Right Versus Left Ventricular Failure

Name: Work Video:
Duration: 3 min 30 s
Mark K. Friedberg; Andrew N. Redington
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3779, 4039, 4054], 'Sick': [62, 88], 'Children': [63, 89], 'University': [65, 91], 'Toronto,': [67, 68, 93, 94], 'ON,': [69, 95], 'Canada.': [70, 96], 'RedingtonAndrew': [74], 'Redington': [76], 'Originally': [97], 'published4': [98], 'Mar': [99], '2014https://doi.org/10.1161/CIRCULATIONAHA.113.001375Circulation.': [100], '2014;129:1033–1044IntroductionVentricular': [101], 'failure': [102, 175, 853, 991, 1105, 1304, 1323, 2036, 2143, 2723, 2742, 2777, 2860, 3031], 'manifests': [103], 'in': [104, 156, 265, 308, 442, 462, 472, 475, 483, 518, 531, 537, 630, 695, 727, 786, 807, 822, 847, 876, 882, 892, 921, 927, 936, 943, 952, 960, 979, 1001, 1007, 1010, 1021, 1029, 1036, 1042, 1047, 1050, 1150, 1251, 1333, 1406, 1565, 1574, 1624, 1632, 1647, 1663, 1676, 1687, 1702, 1732, 1753, 1774, 1780, 1794, 1801, 1808, 1848, 1862, 1881, 1890, 1893, 1929, 1933, 1940, 1987, 2008, 2061, 2100, 2212, 2236, 2261, 2270, 2291, 2334, 2344, 2351, 2364, 2372, 2380, 2388, 2397, 2427, 2437, 2458, 2520, 2545, 2579, 2597, 2615, 2628, 2641, 2660, 2674, 2703, 2726, 2749, 2856, 2865, 2895, 2901, 2947, 2983, 3014, 3024, 3048, 3081, 3093, 3098, 3119, 3145, 3159, 3176, 3188, 3204, 3228, 3247, 3286, 3315, 3322, 3426, 3498, 3506, 3532, 3591, 3606, 3611, 3633, 3638, 3645, 3673, 3707, 3715, 3718, 3737, 3738, 3798, 3824, 3826, 3904, 3911, 3920, 4029, 4060, 4098, 4109, 4142], 'many': [105, 1258, 2933, 3045], 'forms,': [106], 'its': [107, 316, 326, 1097, 1445, 3582], 'underlying': [108], 'physiology': [109, 303, 790, 851], 'ranging': [110, 710], 'from': [111, 133, 226, 233, 299, 671, 711, 766, 1125, 1171, 1198, 1440, 1465, 1557, 1569, 1667, 1694, 1741, 1998, 2027, 2033, 2185, 2194, 2491, 2532, 2647, 2737, 3066, 3087, 3455, 3473, 3581, 3643, 3649, 3866, 3875, 4069], 'overt': [112, 988], 'left': [113, 456, 1348, 1411, 1704, 1734, 3330, 3461, 3884], 'ventricular': [114, 121, 196, 1477, 2425, 2948, 3124, 3880], '(LV)': [115, 457], 'systolic': [116], 'dysfunction': [117, 140, 197, 1382, 1399, 2982, 3573, 3960, 3973], 'isolated': [119, 3151, 3542], 'right': [120, 453, 989, 1354, 1415, 1491, 2171, 3325, 3465], '(RV)': [122, 454, 1478, 3327], 'diastolic': [123], 'dysfunction,': [124], 'wide': [127, 968, 2555], 'portfolio': [128], 'resulting': [130, 842, 3642], 'symptoms': [131, 2099], 'vary': [132], 'chronic': [134, 1024, 1031, 1589, 3197], 'fluid': [135], 'retention': [136], 'acute': [138, 958, 972, 983, 997, 3950], 'multiorgan': [139], 'death.': [142], 'In': [143, 404, 915, 931, 1178, 1344, 2713, 3148, 3332], 'this': [144, 366, 1065, 1345, 1407, 1523, 2042, 3383], 'review,': [145], 'we': [146, 795, 1108, 3163], 'discuss': [147, 168, 796], 'morphological,': [149], 'functional,': [150], 'molecular': [152, 1762, 2312, 2877], 'similarities': [153, 492], 'differences': [155, 515, 520, 691, 949, 1768, 1791, 1807, 2255, 2269, 2379, 2519, 2827, 2941, 3013, 3023], 'RV': [157, 172, 213, 216, 243, 254, 277, 314, 341, 362, 375, 402, 427, 505, 528, 546, 564, 757, 817, 830, 850, 871, 902, 911, 928, 1002, 1008, 1017, 1037, 1058, 1078, 1081, 1087, 1115, 1143, 1165, 1186, 1191, 1211, 1238, 1265, 1303, 1321, 1371, 1381, 1419, 1436, 1527, 1542, 1566, 1572, 1580, 1586, 1613, 1619, 1653, 1688, 1701, 1731, 1754, 1771, 1810, 1827, 1837, 1976, 2054, 2057, 2070, 2081, 2116, 2130, 2151, 2155, 2157, 2160, 2164, 2192, 2205, 2215, 2258, 2292, 2347, 2352, 2362, 2368, 2411, 2440, 2446, 2479, 2487, 2511, 2524, 2576, 2631, 2699, 2709, 2727, 2738, 2741, 2755, 2776, 2829, 2857, 2881, 2898, 3002, 3005, 3015, 3100, 3152, 3165, 3183, 3194, 3230, 3261, 3288, 3366, 3378, 3515, 3520, 3553, 3575, 3592, 3612, 3634, 3639, 3661, 3688, 3708, 3719, 3728, 3744, 3757, 3775, 3790, 3800, 3809, 3846, 3876, 3893, 3897, 3905, 3933, 3951, 3976, 4009, 4014, 4055, 4070, 4095, 4124, 4128, 4152, 4157], 'LV': [159, 170, 218, 224, 351, 408, 413, 434, 503, 698, 744, 821, 867, 937, 944, 1048, 1193, 1409, 1468, 1773, 1822, 1834, 2183, 2203, 2220, 2260, 2409, 2428, 2452, 2526, 2578, 2599, 2677, 2701, 2722, 2750, 2818, 2831, 2866, 2883, 2981, 2987, 3007, 3017, 3082, 3102, 3167, 3200, 3239, 3241, 3375, 3517, 3543, 3569, 3579, 3602, 3617, 3624, 3646, 3695, 3700, 3711, 3765, 3781, 3802, 3811, 3842, 3870, 3890, 3901, 3915, 3922, 3959, 3970, 3972, 3991, 3998, 4018, 4027, 4079, 4085, 4133, 4141, 4155, 4162, 4169, 4180], 'responses': [160, 2878, 3018], 'adverse': [162, 3020, 3051], 'loading': [163, 864, 1518, 1785, 2266, 2529, 3021, 3052, 3571], 'failure.': [165, 2058, 2753, 2821, 2954, 3054], 'We': [166], 'further': [167, 1618, 3563, 3630], 'whether': [169], 'function': [173, 416, 1146, 1250, 2845, 3376, 3379, 3418, 3916, 4028], 'can': [176, 900, 964, 1144, 1285, 3244], 'truly': [177], 'be': [178, 203, 2378, 2999, 3692, 3928], 'discussed': [179], 'as': [180, 256, 466, 540, 794, 811, 887, 1359, 2075, 2123, 2359, 2456, 2499, 2551, 2561, 2591, 2792, 2794, 3182, 3380, 3529, 3760, 3768, 3807, 3961, 4048, 4135], 'separate': [181, 3381, 3858], 'entities': [182], 'thereby': [184, 1604, 4012], 