Publication Information

{'id': 'https://openalex.org/W1974116801', 'doi': 'https://doi.org/10.1021/bi801244u', 'title': 'Thermodynamic Reciprocity of the Inhibitor Binding to the Active Site and the Interface Binding Region of IB Phospholipase A2', 'display_name': 'Thermodynamic Reciprocity of the Inhibitor Binding to the Active Site and the Interface Binding Region of IB Phospholipase A2', 'publication_year': 2009, 'publication_date': '2009-03-20', 'ids': {'openalex': 'https://openalex.org/W1974116801', 'doi': 'https://doi.org/10.1021/bi801244u', 'mag': '1974116801', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19301847'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi801244u', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111406856', 'display_name': 'Otto G. Berg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123387679', 'display_name': 'Uppsala University', 'ror': 'https://ror.org/048a87296', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I123387679']}, {'id': 'https://openalex.org/I86501945', 'display_name': 'University of Delaware', 'ror': 'https://ror.org/01sbq1a82', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86501945']}], 'countries': ['SE', 'US'], 'is_corresponding': False, 'raw_author_name': 'Otto G. Berg', 'raw_affiliation_strings': ['Department of Molecular Evolution, Uppsala University Evolutionary Biology Center, Uppsala, Sweden, and Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Evolution, Uppsala University Evolutionary Biology Center, Uppsala, Sweden, and Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716', 'institution_ids': ['https://openalex.org/I123387679', 'https://openalex.org/I86501945']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112471344', 'display_name': 'Bao-Zhu Yu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I123387679', 'display_name': 'Uppsala University', 'ror': 'https://ror.org/048a87296', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I123387679']}, {'id': 'https://openalex.org/I86501945', 'display_name': 'University of Delaware', 'ror': 'https://ror.org/01sbq1a82', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86501945']}], 'countries': ['SE', 'US'], 'is_corresponding': False, 'raw_author_name': 'Bao-Zhu Yu', 'raw_affiliation_strings': ['Department of Molecular Evolution, Uppsala University Evolutionary Biology Center, Uppsala, Sweden, and Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Evolution, Uppsala University Evolutionary Biology Center, Uppsala, Sweden, and Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716', 'institution_ids': ['https://openalex.org/I123387679', 'https://openalex.org/I86501945']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5027457807', 'display_name': 'Mahendra Kumar Jain', 'orcid': 'https://orcid.org/0009-0009-3736-5867'}, 'institutions': [{'id': 'https://openalex.org/I123387679', 'display_name': 'Uppsala University', 'ror': 'https://ror.org/048a87296', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I123387679']}, {'id': 'https://openalex.org/I86501945', 'display_name': 'University of Delaware', 'ror': 'https://ror.org/01sbq1a82', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86501945']}], 'countries': ['SE', 'US'], 'is_corresponding': False, 'raw_author_name': 'Mahendra K. Jain', 'raw_affiliation_strings': ['Department of Molecular Evolution, Uppsala University Evolutionary Biology Center, Uppsala, Sweden, and Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Evolution, Uppsala University Evolutionary Biology Center, Uppsala, Sweden, and Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716', 'institution_ids': ['https://openalex.org/I123387679', 'https://openalex.org/I86501945']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.805, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 6, 'citation_normalized_percentile': {'value': 0.615276, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 80, 'max': 81}, 'biblio': {'volume': '48', 'issue': '14', 'first_page': '3209', 