Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1969733979', 'doi': 'https://doi.org/10.1016/j.molcel.2013.09.008', 'title': 'Structure of an RNA Silencing Complex of the CRISPR-Cas Immune System', 'display_name': 'Structure of an RNA Silencing Complex of the CRISPR-Cas Immune System', 'publication_year': 2013, 'publication_date': '2013-10-01', 'ids': {'openalex': 'https://openalex.org/W1969733979', 'doi': 'https://doi.org/10.1016/j.molcel.2013.09.008', 'mag': '1969733979', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24119404', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3864027'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molcel.2013.09.008', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S156208185', 'display_name': 'Molecular Cell', 'issn_l': '1097-2765', 'issn': ['1097-2765', '1097-4164'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.molcel.2013.09.008', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5075575430', 'display_name': 'Michael Spilman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I103163165', 'display_name': 'Florida State University', 'ror': 'https://ror.org/05g3dte14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I103163165']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael Spilman', 'raw_affiliation_strings': ['Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA'], 'affiliations': [{'raw_affiliation_string': 'Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA', 'institution_ids': ['https://openalex.org/I103163165']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058456108', 'display_name': 'Alexis Cocozaki', 'orcid': 'https://orcid.org/0000-0002-3547-552X'}, 'institutions': [{'id': 'https://openalex.org/I103163165', 'display_name': 'Florida State University', 'ror': 'https://ror.org/05g3dte14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I103163165']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alexis Cocozaki', 'raw_affiliation_strings': ['Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA'], 'affiliations': [{'raw_affiliation_string': 'Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA', 'institution_ids': ['https://openalex.org/I103163165']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024210489', 'display_name': 'Caryn Hale', 'orcid': 'https://orcid.org/0000-0002-2860-0994'}, 'institutions': [{'id': 'https://openalex.org/I165733156', 'display_name': 'University of Georgia', 'ror': 'https://ror.org/00te3t702', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165733156']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Caryn Hale', 'raw_affiliation_strings': ['Departments of Biochemistry and Molecular Biology, Genetics, and Microbiology University of Georgia, Athens, GA 30602, USA'], 'affiliations': [{'raw_affiliation_string': 'Departments of Biochemistry and Molecular Biology, Genetics, and Microbiology University of Georgia, Athens, GA 30602, USA', 'institution_ids': ['https://openalex.org/I165733156']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058922838', 'display_name': 'Yaming Shao', 'orcid': 'https://orcid.org/0000-0003-3663-1325'}, 'institutions': [{'id': 'https://openalex.org/I103163165', 'display_name': 'Florida State University', 'ror': 'https://ror.org/05g3dte14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I103163165']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yaming Shao', 'raw_affiliation_strings': ['Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA'], 'affiliations': [{'raw_affiliation_string': 'Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA', 'institution_ids': ['https://openalex.org/I103163165']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069447518', 'display_name': 'Nancy Ramia', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I103163165', 'display_name': 'Florida State University', 'ror': 'https://ror.org/05g3dte14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I103163165']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nancy Ramia', 'raw_affiliation_strings': ['Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA'], 'affiliations': [{'raw_affiliation_string': 'Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA', 'institution_ids': ['https://openalex.org/I103163165']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083102930', 'display_name': 'Rebeca Terns', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165733156', 'display_name': 