'examine': [185], 'interactions': [186], 'between': [187, 521, 1102, 1769, 2256, 2522, 2573, 2828, 3513], 'ventricles': [189, 474, 523, 784, 2617, 2931, 3043, 3178, 3388, 3422], 'that': [190, 348, 1094, 1141, 1236, 1297, 1677, 1684, 2049, 2064, 2094, 2109, 2517, 2874, 2928, 3040, 3212, 3258, 3397, 3452, 3666, 3683, 3698, 3773, 3805, 3853, 3949, 4066, 4176], 'on': [191, 199, 1489, 2024, 3574, 3734, 3997, 4026], 'one': [192], 'hand': [193], 'contribute': [194], 'but': [198, 793, 809, 869, 1085, 1835, 1990, 2072, 2348, 2370, 2600, 2618, 2656, 2724, 2899, 3509], 'other': [201, 1222, 2694, 2706], 'may': [202, 1707, 1825, 2136, 2281, 2331, 2376, 2530, 2632, 2719, 2942, 2962, 3128, 3222, 3691, 3927, 4022], 'harnessed': [204], 'therapeutic': [206, 2316, 2563], 'benefit.Embryological': [207], 'Physiological': [209], 'Differences': [210, 595, 1841], 'Between': [211, 596, 1842, 3364], 'LVThe': [215], 'have': [219, 1109, 1209, 2153, 2197, 2314, 2433, 2477, 2566, 3256, 3821], 'different': [220, 1693, 2202, 2534, 2620, 2944, 2995], 'embryological': [221, 2535], 'origins.1': [222], 'The': [223, 360, 459, 526, 1053, 1370, 1487, 1498, 1520, 1651, 2622, 3055, 3112, 3305, 3387, 4168], 'originates': [225], 'primary': [228], 'heart': [229, 236, 609, 611, 990, 1705, 1735, 2172, 3030, 3829, 4036], 'field;': [230], 'RV,': [232, 1183, 4185], 'secondary': [235, 2482, 2678, 3974, 4084], 'field.': [237], 'Consequently,': [238, 374, 560, 1190, 3416], 'several': [239, 2825, 2890, 2939], 'genes': [240, 1778, 1984, 3255], 'specifically': [241], 'control': [242], 'formation,': [244], 'including,': [245], 'among': [246, 3135], 'others,': [247], 'Hand2': [248], 'Tbx20.2': [250], 'During': [251, 262, 2754, 3784], 'gestation,': [252], 'functions': [255], 'systemic': [258, 961, 1051, 1138, 1154, 1255, 1264, 1361, 1652, 1700, 1739, 2088, 2150, 3219], 'ventricle': [259, 1355, 3326, 3462, 3834, 3865], '(Figure': [260, 1203, 1326, 1449, 1471, 1602, 1639, 3179, 3414, 4081], '1A).': [261], 'fetal': [263, 300, 477, 495, 1172, 1199, 1244, 1742, 1980, 1989, 2782, 3056, 3075], 'life,': [264, 1745], 'addition': [266, 3982, 4061], 'supplying': [268], 'modest': [270, 890, 919, 941, 999], 'amount': [271], 'pulmonary': [273, 309, 336, 396, 884, 973, 1139, 1229, 1961, 2066, 2103, 2195, 2484, 3156, 3198, 3215, 3318, 3557, 3942, 3986, 4006, 4044], 'blood': [274, 279, 1366, 3558], 'flow,': [275], 'pumps': [278], 'lower': [282, 567, 587, 591, 906, 1217], 'body': [283], 'placenta': [285], 'contributes': [287], 'more': [288, 1394, 1710, 2210, 2448, 3028], 'than': [289, 433, 578, 1044, 1219, 1396, 2450], 'half': [290], 'combined': [293], 'cardiac': [294, 344, 907, 994, 1214, 1606, 1637, 2134, 2168, 2421, 2669, 4064, 4092, 4106], 'output.3': [295], 'With': [296, 2772], 'transition': [298, 2736], 'postnatal': [302, 327, 340, 1176, 1744, 1992], 'with': [305, 368, 417, 486, 497, 707, 715, 734, 751, 841, 957, 971, 1206, 1221, 1262, 1336, 1457, 1609, 2102, 2182, 2189, 2191, 2217, 2308, 2404, 2463, 2649, 2684, 2746, 2767, 2805, 3274, 3290, 3334, 3546, 3653, 3746, 3988, 4111, 4187], 'reduction': [307, 3797], 'vascular': [310, 885, 962, 1230, 3216, 3220], 'resistance,': [311, 886], 'subpulmonary': [313], 'transforms': [315], 'morphology': [317], 'geometry,': [319], 'becoming': [320], 'a': [321, 333, 343, 354, 387, 467, 484, 541, 566, 575, 586, 716, 742, 763, 772, 967, 1227, 1263, 1334, 1390, 1441, 1452, 1484, 1510, 1538, 1540, 1548, 1558, 1597, 1621, 1629, 1664, 1709, 1761, 1979, 1996, 2090, 2231, 2500, 2554, 2657, 2994, 3072, 3160, 3269, 3406, 3481, 3486, 3588, 3629, 3704, 3726, 3747, 3761, 3795, 3879, 3918, 3940, 3966, 3984, 4042, 4051, 4172], 'thin-walled': [322], 'chamber': [323, 1363], 'adopt': [325], 'physiological': [328, 514, 1641], 'characteristics.4': [329], 'Because': [330], 'it': [331, 1122, 1233, 1293, 1747, 2046, 2106, 2926, 3036, 3369, 3449, 3680, 3854], 'faces': [332, 1738], 'low': [334, 582], 'impedance': [335, 1448], 'circulation,': [337], 'normal': [339, 476, 563, 1182, 1467, 1541, 1669, 2346, 2374, 2630, 2643, 3430, 3552, 3687, 3756, 3764, 3780], 'maintains': [342], 'output': [345, 376, 908, 1009, 1082, 1149, 1638, 2135, 4065], 'equal': [346, 448, 470], 'at': [352, 2084, 2301], 'approximately': [353], 'fifth': [355], 'energy': [358, 1867, 1872, 2295], 'cost.': [359], 'trapezoidal': [361, 1442], 'pressure-volume': [363, 409, 1437, 1469, 1479, 1600, 1626, 3923], 'loop': [364, 1470, 1575, 1583], 'reflects': [365], 'difference,': [367], 'few': [369], 'if': [370, 2120], 'any': [371, 3622], 'isovolumic': [372, 421, 678, 687, 1459], 'periods.': [373], 'starts': [377], 'early': [378], 'during': [379, 665, 675, 896, 2698, 2721, 2734, 3663, 3830, 3838], 'pressure': [380, 584, 658, 895, 898, 1155, 1784, 2082, 2110, 2152, 3554, 3641, 3724, 3758, 3812], 'generation': [381, 3759], 'is': [383, 461, 529, 746, 791, 831, 872, 913, 1039, 1064, 1077, 1083, 1123, 1160, 1294, 1389, 1555, 1673, 1690, 1748, 2037, 2107, 2221, 2341, 2349, 2395, 2496, 2638, 2665, 2672, 2765, 3037, 3078, 3185, 3202, 3266, 3338, 3385, 3423, 3450, 3777, 3855, 3872, 3934, 4046, 4088, 4102], 'later': [384], 'maintained': [385, 