'last_page': '3218'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11908', 'display_name': 'Protein Interaction Studies and Fluorescence Analysis', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13004', 'display_name': 'Vitamin K Research Studies', 'score': 0.9814, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C41183919', 'wikidata': 'https://www.wikidata.org/wiki/Q423026', 'display_name': 'Active site', 'level': 3, 'score': 0.83249706}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.75707597}, {'id': 'https://openalex.org/C107824862', 'wikidata': 'https://www.wikidata.org/wiki/Q616005', 'display_name': 'Binding site', 'level': 2, 'score': 0.7253018}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.537535}, {'id': 'https://openalex.org/C2776551241', 'wikidata': 'https://www.wikidata.org/wiki/Q24768001', 'display_name': 'Phospholipase A2', 'level': 3, 'score': 0.47127908}, {'id': 'https://openalex.org/C67407626', 'wikidata': 'https://www.wikidata.org/wiki/Q5723218', 'display_name': 'Amphiphile', 'level': 4, 'score': 0.43981102}, {'id': 'https://openalex.org/C519063684', 'wikidata': 'https://www.wikidata.org/wiki/Q706', 'display_name': 'Calcium', 'level': 2, 'score': 0.42557377}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.339356}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.3062786}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.20771965}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.11595932}, {'id': 'https://openalex.org/C15920480', 'wikidata': 'https://www.wikidata.org/wiki/Q421281', 'display_name': 'Copolymer', 'level': 3, 'score': 0.07666162}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0648863}, {'id': 'https://openalex.org/C521977710', 'wikidata': 'https://www.wikidata.org/wiki/Q81163', 'display_name': 'Polymer', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D054500', 'descriptor_name': 'Group IB Phospholipases A2', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D013816', 'descriptor_name': 'Thermodynamics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000495', 'descriptor_name': 'Allosteric Site', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001667', 'descriptor_name': 'Binding, Competitive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020134', 'descriptor_name': 'Catalytic Domain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054500', 'descriptor_name': 'Group IB Phospholipases A2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013552', 'descriptor_name': 'Swine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi801244u', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19301847', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation', 'score': 0.42}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1542191530', 'https://openalex.org/W1590150548', 'https://openalex.org/W1969475832', 'https://openalex.org/W1979615065', 'https://openalex.org/W1981995490', 'https://openalex.org/W1988876643', 'https://openalex.org/W1989693197', 'https://openalex.org/W1997414493', 'https://openalex.org/W1998217795', 'https://openalex.org/W2000162559', 'https://openalex.org/W2002434117', 'https://openalex.org/W2005129865', 'https://openalex.org/W2013587333', 'https://openalex.org/W2015942817', 'https://openalex.org/W2017692753', 'https://openalex.org/W2021492290', 'https://openalex.org/W2021972315', 'https://openalex.org/W2021975209', 'https://openalex.org/W2024551959', 'https://openalex.org/W2024994853', 'https://openalex.org/W2043810505', 'https://openalex.org/W2046609888', 'https://openalex.org/W2048537476', 'https://openalex.org/W2058952486', 'https://openalex.org/W2062004826', 'https://openalex.org/W2087033302', 'https://openalex.org/W2090712310', 'https://openalex.org/W2090945725', 'https://openalex.org/W2093299297', 'https://openalex.org/W2116310126', 'https://openalex.org/W2128711965', 'https://openalex.org/W2137637465', 'https://openalex.org/W2144709845', 'https://openalex.org/W2150714032', 'https://openalex.org/W2162988534', 'https://openalex.org/W2169082902', 