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113, 122, 126, 159, 195, 203, 218, 228, 258, 267, 271, 353, 397, 403, 439, 446, 451, 647, 661, 665, 764, 826, 880, 890, 952, 970, 974, 991, 995, 1002, 1006, 1012, 1107, 1150, 1202, 1282, 1290, 1330, 1334, 1424, 1431, 1575, 1584, 1600, 1603, 1628, 1701, 1742, 1746, 1756, 1759, 1775, 1782, 1787, 1799, 1837, 1856, 1930, 2034, 2040, 2044, 2051, 2059, 2170, 2193, 2207, 2269, 2316, 2365, 2390, 2398, 2418, 2426, 2438, 2475, 2485, 2503, 2507, 2513, 2518, 2540, 2546, 2549, 2558, 2590, 2593, 2598, 2627, 2681, 2689, 2700, 2708, 2712, 2810, 2818, 2845, 2858, 2881, 2905, 2919, 2930, 2935, 2950, 2996, 3001, 3067, 3135, 3139, 3152, 3174, 3190, 3199, 3203, 3230, 3241, 3246, 3257, 3275, 3282, 3296, 3310, 3327, 3342, 3345, 3426, 3429, 3504, 3510, 3522, 3533, 3549, 3582, 3681, 3694, 3710, 3755, 3762, 3765, 3815, 3825, 3923, 3944, 3967, 3976, 3983, 4012, 4050, 4074, 4080, 4099, 4107, 4126, 4134, 4142, 4152, 4185, 4191, 4217, 4234, 4244, 4249, 4265, 4269, 4279, 4292, 4318, 4323, 4333, 4338, 4348, 4351], 'vertebrate': [15, 160], 'nervous': [16, 161, 1151], 'system.': [17, 162], 'Here,': [18, 163], 'we': [19, 55, 164, 200, 1394, 2537, 2574, 2831, 2975, 3143, 3293, 3420, 3603, 3813, 4213], 'report': [20, 128, 165, 273], 'biochemical': [21, 166], 'studies': [22, 167], 'addressing': [23, 168], 'proteolytic': [24, 114, 143, 169, 259, 288, 588, 3094], 'processing': [25, 170, 589, 668, 1401, 2572, 2632, 3095, 3332, 3347, 3495, 3584, 3718, 3725, 3826, 4280], 'of': [26, 72, 139, 171, 217, 284, 297, 304, 382, 399, 450, 669, 766, 825, 879, 883, 887, 889, 973, 988, 990, 1009, 1011, 1106, 1204, 1208, 1276, 1284, 1292, 1333, 1433, 1518, 1532, 1602, 1630, 1675, 1745, 1755, 1767, 1790, 1802, 1823, 1836, 1841, 1855, 1894, 1980, 2003, 2066, 2085, 2090, 2117, 2219, 2282, 2308, 2368, 2401, 2414, 2420, 2428, 2433, 2437, 2446, 2463, 2506, 2545, 2557, 2613, 2633, 2655, 2662, 2683, 2702, 2711, 2714, 2723, 2777, 2806, 2812, 2825, 2862, 2883, 2894, 2904, 2923, 2937, 2942, 2955, 2981, 3003, 3070, 3113, 3178, 3229, 3245, 3317, 3322, 3329, 3333, 3341, 3348, 3418, 3428, 3474, 3483, 3496, 3506, 3512, 3529, 3532, 3562, 3585, 3592, 3690, 3702, 3719, 3726, 3741, 3764, 3817, 3827, 3936, 3947, 3985, 4070, 4082, 4101, 4106, 4133, 4137, 4200, 4227, 4240, 4248, 4264, 4275, 4281, 4304], 'γ-protocadherins.': [27, 172], 'These': [28, 173, 873, 1736, 2677, 3713], 'type-I': [29, 174], 'transmembrane': [30, 175, 958, 962, 3176], 'proteins': [31, 176, 1857, 2122, 2344, 2370, 2407, 2591, 2606, 2877, 3205, 3259, 3284, 3304, 3316, 4259, 4357], 'cleaved': [33, 178], 'by': [34, 68, 82, 117, 142, 179, 213, 227, 262, 287, 602, 985, 1201, 1287, 1418, 1613, 1623, 1662, 1798, 1805, 1817, 1896, 2038, 2125, 2232, 2357, 2659, 2695, 2707, 2730, 2878, 3074, 3081, 3116, 3163, 3476, 3747, 3754, 3831, 3913, 4155, 4262, 4308, 4312, 4360], 'a': [35, 40, 45, 62, 133, 180, 185, 190, 207, 278, 294, 350, 597, 603, 641, 655, 956, 965, 1083, 1094, 1111, 1205, 1408, 1411, 1490, 1515, 1529, 1536, 1570, 1806, 1813, 1871, 2238, 2291, 2319, 2434, 2444, 2470, 2500, 2554, 2571, 2617, 2715, 2725, 2732, 2803, 2823, 2837, 2841, 2891, 2960, 3020, 3117, 3164, 3208, 3217, 3415, 3436, 3480, 3515, 3530, 3558, 3569, 3722, 3730, 3818, 3953, 3963, 4029, 4036, 4040, 4158, 4301], 'metalloproteinase': [36, 181, 605, 2736, 3119], 'vivo,': [38, 183], 'generating': [39, 184], 'soluble': [41, 186, 642, 2717, 3122], 'extracellular': [42, 187, 812, 1091, 1880, 2477, 2691, 3111, 3154, 4153, 4193], 'fragment': [43, 47, 60, 74, 101, 115, 188, 192, 205, 219, 246, 260, 645, 753, 1415, 2445, 2489, 2519, 2566, 2719, 2726, 2820, 3674, 4032, 4042, 4059, 4076], 'and': [44, 189, 356, 557, 762, 822, 833, 858, 862, 892, 964, 978, 1079, 1114, 1153, 1220, 1404, 1440, 1449, 1473, 1512, 1577, 1650, 1658, 1682, 1697, 1809, 1846, 1886, 1962, 1969, 1987, 2005, 2013, 2033, 2042, 2061, 2087, 2115, 2143, 2189, 2217, 2285, 2294, 2299, 2318, 2334, 2351, 2422, 2479, 2517, 2553, 2588, 2636, 2864, 2983, 3124, 3147, 3180, 3193, 3236, 3266, 3288, 3302, 3337, 3651, 3662, 3908, 3926, 3991, 4019, 4073, 4084, 4220, 4252], 'carboxyl-terminal': [46, 59, 100, 191, 204, 245, 627, 652, 752, 1414, 2346, 2555, 2565], 'associated': [48, 193, 1348], 'with': [49, 194, 301, 386, 808, 1349, 1461, 1569, 1579, 1690, 1758, 1785, 1899, 1924, 1990, 2000, 2047, 2140, 2200, 2211, 2267, 2275, 2290, 2410, 2459, 2578, 2840, 2890, 2965, 3189, 3207, 3281, 3501, 3521, 3665, 3693, 3900, 4125, 4291, 4317], 'cellular': [51, 196], 'membrane.': [52, 197, 648], 'In': [53, 198, 969, 1103, 1407, 2251, 2404, 2494, 2639, 2880, 3556, 3919], 'addition,': [54, 199, 2252, 2405, 3557], 'show': [56, 201, 1395, 3749], 'that': [57, 202, 519, 888, 1087, 1384, 1396, 1420, 1427, 2539, 2583, 2626, 2667, 2680, 2949, 3228, 3263, 3295, 3472, 3717, 3750, 3772, 3955, 3997, 4026, 4092, 4149, 4184, 4278], 'is': [61, 75, 79, 102, 110, 125, 206, 220, 224, 247, 255, 270, 394, 600, 671, 983, 1347, 1416, 2568, 2669, 2686, 2952, 3278, 3339, 3498, 3752, 3837, 3962, 4096, 4157], 'substrate': [63, 208], 'for': [64, 132, 209, 277, 772, 955, 1546, 1589, 1595, 1834, 1971, 2027, 2156, 2248, 2809, 2875, 3022, 3092, 3109, 3537, 4160, 4225], 'further': [65, 210, 517, 2453], 'cleavage': [66, 211, 599, 2685, 2951, 3112, 3141, 3276, 3298, 3343, 3572, 3733, 3843, 4150], 'mediated': [67, 212, 2694, 3115], 'presenilin.': [69, 214], 'Consequently,': [70, 215], 'accumulation': [71, 216, 3482, 3511, 3591, 3701, 3984], 'found': [76, 221, 1156, 2976, 3471], 'when': [77, 107, 222, 252, 2995, 3492, 3542, 4011, 4045, 4119, 4343], 'γ-secretase': [78, 118, 223, 263, 452, 592, 1419, 3597, 4161], 'inactivated': [80, 225], 'either': [81, 226, 4263], 'specific': [84, 