Catalytic C−H Activation of sp3 C−H Bonds inα-Position to a Nitrogen Atom—Two New Approaches

Name: Work Video:
Duration: 3 min 30 s
Description: A very promising approach for the efficient synthesis of complex amines is provided by the transition metal catalyzed activation of sp3 C−H bonds in the position α to a nitrogen atom. Two recent publications show that this approach can be realized impressively by the use of rhodium and iridium catalysts (see scheme; cod=1,5-cyclooctadiene).
Sven Doye
{'id': 'https://openalex.org/W1965625490', 'doi': 'https://doi.org/10.1002/1521-3773(20010917)40:18<3351::aid-anie3351>3.0.co;2-b', 'title': 'Catalytic C−H Activation of sp3 C−H Bonds inα-Position to a Nitrogen Atom—Two New Approaches', 'display_name': 'Catalytic C−H Activation of sp3 C−H Bonds inα-Position to a Nitrogen Atom—Two New Approaches', 'publication_year': 2001, 'publication_date': '2001-09-17', 'ids': {'openalex': 'https://openalex.org/W1965625490', 'doi': 'https://doi.org/10.1002/1521-3773(20010917)40:18<3351::aid-anie3351>3.0.co;2-b', 'mag': '1965625490', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11592135'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/1521-3773(20010917)40:18<3351::aid-anie3351>3.0.co;2-b', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S67393510', 'display_name': 'Angewandte Chemie International Edition', 'issn_l': '1433-7851', 'issn': ['1433-7851', '1521-3773'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5032369576', 'display_name': 'Sven Doye', 'orcid': 'https://orcid.org/0000-0002-2249-5337'}, 'institutions': [{'id': 'https://openalex.org/I114112103', 'display_name': 'Leibniz University Hannover', 'ror': 'https://ror.org/0304hq317', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114112103']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Sven Doye', 'raw_affiliation_strings': ['Institut für Organische Chemie Universität Hannover Schneiderberg 1 B, 30167 Hannover (Germany).'], 'affiliations': [{'raw_affiliation_string': 'Institut für Organische Chemie Universität Hannover Schneiderberg 1 B, 30167 Hannover (Germany).', 'institution_ids': ['https://openalex.org/I114112103']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5032369576'], 'corresponding_institution_ids': ['https://openalex.org/I114112103'], 'apc_list': {'value': 5250, 'currency': 'USD', 'value_usd': 5250, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.642, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 74, 'citation_normalized_percentile': {'value': 0.95791, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '40', 'issue': '18', 'first_page': '3351', 'last_page': '3353'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10354', 'display_name': 'Catalytic C–H Functionalization Methods', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10354', 'display_name': 'Catalytic C–H Functionalization Methods', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12251', 'display_name': 'Synthesis and Catalytic Reactions', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11611', 'display_name': 'Cyclopropane Reaction Mechanisms', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nitrogen-atom', 'display_name': 'Nitrogen atom', 'score': 0.75024086}, {'id': 'https://openalex.org/keywords/cyclooctadiene', 'display_name': 'Cyclooctadiene', 'score': 0.45258766}, {'id': 'https://openalex.org/keywords/position', 'display_name': 'Position (finance)', 'score': 0.44558185}], 'concepts': [{'id': 'https://openalex.org/C528581852', 'wikidata': 'https://www.wikidata.org/wiki/Q877', 'display_name': 'Iridium', 'level': 3, 'score': 0.86095685}, {'id': 'https://openalex.org/C521398313', 'wikidata': 'https://www.wikidata.org/wiki/Q1087', 'display_name': 'Rhodium', 'level': 3, 'score': 0.7842561}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.7821597}, {'id': 'https://openalex.org/C2993420144', 'wikidata': 'https://www.wikidata.org/wiki/Q627', 'display_name': 'Nitrogen atom', 'level': 3, 