Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1973955621', 'doi': 'https://doi.org/10.1002/bies.950180805', 'title': 'Lens development and crystallin gene expression: many roles for Pax‐6', 'display_name': 'Lens development and crystallin gene expression: many roles for Pax‐6', 'publication_year': 1996, 'publication_date': '1996-08-01', 'ids': {'openalex': 'https://openalex.org/W1973955621', 'doi': 'https://doi.org/10.1002/bies.950180805', 'mag': '1973955621', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8760335'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/bies.950180805', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S27819959', 'display_name': 'BioEssays', 'issn_l': '0265-9247', 'issn': ['0265-9247', '1521-1878'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5064794855', 'display_name': 'Aleš Cvekl', 'orcid': 'https://orcid.org/0000-0002-3957-789X'}, 'institutions': [{'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Aleš Cvekl', 'raw_affiliation_strings': ['Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-2730, USA.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-2730, USA.', 'institution_ids': ['https://openalex.org/I4210139686', 'https://openalex.org/I1299303238']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067297656', 'display_name': 'Joram Piatigorsky', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210139686', 'display_name': 'National Eye Institute', 'ror': 'https://ror.org/03wkg3b53', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joram Piatigorsky', 'raw_affiliation_strings': ['Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-2730, USA.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-2730, USA.', 'institution_ids': ['https://openalex.org/I1299303238', 'https://openalex.org/I4210139686']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.143, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 283, 'citation_normalized_percentile': {'value': 0.999388, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '18', 'issue': '8', 'first_page': '621', 'last_page': '630'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11480', 'display_name': 'Connexins and lens biology', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11480', 'display_name': 'Connexins and lens biology', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 0.906, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/crystallin', 'display_name': 'Crystallin', 'score': 0.8317337}, {'id': 'https://openalex.org/keywords/transdifferentiation', 'display_name': 'Transdifferentiation', 'score': 0.5987332}, {'id': 'https://openalex.org/keywords/pax6', 'display_name': 'PAX6', 'score': 0.4988749}], 'concepts': [{'id': 'https://openalex.org/C7263354', 'wikidata': 'https://www.wikidata.org/wiki/Q2992167', 'display_name': 'Crystallin', 'level': 2, 'score': 0.8317337}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.78180635}, {'id': 'https://openalex.org/C121587040', 'wikidata': 'https://www.wikidata.org/wiki/Q898769', 'display_name': 'Homeobox', 'level': 4, 'score': 0.70678014}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.61973673}, {'id': 'https://openalex.org/C60870556', 'wikidata': 'https://www.wikidata.org/wiki/Q2300675', 'display_name': 'Transdifferentiation', 'level': 3, 'score': 0.5987332}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.58884084}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.56842655}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.5597065}, {'id': 'https://openalex.org/C114696181', 'wikidata': 'https://www.wikidata.org/wiki/Q5422650', 'display_name': 'Eye development', 'level': 4, 'score': 0.5480689}, {'id': 'https://openalex.org/C51816534', 'wikidata': 'https://www.wikidata.org/wiki/Q14916213', 'display_name': 'PAX6', 'level': 4, 'score': 0.4988749}, {'id': 'https://openalex.org/C165864922', 'wikidata': 'https://www.wikidata.org/wiki/Q411391', 'display_name': 'Regulation of gene expression', 'level': 3, 'score': 0.49333516}, {'id': 'https://openalex.org/C15336307', 'wikidata': 'https://www.wikidata.org/wiki/Q1766051', 'display_name': 'Lens (geology)', 'level': 2, 'score': 0.48166335}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.44796634}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.13307178}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003459', 'descriptor_name': 'Crystallins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007908', 'descriptor_name': 'Lens, Crystalline', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003459', 'descriptor_name': 'Crystallins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005136', 'descriptor_name': 'Eye Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007908', 'descriptor_name': 'Lens, Crystalline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007908', 'descriptor_name': 'Lens, Crystalline', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071841', 'descriptor_name': 'PAX6 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051761', 'descriptor_name': 'Paired