229, 3438, 3820], 'presenilin-inhibitor': [85, 230], 'L685,458': [86, 231, 1503, 3477, 3507, 3697, 4321], 'or': [87, 232, 328, 810, 1099, 1563, 1592, 1616, 1635, 1670, 2030, 2120, 2129, 2154, 2529, 2586, 2603, 2860, 3611, 4236, 4246, 4271], 'double': [89, 234, 3612], 'mutant': [90, 235, 3613, 3663, 3682, 3711], 'murine': [91, 236], 'embryonic': [92, 237, 1442, 1445, 2987, 3011], 'fibroblasts': [93, 238, 1452, 2988, 3647], 'lacking': [94, 239, 1985, 3150, 3596, 3617, 4189], 'both': [95, 240, 521, 595, 2512, 2621, 3264, 3300, 3618, 3659, 3922, 4017, 4071, 4102, 4216], 'presenilin': [96, 241, 1501, 3619, 3695, 3977, 4037, 4112, 4127, 4319], 'genes.': [97, 242], 'γ-secretase-generated': [99, 244], 'largely': [103, 248], 'unstable': [104, 249], 'but': [105, 250, 1346, 2483, 2993, 3683, 4336], 'accumulates': [106, 251], 'proteasomal': [108, 253], 'degradation': [109, 254, 765], 'inhibited.': [111, 256], 'Interestingly,': [112, 257, 3066, 4005], 'generated': [116, 261, 984, 1417, 1686], 'can': [119, 264, 442, 1421], 'localize': [120, 265], 'to': [121, 266, 346, 352, 444, 673, 755, 761, 994, 1158, 1281, 1423, 1599, 1751, 1843, 1903, 1929, 1997, 2192, 2323, 2347, 2389, 2644, 2958, 3120, 3134, 3173, 3240, 3309, 3314, 3326, 3509, 3526, 3676, 3705, 3760, 3840, 3982, 4016, 4049, 4207], 'nucleus.': [123, 268], 'This': [124, 269, 1382, 1827, 3223, 4058], 'first': [127, 272, 598, 2476], 'providing': [129, 274, 3089], 'experimental': [130, 275], 'evidence': [131, 276, 3091, 3108], 'cell': [134, 279, 298, 360, 404, 1566, 1641, 1647, 2622, 2865, 2870, 2920, 2971, 3909], 'surface': [135, 280, 405], 'receptor': [136, 281, 894], 'signaling': [137, 282, 1097, 1391], 'function': [138, 283, 1387], 'protocadherins': [140, 285, 1140, 1278], 'regulated': [141, 286], 'events.': [144, 289], 'cadherin': [291, 307, 400, 643, 813], 'superfamily': [292], 'comprises': [293], 'large': [295, 1274], 'number': [296, 1275, 1291], 'adhesion': [299, 361, 806], 'molecules': [300, 807], 'ectodomains': [302], 'composed': [303, 2544], 'multiple': [305], 'Ca2+-binding': [306], 'domains': [308, 817], '(1Angst': [309], 'B.D.': [310], 'Marcozzi': [311], 'C.': [312, 503, 1245, 1261, 2335, 2743, 3881], 'Magee': [313], 'A.I.': [314], 'J.': [315, 368, 412, 427, 467, 526, 548, 566, 691, 719, 741, 782, 924, 926, 1262, 1713, 1715, 1952, 2071, 2794, 3031, 3055, 3354, 3376, 3392], 'Cell': [316, 413, 428, 505, 842, 1436, 2010, 3635], 'Sci.': [317, 480, 704, 903, 2762], '2001;': [318, 484, 708, 939, 1131, 1728], '114:': [319, 575, 791, 3401], '625-626Crossref': [320], 'PubMed': [321, 374, 418, 433, 487, 510, 552, 582, 711, 745, 798, 847, 910, 942, 1044, 1070, 1134, 1190, 1239, 1251, 1268, 1308, 1324, 1377, 1731, 1957, 2076, 2107, 2766, 2799, 3036, 3061, 3380, 3408, 3465, 3640, 3808, 3873, 3892, 4177], 'Google': [322, 377, 421, 436, 490, 513, 555, 585, 714, 748, 801, 850, 913, 945, 1047, 1073, 1137, 1193, 1242, 1254, 1271, 1311, 1327, 1380, 1734, 1958, 2077, 2110, 2769, 2800, 3037, 3064, 3383, 3411, 3468, 3643, 3811, 3876, 3895, 4180], 'Scholar).': [323, 378, 437, 514, 749, 802, 851, 946, 1074, 1138, 1194, 1272, 1328, 1381, 1735, 1959, 2078, 2111, 2770, 2801, 3065, 3412, 3469, 3644, 3896, 4181], 'Classical': [324], 'cadherins': [325, 384, 3350], 'like': [326], 'E-': [327], 'N-cadherin': [329, 558, 751], 'possess': [330], 'five': [331], 'such': [332, 2724], 'domains,': [333], 'typically': [335], 'engage': [336], 'homophilic': [338], 'binding.': [339], 'conserved': [342], 'cytoplasmic': [343, 388, 662, 816, 967], 'domain': [344, 441, 1086, 1113, 1933, 2196, 2367, 2478, 3155, 4154, 4194], 'binds': [345], 'catenins,': [347], 'establish': [349], 'link': [351], 'actin': [354], 'cytoskeleton': [355], 'thus': [357, 1115, 1212, 2624], 'promote': [358], 'cadherin-mediated': [359], '(2Aberle': [362], 'H.': [363, 365, 501, 1174, 1941, 2749, 2783, 3046, 3050, 3052, 3054], 'Schwartz': [364], 'Kemler': [366, 838], 'R.': [367, 570, 786, 839, 1031, 1170, 2753, 3396, 3803, 3868], 'Cell.': [369, 573, 789, 1035, 1315, 3399, 4168], 'Biochem.': [370], '1996;': [371, 3033], '61:': [372, 1249], '514-523Crossref': [373], 'Scopus': [375, 419, 434, 488, 511, 553, 583, 712, 746, 799, 848, 911, 943, 1045, 1071, 1135, 1191, 1240, 1252, 1269, 1309, 1325, 1378, 1732, 2108, 2767, 3062, 3381, 3409, 3466, 3641, 3809, 3874, 3893, 4178], '(724)': [376], 'juxtamembrane': [380], 'region': [381], 'classical': [383, 827, 3349], 'interacts': [385], 'another': [387], 'Armadillo': [389], 'repeat': [390], 'protein,': [391, 768, 959], 'p120,': [392], 'involved': [395, 3580, 4097], 'control': [398], 'levels': [401, 2980, 3069, 3946], 'at': [402, 1005, 1484, 1514, 1528, 1574, 1907, 1974, 2397, 2502, 2844], '(3Davis': [406], 'M.A.': [407], 'Ireton': [408], 'R.C.': [409], 'Reynolds': [410], 'A.B.': [411], 'Biol.': [414, 429, 506, 843, 3636], '2003;': [415, 430, 507, 574, 790, 1265, 1954, 2796, 3400], '163:': [416, 431], '525-534Crossref': [417], '(581)': [420], 'Scholar,': [422, 491, 715, 914, 1048, 1243, 1255, 1312, 3038, 3384, 3877], '4Peifer': [423], 'M.': [424, 471, 695, 837, 928, 1172, 1176, 1178, 1717, 1943, 2755, 2785, 3040, 3048], 'Yap': [425], 'A.S.': [426], '437-440Crossref': [432], '(82)': [435], 'Alternatively,': [438], 'same': [440, 1828], 'bind': [443], 'presenilin,': [445, 3419], 'catalytically': [447], 'active': [448], 'component': [449], 'complex': [453], '(5Baki': [454, 678], 'L.': [455, 536, 679, 729, 1227, 1296, 1947, 2789, 3364, 3624, 3630], 'Marambaud': [456, 680], 'P.': [457, 463, 524, 538, 560, 681, 687, 717, 731, 776, 1027, 1122, 3352, 3366, 3386, 3452, 3785, 3787, 3850, 3852], 'Efthimiopoulos': [458, 539, 682, 732, 3367], 'S.': [459, 482, 532, 540, 683, 