Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2803323662', 'doi': 'https://doi.org/10.1101/330365', 'title': 'Gene function contributes to gene expression levels in<i>S. cerevisiae</i>', 'display_name': 'Gene function contributes to gene expression levels in<i>S. cerevisiae</i>', 'publication_year': 2018, 'publication_date': '2018-05-24', 'ids': {'openalex': 'https://openalex.org/W2803323662', 'doi': 'https://doi.org/10.1101/330365', 'mag': '2803323662'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/330365', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2018/05/24/330365.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.biorxiv.org/content/biorxiv/early/2018/05/24/330365.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068171806', 'display_name': 'Mark J. Hickman', 'orcid': 'https://orcid.org/0000-0003-3643-8023'}, 'institutions': [{'id': 'https://openalex.org/I44265643', 'display_name': 'Rowan University', 'ror': 'https://ror.org/049v69k10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I44265643']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark J. Hickman', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ 08028'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ 08028', 'institution_ids': ['https://openalex.org/I44265643']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088103318', 'display_name': 'Andrea Jackson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I44265643', 'display_name': 'Rowan University', 'ror': 'https://ror.org/049v69k10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I44265643']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrea Jackson', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ 08028'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ 08028', 'institution_ids': ['https://openalex.org/I44265643']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049965393', 'display_name': 'Abigail J. Smith', 'orcid': 'https://orcid.org/0000-0003-0273-9813'}, 'institutions': [{'id': 'https://openalex.org/I44265643', 'display_name': 'Rowan University', 'ror': 'https://ror.org/049v69k10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I44265643']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Abigail Smith', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ 08028'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ 08028', 'institution_ids': ['https://openalex.org/I44265643']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020719585', 'display_name': 'Julianne M. Thornton', 'orcid': 'https://orcid.org/0000-0002-4117-8388'}, 'institutions': [{'id': 'https://openalex.org/I44265643', 'display_name': 'Rowan University', 'ror': 'https://ror.org/049v69k10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I44265643']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julianne Thornton', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ 08028'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ 08028', 'institution_ids': ['https://openalex.org/I44265643']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081294215', 'display_name': 'Amanda Tursi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I44265643', 'display_name': 'Rowan University', 'ror': 'https://ror.org/049v69k10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I44265643']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amanda Tursi', 'raw_affiliation_strings': ['Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ 08028'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, NJ 08028', 'institution_ids': ['https://openalex.org/I44265643']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.501778, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 62, 'max': 70}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10887', 'display_name': 'Bioinformatics and Genomic Networks', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10887', 'display_name': 'Bioinformatics and Genomic Networks', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10015', 'display_name': 'Genomics and Phylogenetic Studies', 'score': 0.9921, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10885', 'display_name': 'Gene expression and cancer classification', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pair-rule-gene', 'display_name': 'Pair-rule gene', 'score': 0.658502}, {'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription', 'score': 0.41033927}], 'concepts': [{'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.8587074}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.7353158}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7107003}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.66794515}, {'id': 'https://openalex.org/C114009990', 'wikidata': 'https://www.wikidata.org/wiki/Q7125117', 'display_name': 'Pair-rule gene', 'level': 5, 'score': 0.658502}, {'id': 'https://openalex.org/C14036430', 'wikidata': 'https://www.wikidata.org/wiki/Q3736076', 'display_name': 'Function (biology)', 'level': 2, 'score': 0.58950615}, {'id': 'https://openalex.org/C165864922', 'wikidata': 'https://www.wikidata.org/wiki/Q411391', 'display_name': 'Regulation of gene expression', 'level': 3, 'score': 0.5121403}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.41033927}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.37333882}, {'id': 'https://openalex.org/C33498276', 'wikidata': 'https://www.wikidata.org/wiki/Q2138797', 'display_name': 'Regulator gene', 'level': 4, 'score': 0.33764938}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/330365', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2018/05/24/330365.