1084], 'by': [386, 858, 889, 1483, 1515, 1582, 1596, 1645, 2077, 3155, 3240, 3268, 3478, 3694, 3835, 3878, 3883, 3937, 3954, 3963, 3980, 4003, 4123, 4182], '"hangout': [388], 'period"': [389], 'when': [390, 910, 996, 1120, 3931, 4041], 'antegrade': [391], 'flow': [392], 'continues': [393], 'into': [394, 1367, 3659, 4139], 'artery': [397, 2067, 3157, 3956], 'despite': [398, 1226], 'onset': [400], 'relaxation.5': [403], 'contrast,': [405, 932, 2714], 'rectangular': [407, 1455], 'loops': [410, 1481, 1513], 'reflect': [411], 'square-wave': [414], 'pump': [415, 655], 'distinct': [418, 3283], 'well-developed': [420, 1458], 'contraction': [422, 664, 679, 745, 765, 1460, 1649, 1657, 1714, 1755, 3538, 3696, 3713, 3891, 4129, 4158], 'relaxation': [424, 1462], 'periods.6': [425], 'Likewise,': [426, 1260, 1696, 1804, 2338, 3084, 3234], 'myocytes': [428, 634, 640, 651, 723, 758], 'display': [429], 'faster': [430], 'twitch': [431], 'velocities': [432], 'myocytes.7Download': [435], 'figureDownload': [436, 1328, 1473, 3293, 3434], 'PowerPointFigure': [437, 1329, 1474, 3294, 3435], '1.': [438, 594], 'A,': [439], 'Fetal': [440], 'echocardiogram': [441, 496], 'short-axis': [444, 481, 729], 'view.': [445], 'Note': [446, 490, 1562, 3467], 'wall': [449, 548, 577, 588, 778, 1194, 2161, 3604, 3619, 3626, 3702], 'thicknesses': [450, 1195], 'ventricles.': [458, 2391, 3095, 3147, 3400], 'septum': [460, 552, 3408, 3668, 4077, 4137], 'neutral': [464, 508], 'position': [465, 509], 'result': [468, 542], 'pressures': [471], 'physiology.': [478], 'B,': [479], 'Parasternal': [480], 'view': [482], 'patient': [485, 1335], 'pretricuspid': [487], 'Eisenmenger': [488, 1136, 1185, 1207], 'syndrome.': [489], 'equally': [498], 'thick': [499], 'walls': [500, 3458], 'interventricular': [512, 551, 4076], 'septum.The': [513], 'are': [516, 692, 703, 724, 759, 802, 854, 950, 1023, 1196, 1300, 1313, 1643, 1792, 1799, 1806, 2252, 2595, 2613, 2803, 2814, 2887, 2893, 3011, 3104, 3116, 3402, 3849], 'reflected': [517, 951], 'morphological': [519], '(Table': [524], '1).': [525], 'low-pressure': [527], 'triangular': [530], 'sagittal': [533], 'plane': [534, 730], 'crescent-shaped': [536], 'cross': [538, 3454], 'section': [539], 'concave': [545], 'free': [547, 777, 3603, 3618, 3625, 3701, 3791], 'convex': [550], 'wrapping': [553], 'around': [554], 'high-pressured,': [556], 'thick-walled,': [557], 'bullet-shaped': [558], 'LV.': [559, 2904, 3534], 'although': [561, 1308, 2080, 2414, 2875, 2929, 3259], 'has': [565, 1239, 1766, 2514, 2541, 2975, 3370], 'ratio': [568], 'volume': [570, 1876, 2132, 2443, 2480, 2528, 3570, 3580, 3584, 3647, 3721, 3906, 3935, 4010], 'surface': [572], 'area': [573], 'thinner': [576], 'LV,8': [580], 'cavity': [583, 3662, 4019], 'determines': [585], 'stress': [589], 'oxygen': [592], 'demands.Table': [593], 'Right': [600, 1476, 1846], 'Ventricles': [601, 1847], 'Under': [602], 'Normal': [603], 'ConditionsLeft': [604], 'VentricleRight': [605], 'VentricleEvolutionary': [606], 'developmentEarlyLateEmbryological': [607], 'originPrimary': [608], 'fieldSecondary': [610], 'fieldMorphological': [612], 'characteristicsBullet': [613], 'shape;': [614], 'prolate': [615], 'ellipsoidComplex,': [616], 'crescenticMyocardial': [617], 'characteristicsThick': [618], 'smooth': [619], 'walls;': [620], 'fine': [621], 'trabeculationsThin,': [622], 'heavily': [623], 'trabeculated': [624], 'wallsMyocardial': [625], 'architecturePredominant': [626], 'radial': [627, 661, 750], 'myocyte': [628, 645, 3470], 'orientation': [629, 1686, 3443], 'midlayers;': [632], 'subendocardial': [633, 701], 'follow': [635], 'right-hand': [636, 3482], 'helix': [637, 3483], 'configuration;': [638], 'subepicardial': [639, 699], 'form': [641], 'left-hand': [642], 'helixPredominant': [643], 'longitudinal': [644, 1661, 1713], 'orientation;': [646], 'angulated': [647], 'intrusion': [648], 'superficial': [650], 'toward': [652, 779, 2993], 'endocardiumPhysiological': [654], 'conditionsHigh-resistance,': [656], 'high': [657, 1446], 'pump;': [659, 668], 'dominant': [660], 'thickening': [662], 'ejectionLow-resistance,': [666], 'low-capacitance': [667], 'peristaltic-like': [669], 'motion': [670, 774], 'inflow': [672], 'outflow': [674, 1018], 'ejectionFlow': [676], 'characteristicsWell-defined': [677], 'relaxation;': [681], 'no': [682, 3279], 'hangout': [683, 689], 'periodNo': [684], 'or': [685, 844, 861, 1068, 1277, 1454, 2752, 2859, 2863, 2868, 3218, 3837, 3882, 4057], 'minimal': [686], 'periods;': [688], 'periodAnatomic': [690], 'also': [693, 810, 865, 1295, 2377, 3038, 3079, 3468, 3898], 'apparent': [694, 1296], 'myocardial': [696, 1322, 1397, 1648, 3493], 'architecture.': [697], 'fibers': [702, 3396, 3453], 'oblique': [704], 'helical': [706], 'fiber': [708, 735, 1685], 'angles': [709, 736], '30°': [712], '80°': [714], 'mean': [717, 893], '≈60°,': [719], 'whereas': [720, 3595, 4094], 'midmyocardial': [722], 'oriented': [725], 'predominantly': [726, 747, 760], 'equator': [733], '20°': [738], '−20°.9': [740], 'As': [741], 'result,': [743], 'circumferential': [748, 1656, 1711], 'additional': [752, 3608], 'rotational': [753], 