706, 725, 733, 905, 1054, 1166, 1361, 3360, 3368, 3885], 'Georgakopoulos': [460, 529, 684, 722, 3357], 'A.': [461, 483, 530, 564, 568, 685, 707, 723, 780, 784, 906, 1058, 1365, 1945, 2787, 3358, 3390, 3394, 3454, 3622, 3801, 3866, 4166], 'Wen': [462, 537, 561, 686, 730, 777, 3365, 3387], 'Cui': [464, 688], 'W.': [465, 689, 3626, 3783, 3848], 'Shioi': [466, 525, 565, 690, 718, 781, 3353, 3391], 'Koo': [468, 692], 'E.': [469, 495, 693, 1125], 'Ozawa': [470, 694], 'Friedrich': [472, 696], 'Jr.,': [473, 697], 'V.L.': [474, 698], 'Robakis': [475, 545, 571, 699, 738, 787, 3373, 3397], 'N.K.': [476, 546, 572, 700, 739, 788, 3374, 3398], 'Proc.': [477, 701, 900], 'Natl.': [478, 702, 901], 'Acad.': [479, 703, 902, 2761], 'U.': [481, 705, 904], '98:': [485, 709, 1317], '2381-2386Crossref': [486, 710], '(159)': [489, 713], '6Edbauer': [492], 'D.': [493, 1257, 1259, 3444, 3628], 'Winkler': [494], 'Regula': [496], 'J.T.': [497], 'Pesold': [498], 'B.': [499, 1015, 2757, 3633, 3781, 3846], 'Steiner': [500], 'Haass': [502, 3880], 'Nat.': [504, 3634], '5:': [508], '486-488Crossref': [509], '(788)': [512], 'Recent': [515], 'reports': [516], 'showed': [518, 2443], 'indeed': [520, 3579], 'E-cadherin': [522, 670], '(7Marambaud': [523, 3351], 'Serban': [527, 720, 3355], 'G.': [528, 721, 3356, 3458, 4164], 'Sarner': [531, 724, 3359], 'Nagy': [533, 726, 3361], 'V.': [534, 727, 3362, 3795, 3860], 'Baki': [535, 728, 3363], 'Shao': [541, 734, 3369], 'Z.': [542, 735, 3370], 'Wisniewski': [543, 736, 3371], 'T.': [544, 737, 899, 918, 936, 1033, 1180, 1314, 1707, 1725, 3042, 3372, 3450, 3879], 'EMBO': [547, 740, 3375], '2002;': [549, 742, 844, 1036, 1062, 1369, 3058, 3377], '21:': [550, 743, 3378], '1948-1956Crossref': [551, 744, 3379], '(632)': [554, 747, 3382], 'Scholar)': [556, 586], '(8Marambaud': [559, 775], 'P.H.': [562, 778, 3388], 'Dutt': [563, 779, 3389], 'Takashima': [567, 783, 3393], 'Siman': [569, 785, 3395], '635-645Abstract': [576, 792, 3402], 'Full': [577, 579, 793, 795, 1039, 1041, 1065, 1067, 1185, 1187, 1234, 1236, 1303, 1305, 1319, 1321, 1372, 1374, 2104, 3403, 3405, 4172, 4174], 'Text': [578, 580, 794, 796, 1040, 1042, 1066, 1068, 1186, 1188, 1235, 1237, 1304, 1306, 1320, 1322, 1373, 1375, 2105, 3404, 3406, 4173, 4175], 'PDF': [581, 797, 1043, 1069, 1189, 1238, 1307, 1323, 1376, 2106, 3407, 4176], '(432)': [584, 800, 3410], 'undergo': [587, 1399], 'events': [590], 'involving': [591], 'activity.': [593, 3598], 'For': [594, 1553, 1765, 1781, 2021, 2973, 4141], 'executed': [601], 'matrix': [604, 612, 3118], '(MMP)': [606], '1The': [607], 'abbreviations': [608], 'used': [609, 1483, 1513, 1527, 1833, 2155, 2337, 3018, 3604, 4204], 'are:': [610], 'MMP,': [611], 'metalloproteinase;': [613], 'GFP,': [614, 1786], 'green': [615, 620, 1761], 'fluorescent': [616, 621, 1762], 'protein;': [617, 622, 625], 'eGFP,': [618], 'enhanced': [619, 1760], 'CBP,': [623], 'CREB-binding': [624, 767], 'CTF,': [626], 'fragment;': [628, 631], 'NTF,': [629, 2830], 'amino-terminal': [630, 644], 'MEF,': [632], 'mouse': [633, 1676, 2986], 'embryo': [634], 'fibroblast(s);': [635], 'WT,': [636], 'wild': [637, 3608, 3660], 'type.': [638], 'activity,': [639, 4113], 'shedding': [640, 2709], 'off': [646, 2710], 'remaining,': [650], 'membrane-associated,': [651], 'part': [653], 'undergoes': [654], 'presenilin-dependent': [656, 1405, 3493, 3723, 3766], 'intramembrane': [657], 'cleavage,': [658], 'releases': [660], 'portion': [663, 2556], 'into': [664, 1093, 1741, 1774, 2310, 2328, 2649, 3272, 3335, 3770, 4283], 'cytosol.': [666], 'proposed': [672], 'modulate': [674], 'its': [675], 'adhesive': [676, 1215, 1293], 'properties': [677, 832, 3244], '7Marambaud': [716], 'seems': [754, 2957], 'affect': [756, 3841], 'expression': [758, 1203, 1610, 1748, 1766, 1777], 'via': [759], 'binding': [760, 831], 'inducing': [763], 'an': [769, 1214, 1879, 1887, 2311, 2361, 2670, 2696, 2773, 3110, 3590, 3700, 3992, 4093], 'essential': [770], 'co-factor': [771], 'CREB-mediated': [773], 'transcription': [774, 1664], 'Protocadherins': [803], 'six': [809], 'seven': [811], 'motifs.': [814], 'Their': [815], 'diverge': [818], 'from': [819, 823, 1142, 1489, 1535, 1687, 1812, 2058, 2315, 2527, 2570, 2630, 3607, 4314], 'each': [820, 950, 972, 1010], 'other': [821, 1100], 'those': [824, 3097], 'cadherins,': [828, 1209], 'indicating': [829, 3262, 4091, 4277], 'different': [830, 1090, 2342, 2461, 3210, 3242], 'intracellular': [834, 1096, 1888], 'functions': [835, 1429], '(9Frank': [836], 'Curr.': [840], 'Opin.': [841], '14:': [845], '557-562Crossref': [846], '(221)': [849], 'α,': [856], 'β,': [857], 'γ': [859, 1081, 1337, 1386, 1398], '(Pcdhα,': [860], '-β,': [861], '-γ)': [863], 'together': [866, 1000, 4086], 'more': [868, 2646, 4197], 'than': [869, 2651, 4065], '50': [870], 'proteins.': [872, 3248], 'have': [875, 1154, 1934, 2772, 2822, 3015, 3216], 'attracted': [876], 'attention': [877], 'because': [878], 'unusual': [881], 'organization': [882], 'arrayed': [884], 'genes,': [885], 'reminiscent': [886, 3340], 'immunoglobulin': [891], 'T-cell': [893], 'loci': [895], '(10Wu': [896], 'Q.': [897, 916, 1029, 1705], 'Maniatis': [898, 935, 1032, 1724], '2000;': [907, 1248, 3462, 3637, 4169], '97:': [908], '3124-3129Crossref': [909], '(98)': [912], '11Wu': [915], 'Zhang': [917, 931, 1706, 1720], 'Cheng': [919, 1708], 'J.F.': [920, 1709], 'Kim': [921, 1020, 1710], 'Y.': [922, 1021, 1711, 2760, 3044, 3887], 'Grimwood': [923, 1712], 'Schmutz': [925, 1714], 'Dickson': [927, 1716], 'Noonan': [929, 1718], 'J.P.': [930, 1719], 'M.Q.': [932, 1721], 'Myers': [933, 1722], 'R.M.': [934, 1723], 'Genome': [937, 1726], 'Res.': [938, 1727, 3057], '11:': [940, 1729], '389-404Crossref': [941, 