'score': 0.75024086}, {'id': 'https://openalex.org/C58312451', 'wikidata': 'https://www.wikidata.org/wiki/Q4817200', 'display_name': 'Atom (system on chip)', 'level': 2, 'score': 0.64849913}, {'id': 'https://openalex.org/C537208039', 'wikidata': 'https://www.wikidata.org/wiki/Q627', 'display_name': 'Nitrogen', 'level': 2, 'score': 0.6099136}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.561645}, {'id': 'https://openalex.org/C106773901', 'wikidata': 'https://www.wikidata.org/wiki/Q19588', 'display_name': 'Transition metal', 'level': 3, 'score': 0.45651555}, {'id': 'https://openalex.org/C2779910884', 'wikidata': 'https://www.wikidata.org/wiki/Q867322', 'display_name': 'Cyclooctadiene', 'level': 3, 'score': 0.45258766}, {'id': 'https://openalex.org/C198082294', 'wikidata': 'https://www.wikidata.org/wiki/Q3399648', 'display_name': 'Position (finance)', 'level': 2, 'score': 0.44558185}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.33345765}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.14721146}, {'id': 'https://openalex.org/C2781311116', 'wikidata': 'https://www.wikidata.org/wiki/Q83306', 'display_name': 'Group (periodic table)', 'level': 2, 'score': 0.074888945}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.05571726}, {'id': 'https://openalex.org/C149635348', 'wikidata': 'https://www.wikidata.org/wiki/Q193040', 'display_name': 'Embedded system', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C10138342', 'wikidata': 'https://www.wikidata.org/wiki/Q43015', 'display_name': 'Finance', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C162324750', 'wikidata': 'https://www.wikidata.org/wiki/Q8134', 'display_name': 'Economics', 'level': 0, 'score': 0.0}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/1521-3773(20010917)40:18<3351::aid-anie3351>3.0.co;2-b', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S67393510', 'display_name': 'Angewandte Chemie International Edition', 'issn_l': '1433-7851', 'issn': ['1433-7851', '1521-3773'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11592135', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 14, 'referenced_works': ['https://openalex.org/W1979480323', 'https://openalex.org/W2040299058', 'https://openalex.org/W2048770265', 'https://openalex.org/W2050605218', 'https://openalex.org/W2053820095', 'https://openalex.org/W2054994580', 'https://openalex.org/W2082051792', 'https://openalex.org/W2086165010', 'https://openalex.org/W2086727951', 'https://openalex.org/W2133502386', 'https://openalex.org/W2170583589', 'https://openalex.org/W2476269901', 'https://openalex.org/W2951751905', 'https://openalex.org/W4243744934'], 'related_works': ['https://openalex.org/W2951154062', 'https://openalex.org/W2486993578', 'https://openalex.org/W2352545358', 'https://openalex.org/W2172104651', 'https://openalex.org/W2123957762', 'https://openalex.org/W2064085683', 'https://openalex.org/W2056282397', 'https://openalex.org/W2047587718', 'https://openalex.org/W2035871937', 'https://openalex.org/W1984241065'], 'abstract_inverted_index': {'A': [0], 'very': [1], 'promising': [2], 'approach': [3, 37], 'for': [4], 'the': [5, 14, 24, 43], 'efficient': [6], 'synthesis': [7], 'of': [8, 19, 45], 'complex': [9], 'amines': [10], 'is': [11], 'provided': [12], 'by': [13, 42], 'transition': [15], 'metal': [16], 'catalyzed': [17], 'activation': [18], 'sp3': [20], 'C−H': [21], 'bonds': [22], 'in': [23], 'position': [25], 'α': [26], 'to': [27], 'a': [28], 'nitrogen': [29], 'atom.': [30], 'Two': [31], 'recent': [32], 'publications': [33], 'show': [34], 'that': [35], 'this': [36], 'can': [38], 'be': [39], 'realized': [40], 'impressively': [41], 'use': [44], 'rhodium': [46], 'and': [47], 'iridium': [48], 'catalysts': [49], '(see': [50], 'scheme;': [51], 'cod=1,5-cyclooctadiene).': [52]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1965625490', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-15T17:01:44.056822', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
