': [2502], '(16Urabe': [2503], 'Hasumi': [2505], 'Ogasawara': [2507], 'Matsushita': [2509], 'Kamoshita': [2511], 'Nomoto': [2513], 'Colosi': [2515], 'Kurtzman': [2517], 'G.J.': [2518], 'Tobita': [2519], 'Ozawa': [2521], 'Gene': [2523], '(Amst.).': [2524], '200:': [2526], 'Scholar)': [2532, 2567], 'encoding': [2533], '(luc)': [2535], 'calcium': [2544], 'phosphate': [2545], 'precipitation': [2546, 2924], 'method': [2547], '(17Wigler': [2548], 'Pellicer': [2550], 'Silverstein': [2552], 'Axel': [2554], '1978;': [2557], '14:': [2558], '725-731Abstract': [2559], '(776)': [2565], 'selected': [2605, 3796], 'presence': [2608, 2641], '10': [2610, 2643, 3181], 'mg/ml': [2611, 2644], 'blasticidin': [2612, 2645], 'S': [2613, 2646], 'hydrochloride': [2614], '(Funakoshi': [2615], 'Ltd.,': [2617], 'Tokyo,': [2618], 'Resistant': [2620], 'after': [2624, 3053, 4085], '4': [2625, 2857, 2985, 4243], 'weeks,': [2626], 'andbik+': [2627], 'transfectants': [2628, 2723], 'aluc+': [2630], 'transfectant': [2631], 'obtained.': [2633], 'subsequently': [2637], 'maintained': [2638], 'hydrochloride.': [2647], 'initial': [2649], 'bik+': [2650, 2667, 2683], 'mass': [2651], 'cultures': [2652], 'subjected': [2654], 'rounds': [2659], 'subcloning': [2661], 'order': [2663], 'obtain': [2665], 'stable': [2666, 3787], '(Clones': [2669], '1–5).': [2670], 'DNA': [2671], 'sequencing': [2672], 'verified': [2673], 'insertion': [2676], 'bik': [2679, 2689], 'cDNA.': [2680], 'Finally,': [2681], 'inducible': [2688], 'immunocytochemical': [2695], 'staining': [2696], 'Western': [2698, 2882], '(18Chen': [2701], 'Y.T.': [2702], 'Holcomb': [2703], 'Moore': [2705], 'H.P.': [2706], '1993;': [2714], '90:': [2715], '6508-6512Crossref': [2716], '(139)': [2719], 'luc+': [2722], 'Antisense': [2760], '18-base': [2761], 'phosphorothioate': [2762], 'oligodeoxynucleotides': [2763], 'corresponding': [2764, 3903], 'MT-SP1and': [2768], 'synthesized': [2772], 'consisted': [2774], 'antisense': [2777], '5′-AGC': [2780], 'TGC': [2781], 'TCA': [2782], 'TCC': [2783], 'TAG': [2784], 'GCA-3′': [2785], '(AS-MT-SP1)': [2786], '5′-GCC': [2788], 'CAA': [2789], 'CTC': [2790], 'CTG': [2791, 2792], 'GAA-3′': [2793], '(AS-PAPP-A),': [2794], 'respectively.': [2795, 4015, 4088], 'Oligonucleotides': [2796], 'mixed': [2797], 'lipofectin': [2799], '15': [2804], 'min': [2805], 'Thereafter,': [2809], 'oligonucleotide-liposome': [2811], 'complexes': [2812], 'twice': [2820], '(19Felgner': [2823], 'P.L.': [2824], 'Gadek': [2825], 'T.R.': [2826], 'Holm': [2827], 'Roman': [2829], 'Chan': [2831], 'H.W.': [2832], 'Wenz': [2833], 'Northrop': [2835], 'J.P.': [2836], 'Ringold': [2837], 'G.M.': [2838], 'Danielsen': [2839], '1987;': [2848], '84:': [2849], '7413-7417Crossref': [2850], '(4388)': [2853], 'h,': [2858], 'fresh': [2859], 'normal': [2860], 'added.': [2869], 'Forty-eight': [2870], 'hours': [2871], 'later': [2872], 