1730], '(204)': [944, 1733], 'Large': [947], '“variable”': [948], 'exons': [949, 993], 'comprise': [951], 'coding': [953], 'information': [954, 1092], 'complete': [957, 2048, 3153], 'including': [960, 1353, 1402], 'ectodomain,': [961], 'segment,': [963], 'short': [966, 1412, 3777], 'tail.': [968], 'mouse,': [971], '14': [975], 'possible': [976, 980, 3416], 'Pcdhα': [977], '22': [979], 'Pcdhγ': [981, 1428, 1671, 1702, 1931, 2194, 2309, 2331, 2343, 2369, 2541, 2550, 2690, 2967, 3114, 3130], 'transcripts': [982], 'alternative': [986], 'splicing': [987], 'one': [989, 3587], 'variable': [992, 2509, 2559], 'three': [996, 2329], 'small': [997, 4108, 4302], 'exons,': [998], 'constant': [1003, 1085, 1112, 1672, 1932, 2195, 2366, 2551], 'portion,': [1004], '3′-': [1007], 'end': [1008, 2505], '(12Tasic': [1014], 'Nabholz': [1016], 'C.E.': [1017], 'Baldwin': [1018], 'K.K.': [1019], 'Rueckert': [1022], 'E.H.': [1023, 3793, 3858], 'Ribich': [1024], 'S.A.': [1025], 'Cramer': [1026], 'Wu': [1028], 'Axel': [1030], 'Mol.': [1034, 4167], '10:': [1037], '21-33Abstract': [1038], '(246)': [1046], '13Wang': [1049], 'X.': [1050, 1357], 'Weiner': [1051, 1358], 'J.A.': [1052, 1359], 'Levi': [1053, 1360], 'Craig': [1055, 1362], 'A.M.': [1056, 1363], 'Bradley': [1057, 1364], 'Sanes': [1059, 1366], 'J.R.': [1060, 1367], 'Neuron.': [1061, 1181, 1230, 1299, 1368], '36:': [1063, 1370, 3890], '843-854Abstract': [1064, 1371], '(211)': [1072, 1379], 'Thus,': [1075], 'all': [1076, 1854, 2640, 4242], 'Pcdhs': [1077, 1080, 1105, 1397, 1757, 1769, 1842], 'α': [1078], 'share': [1082], 'family-specific': [1084], 'could': [1088, 1279, 3237, 4214], 'transduce': [1089], 'common': [1095], 'pathway': [1098], 'executive': [1101], 'functions.': [1102], 'contrast,': [1104, 2495], 'β': [1108], 'cluster': [1109, 1338, 1703], 'lack': [1110], 'represent': [1116], 'single-exon': [1117], 'genes': [1118, 3620], '(14Vanhalst': [1119], 'K.': [1120, 1164, 3789, 3854], 'Kools': [1121], 'Vanden': [1123], 'Eynde': [1124], 'van': [1126], 'Roy': [1127], 'F.': [1128, 2747], 'FEBS': [1129], 'Lett.': [1130], '495:': [1132], '120-125Crossref': [1133], '(26)': [1136], 'derived': [1141, 2569], 'these': [1143, 1900, 2455, 2535, 3291, 3646], 'predominantly': [1147], 'system': [1152], 'been': [1155, 1935, 3016, 3999, 4147], 'localized': [1157], 'synaptic': [1159], 'junctions': [1160], '(15Kohmura': [1161], 'N.': [1162, 1168, 2759, 3028], 'Senzaki': [1163], 'Hamada': [1165], 'Kai': [1167], 'Yasuda': [1169, 1175], 'Watanabe': [1171], 'Ishii': [1173], 'Mishina': [1177], 'Yagi': [1179], '1998;': [1182], '20:': [1183], '1137-1151Abstract': [1184], '(392)': [1192], 'Functionally': [1195], 'connected': [1196], 'neurons': [1197], 'often': [1199], 'characterized': [1200], 'distinct': [1206, 1277], 'set': [1207], 'may': [1211, 3775], 'provide': [1213, 3106], 'code': [1216], 'regulating': [1217], 'neuronal': [1218, 1285, 1354, 3023], 'differentiation': [1219, 3024, 3079], 'synaptogenesis': [1221], '(for': [1222], 'reviews,': [1223], 'see': [1224, 2990], 'Refs.': [1225], '16Shapiro': [1226], 'Colman': [1228, 1297, 1950, 2792], 'D.R.': [1229, 1298, 1951, 2793], '1999;': [1231, 1300, 1316, 3805, 3870], '23:': [1232, 1301, 1955, 2797], '427-430Abstract': [1233, 1302], '(186)': [1241, 1310], '17Redies': [1244], 'Prog.': [1246], 'Neurobiol.': [1247], '611-648Crossref': [1250], '(287)': [1253], '18Heyers': [1256], 'Kovjanic': [1258], 'Redies': [1260], 'Comp.': [1263], 'Neurol.': [1264], '460:': [1266], '155-166Crossref': [1267], '(25)': [1270], 'contribute': [1280], 'complexity': [1283], 'connections': [1286], 'significantly': [1288], 'increasing': [1289], 'combinations': [1294], '(16Shapiro': [1295], '19Serafini': [1313], '133-136Abstract': [1318], '(62)': [1326], 'However,': [1329, 3274], 'genetic': [1331], 'loss': [1332], 'entire': [1335, 4192], 'Pcdh': [1336, 1385], 'has': [1339, 4146], 'no': [1340, 2525, 3940], 'obvious': [1341], 'effect': [1342, 3816, 3942], 'on': [1343, 1559, 1564, 1652, 1693, 1698, 1919, 2127, 2226, 2237, 2260, 2273, 3824, 3943], 'synapse': [1344], 'formation': [1345], 'severe': [1350], 'neurological': [1351], 'defects,': [1352], 'degeneration': [1355], '(13Wang': [1356], 'indicates': [1383], 'also': [1388, 2442, 2963, 3007, 3524, 4033], 'involves': [1389, 3721], 'unknown': [1390, 3563], 'processes.': [1392], 'Here': [1393], 'endoproteolytic': [1400, 2631, 2684], 'metalloproteinase-': [1403], 'cleavages.': [1406], 'final': [1409, 1487, 1516, 1530], 'step,': [1410], 'lived': [1413, 3778], 'translocate': [1422], 'nucleus,': [1425], 'suggesting': [1426, 4025], 'regulation': [1432], 'transcription.': [1435], 'Culture,': [1437], 'Drug': [1438], 'Treatments,': [1439], 'Transfections—Mouse': [1441], 'fibroblasts,': [1443], 'human': [1444], 'kidney': [1446], '293': [1447, 1590, 1920, 2338, 2581, 2834, 3184, 3423, 3543, 3834], 'cells,': [1448, 1597, 2885, 3013, 3921], 'COS-7': [1450, 1596], 'monkey': [1451], 'were': [1453, 1544, 1557, 1621, 1643, 1685, 1739, 1772, 1876, 1917, 1964, 2016, 2025, 2056, 2080, 2123, 2138, 2167, 2209, 2271, 2288, 2297, 2355, 2408, 2465, 2607, 2873, 2944, 2998, 3186, 3196, 3252, 3268, 3898, 3911, 3928, 4014, 4047, 4077, 4230, 4260, 4363], 'cultured': [1454, 1965, 2999, 3421], "Dulbecco's": [1456, 1981], 'modified': [1457, 1982], "Eagle's": [1458, 1983], 'medium': [1459, 1984, 2046], 'supplemented': [1460, 1989], '10%': [1462, 1991], 'fetal': [1463, 1993], 'calf': [1464, 1994], 'serum,': [1465, 1995], '100': [1466, 1470, 1474], 'μm': [1467, 1486], 'sodium': [1468], 'pyruvate,': [1469], 'units/ml': [1471], 'penicillin,': [1472], 'μg/ml': [1475, 1534], 'streptomycin.': [1476], 'proteasome': [1478, 3821, 4051], 