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/330365', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2018/05/24/330365.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Affordable and clean energy', 'id': 'https://metadata.un.org/sdg/7', 'score': 0.81}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W1528221774', 'https://openalex.org/W1968164444', 'https://openalex.org/W1973268693', 'https://openalex.org/W1980679527', 'https://openalex.org/W1984708728', 'https://openalex.org/W2013947447', 'https://openalex.org/W2014975375', 'https://openalex.org/W2016097940', 'https://openalex.org/W2028075953', 'https://openalex.org/W2036573675', 'https://openalex.org/W2042380859', 'https://openalex.org/W2044762155', 'https://openalex.org/W2064295826', 'https://openalex.org/W2068872007', 'https://openalex.org/W2074330253', 'https://openalex.org/W2079121387', 'https://openalex.org/W2098412979', 'https://openalex.org/W2102221598', 'https://openalex.org/W2103017472', 'https://openalex.org/W2103453943', 'https://openalex.org/W2107493728', 'https://openalex.org/W2108078395', 'https://openalex.org/W2110065044', 'https://openalex.org/W2116041602', 'https://openalex.org/W2118956583', 'https://openalex.org/W2133636765', 'https://openalex.org/W2138316324', 'https://openalex.org/W2139708137', 'https://openalex.org/W2140191158', 'https://openalex.org/W2140729960', 'https://openalex.org/W2144504620', 'https://openalex.org/W2145750053', 'https://openalex.org/W2146771637', 'https://openalex.org/W2147398075', 'https://openalex.org/W2147555013', 'https://openalex.org/W2154431984', 'https://openalex.org/W2161408515', 'https://openalex.org/W2161950511', 'https://openalex.org/W2166574880', 'https://openalex.org/W2168342464', 'https://openalex.org/W2171137634', 'https://openalex.org/W2177691638', 'https://openalex.org/W2236822143', 'https://openalex.org/W2239771388', 'https://openalex.org/W2340761255', 'https://openalex.org/W2468926998', 'https://openalex.org/W2480009166', 'https://openalex.org/W2487072791', 'https://openalex.org/W2559018305', 'https://openalex.org/W2582743722', 'https://openalex.org/W2596086955', 'https://openalex.org/W2952535963', 'https://openalex.org/W309394194', 'https://openalex.org/W4213265720'], 'related_works': ['https://openalex.org/W3151254369', 'https://openalex.org/W3136439449', 'https://openalex.org/W3135563716', 'https://openalex.org/W3103981777', 'https://openalex.org/W2392598250', 'https://openalex.org/W2277277196', 'https://openalex.org/W2083903372', 'https://openalex.org/W2059282377', 'https://openalex.org/W2043274041', 'https://openalex.org/W2002797053'], 'abstract_inverted_index': {'ABSTRACT': [0], 'It': [1], 'is': [2, 43, 82, 208, 226], 'not': [3], 'understood': [4], 'what': [5], 'evolutionary': [6], 'factors': [7], 'drive': [8], 'some': [9], 'genes': [10, 70, 109, 133, 141, 152], 'to': [11, 169], 'be': [12, 215], 'expressed': [13, 150], 'at': [14, 45], 'a': [15, 24, 46, 181, 186, 206], 'higher': [16], 'level': [17, 49], 'than': [18], 'others.': [19], 'Here,': [20], 'we': [21, 36, 58, 100, 166], 'hypothesized': [22], 'that': [23, 38, 60, 76, 128, 184, 223], 'gene’s': [25, 187, 192], 'function': [26, 95, 121, 225], 'plays': [27], 'an': [28, 227], 'important': [29, 83, 228], 'role': [30, 92], 'in': [31, 71, 80, 84, 96, 143, 154, 194], 'setting': [32, 85, 97], 'expression': [33, 48, 86, 98, 137, 171, 188, 213, 231], 'level.': [34, 87, 232], 'First,': [35], 'established': [37], 'each': [39], 'S.': [40, 72, 107], 'cerevisiae': [41, 108], 'gene': [42, 77, 94, 111, 120, 207, 224], 'maintained': [44, 66], 'specific': [47], 'by': [50], 'analyzing': [51], 'RNA-seq': [52], 'data': [53], 'from': [54], 'multiple': [55], 'studies.': [56], 'Next,': [57], 'found': [59, 127], 'mRNA': [61, 102], 'and': [62, 103, 160, 179], 'protein': [63, 104], 'levels': [64, 105, 172], 'were': [65, 167], 'for': [67, 139], 'the': [68, 91, 191, 210], 'orthologous': [69], 'pombe': [73], ',': [74], 'showing': [75], 'function,': [78], 'conserved': [79], 'orthologs,': [81], 'To': [88], 'further': [89], 'explore': [90], 'of': [93, 106, 201, 230], 'level,': [99], 'analyzed': [101], 'within': [110], 'ontology': [112], '(GO)': [113], 'categories.': [114, 197], 'The': [115, 198], 'GO': [116, 130, 174, 196, 202], 'framework': [117], 'systematically': [118, 221], 'defines': [119], 'based': [122, 189], 'on': [123, 190], 'experimental': [124], 'evidence.': [125], 'We': [126, 177], 'several': [129], 'categories': [131, 203], 'contain': [132], 'with': [134, 204], 'statistically': [135], 'significant': [136], 'extremes;': [138], 'example,': [140], 'involved': [142, 153], 'translation': [144], 'or': [145], 'energy': [146], 'production': [147], 'are': [148, 162], 'highly': [149], 'while': [151], 'chromosomal': [155], 'activities,': [156], 'such': [157], 'as': [158], 'replication': [159], 'transcription,': [161], 'weakly': [163], 'expressed.': [164], 'Finally,': [165], 'able': [168], 'predict': [170], 'using': [173], 'information': [175], 'alone.': [176], 'created': [178], 'optimized': [180], 'linear': [182], 'equation': [183], 'predicted': [185], 'membership': [193], '161': [195], 'greater': [199], 'number': [200], 'which': [205], 'associated,': [209], 'more': [211], 'accurately': [212], 'could': [214], 'predicted.': [216], 'Taken': [217], 'together,': [218], 'our': [219], 'analysis': [220], 'demonstrates': [222], 'determinant': [229]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2803323662', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-12-11T01:30:34.909097', 'created_date': '2018-06-01'}