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[187, 252, 288, 585, 657, 900, 928, 1575, 1862], 'might': [188, 399, 1684], 'be': [189, 322, 333, 532, 858, 1118, 1323, 1356, 1548], 'marker': [191], 'CVD': [193, 225, 254, 1621, 1786], 'rather': [194, 506, 668], 'than': [195, 359, 669, 1580, 2124], 'independent': [197], 'factor.': [199], 'Both': [200], 'fasting': [201], 'nonfasting': [203], 'triglyceride': [205, 357, 561], 'levels': [206, 562, 1680, 2647, 3097], 'vary': [207], 'widely,': [208], 'concentrations': [210, 227], '2': [212, 910, 949, 1444], '10': [214, 791], 'mmol/L': [215, 229], '(177–885': [216], 'mg/dL)': [217, 905, 1579], 'conferring': [218, 230], 'association': [220], 'increased': [222, 231, 1231, 1245, 1688, 1696], '>10': [228, 866], 'acute': [234], 'pancreatitis.2': [235], 'Large-scale': [236], 'clinical': [237], 'on': [239, 491, 519, 658, 718, 1172, 1339, 1478, 1632, 1711, 2836], 'well-defined': [240], 'subject': [241], 'populations': [242], 'needed': [244, 1324], 'shed': [246], 'light': [247], 'onto': [248], 'risk.Article,': [255], 'see': [256], 'p': [257], '624Triglyceride-rich': [258], 'chylomicrons': [259, 290, 554, 1876], 'generated': [261], 'postprandial': [264], 'state': [265], 'by': [266, 295, 430, 502, 507, 790, 852, 860, 1029, 1379, 1461, 1676, 1746, 1894, 1929, 1964, 1979, 2152, 2840], 'intestinal': [267, 272], 'enterocytes,': [268], 'secreted': [269], 'into': [270, 277, 410, 2303], 'lymph,': [273], 'then': [275, 415], 'released': [276], 'circulation': [278], 'through': [279, 476, 632, 1687, 1695], 'thoracic': [281], 'duct.3,4': [282], 'After': [283], 'reaching': [284], 'bloodstream,': [286], 'within': [289, 2598], 'VLDL': [292], 'hydrolyzed': [294], 'lipoprotein': [296, 591, 1825, 1888, 2117, 2150, 2169, 2202, 2301, 2356, 2508, 2610, 2645, 2746, 3007], 'lipase': [297, 1826, 2118, 2151, 2163, 2218, 2302, 2357, 2509, 2646, 3002], '(LpL)': [298, 1827], 'along': [299], 'luminal': [301, 384, 525, 706, 1849], 'surface': [302, 493, 707, 837, 847, 2195], 'capillaries,': [304], 'mainly': [305], 'heart,': [307], 'skeletal': [308], 'muscle,': [309], 'adipose': [311, 355, 2881, 3100], 'tissue.': [312], 'This': [313, 1099, 1881], 'process': [314, 1882], 'allows': [315], 'release': [316, 444], 'fatty': [318, 448, 1639, 1865], 'acids': [319, 449, 989, 1284, 1866], 'that': [320, 347, 406, 437, 468, 539, 604, 642, 664, 750, 795, 827, 1010, 1034, 1087, 1114, 1243, 1304, 1374, 1384, 1420, 1422, 1486, 1509, 1595, 1706, 1717, 1840, 1899, 2743], 'can': [321, 857], 'used': [323, 334], 'energy': [326, 338], 'source': [327], 'stored': [329], 'for': [330, 613, 830, 839, 1082, 1136, 1608, 1858, 2082, 2201, 2297, 2385, 2415, 2504, 2606, 2927], 'safekeeping': [331], 'times': [336], 'deprivation.': [339], 'recent': [341], 'studies': [342, 602, 1112, 1315, 1336, 1745], 'mice': [344, 540], 'demonstrated': [346, 538, 641, 1418], 'adipocyte-derived': [348], 'LpL': [349, 380, 407, 469, 512, 572, 617, 654, 702, 1125, 1137, 1183, 1236, 1423, 1441, 1759, 1842, 1918], 'plays': [350, 2252], 'smaller': [352, 377, 411], 'tissue': [356, 2882, 3101], 'accumulation': [358, 552, 1021], 'previously': [360, 1445], 'thought.5': [361], 