'inhibitor': [1479, 1502, 1523, 2737, 3440, 3523, 3696, 3978, 4052, 4128, 4320], 'lactacystin': [1480, 4053, 4083, 4120, 4251, 4344], '(Calbiochem)': [1481], 'was': [1482, 1505, 1526, 1611, 1660, 1794, 1832, 2036, 2230, 2255, 2532, 2855, 2897, 2915, 2932, 3006, 3086, 3167, 3565, 3656, 3678, 3707, 3758, 4009, 4060, 4116, 4121, 4285, 4306, 4341, 4345], '5': [1485, 1491, 4238, 4273], 'concentration': [1488, 1517, 1531], 'mm': [1492], 'stock': [1493, 1539], 'solution': [1494], 'prepared': [1495, 4231], 'dimethyl': [1497], 'sulfoxide': [1498], '(Me2SO).': [1499], '(Sigma)': [1504], 'dissolved': [1506], 'Me2SO': [1508], '(at': [1509], '2': [1510, 4062], 'mm)': [1511], '2–10': [1519], 'μm.': [1520], 'metalloprotease': [1522], 'GM6001': [1524, 3937, 4020, 4085, 4138], '(Biomol)': [1525], '10': [1533, 2128], '1': [1537, 1978, 2031], 'mg/ml': [1538], 'Me2SO.': [1541], 'Inhibitor': [1542], 'treatments': [1543], 'performed': [1545, 2081, 2575, 2856, 2933, 3197], '12–16': [1547], 'h': [1548, 1973, 4239, 4274], 'if': [1549, 3959], 'not': [1550, 2450, 2484, 2675, 2994, 3100, 3486, 3684, 3839, 4117, 4286, 4311, 4337, 4358], 'indicated': [1551, 2666], 'otherwise.': [1552], 'transient': [1554], 'transfections,': [1555], 'cells': [1556, 1591, 1626, 1921, 2015, 2024, 2041, 2055, 2224, 2258, 2339, 2531, 2582, 2665, 2835, 2925, 3076, 3098, 3185, 3424, 3544, 3595, 4013, 4046], 'plated': [1558], '6-well': [1560, 1967, 2263], 'plates': [1561, 1654, 1968, 2060], '(Costar)': [1562], '35-mm': [1565], 'culture': [1567, 2011, 2871, 2921], 'dishes': [1568, 2229], 'glass': [1571, 2227], 'coverslip': [1572], 'attached': [1573], 'bottom': [1576, 2228], 'transfected': [1578, 1625, 1923, 2580, 2833, 2884, 2924, 3188, 3833], 'DNA': [1580], '(5': [1581], 'μg/well)': [1582], 'using': [1583, 1645, 1668, 2082, 2169, 2244, 2360, 3198, 3916], 'calcium': [1585], 'phosphate': [1586], 'precipitation': [1587], 'method': [1588], 'Polyfect': [1593], 'reagent': [1594], 'according': [1598], 'instructions': [1601], 'manufacturer': [1604], '(Qiagen,': [1605], 'Germany).': [1606, 1780, 1826, 1914, 2136], 'After': [1607, 2050, 2198, 2265], '48–72': [1608], 'h,': [1609, 2032], 'analyzed': [1612, 1858, 1864, 2256, 2356, 2832, 2874, 3912], 'Western': [1614, 2113, 2286, 2358, 3194, 3914, 4293], 'blotting': [1615, 2359], 'fluorescence': [1617, 2221, 2254], 'microscopy.': [1618], 'Stable': [1619], 'transfectants': [1620], 'obtained': [1622, 1661, 2658], 'culturing': [1624], 'presence': [1629, 2861, 2936, 3002, 3427, 3505, 4081, 4136, 4247], 'G418': [1631], '(700': [1632], 'μg/ml;': [1633, 1638], 'Invitrogen)': [1634, 1667], 'zeocyin': [1636], '(500': [1637], 'Invitrogen).': [1639], 'Clonal': [1640], 'lines': [1642], 'established': [1644, 3606], 'fluorescence-activated': [1646], 'sorting': [1648], 'technology': [1649], 'selection': [1651], '96-well': [1653], '(Greiner).': [1655], 'cDNA': [1656, 1694], 'Constructs': [1657], 'Antibodies—cDNA': [1659], 'reverse': [1663], '(Superscript': [1665], 'II;': [1666], 'oligo(dT)': [1669], 'region-specific': [1673], 'priming': [1674], 'brain': [1677], 'total': [1678], 'RNA.': [1679], 'Full-length': [1680], 'PcdhγA3': [1681, 2642, 3146, 3179, 3301], 'PcdhγC3': [1683, 1791, 1895, 2464, 2508, 2814, 2838, 2982, 3072, 3148, 3181, 3547, 3649, 3653, 3828], 'constructs': [1684, 1771], 'PCR': [1688, 1737], 'amplifications': [1689], 'Pcdh-specific': [1691], 'primers': [1692], '(constant': [1695], 'region)': [1696], 'BAC-DNA': [1699], 'spanning': [1700], '(11Wu': [1704], 'products': [1738], 'cloned': [1740, 1773], 'reading': [1743], 'frame': [1744, 1797], 'pEGFPN1': [1747], 'vector': [1749, 1778], '(Clontech)': [1750], 'give': [1752], 'COOH-terminal': [1753, 1848, 3732], 'fusions': [1754], 'protein': [1763, 2157, 2516, 2526, 2673, 2839, 2889, 2968, 3531, 3829, 3925, 4331], '(eGFP).': [1764], 'untagged': [1768], 'γ,': [1770], 'pcDNA3.1.zeo': [1776, 1793], '(Invitrogen,': [1779], 'NH2-terminal': [1783, 2718, 2819, 3172], 'fusion': [1784, 2393, 2605], 'signal': [1788, 1800, 3160], 'sequence': [1789, 1801, 1829, 2324, 3161], 'replaced': [1795], 'Igα': [1803], 'followed': [1804, 3162], 'FLAG': [1807, 3165, 4339], 'tag': [1808, 2843, 3166, 3551, 4222, 4335, 4340], 'eGFP': [1810, 2220, 2249, 2253], 'taken': [1811], 'construct': [1814, 4206], 'kindly': [1815], 'provided': [1816], 'Dr.': [1818], 'Stefan': [1819], 'Kuppig': [1820], '(Max-Planck': [1821], 'Institute': [1822], 'Immunobiology,': [1824], 'Freiburg,': [1825], '(without': [1830], 'GFP)': [1831], 'cloning': [1835], 'extracellularly': [1838], 'truncated': [1839, 3145], 'version': [1840], 'produce': [1844, 3121], 'FLAG-γA3': [1845], 'FLAG-γC3': [1847], 'GFP': [1849, 2348, 2547, 2594, 2842, 2911, 3550, 4334], 'fusions.': [1850], 'Table': [1851, 2851, 3157], 'I': [1852], 'lists': [1853], 'this': [1860, 1866, 2564, 3502, 3601, 4006, 4205], 'study.Table': [1861], 'IProtocadherin': [1862], 'γ-molecules': [1863], 'study': [1867], 'Open': [1868], 'table': [1869], 'new': [1872], 'tab': [1873], 'Anti-PcdhγC3': [1874], 'antibodies': [1875, 1928, 2191, 2203, 2379, 2385, 2457, 2468, 3251, 3667, 4224, 4362], 'raised': [1877, 2498], 'against': [1878, 2364, 2499], 'epitope': [1881, 1889, 2472], '(γC3a,': [1882], 'amino': [1883, 1891, 3170], 'acids': [1884, 1892, 3171], '71–86)': [1885], '(γC3b,': [1890], '792–809)': [1893], 'boosting': [1897], 'rabbits': [1898], 'peptides': [1901], 'coupled': [1902], 'keyhole': [1904], 'limpet': [1905], 'hemocyanin': [1906], '30-day': [1908], 'intervals': [1909], '(Pineda': [1910], 'Antibody': [1911], 'Service,': [1912], 'Berlin,': [1913], 'antisera': [1916], 'tested': [1918], 'transiently': [1922, 3187], 'PcdhγC3-eGFP.': [1925], 'rabbit': [1927, 