'analyzed': [2876, 2936], 'blot,': [2883], 'below.': [2895], 'transiently': [2898], 'AS-PAPP-A': [2902], 'stably': [2906, 3777], 'harvested': [2911], 'ice-cold': [2913], '1×': [2914], 'phosphate-buffered': [2915], 'saline,': [2916], 'pellets': [2919], 'lysed': [2921], 'radioimmune': [2923], 'assay': [2925, 3178, 3298], 'buffer.': [2926], 'Centrifuged': [2927], 'lysates': [2928], '(50': [2929], 'line': [2934, 3048, 3240], 'SDS-polyacrylamide': [2938], 'gel': [2939], '15%': [2942], 'polyvinylidene': [2948], 'difluoride': [2949], 'semi-dry': [2952], 'transfer.': [2953], 'Membranes': [2954], 'blocked': [2956], 'temperature': [2962], 'Tris-buffered': [2964], 'saline': [2965], 'Tween': [2968], '20': [2969], '2%': [2971], 'albumin.': [2974], 'Blots': [2975], 'probed': [2977], 'primary': [2981, 3199], 'overnight': [2983], '°C:': [2986], 'rabbit': [2987], 'polyclonal': [2988], 'anti-bikunin': [2989], '(1:1000)': [2990], '(1:1000).': [2994], 'followed': [2997], 'incubation': [2999, 3147], 'appropriate': [3002], 'horseradish': [3003], 'peroxidase-conjugated': [3004], 'secondary': [3005], 'antibody': [3006, 4270, 4301], '(Dako,': [3007], 'Copenhagen,': [3008], 'Denmark)': [3009], 'dilution': [3012], '1:50,000': [3014], 'h.': [3017, 3154], 'Detection': [3018], 'achieved': [3020], 'enhanced': [3022], 'chemiluminescence': [3023], '(Amersham': [3024], 'Biosciences).': [3025], 'examine': [3027], 'proliferation': [3029, 3703, 4219, 4237, 4251], '5': [3034], '103': [3036], 'seeded,': [3039], 'counted': [3050, 3185], 'triplicate': [3052], '24': [3054, 3153], 'assess': [3057], 'plating': [3058], 'efficiency.': [3059], 'Each': [3060, 3862], 'experiment': [3061], 'done': [3063], 'triplicate.': [3065], 'Chemoinvasion': [3066], 'assays': [3067], 'Boyden': [3073, 3296], 'chamber': [3074, 3107, 3133, 3297], 'upper': [3104, 3129], 'precoated': [3109], 'layer': [3112], 'artificial': [3114], 'basement': [3115], 'membrane,': [3116], 'Matrigel.': [3117], 'suspension': [3120], '105': [3123], 'cells/well)': [3124], 'chamber.': [3130], 'filled': [3135], 'fibroblast-conditioned': [3137], 'medium,': [3138], 'acted': [3140], 'chemoattractant.': [3143], 'measure': [3145], '37': [3150], '°C': [3151], 'invaded': [3156], 'side': [3161], 'filter': [3164, 3187], 'stained': [3166], 'hematoxylin.': [3168], 'Triplicate': [3169], 'condition,': [3179], 'fields': [3183], 'per': [3186], 'microscope': [3190], '(×400).': [3191], 'repeated': [3195], 'duplicate.': [3197], 'goal': [3200], 'regulated': [3208, 4175], 'level': [3212], 'evaluated': [3224], 'suitability': [3227], 'studying': [3229], 'changes': [3232], 'response': [3234], 'stimulation.': [3237], 'found': [3242, 4002], 'express': [3245], 'invasive': [3291], '(5–8,10).': [3303], 'Furthermore,': [3304], 'significant': [3317], 'decrease': [3318, 3691, 3700], 'invasiveness': [3321, 3694], 'had': [3354], 'negligible': [3355], 