'Two': [362], 'hypotheses,': [363], 'which': [364, 413, 453, 856, 1627, 1683, 1726], 'not': [366, 500, 693, 951, 1045, 1365, 1400, 1590, 1902, 1995, 2010], 'mutually': [367], 'exclusive,': [368], 'put': [371], 'forward': [372], 'explain': [374], 'how': [375, 1756], 'fraction': [378], 'bound': [381, 394], 'endothelium': [385, 420, 516, 697, 1141], 'larger': [387, 1659], 'arteries,': [388], 'compared': [390, 1292, 1715], 'majority': [393, 581, 1488], 'capillary': [397, 515, 608, 623, 690, 1850, 2391], 'endothelium,': [398, 691], 'promote': [400, 456], 'atherosclerosis.': [401], 'The': [402, 432, 462, 759, 773, 783, 809, 970, 1507, 1624, 1892, 1984, 2410, 2497, 2819], 'remnant': [403, 1689], 'hypothesis': [404, 435], 'states': [405, 436], 'hydrolyzes': [408], 'TRLs': [409, 441, 1781], 'able': [416], 'traverse': [418], 'enter': [422], 'artery': [424], 'wall,': [425], 'where': [426, 1854], 'they': [427, 1436], 'engulfed': [429], 'macrophages.': [431], 'lipolytic': [433, 597, 2258], 'toxin': [434], 'LpL-mediated': [438, 1859], 'hydrolysis': [439, 655, 1860], 'results': [442, 1883], 'lipids,': [445, 452], 'oxidized': [451], 'turn': [455], 'proatherosclerotic': [457, 1669], 'changes': [458, 876], 'endothelial': [460, 473, 495, 503, 609, 1197, 1851, 2193, 2392], 'cells.1': [461], 'dogma': [463], 'field': [466], 'held': [467], 'was': [470, 939, 950, 1007, 1080, 1152, 1297, 1397, 1556, 1589], 'tethered': [471, 844], 'cells': [474, 610, 1186, 1202], 'only': [475, 528], 'interaction': [478, 780], 'its': [480, 520, 853, 1179, 1821, 2968], 'positively': [481], 'charged': [482, 487, 730], 'heparin-binding': [483, 2142], 'domains6': [484], 'via': [485], 'negatively': [486], 'heparan': [488, 644, 672, 719, 1922, 2196], 'sulfate': [489, 645, 673, 720, 1923, 2197], 'glycosaminoglycans': [490, 646], 'cells.7–9': [496], 'LpL,': [497, 1302], 'however,': [498, 1027, 1705], 'is': [499, 611, 675, 687, 714, 766, 788, 828, 843, 1363, 1611, 1703, 1713, 1789, 1856, 1977, 1986, 2295, 2413, 2502, 2827], 'synthesized': [501], 'cells,': [504, 1198], 'but': [505, 692, 953, 1409, 1901], 'myocytes': [508], 'adipocytes.': [510], 'How': [511], 'transverses': [513], 'details': [518, 1329], 'subsequent': [521], 'tethering': [522, 703], 'side': [526], 'recently': [529, 663], 'begun': [530], 'illuminated.In': [533], '2007,': [534], 'Young': [536, 2290, 2311, 2343, 2381, 2493, 2593, 2621, 2683, 2735, 2758, 2874, 3021], 'laboratory': [537], 'deficient': [541], 'glycosylphosphatidylinositol-anchored': [543, 1801, 2388, 2466, 2788], 'high-density': [544, 1802, 2097, 2248], 'lipoprotein-binding': [545, 1803, 2249, 2469, 2791], 'protein': [546, 880, 1501, 1804, 2250, 2389, 2792, 3096], '1': [547, 947, 1805, 2251, 2560, 2793], '(GPIHBP1)': [548, 1806, 2794], 'exhibited': [549], 'striking': [551], 'had': [559, 896, 914], 'excess': [564], '1000': [566], 'mg/dL': [567, 934], '(11': [568], 'mmol/L)': [569], 'without': [570], 'altered': [571], 'expression': [573, 606, 1588, 1599], 'adipocytes': [575], 'myocytes.10': [577], 'Furthermore,': [578, 1273, 1333, 1415], 'vast': [580], 'were': [586, 1062, 1216, 1248], 'located': [587, 1249], 'large': [590, 695, 709, 1692, 1728], 