'University of Georgia', 'ror': 'https://ror.org/00te3t702', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165733156']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rebeca Terns', 'raw_affiliation_strings': ['Departments of Biochemistry and Molecular Biology, Genetics, and Microbiology University of Georgia, Athens, GA 30602, USA'], 'affiliations': [{'raw_affiliation_string': 'Departments of Biochemistry and Molecular Biology, Genetics, and Microbiology University of Georgia, Athens, GA 30602, USA', 'institution_ids': ['https://openalex.org/I165733156']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002716376', 'display_name': 'Michael P. Terns', 'orcid': 'https://orcid.org/0000-0001-8330-1789'}, 'institutions': [{'id': 'https://openalex.org/I165733156', 'display_name': 'University of Georgia', 'ror': 'https://ror.org/00te3t702', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165733156']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael Terns', 'raw_affiliation_strings': ['Departments of Biochemistry and Molecular Biology, Genetics, and Microbiology University of Georgia, Athens, GA 30602, USA'], 'affiliations': [{'raw_affiliation_string': 'Departments of Biochemistry and Molecular Biology, Genetics, and Microbiology University of Georgia, Athens, GA 30602, USA', 'institution_ids': ['https://openalex.org/I165733156']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100730821', 'display_name': 'Hong Li', 'orcid': 'https://orcid.org/0000-0003-2046-9861'}, 'institutions': [{'id': 'https://openalex.org/I103163165', 'display_name': 'Florida State University', 'ror': 'https://ror.org/05g3dte14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I103163165']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Hong Li', 'raw_affiliation_strings': ['Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA', 'Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA', 'institution_ids': ['https://openalex.org/I103163165']}, {'raw_affiliation_string': 'Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA', 'institution_ids': ['https://openalex.org/I103163165']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5068698824', 'display_name': 'Scott M. Stagg', 'orcid': 'https://orcid.org/0000-0001-8855-4152'}, 'institutions': [{'id': 'https://openalex.org/I103163165', 'display_name': 'Florida State University', 'ror': 'https://ror.org/05g3dte14', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I103163165']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Scott Stagg', 'raw_affiliation_strings': ['Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA', 'Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA', 'institution_ids': ['https://openalex.org/I103163165']}, {'raw_affiliation_string': 'Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA', 'institution_ids': ['https://openalex.org/I103163165']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5100730821', 'https://openalex.org/A5068698824'], 'corresponding_institution_ids': ['https://openalex.org/I103163165', 'https://openalex.org/I103163165'], 'apc_list': {'value': 9080, 'currency': 'USD', 'value_usd': 9080, 'provenance': 'doaj'}, 'apc_paid': {'value': 9080, 'currency': 'USD', 'value_usd': 9080, 'provenance': 'doaj'}, 'fwci': 8.903, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 130, 'citation_normalized_percentile': {'value': 0.907359, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '52', 'issue': '1', 'first_page': '146', 'last_page': '152'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11112', 'display_name': 'Viral Infections and Immunology Research', 'score': 0.975, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12786', 'display_name': 'Innovation and Socioeconomic Development', 'score': 0.9399, 'subfield': {'id': 'https://openalex.org/subfields/1403', 'display_name': 'Business and International Management'}, 'field': {'id': 'https://openalex.org/fields/14', 'display_name': 'Business, Management and Accounting'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rna-silencing', 'display_name': 'RNA Silencing', 'score': 0.6170366}, {'id': 'https://openalex.org/keywords/rna-induced-silencing-complex', 'display_name': 'RNA-induced silencing complex', 'score': 0.54834145}, {'id': 'https://openalex.org/keywords/trans-acting-sirna', 'display_name': 'Trans-acting siRNA', 'score': 0.51262444}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.9605098}, {'id': 