'twisting': [755], 'motion.': [756], 'longitudinal,': [761], 'creating': [762], 'peristaltic': [764], 'inlet': [768], 'outlet': [770], 'bellows-like': [773], 'septum.10': [781], 'That': [782], 'differ': [785], 'their': [787, 2262], 'anatomy': [788], 'irrefutable,': [792], 'later,': [797], 'morphologically': [798], 'functionally,': [800], 'they': [801, 812, 1824, 3750], 'inextricably': [803, 3424], 'linked': [804, 2833, 3425], 'not': [805, 832, 1691, 1836, 1991, 2050, 2073, 2097, 2114, 2342, 2371, 2434, 2601, 2639, 2900, 3510, 4103], 'only': [806, 940, 2085], 'health': [808], 'react': [813], 'disease.Does': [815], 'Differ': [818, 1428], 'Its': [823], '(Mal)': [824], 'Adaptation': [825], 'Adverse': [827, 863, 1851], 'Loading?Although': [828], 'immune': [833], 'direct': [836], 'effects': [837, 2313, 2432, 3567, 3926, 3996, 4025], 'coronary': [839, 3598, 3650, 3955], 'disease': [840, 1610, 4037], 'global': [843], 'regional': [845, 3130], 'ischemia,': [846, 3131], 'clinical': [848, 953, 1012, 1126, 2170, 4031], 'practice,': [849], 'most': [855, 1011], 'frequently': [856, 986], 'affected': [857], 'increased': [859, 1061, 1117, 1306, 1433, 1593, 1655, 1758, 1973, 2078, 2128, 2265, 2298, 2442, 2504, 2654, 2787, 2885, 2894, 3123, 3313, 3335], 'preload': [860, 912], 'afterload.': [862, 878], 'affects': [866, 3900], 'function,': [868, 1099, 1212], 'exquisitely': [873], 'dependent': [874], 'on,': [875], 'particular,': [877], 'Even': [879], 'small': [880], 'changes': [881, 935, 942, 959, 1020, 1642, 1646, 1752, 2280, 3644, 3910], 'total': [883], 'demonstrated': [888, 2198, 2457, 3497], 'increases': [891, 920, 1000, 2122, 3717], 'airway': [894], 'positive': [897], 'ventilation,': [899], 'reduce': [901], 'contractile': [903, 1398], 'performance': [904, 2426], 'even': [909, 918, 998, 2119, 2489], 'maintained.11': [914], 'animal': [916], 'models,': [917], 'afterload': [922, 938, 1003, 1022, 1038, 1049, 1590, 1759, 1894, 2055, 2710, 2886, 3153, 3195, 4125], 'lead': [923, 1384, 2283, 2963, 3907], 'profound': [925], 'decreases': [926], 'stroke': [929, 945, 2131, 3720, 3815], 'volume.12': [930, 946], 'much': [933, 1040], 'larger': [934], 'induced': [939, 3154, 3953, 3958, 4122], 'These': [947, 2278, 2311, 2809, 2905, 3818, 3925, 3994], 'experimental': [948, 1891, 2022, 2365, 2460, 3139, 3500, 3819], 'practice.': [954], 'Although': [955, 1818, 2105], 'patients': [956, 970, 1220, 1261, 1299, 2101, 2468, 4110], 'resistance': [963, 1170, 1256, 1740, 3217, 3221], 'compensate': [965], 'over': [966, 1156, 1257, 1374], 'range,': [969], 'arterial': [974, 1962, 3319], 'hypertension': [975], '(PAH),': [976], 'example,': [978, 2324, 4040], 'setting': [981, 3121, 3190, 4032], 'lung': [984], 'failure,': [985, 2074, 2117, 2156, 2173, 4071], 'develop': [987, 2486], 'compromised': [993, 1636], 'output.Although': [995], 'cause': [1004], 'dramatic': [1005], 'reductions': [1006], 'scenarios,': [1013], 'including': [1014, 1815, 2241, 2605, 3344], 'PAH': [1015, 1043, 2438, 2651], 'obstruction,': [1019], 'occur': [1026], 'progressively.': [1027], 'Indeed,': [1028], 'setting,': [1032], 'relative': [1034, 1658], 'increase': [1035, 1046, 1821, 2007, 2332, 2361, 2720], 'greater': [1041], 'hypertension.': [1052], 'question': [1054, 1071], 'becomes,': [1055], 'Can': [1056], 'adapt': [1059, 1708], 'afterload,': [1062, 1118, 1434, 1974, 2129, 3125], 'response': [1066, 1782, 1811, 1874, 1971, 2126, 2521, 2935, 3025, 3049, 3149, 3262, 3272, 3316], 'adaptive': [1067, 2028, 2125, 2206], 'maladaptive?': [1069], 'This': [1070, 1427, 1671, 1994, 2495, 2682, 4083], 'relates': [1072], 'another': [1074], 'question:': [1075], 'What': [1076], 'failure?': [1079], 'If': [1080], 'myocardium': [1088, 1187, 3745], 'suffers': [1089], 'detrimental': [1090], 'remodeling': [1091], 'injury': [1093, 3143, 3391], 'ultimately': [1095, 1614], 'affect': [1096], 'long-term': [1098, 1920], 'border': [1101], 'adaptation': [1103, 1166, 1587, 2263], 'becomes': [1106, 3895], 'indistinct.Although': [1107], 'emphasized': [1110], 'vulnerability': [1112], 'especially': [1119], 'acute,13': [1121], 'clear': [1124, 2108], 'experience': [1127], '(eg,': [1128], 'congenitally': [1129, 1278, 1337], 'corrected': [1130, 1279, 1338], 'transposition': [1131, 1272, 1280, 1339], 'great': [1134, 1275, 1283, 1342], 'arteries,': [1135], 'syndrome,': [1137], 'shunts)': [1140], 'maintain': [1145, 1248], 'adequate': [1148, 1249], 'face': [1152, 1253], 'prolonged': [1157, 4119, 4127], 'periods.Eisenmenger': [1158], 'syndrome': [1159, 1208, 1706, 1736, 3032], 'an': [1161, 1267, 2006, 2124, 2302, 2459, 2464, 3499, 3550, 3607, 3670], 'interesting': [1162, 3769], 'example': [1163], 'continuous': [1168], 'system-level': [1169], 'life': [1173, 1202], 'throughout': [1175], 'life.': [1177], 'contrast': [1179], 'never': [1188], 'thins.': [1189], 'similar': [1197, 2200, 2430, 2816, 2989, 4024], 'adult': [1201], '1B).14': [1204], 'Patients': [1205], 'better': [1210, 2956], 'higher': [1213, 1228, 1534], 'index,': [1215, 4171], 'mortality': [1218, 1319, 1405], 'causes': [1223], 'PAH,': [1225, 1960, 4059], 'resistance.15': [1231], 'Therefore,': [1232, 