'https://openalex.org/W2171832378', 'https://openalex.org/W2949246524'], 'related_works': ['https://openalex.org/W4390830021', 'https://openalex.org/W2466802636', 'https://openalex.org/W2397671206', 'https://openalex.org/W2103687648', 'https://openalex.org/W2078051788', 'https://openalex.org/W1988180979', 'https://openalex.org/W1980625821', 'https://openalex.org/W1974116801', 'https://openalex.org/W1973602142', 'https://openalex.org/W1933686656'], 'abstract_inverted_index': {'Interfacial': [0], 'activation': [1, 277, 286, 317], 'of': [2, 13, 32, 43, 58, 89, 96, 106, 122, 131, 142, 163, 172, 251, 287, 295, 318], 'pig': [3], 'pancreatic': [4], 'IB': [5], 'phospholipase': [6], 'A(2)': [7], '(PLA2)': [8], 'is': [9, 62, 113, 198, 214, 234, 312], 'modeled': [10], 'in': [11, 93, 103, 160, 178, 209, 222, 248, 303], 'terms': [12], 'the': [14, 29, 37, 44, 55, 59, 70, 86, 90, 94, 99, 104, 116, 127, 132, 150, 157, 161, 170, 175, 179, 184, 190, 194, 202, 218, 229, 249, 252, 255, 262, 265, 282, 285, 288, 292, 296, 301, 304, 310, 315, 319, 323, 327], 'three': [15], 'discrete': [16], 'premicellar': [17, 74, 91, 180], 'complexes': [18, 75, 92, 134], '(E(i)(#),': [19], 'i': [20, 77], '=': [21, 78], '1,': [22], '2,': [23], 'or': [24, 47, 80], '3)': [25], 'consecutively': [26], 'formed': [27, 102, 144], 'by': [28, 309], 'cooperative': [30, 240], 'binding': [31, 41, 171, 188, 204, 242, 263, 290, 321], 'a': [33, 63, 120, 225, 236, 245], 'monodisperse': [34], 'amphiphile': [35, 241], 'to': [36, 69, 72, 85, 115, 126, 140, 149, 156, 174, 183, 200, 224, 244, 264, 271, 291, 306, 314, 322, 326], 'i-face': [38, 71, 151, 191], '(the': [39], 'interface': [40], 'region': [42], 'enzyme)': [45], 'without': [46], 'with': [48, 135, 145, 169], 'an': [49], 'occupied': [50], 'active': [51, 87, 117, 158, 176, 195, 256, 266, 293], 'site.': [52, 257], 'Monodisperse': [53], 'PCU,': [54], 'sn-2-amide': [56], 'analogue': [57], 'zwitterionic': [60], 'substrate,': [61], 'competitive': [64], 'inhibitor.': [65], 'PCU': [66, 107, 136, 173, 268], 'cooperatively': [67], 'binds': [68, 84, 148, 270], 'form': [73], '(E(i),': [76], '1': [79], '2)': [81], 'and': [82, 108, 119, 192, 274], 'also': [83, 269], 'site': [88, 118, 159, 177, 208, 273, 294], 'presence': [95, 105, 162], 'calcium.': [97], 'In': [98], 'E(i)I': [100], 'complex': [101, 298], 'calcium,': [109, 164], 'one': [110], 'inhibitor': [111, 253, 289, 311], 'molecule': [112], 'bound': [114, 125, 325], 'number': [121], 'others': [123], 'are': [124, 137], 'i-face.': [128, 283], 'The': [129], 'properties': [130], 'E(i)': [133], 'qualitatively': [138], 'similar': [139], 'those': [141], 'E(i)(#)': [143], 'decylsulfate.': [146], 'Decylsulfate': [147], 'but': [152], 'does': [153, 166], 'not': [154], 'bind': [155], 'nor': [165], 'it': [167, 197], 'interfere': [168], 'complexes.': [181, 211, 230], 'Due': [182], 'strong': [185], 'coupling': [186], 'between': [187, 228], 'at': [189, 193], 'site,': [196, 267], 'difficult': [199], 'estimate': [201], 'primary': [203], 'constants': [205], 'for': [206, 254], 'each': [207], 'these': [210], 'A': [212, 231], 'model': [213], 'developed': [215], 'that': [216, 235, 260, 275], 'incorporates': [217], 'above': [219], 'boundary': [220], 'conditions': [221], 'relation': [223], 'detailed': [226], 'balance': [227], 'key': [232], 'result': [233], 'modest': [237], 'effect': [238], 'on': [239, 281], 'corresponds': [243], 'large': [246], 'change': [247], 'affinity': [250], 'We': [258], 'suggest': [259], 'besides': [261], 'another': [272], 'full': [276], 'requires': [278], 'additional': [279], 'amphiphiles': [280], 'Thus,': [284], 'E(2)(#)': [297, 307], 'or,': [299], 'equivalently,': [300], 'shift': [302], 'E(1)(#)': [305], 'equilibrium': [308], 'analogous': [313], 'allosteric': [316], 'substrate': [320], 'enzyme': [324], 'interface.': [328]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1974116801', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-12T13:30:08.874294', 'created_date': '2016-06-24'}