2174, 2178, 2182, 2185, 2190], 'previously': [1937], '(20Phillips': [1938, 2780], 'G.R.': [1939, 2781], 'Tanaka': [1940, 2782], 'Frank': [1942, 2784], 'Elste': [1944, 2786], 'Fidler': [1946, 2788], 'Benson': [1948, 2790], 'D.L.': [1949, 2791], 'Neurosci.': [1953, 2795, 3032, 3056], '5096-5104Crossref': [1956, 2798], 'Metabolic': [1960], 'Labeling': [1961], 'Immunoprecipitations—Cells': [1963], 'starved': [1970], '1–2': [1972, 2083], '37': [1975], '°C': [1976], 'ml/well': [1979], 'methionine': [1986], 'cysteine,': [1988], 'dialyzed': [1992], 'prior': [1996], 'biosynthetic': [1998], 'labeling': [1999, 2045, 2854, 2931], '80': [2001], 'μCi': [2002], '[35S]methionine': [2004], '[35S]cysteine': [2006], '(Promix™;': [2007], 'Amersham': [2008], 'Biosciences).': [2009], 'supernatants': [2012, 2872], 'washed': [2014, 2054], 'collected': [2017], 'after': [2018, 2597, 4233, 4237, 4268, 4272], 'overnight': [2019], 'incubation.': [2020], 'pulse-chase': [2022, 2576, 3968, 4209], 'experiments,': [2023, 2641], 'labeled': [2026], '30': [2028], 'min': [2029], 'chase': [2035, 3517, 4349], 'initiated': [2037], 'washing': [2039], 'replacing': [2043], 'medium.': [2049], 'times': [2052], 'indicated,': [2053], 'scraped': [2057], 'solubilized': [2062], '300': [2064], 'μl': [2065, 2089], 'NET': [2067], 'buffer': [2068], '(21Kessler': [2069], 'S.W.': [2070], 'Immunol.': [2072], '1975;': [2073], '115:': [2074], '1617-1624Crossref': [2075], 'Immunoprecipitations': [2079], 'μg': [2084], 'antibody': [2086], '25': [2088], 'postnuclear': [2091], 'supernatant/sample,': [2092], 'essentially': [2093], 'as': [2094, 2375, 2377, 2848, 2867, 2869, 3019, 3903, 4035, 4254], '(22Kaloff': [2096], 'C.R.': [2097], 'Haas': [2098], 'I.G.': [2099], 'Immunity.': [2100], '1995;': [2101], '2:': [2102, 3638], '629-637Abstract': [2103], '(68)': [2109], 'SDS-PAGE,': [2112], 'Blotting,': [2114], 'Detection': [2116], 'Radiolabeled': [2118], 'Proteins—Lysate': [2119], 'immunoprecipitated': [2121, 2589, 4261, 4359], 'separated': [2124], 'SDS-PAGE': [2126], '8–16%': [2130], 'gradient': [2131], 'gels': [2132], '(Fermentas,': [2133], 'St.': [2134], 'Leon-Rot,': [2135], 'Gels': [2137], 'stained': [2139], 'Coomassie': [2141], 'Blue': [2142], 'incubated': [2144], 'Amplify': [2146], '(Amersham': [2147], 'Biosciences)': [2148], 'before': [2149, 4001], 'fluorography': [2150], '(Eastman': [2151], 'Kodak': [2152], 'Co.)': [2153], 'transfer': [2158], 'onto': [2159], 'nitrocellulose': [2160], 'membranes': [2161], '(Schleicher': [2162], '&': [2163], 'Schuell).': [2164], 'Reactive': [2165], 'bands': [2166, 2387, 3255], 'detected': [2168, 2386, 2480, 2608, 2898, 2916, 2964, 3008, 3657, 3679, 3929, 4078, 4118, 4342], 'following': [2171], 'primary': [2172], 'antibodies:': [2173], 'anti-GFP': [2175, 2378, 3250, 4218, 4309], '(1:500;': [2176], 'Clontech),': [2177], 'anti-FLAG': [2179, 3200, 4221, 4361], '(1:400;': [2180], 'Sigma),': [2181], 'anti-C3a': [2183], '(1:2,000),': [2184], 'anti-C3b': [2186, 2496, 3666, 3917], '(1:': [2187], '20,000),': [2188], '(1:2,000).': [2197], 'incubation': [2199], 'peroxidase-coupled': [2201], 'anti-rabbit': [2202], '(Jackson/Dianova,': [2204], 'Heidelberg,': [2205], 'Germany),': [2206], 'blots': [2208, 2287, 3195], 'developed': [2210], 'chemiluminiscent': [2212], 'reagents': [2213], '(Pierce).': [2214], 'Fluorescence': [2215], 'Microscopy': [2216], 'Imaging—Analysis': [2218], 'living': [2223], 'grown': [2225, 2259], 'done': [2231], 'confocal': [2233], 'laser': [2234], 'scanning': [2235], 'microscopy': [2236], 'Leica': [2239], 'DMIre2': [2240], 'inverted': [2241], 'microscope': [2242], 'setup': [2243], 'appropriate': [2245], 'filter': [2246], 'settings': [2247], 'detection.': [2250], 'coverslips': [2261, 2270], 'plates.': [2264], 'fixation': [2266], 'paraformaldehyde,': [2268], 'mounted': [2272], 'slides': [2274], 'Fluoromount-G': [2276], '(Southern': [2277], 'Biotechnology,': [2278], 'Birmingham,': [2279], 'AL).': [2280], 'Films': [2281], 'fluorographs,': [2283], 'gels,': [2284], 'scanned': [2289], 'flatbed': [2292], 'scanner,': [2293], 'digital': [2295], 'images': [2296], 'imported': [2298], 'processed': [2300, 2648, 3271, 3753], 'Photoshop': [2302], 'software': [2303], '(Adobe).': [2304], 'Matrix': [2305], 'Metalloproteinase-mediated': [2306], 'Cleavage': [2307, 3128, 3739], 'Amino-terminal': [2312], 'Fragment': [2313], 'Shed': [2314], 'Membrane': [2317], 'Membrane-bound': [2320], 'Carboxyl-terminal': [2321], 'Fragment—According': [2322], 'homologies,': [2325], 'γ-protocadherins': [2326, 2956, 3334, 3720], 'fall': [2327], 'subclasses,': [2330], 'A,': [2332], 'B,': [2333], 'We': [2336, 3470, 4182, 4203], 'expressing': [2340], 'two': [2341, 2460, 3204], 'fused': [2345], '(i.e.': [2349], 'PcdhγC3-GFP': [2350, 2421, 2482, 2515, 2587, 2604], 'PcdhγA3-GFP).': [2352], 'Cellular': [2353], 'extracts': [2354, 3910], 'antiserum': [2362], 'directed': [2363], '(Fig.': [2371, 2380, 2430, 2490, 2520, 2609, 2899, 2926, 3182, 3212, 3221, 3518, 3552, 3668, 3930, 3949, 3987, 4021, 4054, 4087], '1A,': [2372, 2381, 2491, 2521], 'lanes': [2373, 2382], '1–3)': [2374], 'well': [2376, 2868], '4–6).': [2383], 'Both': [2384], 'corresponding': [2388, 2716, 3675], 'full-length': [2391, 2481, 2514, 2601, 2634, 2887, 3652, 3924, 4257], 'Pcdhγ-GFP': [2392], 'migrated': [2396, 3206], 'expected': [2399, 2906, 3491, 3536, 3958], 'position': [2400], '∼150': [2402, 2895], 'kDa.': [2403, 2827], 'smaller': [2406, 4041, 4064, 4075, 4330], 'detected,': [2409, 2945, 3088, 3566], 'apparent': [2411, 2774, 4044], 'molecular': [2412, 2487, 2775, 2804, 2892, 3219, 3319, 3534], 'masses': [2413], '∼50': [2415], 'kDa': [2416, 2424, 2448, 2779, 2808, 2896, 2909, 