2250], 'would': [1234], 'seem': [1235], 'some': [1240, 2606], 'capacity': [1241], 'retain': [1243], 'characteristics': [1245], 'years.': [1259], 'after': [1266, 1716, 2469], 'atrial': [1268, 2635], 'switch': [1269], 'procedure': [1270], 'arteries': [1276, 1284], 'live': [1286], 'decades.': [1288], 'At': [1289], 'same': [1291], 'time,': [1292], 'these': [1298, 1727, 1790, 2518, 2745, 2871, 2924, 2959, 3678, 3735], 'prone': [1301, 2449], 'mortality,': [1307], 'arrhythmias': [1309], 'tricuspid': [1311, 1377, 1386], 'regurgitation': [1312], 'important': [1314, 1395, 2498, 3671], 'drivers': [1315], 'morbidity': [1317, 1403], 'beyond': [1320, 2038], 'per': [1324, 1400], 'se': [1325], '2).16,17Download': [1327], '2.': [1330, 1839], 'Color-flow': [1331], 'Doppler': [1332], 'arteries.': [1343], 'abnormality,': [1346], 'atrium': [1349], '(LA)': [1350], 'connects': [1351], '(RV),': [1356], 'which': [1357, 1388, 2326, 2764, 2802, 2853, 3507], 'acts': [1358], 'pumping': [1362], 'eject': [1365], 'aorta.': [1369], 'commonly': [1372, 1383, 3186], 'fails': [1373], 'time.': [1375], 'Structural': [1376], 'abnormalities': [1378], 'progressive': [1380, 2065, 3796], 'regurgitation,': [1387, 3199], 'major': [1391], 'factor,': [1392], 'perhaps': [1393], 'se,': [1401], 'driving': [1402], 'condition.': [1408], 'indicates': [1410, 1950], 'ventricle;': [1412], 'RA,': [1414], 'atrium.How': [1416], 'Does': [1417, 1426], 'Adapt': [1420], 'Chronically': [1422], 'Increased': [1423], 'Afterload,': [1424], 'LV?In': [1431], 'chronically': [1432, 1550], 'relation': [1438, 1601], 'shifts': [1439], 'shape,': [1443, 1456], 'reflecting': [1444], 'efficiency/low': [1447], '3),': [1450], 'square': [1453], 'periods,': [1463], 'indistinguishable': [1464, 1666], '3).Download': [1472], '3.': [1475], '(P-V)': [1480], 'obtained': [1482, 1556], 'conductance': [1485], 'catheter.': [1486], 'diagram': [1488], 'demonstrates': [1492, 1654], 'use': [1494], 'P-V': [1496, 1507, 1543], 'loops.': [1497], 'white': [1499], 'solid': [1500], 'lines': [1501], 'pass': [1502], 'tangential': [1503], 'end-systolic': [1506, 1528, 1535, 1567, 1599, 1633, 3964, 3992], 'points': [1508], '"family"': [1511], 'produced': [1514], 'varying': [1516, 2571], 'conditions.': [1519], 'slope': [1521, 1532], 'line': [1524], 'gives': [1525], 'elastance.': [1529, 1536, 3993], 'A': [1530, 2955], 'steeper': [1531, 1598], 'depicts': [1533, 1539], 'Loop': [1537, 1545, 1553], 'loop.': [1544], 'b': [1546, 1576], 'represents': [1547], 'compensated,': [1549], 'hypertensive': [1551, 1560], 'RV.': [1552, 1561, 1993, 2322, 2603], 'c': [1554], 'decompensated': [1559, 1579, 3090], 'decrease': [1564, 1631, 1826, 2659, 2725, 3213, 3590, 3610, 3632], 'elastance': [1568, 1634], 'compensated': [1571, 1585, 3088], 'depicted': [1573, 1581], 'c.This': [1584], 'occurs': [1591, 3092], 'through': [1592, 1743, 3405], 'contractility,': [1594, 1823], 'manifested': [1595], '3),18,19': [1603], 'preserving': [1605], 'output.19': [1607], 'However,': [1608, 2044, 2413, 2822], 'progression,': [1611], 'fails,': [1615], 'leading': [1616], 'dilatation,': [1620], 'rightward': [1622], 'shift': [1623, 1997, 3065, 3919, 4121], 'curve,': [1627], 'resultant': [1630], '3).18These': [1640], 'mirrored': [1644], 'patterns.': [1650], 'decreased': [1660, 2159, 2167, 2175, 2673, 4063], 'shortening': [1662], 'pattern': [1665, 1715, 3058], 'LV.20': [1670], 'observation': [1672, 3772], 'somewhat': [1674], 'surprising': [1675], 'diffusion': [1678], 'tensor': [1679, 3438], 'magnetic': [1680, 3439], 'resonance': [1681, 3440], 'imaging': [1682], 'shows': [1683, 3312], 'hypertrophy': [1689, 2031, 2034, 2071, 2184, 2193, 2369, 2739, 2751, 2819, 2858, 2867, 2949, 3091, 3103, 3265], 'fundamentally': [1692], 'normal.21': [1695], 'functionally': [1698], 'single': [1699], 'hypoplastic': [1703, 1733], 'versus': [1712], 'stage': [1717, 2304], '1': [1718, 3833, 3864], 'surgical': [1720, 2470, 2492], 'palliation': [1721], '(a': [1722], 'particularly': [1723, 3060], 'vulnerable': [1724], 'period': [1725], 'patients).22': [1728], 'Yet,': [1729], 'continuously': [1737], 'difficult': [1749, 3856], 'attribute': [1751], 'patterns': [1756, 2810], 'alone.At': [1760], 'level,': [1763], 'recent': [1764], 'literature': [1765, 2023], 'highlighted': [1767, 2567], 'expression': [1776, 1880, 1889, 1928, 2004, 2572, 2748, 2760, 2788, 2813], 'involved': [1779], 'failure.23': [1787], 'Some': [1788, 2587], 'detailed': [1793, 2017], 'following': [1796], 'text': [1797, 1968], 'summarized': [1800], 'Table': [1802], '2.24–34': [1803], 'there': [1805, 2251, 2757, 2785, 2823, 3010, 3277, 3337, 3793], 'certain': [1813], 'effectors,': [1814], 'adrenergic': [1816, 1914, 2009], 'hormones.': [1817], 'α1-adrenergic': [1819], 'agonists': [1820], 'contractility.24': [1828], 'Long-term': [1829], 'infusion': [1830], 'norepinephrine': [1832, 1921], 'induces': [1833, 2069], 'hypertrophy.25Table': [1838], 'Molecular': [1840], 'Response': [1849], 'Loading*Molecular': [1852], 'ResponseRight': [1853], 'VentricleLeft': [1854], 'VentricleWnt': [1855], 'pathway': [1856, 2209], 'activation': [1857, 3844, 3848, 3871, 3877], 