'fraction,': [592], 'suggesting': [593, 1303], 'defect': [595], 'processing': [598, 2259], 'chylomicrons.': [600], 'Further': [601, 1314, 1773], 'revealed': [603, 1033, 1113], 'GPIHBP1': [605, 686, 723, 833, 842, 872, 879, 895, 1023, 1051, 1084, 1115, 1134, 1169, 1177, 1190, 1192, 1246, 1271, 1346, 1404, 1413, 1429, 1431, 1447, 1490, 1510, 1560, 1598, 1619, 1757, 1766, 1779, 1818, 1835, 1906, 2294, 2345, 2352, 2501, 2537, 2574, 2603, 2652, 2698, 2741, 2803, 2824, 3004, 3035, 3095], 'critical': [612, 829, 1252, 2254], 'transportation': [615], 'from': [618, 1843, 2798], 'basolateral': [620], 'apical': [624, 660], 'surface,11,12': [625], 'shown': [627], 'Figure': [629], 'A.': [630, 2067, 2138], 'Moreover,': [631], 'series': [634], 'elegant': [636], 'experiments,': [637], 'this': [638, 1154, 1305, 1565, 1584, 2007], 'group': [639], 'neither': [648], 'required': [649, 1857], 'nor': [650], 'sufficient': [651], 'mediate': [653], 'surface14': [661], 'LpL-binding': [665, 670, 992, 1505, 1544], 'GPIHBP1,': [667, 1109, 1295, 1915, 2386], 'glycosaminoglycans,': [674], 'main': [677], 'determinant': [678], 'TRL': [680], 'margination': [681, 2417], 'heart': [683, 1195, 2051], 'capillaries.15': [684], 'Interestingly,': [685], 'expressed': [688, 2005], 'vessel': [696], 'brain': [699], 'capillaries.10,11': [700], 'Therefore,': [701], 'arteries': [710, 1650, 1693], 'susceptible': [711], 'atherosclerosis': [713, 1643, 1686, 1712, 2971], 'presumably': [715], 'more': [716, 2120], 'dependent': [717], 'glycosaminoglycans.Mature': [721], 'contains': [724, 815], 'signal': [726], 'peptide,': [727], 'acidic/negatively': [729], 'amino-terminal': [731], 'domain,': [732, 736], 'short': [734], 'linker': [735], 'highly': [738, 1306], 'conserved': [739, 792, 984, 1307, 2596, 2691], 'lymphocyte': [740, 784, 810], 'antigen': [741, 785, 811], '6': [742, 786, 812], 'motif': [743, 813], '(residues': [744], '65–136),': [745], 'hydrophobic': [748], 'carboxyl-terminal': [749, 2147], 'triggers': [751], 'addition': [753], 'glycosylphosphatidylinositol': [756], '(GPI)': [757], 'anchor.16': [758], 'aspartic': [760], 'glutamic': [762], 'acid–enriched': [763], 'acidic': [764, 774, 2498], 'domain': [765, 775, 787, 1041, 1094, 1228, 1474, 1799, 2143, 2499, 2601, 2696], 'involved': [767], 'binding': [770, 840, 1065, 1208, 1237, 1301, 1442, 1521, 2506, 2608], 'LpL.17': [772], 'also': [776, 814, 1204, 1244, 1432, 1518], 'mediates': [777, 1758], 'apolipoprotein': [778, 1523], 'A-V': [779, 1524], 'GPIHBP1.': [782], 'characterized': [789], 'cysteine': [793, 802, 1014, 1036, 1223, 1261, 1389], 'residues': [794, 803, 1015, 1037, 1224], 'defined': [798], 'disulfide-bonding': [799], 'pattern.': [800], 'These': [801, 1668], 'generate': [804], '3-fingered': [806], 'structural': [807], 'motif.': [808, 969], 'N-linked': [817], 'glycosylation': [818], 'site': [819], '(Asn-78': [820], 'and,': [823], 'Asn-76': [824], 'mouse)': [826], 'trafficking': [831, 1402], 'cell': [836, 1055, 1407, 1852, 2194], 'LpL.': [841, 1313], 'membrane': [851], 'GPI': [854], 'anchor,': [855], 'cleaved': [859], 'phosphatidylinositol-specific': [862], 'phospholipase': [863], 'C.16To': [864], 'date,': [865], 