4063], 'case': [2419, 2427], '∼65': [2423], 'PcdhγA3-GFP': [2429, 2585, 2635], '1A).': [2431, 3289], 'Analysis': [2432], 'second': [2435, 3570, 3731, 4030], 'member': [2436], 'PcdhγA': [2439], 'subclass,': [2440], 'PcdhγA1-GFP,': [2441], '65': [2447], '(data': [2449, 2674, 3099, 3485], 'shown).': [2451, 2676, 3101], 'To': [2452, 2561, 2828, 3413, 3599], 'characterize': [2454], 'fragments,': [2456], 'reacting': [2458], 'epitopes': [2462], 'used.': [2466], 'Anti-C3a': [2467], 'recognize': [2469], 'peptide': [2471, 2501], 'present': [2473, 4346], 'lower': [2486, 4068], 'weight': [2488], 'lane': [2492, 2522, 3932, 3951, 3989, 4023, 4056, 4089], '7).': [2493], 'antibodies,': [2497, 4266], 'very': [2504, 4287], 'domain,': [2510, 2552, 2692], 'recognized': [2511], '10),': [2523], 'whereas': [2524], 'untransfected': [2528], 'PcdhγA3-GFP-expressing': [2530, 3422], 'labeled.': [2533], 'From': [2534, 3290], 'results,': [2536, 3292], 'conclude': [2538, 3294], 'fragments': [2542, 2628, 3774], 'moiety,': [2548], 'domain.': [2560], 'investigate': [2562, 3414], 'whether': [2563], '(CTF)': [2567], 'event,': [2573], 'experiments': [2577, 4210], 'stably': [2579, 3832], 'express': [2584, 3648], 'carrying': [2592, 4332], 'moiety.': [2595], 'Directly': [2596], 'pulse,': [2599], 'only': [2600, 2886, 2939, 4300], 'PcdhγA3-': [2602], '1B).': [2610, 3973], 'Increasing': [2611], 'amounts': [2612, 2941, 4069], 'CTF': [2614, 2650, 2668, 2703, 2811, 2984, 3315, 3336, 3484, 3497, 3539, 3927, 3960, 4072, 4284, 4305], 'appeared': [2615, 2643], 'time-dependent': [2618, 3481], 'fashion': [2619], 'lines,': [2623], 'demonstrating': [2625], 'result': [2629, 3954], 'PcdhγC3-GFP,': [2637], 'respectively.': [2638], 'be': [2645, 2705, 2728, 2959, 3238, 3490, 3776, 3957], 'rapidly': [2647], 'PcdhγC3.': [2652, 3575], 'Carbonate': [2653], 'extraction': [2654], 'membrane': [2656, 2672, 2713], 'fractions': [2657], 'differential': [2660], 'centrifugation': [2661], 'mechanically': [2663], 'broken': [2664], 'integral': [2671], 'findings': [2678], 'suggest': [2679], 'site': [2682, 3573], 'located': [2687], 'possibly': [2693, 3567], 'MMP.': [2697], 'If': [2698, 3576], 'so,': [2699], 'generation': [2701, 3763, 4100, 4105], 'should': [2704, 2727, 2821], 'accompanied': [2706], '(NTF).': [2720], 'release': [2722], 'inhibited': [2729], 'GM6001,': [2731, 2863, 2938], 'synthetic': [2733], 'broad': [2734], 'range': [2735], '(23Galardy': [2738], 'R.E.': [2739], 'Cassabonne': [2740], 'M.E.': [2741, 2751], 'Giese': [2742], 'Gilbert': [2744], 'J.H.': [2745], 'Lapierre': [2746], 'Lopez': [2748], 'Schaefer': [2750], 'Stack': [2752], 'Sullivan': [2754], 'Summers': [2756], 'Ann.': [2758], '1994;': [2763], '732:': [2764], '315-323Crossref': [2765], '(153)': [2768], 'γ-Protocadherins': [2771], 'mass': [2776, 2805, 2824, 2893, 3220, 3535], '∼120': [2778], 'Calculating': [2802], '20–25': [2807], 'unmodified': [2813, 3538], '(see': [2815, 3156, 4002, 4322, 4350], 'Fig.': [2816, 3234, 3906, 3972, 4003, 4297, 4326, 4354], '3B),': [2817], '∼100': [2826], 'detect': [2829], 'producing': [2836], 'NH2': [2846], 'terminus,': [2847], 'pictured': [2849], 'I.': [2852], 'Biosynthetic': [2853], 'absence': [2859, 4245], 'lysates': [2866], 'GFP-tagged': [2876], 'immunoprecipitation.': [2879], 'lysate': [2882], 'GFP-PcdhγC3': [2888], '1C).': [2900], 'A': [2901, 3159], 'GFP-containing': [2902], 'NTF': [2903, 2943, 3338], 'size': [2907], '(100': [2908], '+': [2910], '=': [2912], '130': [2913], 'kDa)': [2914, 3541, 3655], 'exclusively': [2917], 'supernatant': [2922], '1C,': [2927], 'arrowhead).': [2928], 'When': [2929, 3249], 'marginal': [2940], 'supporting': [2946], 'our': [2947, 3104], 'hypothesis': [2948], 'MMP-dependent.': [2953], 'Processing': [2954], 'general': [2961], 'phenomenon,': [2962], 'endogenous': [2966, 3071], 'several': [2970], 'lines.': [2972], 'example,': [2974], 'low': [2977, 3068], 'steady': [2978], 'state': [2979, 3433], '(MEF;': [2989], 'results': [2991, 3105, 3714], 'below),': [2992], 'MEF': [2997, 3605, 3664, 3692], 'GM6001.': [3004], 'PcdhγC3-CTF': [3005, 3085, 3677, 3751, 3948], 'P19': [3010, 3075], 'carcinoma': [3012], 'widely': [3017], 'model': [3021], '(24Finley': [3025], 'M.F.': [3026], 'Kulkarni': [3027], 'Huettner': [3029], 'J.E.': [3030], '16:': [3034], '1056-1065Crossref': [3035], '25Kotani': [3039], 'Osanai': [3041], 'Tajima': [3043], 'Kato': [3045], 'Imada': [3047], 'Kaneda': [3049], 'Kubo': [3051], 'Sakuraba': [3053], '67:': [3059], '595-606Crossref': [3060], '(30)': [3063], 'increased': [3077], 'upon': [3078], 'induced': [3080], 'retinoic': [3082], 'acid.': [3083], 'Accordingly,': [3084], 'readily': [3087], 'suggestive': [3090], 'efficient': [3093, 4198], 'Taken': [3102], 'together,': [3103], 'strong': [3107, 3527], 'Pcdhγ-NTF': [3123], 'membrane-bound': [3125], 'Pcdhγ-CTF.': [3126, 4066], 'MMP': [3127, 3140, 3297, 3571, 4094, 4156], 'Ectodomains': [3131], 'Occurs': [3132], 'Close': [3133], 'Membrane—To': [3136], 'narrow': [3137], 'down': [3138], 'sites,': [3142], 'designed': [3144], 'molecules,': [3149], 'almost': [3151], 'I).': [3158], 'introduced': [3168], '18': [3169], 'respective': [3175, 3231, 3247], 'segment': [3177], '2A).': [3183, 3222], 'FLAG-tagged': [3191, 3258, 4186], 'constructs,': [3192], 'antibodies.': [3201, 3918], 'Remarkably,': [3202, 3645], 'considerably': [3209], 'mobility': [3211, 3226], '2B),': [3213], 'although': [3214], 'they': [3215], 'similar': [3218, 3318, 3704], 'difference': [3224], 'resembled': [3227], 'CTFs': [3232], '1A': [3235], 'due': [3239], 'charge': [3243], 'used,': [3253], 'faint': [3254], 'below': [3256], 'became': [3260, 4043], 'detectable,': [3261], 'FLAG-γA3-GFP': [3265], 'FLAG-γC3-GFP': [3267, 