'glycolysis-to-glucose': [1859, 2275, 2328], 'oxidation': [1860, 2276, 2329], 'metabolism': [1861], 'afterloadHigher': [1863], 'activation;': [1864, 1869], 'potentially': [1865, 1870, 2253], 'inefficient': [1866, 2294], 'metabolism26Lower': [1868], 'improved': [1871], 'metabolism26Fibrotic': [1873], 'loadingStronger27Weaker27Irx2': [1877], 'transcription': [1878, 2581, 2588], 'factor': [1879, 2502, 3352], 'afterloadNot': [1882], 'expressed28Expressed28Atrial': [1883], 'natriuretic': [1884, 1952, 2386, 2393, 2417, 2636], 'peptide': [1885, 2387, 2394, 2418, 2637], 'expressionNot': [1886], 'expressed29Expressed29miRNA': [1887], '133a': [1888, 2664], 'PAHDecreased28…Expression': [1892], 'clusterin,': [1896, 2907], 'neuroblastoma': [1897, 2908], 'suppression': [1898, 2909], 'tumorigenicity': [1900, 2911], '1,': [1901, 2801, 2912], 'Dkk3,': [1902, 2913], 'Sfrp2,': [1903, 2914], 'formin': [1904, 2915], 'binding': [1905, 2916], 'protein,': [1906, 2917], 'annexin': [1907, 2918], 'A7,': [1908, 2919], 'lysyl': [1909, 2921], 'oxidaseIncreased30Not': [1910], 'increased30Response': [1911], 'α-1': [1913], 'receptor': [1915], 'agonistsDecrease': [1916], 'contractility24Increase': [1917], 'contractility24Response': [1918], 'infusionNo': [1922], 'hypertrophy25hypertrophy25miRNA': [1923], '28,': [1924, 2847], '148a,': [1925, 2849], '93': [1927], 'failureIncreased30Decreased30Response': [1930], 'dichloroacetate': [1932], 'hypertrophyIncreased': [1934, 1941], 'inotropy26Unchanged': [1935], 'inotropy26Response': [1936], 'PDE5': [1938], 'inhibitors': [1939, 2357], 'inotropy31Unchanged': [1942], 'inotropy31Response': [1943], 'recombinant': [1945, 2415], 'BNP': [1946], 'infusionUnchanged': [1947], 'inotropy33,34Increased': [1948], 'inotropy32BNP': [1949], 'brain': [1951, 2385, 2416], 'peptide;': [1953], 'Irx2;': [1954], 'Iroquois': [1955, 2592, 2625], 'homeobox': [1956, 2593, 2626], '2;': [1957], 'miRNA,': [1958], 'microRNA;': [1959], 'hypertension;': [1963], 'PDE5,': [1965], 'phosphodiesterase': [1966, 2014, 2339, 2355], 'type-5.*See': [1967], 'details.In': [1970], 'reverts': [1977], 'gene': [1981, 2177, 2783, 3057, 3076], 'pattern,': [1982], 're-expressing': [1983], 'normally': [1985], 'expressed': [1986, 2343, 2396, 2596, 2614, 2640], 'includes': [1995], 'α-': [1999], 'β-myosin': [2001], 'heavy': [2002, 3063], 'chain': [2003, 3064], 'receptors,': [2010], 'calcineurin': [2011], 'activation,35–37': [2012], 'type-5': [2015, 2340, 2356], 'expression.31A': [2016], 'analysis': [2018, 3311], 'accumulating': [2021], 'progression': [2026, 2774, 2952, 3086, 3225], 'maladaptive': [2030], 'scope': [2040], 'review.': [2043], 'suffice': [2045], 'say': [2048], 'all': [2051], 'studies': [2052, 2148, 2179, 3251], 'show': [2056, 2652, 3754], 'One': [2059, 2208, 4021], 'study': [2060, 3501], 'rodents': [2062, 2648], 'found': [2063, 2873, 3164], 'banding': [2068, 2187, 2196, 3158, 3320], 'evidenced': [2076], 'contractility;': [2079], 'was': [2083, 2758, 2786, 3278, 3495, 3518, 3544, 3681, 3770, 3794, 3978], '≈60%': [2086], 'levels,': [2089], 'degree': [2091, 3655], 'severity': [2093, 2406], 'usually': [2095], 'does': [2096, 2113], 'induce': [2098, 2115], 'stenosis.38': [2104], 'overload': [2111], 'alone': [2112], 'contractility': [2121, 2363, 3999], 'still': [2137], 'decrease,': [2138], 'fulfilling': [2139], 'definition': [2141], 'some.39': [2145], 'Other': [2146], 'rodent': [2147, 2984], 'inducing': [2149, 3114], 'shown': [2154, 2436, 2978, 3257, 3823], 'dilation,': [2158], 'motion,': [2162], 'elevated': [2163], 'end-diastolic': [2165, 4096], 'pressure,': [2166, 3594], 'output,': [2169, 2422, 4093], 'survival.40Microarray': [2176], 'chip': [2178], 'mice': [2181, 2190], 'aortic': [2186, 2680, 3206], 'compared': [2188, 2216, 2307, 2744, 3273, 3289], 'both': [2199, 2398, 2408, 2568, 2616, 3094, 3099, 3146, 3177, 3192, 3205, 3248, 3323, 3399, 3427, 3799], 'mechanisms.40': [2207], 'activated': [2211], 'pressure-loaded': [2214, 2219, 2321], 'Wnt': [2223, 2225], 'pathway.': [2224], 'regulates': [2226], 'glycogen': [2227], 'synthase': [2228], 'kinase-3b': [2229], 'activity,': [2230], 'serine/threonine': [2232], 'protein': [2233], 'kinase': [2234], 'active': [2235], 'multiple': [2237, 2254], 'intracellular': [2238], 'signaling': [2239, 2696, 3175, 3342], 'pathways,': [2240], 'cell': [2242, 2835], 'proliferation,': [2243, 2837], 'migration,': [2244], 'inflammation,': [2245], 'glucose': [2246], 'regulation,': [2247], 'apoptosis.41,42': [2249], 'potential': [2268, 2290, 2315], 'metabolism,': [2271, 2296, 2838], 'mitochondrial': [2272, 2288], 'remodeling,': [2273], 'coupling.': [2277], 'metabolic': [2279], 'subsequently': [2282], 'hyperpolarization': [2285], 'membrane': [2289], 'hypertrophy,': [2293, 2756], 'lactate': [2299], 'production': [2300], 'earlier': [2303], 'maladaptation': [2306], 'LV.26': [2310], 'implications': [2317], 'specific': [2318, 2658], 'For': [2323], 'dichloroacetate,': [2325], 'improves': [2327, 2420, 4161, 4165], 'coupling,': [2330], 'inotropy': [2333], 'hypertrophied': [2336], 'RV.26': [2337], 'upregulated': [2350, 2855], 'hypertrophy.31': [2353], 'Accordingly,': [2354], 