'https://openalex.org/C98108389', 'wikidata': 'https://www.wikidata.org/wiki/Q412563', 'display_name': 'CRISPR', 'level': 3, 'score': 0.86197394}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.6179792}, {'id': 'https://openalex.org/C2191507', 'wikidata': 'https://www.wikidata.org/wiki/Q7277185', 'display_name': 'RNA silencing', 'level': 5, 'score': 0.6170366}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.5672929}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.5499437}, {'id': 'https://openalex.org/C155330019', 'wikidata': 'https://www.wikidata.org/wiki/Q21106117', 'display_name': 'RNA-induced silencing complex', 'level': 5, 'score': 0.54834145}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.5142062}, {'id': 'https://openalex.org/C60723119', 'wikidata': 'https://www.wikidata.org/wiki/Q7833577', 'display_name': 'Trans-acting siRNA', 'level': 5, 'score': 0.51262444}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.4793035}, {'id': 'https://openalex.org/C166703698', 'wikidata': 'https://www.wikidata.org/wiki/Q201993', 'display_name': 'RNA interference', 'level': 4, 'score': 0.45549166}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1618731}], 'mesh': [{'descriptor_ui': 'D019843', 'descriptor_name': 'Archaeal Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D064130', 'descriptor_name': 'CRISPR-Associated Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020027', 'descriptor_name': 'Pyrococcus furiosus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019642', 'descriptor_name': 'RNA, Archaeal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012260', 'descriptor_name': 'Ribonucleases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019843', 'descriptor_name': 'Archaeal Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019843', 'descriptor_name': 'Archaeal Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D019843', 'descriptor_name': 'Archaeal Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D064130', 'descriptor_name': 'CRISPR-Associated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064130', 'descriptor_name': 'CRISPR-Associated Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D064130', 'descriptor_name': 'CRISPR-Associated Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D064112', 'descriptor_name': 'Clustered Regularly Interspaced Short Palindromic Repeats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020285', 'descriptor_name': 'Cryoelectron Microscopy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019848', 'descriptor_name': 'Gene Expression Regulation, Archaeal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021122', 'descriptor_name': 'Protein Subunits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020027', 'descriptor_name': 'Pyrococcus furiosus', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D020027', 'descriptor_name': 'Pyrococcus furiosus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020027', 'descriptor_name': 'Pyrococcus furiosus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019642', 'descriptor_name': 'RNA, Archaeal', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019642', 'descriptor_name': 'RNA, Archaeal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012260', 'descriptor_name': 'Ribonucleases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012260', 'descriptor_name': 'Ribonucleases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D012260', 'descriptor_name': 'Ribonucleases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molcel.2013.09.008', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S156208185', 'display_name': 'Molecular Cell', 'issn_l': '1097-2765', 'issn': ['1097-2765', '1097-4164'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3864027', 'pdf_url': 'https://europepmc.org/articles/pmc3864027?