'vitro': [3360], '8Hirashima': [3427, 3598], '10Kobayashi': [3461, 3632], '11Suzuki': [3487, 3658], 'Previous': [3518], 'work': [3519], 'down-regulate': [3525], 'lines': [3536], 'Thus,': [3689], 'due': [3697], 'rather': [3705], 'Therefore,': [3714], 'methods': [3717], '(bikunin': [3718], 'transfection)': [3723], 'technologies.': [3738], 'first': [3741], 'tried': [3746], 'achieve': [3748], '1,': [3759], 'Table': [3760], 'I).': [3761], 'test': [3763], 'whether': [3764], 'activate': [3768], 'inactivate': [3770], '(luc+).': [3784], 'Of': [3785], 'transfectants,': [3789], 'clone': [3791], '(C1)': [3793], 'because': [3801], 'showed': [3803], 'greatest': [3805], 'purified': [3842], 'samples,': [3845, 3868], 'Cy3': [3849], 'Cy5': [3851], 'fluorescence,': [3852], 'hybridized': [3855], 'CHIP.': [3861], 'contained': [3864], 'duplicate': [3865, 3880], 'sets': [3866, 3933], 'colors': [3871], 'reversed': [3878], 'assays.': [3881], 'Quantitation': [3882], 'produced': [3886], 'kinds': [3888], 'information:': [3890], 'intensity': [3892, 3929, 3950], 'proportional': [3897], 'abundance': [3900], 'mRNA,': [3904], 'degree': [3907], 'redness': [3909], 'greenness': [3911], 'indicated': [3912], 'fold': [3914], 'repression': [3917], 'average': [3927], 'across': [3930], 'probe': [3932], 'C1': [3935, 3982, 3996, 4013], 'luc+.': [3945], 'gene,': [3948], 'C1/luc+was': [3953], 'calculated.': [3954], 'Ratios': [3955, 3973], 'equal': [3959], 'and,': [3961], 'therefore,': [3962], 'no': [3963], 'change': [3964], 'lines.': [3972], 'below': [3974], '0.5': [3975], 'contrast,': [3985], 'ratios': [3986], '2.0': [3988], 'up-regulation': [3991], 'Using': [3998], 'criterion,': [4000], '12': [4004], '31': [4006], 'up-': [4009], 'our': [4017], 'analyses': [4018], '3': [4021, 4104, 4184], 'mRNAs': [4022, 4035], '(D30612,': [4023], 'BC012816,': [4024], 'NM005399)': [4026], '3.0-fold': [4030, 4046], 'more,': [4032], '7': [4034], '(NM030941,': [4036], 'NM021978,': [4037], 'NM003992,AB028983,': [4038], 'NM006482,': [4039], 'NM002375,': [4040], 'U28727)': [4042], 'more': [4048, 4095], '(Table': [4049], 'I,': [4050], '1).Table': [4052], 'IMicroarray': [4053], 'cellsGenBank™': [4057], 'accession': [4058], 'no.-Fold': [4059], 'change1-aThe': [4060], 'numbers': [4061], '-fold': [4064], 'determined': [4070], 'software.': [4075], '+': [4076], '−': [4078], 'increased': [4080], 'decreased': [4082], 'treatment,': [4087], 'Some': [4089], '(parentheses)': [4091], 'listed': [4093], 'category.DescriptionExp.': [4098], '1Exp.': [4099], '2Transcription': [4100], 'NM003992−3.56−4.00CDC-like': [4102], 'NM005643−2.70−2.92TAF11': [4105], 'polymerase': [4107], 'II,': [4108], 'TATA': [4109], 'box-binding': [4110], '(TBP)–associated': [4112], '28': [4114], 'kDa,': [4115], 'NM001290−2.60−3.02LIM': [4118], 'NM002040−2.54−3.18GA-binding': [4122], 'α': [4126], 'subunit': [4127], '(60': [4128], 'kD)': [4129], 