'different': [867, 1469], 'rare': [868], 'mutations/deletions': [869], 'gene': [873, 1561, 1587, 2825], 'resulting': [874], 'patients': [882], 'severe': [884, 1077, 1629, 2539], 'hypertriglyceridemia': [885, 1078, 1151, 1809, 1909, 2830], 'reported.': [888], 'One': [889], 'patient': [890, 1075], 'total': [892], 'loss': [893, 1234, 1503], 'extremely': [897], 'high': [898, 2467, 2789], 'serum': [899, 927], '(>280': [901], 'mmol/L;': [902, 1577], '25': [903], '000': [904], 'at': [906, 1651, 1663, 1737, 1969], 'age': [908, 1657], 'months.18': [911], 'Another': [912], 'family': [913, 1396], 'deletion': [916, 954, 2566], 'exons': [918, 946, 956, 2568], '3': [919, 957, 2569], '4': [921, 923, 959, 2571, 3120], 'adult': [924], 'individuals': [925], 'ranging': [929], 'between': [930, 1369], '<2000': [931], '9000': [933], '(23–102': [935], 'mmol/L).19': [936], 'Whether': [937], 'there': [938], 'some': [940], 'partial': [941], 'function': [942], 'remaining': [945], 'determined,': [952], 'eliminates': [960], 'GPI-membrane': [962], 'anchor': [963], 'well': [965], 'Ly6': [968, 993, 1040, 1093, 1227, 1257, 1473, 1798, 2600, 2695, 2804], 'most': [971], 'common': [972], 'mutations': [973, 979, 998, 1011, 1148, 1171, 1214, 1242, 1264, 1470, 1491, 1514, 1768, 1795, 1904, 2347], 'GPIHBP1-associated': [975], 'chylomicronemia': [976, 1494, 1630, 2797], 'missense': [978, 2346], 'one': [981, 1279], 'cysteines': [985, 2597, 2692], 'amino': [988, 1283], 'motif,20–23': [994], 'C65S,': [999], 'C65Y,': [1000], 'C68G,': [1001], 'C68Y,': [1002], 'C89F,': [1003], 'Q115P.': [1005], 'It': [1006, 1702], 'first': [1008], 'hypothesized': [1009], 'would': [1016, 1355], 'result': [1017, 1411, 1812], 'misfolding': [1019], 'ER;': [1026], 'work': [1028], 'Beigneux': [1030, 1160, 1462, 1747, 1895, 2239, 2270, 2329, 2367, 2495, 2581, 2639, 2681, 2709, 2784, 2870, 3023], 'colleagues20': [1032], 'mutating': [1035], 'alanines': [1043], 'did': [1044], 'markedly': [1046, 1678], 'affect': [1047, 1401], 'ability': [1049, 1180, 1822], 'reach': [1053], 'surface.': [1056], 'Instead,': [1057], 'cysteine-to-alanine': [1059], 'substitution': [1060, 2801], 'mutants': [1061, 1448], 'incapable': [1063], 'transporting': [1067], 'LpL.20': [1068], 'Recently,': [1069], 'Plengpanich': [1070, 1376, 2756], 'et': [1071, 1377, 1463, 1896, 2114, 2245, 2408], 'al': [1072], 'identified': [1073, 1446, 1557], 'who': [1079], 'homozygous': [1081], 'point': [1085, 1100, 1147, 1170, 1213, 1767], 'mutation': [1086, 1101, 1275, 1391], 'converted': [1088], 'serine': [1090, 1387], '(S107)': [1095], 'cysteine.24': [1098], 'resulted': [1102, 1229, 1285], 'increase': [1105], 'multimerization': [1107, 1175, 1232, 1247, 1291, 1349, 1498, 1816, 1913, 2350], 'follow-up': [1111], 'needs': [1116], 'monomeric': [1121, 1133, 1428], 'form': [1122], 'bind': [1124, 1182, 1427, 2745], '(Figure': [1126, 1238], 'A).24': [1127], 'whether': [1129, 1583], 'concept': [1131], 'requirement': [1135], 'transport': [1138, 1760, 1824, 2095], 'across': [1139], 'extended': [1142], 'reported': [1145], 'unanswered.In': [1153], 'present': [1155], 'issue': [1156], 'Circulation': [1158], 'Research,': [1159, 2934], 'colleagues': [1162], 