'such': [2358, 2590], 'sildenafil': [2360], 'models': [2366, 2707, 2985], 'RV.31There': [2375], 'beneficial': [2382, 2431], 'action': [2383], '2': [2390, 2539, 2594, 2627, 3042, 3358, 3421], 'Brain': [2392], 'ventricles,': [2399], 'serum': [2401], 'levels': [2402], 'correlate': [2403], 'failure.43': [2412], '(neseritide)': [2419], 'symptoms,': [2423], 'failure,32': [2429], 'been': [2435, 2515, 2542, 2977, 3371, 3822], 'failure.33,34In': [2441], 'loading,': [2444], 'appears': [2447], 'developing': [2454], 'fibrosis,': [2455, 2488, 3107, 3336], 'pig': [2461], 'model': [2462], 'aortocaval': [2465], 'shunt.27': [2466], 'Similarly,': [2467, 2870, 3710, 4108], 'repair': [2471], 'tetralogy': [2473, 4112], 'Fallot': [2475, 4114], 'who': [2476], 'long-standing': [2478], 'load': [2481], 'insufficiency': [2485], 'remote': [2490], 'incision': [2493], 'sites.44': [2494], 'clinically': [2497, 3929], 'risk': [2501], 'propensity': [2505], 'arrhythmias,': [2507], 'exercise': [2508, 4166], 'intolerance,': [2509], 'failure.44,45': [2512], 'It': [2513], 'suggested': [2516], 'stem': [2531], 'origin': [2536], 'ventricles.27There': [2540], 'increasing': [2543], 'interest': [2544], 'role': [2547, 3672, 3706], 'microRNAs': [2549], '(miRNA)': [2550], 'regulators': [2552], 'range': [2556], 'cardiovascular': [2558], 'processes': [2559], 'possible': [2562], 'targets.46,47': [2564], 'Studies': [2565], 'overlapping': [2569], 'failing': [2575, 2676], 'various': [2580, 3034, 4034], 'factors,': [2582], 'mRNA,': [2583], 'miRNA': [2585, 2655, 2661, 2663, 2715, 2747, 2790, 2795, 2797, 2800, 2812, 2848, 2851, 2973, 2996], 'expression.': [2586], 'factors': [2589], 'Others,': [2604], 'nuclear': [2607], 'receptors': [2608], 'insulin': [2610], 'growth': [2611, 2691, 3173, 3346, 3351], 'factor-1,': [2612], 'degrees.28': [2621], 'lack': [2623], 'explain': [2633], 'why': [2634], 'RV.29': [2644], 'Failing': [2645], 'RVs': [2646], 'SU5416/hypoxia-induced': [2650], 'overall': [2653], '133a.28': [2662], 'thought': [2666], 'suppress': [2668], 'fibrosis': [2670, 2702, 3115, 3168, 3184, 3201, 3227, 3246], 'constriction.46,48': [2681], 'aligns': [2683], 'marked': [2686], 'upregulation': [2687, 3170, 3339], 'connective': [2689, 3349], 'tissue': [2690, 3350], 'factor/CCN2': [2692], 'profibrotic': [2695, 3341], 'molecules': [2697], 'our': [2704], 'failure.28,49': [2712], '21': [2716], '34c*': [2718], 'failure.28': [2728], 'Reddy': [2729], 'et': [2730, 3561, 3731, 3945], 'al30': [2731], 'investigated': [2732], 'miRNAs': [2733, 2762, 2832], 'altered': [2759], '199a-3p,': [2763], 'associated': [2766, 2804, 3545], 'cardiomyocyte': [2768], 'survival': [2769], 'growth.': [2771], 'reactivation': [2779], 'program,': [2784], '208b,': [2791], 'well': [2793], '34,': [2796], '21,': [2798], 'apoptosis': [2806], 'fibrosis.': [2808], 'largely': [2815], 'were': [2824, 2854, 3751, 4000], 'notable': [2826], 'survival,': [2836], 'extracellular': [2839, 3109], 'matrix': [2840, 3110, 3355], 'turnover,': [2841], 'impaired': [2843], 'proteasomal': [2844], '(miRNA': [2846], '93),': [2852], 'downregulated': [2862], 'unchanged': [2864], 'failure.30': [2869], 'investigators': [2872], 'mostly': [2888], 'concordant,': [2889], 'key': [2891, 2940], 'transcripts': [2892], 'afterloaded': [2897, 2903], 'included': [2906], 'oxidase.': [2922], 'studies,': [2925], 'seems': [2927], 'share': [2932, 3044, 3389, 3395, 3410], 'common': [2934, 3046, 3142, 3203, 3390, 3407], 'mechanisms': [2936, 3113, 3392], 'stress,': [2938], 'warrant': [2943], 'management': [2945], 'strategies': [2946], 'understanding': [2957], 'subcellular': [2960], 'events': [2961], 'development': [2966, 3548, 3813], 'novel,': [2968], 'ventricle-specific': [2969], 'treatments.': [2970], 'Inhibition': [2971], '208a': [2974], 'recently': [2976], 'abrogate': [2980], 'failure50;': [2988], 'responses,': [2990], 'albeit': [2991], 'targeted': [2992], 'signature,': [2997], 'might': [2998], 'anticipated': [3000], 'failure.Are': [3003], 'Really': [3008], 'Different?Although': [3009], 'undoubtedly': [3012], 'complex': [3029], 'therapies,': [3035], 'evident': [3039, 3451], 'features': [3047], 'shift,': [3059], 'myosin': [3062], 'α': [3068], 'β': [3070], 'isoform,': [3071], 'hallmark': [3073], 'reactivation,': [3077], 'triggered': [3080], 'failure.35': [3083], 'Common': [3096], 'findings': [3097], 'collagen': [3105, 3303, 3314], 'deposition,': [3106], 'remodeling.51': [3111], 'multiple,': [3117], 'putative': [3126], 'triggers': [3127], 'include': [3129], 'necrosis,': [3132], 'apoptosis,': [3134], 'others.52': [3136], 'Our': [3137], 'own': [3138], 'data': [3140], 'suggest': [3141], 'pathways': [3144, 3285, 3471], 'rabbit': [3161], 'model,': [3162], 'transforming': [3172, 3345], 'factor-β1': [3174], '4).': [3180], 'Just': [3181, 3767], 'seen': [3187], 'severe': [3193], 'stenosis': [3207, 4147], 'regurgitation.44,53,54': [3209], 'Pharmacological': [3210], 'agents': [3211], 'either': [3214], 'attenuate': [3223, 3245], 'LV,': [3232, 3276], 'respectively.': [3233], 'mechanical': [3235, 3511, 3526, 3689, 3782, 3803], 'unloading': [3236], 'assist': [3242], 'devices': [3243], 