'D42046−2.46−2.79DNA2': [4130], '(DNA': [4131], 'replication': [4132], 'helicase,': [4133], 'yeast,': [4134], 'homolog)-like': [4135], 'NM033334−2.44−1.98Nuclear': [4136], 'subfamily': [4138], '6,': [4139], 'group': [4140], 'A,': [4141], 'member': [4142, 4164], 'NM001515−2.36−2.46Homo': [4144], 'sapiens': [4145, 4216, 4248, 4256], 'general': [4146], 'IIH,': [4149], 'polypeptide': [4150, 4204], '2,': [4151], '44': [4152], 'kDa': [4153], '(GTF2H2),': [4154], 'NM006874−2.28−1.97E74-like': [4156], '(cts': [4159], 'factor)': [4162], 'NM004663−2.06−2.17RAB11A': [4163], 'RAS': [4165], 'oncogene': [4166, 4196], 'familySignal': [4167], 'transductions': [4168], 'AB028983−3.50−3.79Adenylate': [4169], 'cyclase': [4170], '(brain)': [4172], 'NM006482−3.44−4.86Dual-specificity': [4173], 'tyrosine-(Tyr)-phosphorylation': [4174], 'NM004468−2.86−3.41Four': [4178], 'half': [4181], 'domains': [4183], 'NM001173−2.82−2.65Rho': [4185, 4210], 'GTPase': [4186, 4211], 'activating': [4187, 4212], '5Oncogenes/Tumor': [4189], 'NM006509−2.90−3.54v-rel': [4192], 'avian': [4193], 'reticuloendotheliosis': [4194], 'viral': [4195], 'homolog': [4197], 'B': [4198], '(nuclear': [4199], 'Kappa': [4202], 'light': [4203], 'enhancer': [4206], 'B-cells': [4208], '3)': [4209], '5)': [4214], 'NM014221−2.44−2.19Homo': [4215, 4247], 'mature': [4217, 4249], 'T-cell': [4218, 4250], '(MTCP1),': [4221, 4253], 'NM007118−2.32−2.43Triple': [4223], '(PTPRF': [4226], 'interacting)': [4227], 'NM002444+2.24+2.59Mocsin': [4228], 'D30612+8.04+8.57Zinc': [4229], 'finger': [4230], '282,': [4232], 'apoptosis': [4233], 'suppressionGrowth,': [4236], 'differentiation/cell': [4239], 'cycle': [4240], 'NM002375−3.34−3.75Microtubule-associated': [4241], 'NM004132−2.70−4.03Hyaluronad-binding': [4244], 'NM003165−2.44−2.17Homo': [4255], 'syntaxin': [4257], '(STXBP1),': [4261], 'NM003872−2.24−2.58Neuropilin': [4263], 'NM004356+2.51+3.28CD81': [4265, 4296], 'antigen': [4266, 4297], '(target': [4267, 4298], 'antiproliferative': [4269, 4300], 'NM004102+2.62+3.59Fatty': [4272], 'acid-binding': [4273], '3,': [4275], 'muscle': [4276], 'heart': [4278], '(mammary-derived': [4279], 'inhibitor)Invasion/Metastasis': [4281], 'NM021978−5.00−7.12Suppression': [4282], '(colon': [4286], 'carcinoma,': [4287], 'epithin)': [4289], 'NM002375−3.08−3.52Microtubule-associated': [4290], '4)': [4292], 'NM002291+2.28+2.17Laminin': [4293], 'β': [4294], 'I': [4295], '1))Cytokines': [4302], 'NM001569−2.94−3.19Interleukin-1': [4303], 'receptor-associated': [4304], 'BC012816+5.49+4.14TGFβ-induced': [4307], '(TALE': [4310], 'family': [4311], 'homcobox)Apoptosis': [4312], 'NM013979−2.10−2.54BCL2/adenovirus': [4313], 'E1B': [4314], '19kD-interacting': [4315], 'p': [4316]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1974442900', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-10T03:17:47.008535', 'created_date': '2016-06-24'}