Box Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012097', 'descriptor_name': 'Repressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/bies.950180805', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S27819959', 'display_name': 'BioEssays', 'issn_l': '0265-9247', 'issn': ['0265-9247', '1521-1878'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8760335', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 71, 'referenced_works': ['https://openalex.org/W1262514376', 'https://openalex.org/W142333331', 'https://openalex.org/W1486241893', 'https://openalex.org/W1501165471', 'https://openalex.org/W1598597199', 'https://openalex.org/W1739497080', 'https://openalex.org/W1784478130', 'https://openalex.org/W1826330550', 'https://openalex.org/W1833110878', 'https://openalex.org/W1923107379', 'https://openalex.org/W1958671947', 'https://openalex.org/W1964761197', 'https://openalex.org/W1965921684', 'https://openalex.org/W1967460110', 'https://openalex.org/W1967778139', 'https://openalex.org/W1971338308', 'https://openalex.org/W1975580682', 'https://openalex.org/W1980134469', 'https://openalex.org/W1986039833', 'https://openalex.org/W1987316236', 'https://openalex.org/W1994881558', 'https://openalex.org/W2002652075', 'https://openalex.org/W2002821352', 'https://openalex.org/W2004069864', 'https://openalex.org/W2012892360', 'https://openalex.org/W2015615191', 'https://openalex.org/W2027402215', 'https://openalex.org/W2029846973', 'https://openalex.org/W2030180991', 'https://openalex.org/W2030447376', 'https://openalex.org/W2033690523', 'https://openalex.org/W2055166643', 'https://openalex.org/W2056418457', 'https://openalex.org/W2067315256', 'https://openalex.org/W2069871555', 'https://openalex.org/W2077185524', 'https://openalex.org/W2079048746', 'https://openalex.org/W2079277502', 'https://openalex.org/W2081530863', 'https://openalex.org/W2081562228', 'https://openalex.org/W2087772215', 'https://openalex.org/W2088432973', 'https://openalex.org/W2101002012', 'https://openalex.org/W2102589238', 'https://openalex.org/W2104302625', 'https://openalex.org/W2108177555', 'https://openalex.org/W2109204015', 'https://openalex.org/W2120272758', 'https://openalex.org/W2121674707', 'https://openalex.org/W2127510589', 'https://openalex.org/W2132549779', 'https://openalex.org/W2133150554', 'https://openalex.org/W2133571580', 'https://openalex.org/W2138434278', 'https://openalex.org/W2139103260', 'https://openalex.org/W2141568746', 'https://openalex.org/W2145297890', 'https://openalex.org/W2146105285', 'https://openalex.org/W2152179968', 'https://openalex.org/W2154040587', 'https://openalex.org/W2161687343', 'https://openalex.org/W2171181428', 'https://openalex.org/W2171508208', 'https://openalex.org/W2173218272', 'https://openalex.org/W2183066763', 'https://openalex.org/W2276595824', 'https://openalex.org/W2432769034', 'https://openalex.org/W4241819085', 'https://openalex.org/W4323238746', 'https://openalex.org/W49271989', 'https://openalex.org/W56466504'], 'related_works': ['https://openalex.org/W2857798364', 'https://openalex.org/W2149404122', 'https://openalex.org/W2144745574', 'https://openalex.org/W2134321528', 'https://openalex.org/W2120213194', 'https://openalex.org/W2058465300', 'https://openalex.org/W2003241066', 'https://openalex.org/W1989799443', 'https://openalex.org/W1589588578', 'https://openalex.org/W1566190075'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1, 69], 'vertebrate': [2], 'eye': [3], 'lens': [4, 60], 'has': [5], 'been': [6], 'used': [7], 'extensively': [8], 'as': [9, 16, 103], 'a': [10, 30, 45, 50, 56, 80], 'model': [11], 'for': [12, 73], 'developmental': [13, 85], 'processes': [14], 'such': [15], 'determination,': [17], 'embryonic': [18], 'induction,': [19], 'cellular': [20], 'differentiation,': [21], 'transdifferentiation': [22], 'and': [23, 53, 62, 86, 93], 'regeneration,': [24], 'with': [25], 'the': [26, 67, 84, 90], 'crystallin': [27, 63, 77], 'genes': [28, 78], 'being': [29], 'prime': [31], 'example': [32], 'of': [33, 71, 75], 'developmentally': [34], 'controlled,': [35], 'tissue‐preferred': [36], 'gene': [37, 64], 'expression.': [38], 'Recent': [39], 'studies': [40], 'have': [41], 'shown': [42], 'that': [43], 'Pax‐6,': [44], 'transcription': [46], 'factor': [47], 'containing': [48], 'both': [49], 'paired': [51], 'domain': [52], 'homeodomain,': [54], 'is': [55], 'key': [57], 'protein': [58], 'regulating': [59], 'determination': [61], 'expression': [65, 74], 'in': [66], 'lens.': [68], 'use': [70], 'Pax‐6': [72], 'different': [76], 'provides': [79], 'new': [81, 97], 'link': [82], 'at': [83], 'transcriptional': [87], 'level': [88], 'among': [89], 'diverse': [91], 'crystallins': [92], 'may': [94], 'lead': [95], 'to': [96], 'insights': [98], 'into': [99], 'their': [100], 'evolutionary': [101], 'recruitment': [102], 'refractive': [104], 'proteins.': [105]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1973955621', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-16T12:37:04.487321', 'created_date': '2016-06-24'}