'ventricles.55': [3249], 'Microarray': [3250], 'thousands': [3253], 'pressure-induced': [3264], 'characterized': [3267], 'stronger': [3270], 'transcriptional': [3271], 'evidence': [3280], 'qualitatively': [3282], 'regulatory': [3284], 'LV.56Download': [3292], '4.': [3295], 'Representative': [3296], 'sections': [3297], 'showing': [3298], 'Masson': [3299], 'trichrome': [3300], 'staining': [3301], 'content.': [3304], 'bar': [3306], 'graph': [3307], 'quantitative': [3310], '(PAB)': [3321], 'ventricle.': [3331, 3466], 'association': [3333], 'molecules,': [3343], 'factor-β': [3347], '(TGFβ),': [3348], '(CTGF),': [3353], 'metalloproteinases': [3356], '(MMP)': [3357], '9.49Mechanical': [3360], 'Functional': [3362], 'Interdependence': [3363], 'LVAlthough': [3368], 'customary': [3372], 'consider': [3374], 'entities,': [3382], 'approach': [3384], 'flawed.': [3386], 'anatomically': [3394], 'encircle': [3398], 'They': [3401], 'intimately': [3403], 'attached': [3404], 'pericardial': [3412], 'space': [3413], '5).57–60': [3415], 'structurally': [3429], 'abnormal': [3432], 'heart.Download': [3433], '5.': [3436], 'Diffusion': [3437], 'image': [3441], 'demonstrating': [3442], 'myocytes.': [3445], 'figure,': [3448], 'parietal': [3457], 'how': [3469], 'intrude': [3472], 'epicardium': [3475], 'endocardium': [3477], 'means': [3479], 'movement': [3484], 'about': [3485], 'transverse': [3487], 'circular': [3488], 'axis.60The': [3489], 'importance': [3490], 'LV-to-RV': [3492], 'cross-talk': [3494], 'elegantly': [3496], 'intact': [3503, 3774], 'explanted': [3504], 'hearts': [3505], 'electric': [3508, 3843, 3847], 'continuity': [3512], 'interrupted.61': [3519], 'pacing': [3521, 3836], 'led': [3522], 'little': [3524], 'detectable': [3525], 'activity': [3527], '(measured': [3528], 'developed': [3530, 3576, 3593, 3613, 3623, 3635, 3640, 3723], 'pressure)': [3531], 'Conversely,': [3535], 'however,': [3536], 'pacing-induced': [3537], 'electrically': [3541], 'almost': [3551], 'trace': [3555], 'flow.61': [3559], 'Santamore': [3560], 'al62': [3562], 'elucidated': [3564], 'individual': [3566], 'pressure.': [3577, 3614, 3636], 'Reducing': [3578], 'optimal': [3583], 'zero': [3586], 'caused': [3587, 3628], '5.7%': [3589], 'ligating': [3596], 'supply': [3599], 'resulted': [3605], '9.3%': [3609], 'Cutting': [3615], 'prevent': [3621], 'force': [3627], '45%': [3631], 'Changes': [3637, 3903], 'occlusion': [3651], 'correlated': [3652], 'septal': [3657, 4120, 4149], 'bulging': [3658], 'systole,': [3664], 'suggesting': [3665], 'plays': [3669, 3703], 'mediating': [3674], 'ventricular-ventricular': [3675], 'interactions.': [3676], 'experiments,': [3679], 'estimated': [3682], '>50%': [3684], 'work': [3690, 3816], 'generated': [3693], 'pivotal': [3705], 'function.62': [3709], 'isovolumetric': [3712], 'results': [3714, 4067], 'simultaneous': [3716], 'constant': [3727], 'volume.63': [3729], 'Hoffman': [3730], 'al64': [3732], 'expanded': [3733], 'observations': [3736], 'vivo': [3739, 3825], 'experiments.': [3740], 'By': [3741], 'replacing': [3742], 'noncontractile': [3748, 3789], 'prosthesis,': [3749], 'able': [3752], 'virtually': [3755], 'consequence': [3762], 'shortening.': [3766], 'geometry': [3776], 'crucial': [3778], 'performance.': [3783, 3902], 'gradual': [3785], 'enlargement': [3786], 'wall,': [3792], 'work;': [3804], 'is,': [3806], 'dilated,': [3810], 'decreased.': [3817], 'phenomena': [3820], 'human': [3828], 'pre-excitation': [3831], 'extrasystolic': [3839], 'beats.65': [3840], 'Normally,': [3841], 'temporally': [3850], 'close': [3851], 'enough': [3852], 'peak': [3860], 'dP/dt': [3861, 3894], 'spike': [3862], 'other.': [3868], 'When': [3869], 'sufficiently': [3873], 'separated': [3874], 'extrasystole': [3881], 'bundle-branch': [3885], 'block,': [3886], 'contribution': [3888], 'apparent.65The': [3896], 'profoundly': [3899], 'substantial': [3909], 'load-independent': [3912, 3967, 3995], 'measures': [3913], 'relation.66': [3924], 'relevant': [3930], 'unloaded': [3936], 'placement': [3938], 'caval': [3941, 3985, 4005, 4043], 'shunt.': [3943], 'Danton': [3944], 'al67': [3946], 'showed': [3947], 'experimentally': [3948], 'ischemia': 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'shortens': [4151], 'contraction,': [4153], 'synchronizes': [4154], 'relaxation,': [4160], 'filling,': [4163], 'capacity.74': [4167], 'eccentricity': [4170], 'simple': [4173], 'echocardiographic': [4174], 'index': [4175], 'quantifies': [4177], 'anterior-posterior': [4179], 'compression': [4181], 'distended': [4184], 'correlates': [4186]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1968814354', 'counts_by_year': [{'year': 2024, 'cited_by_count': 32}, {'year': 2023, 'cited_by_count': 28}, {'year': 2022, 'cited_by_count': 36}, {'year': 2021, 'cited_by_count': 38}, {'year': 2020, 'cited_by_count': 36}, {'year': 2019, 'cited_by_count': 27}, {'year': 2018, 'cited_by_count': 32}, {'year': 2017, 'cited_by_count': 38}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 12}], 'updated_date': '2024-12-29T13:32:14.940960', 'created_date': '2016-06-24'}
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