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864027', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24119404', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molcel.2013.09.008', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S156208185', 'display_name': 'Molecular Cell', 'issn_l': '1097-2765', 'issn': ['1097-2765', '1097-4164'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Life on land', 'id': 'https://metadata.un.org/sdg/15', 'score': 0.49}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W1967046461', 'https://openalex.org/W1969479889', 'https://openalex.org/W1977531433', 'https://openalex.org/W1978094899', 'https://openalex.org/W1986171241', 'https://openalex.org/W1989568784', 'https://openalex.org/W1990487336', 'https://openalex.org/W1997194352', 'https://openalex.org/W2005328221', 'https://openalex.org/W2006158980', 'https://openalex.org/W2006494972', 'https://openalex.org/W2006995959', 'https://openalex.org/W2007545739', 'https://openalex.org/W2010986636', 'https://openalex.org/W2016675163', 'https://openalex.org/W2019670881', 'https://openalex.org/W2028470175', 'https://openalex.org/W2039731535', 'https://openalex.org/W2045435533', 'https://openalex.org/W2046563455', 'https://openalex.org/W2048982317', 'https://openalex.org/W2058416403', 'https://openalex.org/W2062008243', 'https://openalex.org/W2063148079', 'https://openalex.org/W2064815984', 'https://openalex.org/W2074862753', 'https://openalex.org/W2076449818', 'https://openalex.org/W2086860427', 'https://openalex.org/W2088154229', 'https://openalex.org/W2092185451', 'https://openalex.org/W2097379120', 'https://openalex.org/W2100226515', 'https://openalex.org/W2120503144', 'https://openalex.org/W2124741861', 'https://openalex.org/W2131157113', 'https://openalex.org/W2132629607', 'https://openalex.org/W2132821335', 'https://openalex.org/W2133464522', 'https://openalex.org/W2143772974', 'https://openalex.org/W2148085578', 'https://openalex.org/W2149751339', 'https://openalex.org/W2153355254', 'https://openalex.org/W2153537688', 'https://openalex.org/W2160010342', 'https://openalex.org/W2161606262', 'https://openalex.org/W2161661741', 'https://openalex.org/W2163241233', 'https://openalex.org/W2166139447', 'https://openalex.org/W2168933209', 'https://openalex.org/W2169244146'], 'related_works': ['https://openalex.org/W633773340', 'https://openalex.org/W606763619', 'https://openalex.org/W2411312501', 'https://openalex.org/W2160381063', 'https://openalex.org/W2129401531', 'https://openalex.org/W2111383435', 'https://openalex.org/W2072680951', 'https://openalex.org/W2039740951', 'https://openalex.org/W1982264400', 'https://openalex.org/W1930224804'], 'abstract_inverted_index': {'Bacterial': [0], 'and': [1, 13, 16, 21, 78, 101, 110, 112, 123], 'archaeal': [2], 'clustered': [3], 'regularly': [4], 'interspaced': [5], 'short': [6], 'palindromic': [7], 'repeat': [8], '(CRISPR)': [9], 'loci': [10], 'capture': [11], 'virus': [12], 'plasmid': [14], 'sequences': [15, 31], 'use': [17], 'them': [18], 'to': [19, 52, 133], 'recognize': [20], 'eliminate': [22], 'these': [23], 'invaders.': [24], 'CRISPR': [25], 'RNAs': [26], '(crRNAs)': [27], 'containing': [28], 'the': [29, 53, 76, 96, 104, 115, 119, 126, 134], 'acquired': [30], 'are': [32], 'incorporated': [33], 'into': [34], 'effector': [35, 46], 'complexes': [36], 'that': [37, 85], 'destroy': [38], 'matching': [39], 'invader': [40], 'nucleic': [41], 'acids.': [42], 'The': [43, 121], 'multicomponent': [44], 'Cmr': [45, 64, 128], 'complex': [47, 65, 129], 'cleaves': [48], 'RNA': [49, 70], 'targets': [50], 'complementary': [51], 'crRNAs.': [54], 'Here,': [55], 'we': [56], 'report': [57], 'cryoelectron': [58], 'microscopy': [59], 'reconstruction': [60], 'of': [61, 75, 95, 118, 125], 'a': [62, 68, 82, 141], 'functional': [63], 'bound': [66], 'with': [67], 'target': [69], 'at': [71, 103], '∼12': [72], 'Å.': [73], 'Pairs': [74], 'Cmr4': [77], 'Cmr5': [79], 'proteins': [80], 'form': [81], 'helical': [83], 'core': [84], 'is': [86, 130], 'asymmetrically': [87], 'capped': [88], 'on': [89], 'each': [90], 'end': [91, 117], 'by': [92], 'distinct': [93], 'pairs': [94], 'four': [97], 'remaining': [98], 'subunits:': [99], 'Cmr2': [100], 'Cmr3': [102], 'conserved': [105, 143], '5′': [106], 'crRNA': [107], 'tag': [108], 'sequence': [109], 'Cmr1': [111], 'Cmr6': [113], 'near': [114], '3′': [116], 'crRNA.': [120], 'shape': [122], 'organization': [124], 'RNA-targeting': [127], 'strikingly': [131], 'similar': [132], 'DNA-targeting': [135], 'Cascade': [136], 'complex.': [137], 'Our': [138], 'results': [139], 'reveal': [140], 'remarkably': [142], 'architecture': [144], 'among': [145], 'very': [146], 'distantly': [147], 'related': [148], 'CRISPR-Cas': [149], 'complexes.': [150]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969733979', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 23}, {'year': 2014, 'cited_by_count': 31}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2025-01-15T23:58:44.858739', 'created_date': '2016-06-24'}