4258, 4282], 'still': [3269], 'slowly': [3270], 'CTF.': [3273], 'efficiency': [3277], 'apparently': [3279], 'higher': [3280], 'nontruncated': [3283], '(compare': [3285, 3966], 'Figs.': [3286], '2B': [3287], '-C3': [3303], 'occurs': [3305], 'close': [3307], 'vicinity': [3308], 'membrane,': [3311], 'giving': [3312], 'rise': [3313], 'weight.': [3320], 'Inhibition': [3321], 'Presenilin': [3323], 'Action': [3324], 'Leads': [3325], 'Accumulation': [3328], 'Pcdhγ-CTF—The': [3330], 'MMP-dependent': [3331, 4031], 'preceding': [3344], 'presenilin-mediated': [3346], '8Marambaud': [3385], 'involvement': [3417], 'aspartyl': [3430], 'protease': [3431], 'transition': [3432], 'mimic': [3434], 'L685,458,': [3435, 4253], 'presenilin-1': [3439, 3475], '(26Shearman': [3441], 'M.S.': [3442, 3797, 3862], 'Beher': [3443], 'Clarke': [3445], 'E.E.': [3446], 'Lewis': [3447], 'H.D.': [3448], 'Harrison': [3449], 'Hunt': [3451], 'Nadin': [3453], 'Smith': [3455], 'A.L.': [3456], 'Stevenson': [3457], 'Castro': [3459], 'J.L.': [3460], 'Biochemistry.': [3461, 3888], '39:': [3463], '8698-8704Crossref': [3464], '(370)': [3467], 'inhibition': [3473], 'resulted': [3478, 3698], 'shown),': [3487], 'would': [3489, 3588], 'downstream': [3494, 3583, 3724], 'blocked.': [3499], 'Consistent': [3500], 'scenario,': [3503], 'led': [3508, 3525, 3981], 'PcdhγA3-GFP-CTF': [3513], 'pulse': [3516, 4235, 4270], '3A).': [3519], 'Treatment': [3520], 'enrichment': [3528], '(∼25': [3540], 'recombinant': [3546], 'without': [3548], '3B,': [3553, 3669], 'left': [3554], 'panel).': [3555, 3671], 'slightly': [3559, 3994], 'larger': [3560, 3995, 4007], 'band': [3561, 3996, 4008], 'origin': [3564], 'reflecting': [3568], 'presenilins': [3577], 'Pcdhγ-CTF,': [3586, 3727, 3742], 'expect': [3589], 'Pcdhγ-CTF': [3593, 3986], 'address': [3600], 'possibility,': [3602], 'type': [3609, 3661], '(WT)': [3610], 'embryos': [3614], '(PS1–/–;': [3615], 'PS2–/–)': [3616], '(27Herreman': [3621], 'Serneels': [3623], 'Annaert': [3625, 3782, 3847], 'Collen': [3627], 'Schoonjans': [3629], 'De': [3631], 'Strooper': [3632, 3780, 3845], '461-462Crossref': [3639], '(454)': [3642], 'endogenously,': [3650], '(∼120': [3654], 'right': [3670], 'An': [3672, 4328], 'additional': [3673, 4135, 4329], 'WT': [3686, 3691], 'MEF.': [3687], 'Importantly,': [3688, 4104], 'treatment': [3689], 'PcdhγC3-CTF,': [3703], 'what': [3706], 'observed': [3708, 4000], 'cells.': [3712, 3835], 'strongly': [3715], 'indicate': [3716], 'resulting': [3728], 'product,': [3734], 'termed': [3735], 'Pcdhγ-CTF2.': [3736, 4202], 'Presenilin-induced': [3738], 'Product': [3740], 'Pcdhγ-CTF2,': [3743, 4110], 'Is': [3744], 'Rapidly': [3745], 'Degraded': [3746], 'Proteasomes—To': [3748], 'γ-secretase,': [3756], 'it': [3757, 4027, 4115, 4145], 'crucial': [3759], 'demonstrate': [3761], 'fragment,': [3767, 4109], 'PcdhγC3-CTF2.': [3768], 'Taking': [3769], 'consideration': [3771], 'γ-secretase-induced': [3773], '(28De': [3779, 3844], 'Cupers': [3784, 3849], 'Saftig': [3786, 3851], 'Craessaerts': [3788, 3853], 'Mumm': [3790, 3855], 'J.S.': [3791, 3856], 'Schroeter': [3792, 3857], 'Schrijvers': [3794, 3859], 'Wolfe': [3796, 3861], 'Ray': [3798, 3863], 'W.J.': [3799, 3864], 'Goate': [3800, 3865], 'Kopan': [3802, 3867], 'Nature.': [3804, 3869], '398:': [3806, 3871], '518-522Crossref': [3807, 3872], '(1825)': [3810, 3875], 'Scholar),': [3812], 'investigated': [3814], 'inhibitor,': [3822], 'lactacystin,': [3823], 'Lactacystin': [3836], 'known': [3838], 'γ-secretase-mediated': [3842], '29Yamazaki': [3878], 'Saido': [3882], 'T.C.': [3883], 'Omura': [3884], 'Ihara': [3886], '1997;': [3889], '8377-8383Crossref': [3891], '(56)': [3894], 'Cells': [3897], 'treated': [3899, 4316], 'various': [3901], 'inhibitors,': [3902], 'listed': [3904], '4A,': [3907, 3931, 3950, 3988, 4022, 4055, 4088], 'blot': [3915, 4294], 'control-treated': [3920], '1).': [3933], 'addition': [3935], 'alone': [3938, 3980], 'had': [3939, 3998], 'major': [3941], 'steady-state': [3945], '2),': [3952], 'might': [3956, 4195], 'production': [3961, 4199], 'slow': [3964], 'process': [3965], 'experiment': [3969], 'shown': [3970, 4148, 4295], 'As': [3974], 'expected,': [3975], 'L695,458': [3979, 4018, 4129], '3)': [3990], 'additional,': [3993], '3B).': [4004], 'absent': [4010], 'exposed': [4015, 4048], '5),': [4024], 'represents': [4028], 'serving': [4034], 'substrate.': [4038], 'Strikingly,': [4039], '4).': [4057], 'about': [4061], 'Slightly': [4067], '6),': [4090], 'activity': [4095], 'fragments.': [4103], 'required': [4111], 'since': [4114], 'added': [4122], 'combination': [4124], '(lane': [4130, 4139], '7)': [4131], 'irrespective': [4132], '8).': [4140], 'Notch': [4143], 'receptor,': [4144], 'prerequisite': [4159], 'action': [4162], '(30Struhl': [4163], 'Adachi': [4165], '6:': [4170], '625-636Abstract': [4171], '(360)': [4179], 'reasoned': [4183], 'γC3': [4187], 'molecule': [4188], 'nearly': [4190], 'allow': [4196], 'γ-secretase-dependent': [4201], 'perform': [4208], 'use': [4215], '(G)': [4219], '(F)': [4223], 'immunoprecipitation': [4226], 'FLAG-γC3-GFP.': [4228], 'Lysates': [4229], 'directly': [4232, 4267], 'chase,': [4241, 4276], 'inhibitors': [4250], 'indicated.': [4255], 'Only': [4256], 'efficient,': [4288], 'accord': [4290], '2B.': [4298], 'Likewise,': [4299], 'amount': [4303], 'precipitated': [4307], '(but': [4310], 'anti-FLAG)': [4313], 'samples': [4315], 'arrow': [4324], '4B).': [4327, 4355], 'during': [4347], 'asterisk': [4352], 'All': [4356], 'fully': [4364], 're': [4365]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1971775650', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-29T13:55:57.415044', 'created_date': '2016-06-24'}