'investigated': [1163], 'effects': [1165, 1670], 'several': [1167, 1281], 'known': [1168], 'dimerization': [1173, 1347, 1814, 1911], 'CHO': [1185], 'expressing': [1187], 'wild-type': [1188, 1294], 'mutants,': [1193], 'rat': [1194], 'microvascular': [1196], 'Drosophila': [1200], 'S2': [1201], 'performed': [1205], 'cell-free': [1206], 'LpL–GPIHBP1': [1207], 'assays.13': [1209], 'Many': [1210, 1794], 'evaluated': [1215], 'discovered': [1217, 1392], 'chylomicronemic': [1219], 'patients.': [1220], 'Mutation': [1221, 2689], 'B).': [1239], 'Several': [1240], 'noncysteine': [1241, 1263], 'second': [1253], 'finger': [1254], 'domain.': [1258], 'Thus,': [1259], 'both': [1260, 1482], 'reduce': [1265], 'formation': [1267, 1690, 1886], 'functionally': [1269], 'active': [1270], 'monomers.': [1272, 1456], 'W109': [1277], 'decreased': [1288], 'rate': [1289], 'although': [1296], 'still': [1298, 2053], 'defective': [1299, 2842], 'residue': [1308], 'may': [1309], 'directly': [1310], 'interact': [1311], 'crystallography': [1317], 'nuclear': [1319], 'magnetic': [1320], 'resonance': [1321], 'will': [1322], 'determine': [1326], 'specific': [1328], 'interaction.': [1332], 'these': [1335], 'based': [1338], 'vitro': [1341], 'overexpression': [1342], 'systems,': [1343], 'analysis': [1344], 'animal': [1351], 'models': [1352], 'humans': [1354, 1517, 1770, 1788, 1811], 'logical': [1358], 'interesting': [1360, 1612], 'next': [1361], 'step.It': [1362], 'hard': [1364], 'draw': [1367], 'similarity': [1368], 'current': [1371, 1459], 'article13': [1372], 'al24': [1378], 'same': [1381], 'group.': [1382], 'In': [1383, 1457], 'article,': [1385], 'S107C': [1390], 'Thai': [1395], 'found': [1398, 1515], 'surface,': [1408, 1853], 'multimerization.': [1414], 'authors': [1417, 1466, 1992], 'study': [1421, 1460, 1893], 'greatly': [1424], 'prefers': [1425], '(wild-type': [1430], 'forms': [1433], 'multimers);': [1434], 'moreover,': [1435], 'attributed': [1437], 'lack': [1439], '(S107C': [1449], 'C68G22)': [1451], 'reduction': [1454], 'al,13': [1464], 'studied': [1467, 1740], '>15': [1468], 'special': [1476], 'emphasis': [1477], 'cysteines.': [1480], 'Together,': [1481], 'manuscripts13,24': [1483], 'strongly': [1484], 'suggest': [1485], 'correlated': [1496], 'capacity.': [1506], 'possibility': [1508], 'dimerization/multimerization': [1511], 'interfere': [1519], '(a': [1525], 'component': [1526], 'chylomicrons,': [1528], 'VLDL,': [1529], 'lipoproteins),': [1532], 'relative': [1535], 'physiological': [1536], 'relevance': [1537], 'effect': [1541, 1545, 1708, 1764, 2835], 'visavi': [1542], 'need': [1546], 'addressed': [1549], 'future': [1551], 'studies.Recently,': [1552], 'polymorphism': [1554, 1567, 1585, 2821], '(rs72691625)': [1555], 'promoter.25': [1562], 'Carriers': [1563], 'g.-469G>A': [1566, 2820], 'significantly': [1570], 'higher': [1571], '(2.0': [1576], '177': [1578], 'noncarriers.': [1581], 'affects': [1586, 2122], 'determined.': [1591], 'Nonetheless,': [1592], 'it': [1593, 1610, 1855], 'suggests': [1594], 'modulation': [1596], 'activity': [1601], 'could': [1602], 'offer': [1603], 'therapeutic': [1605, 2925], 'treatment': [1606, 2929], 'strategy': [1607], 'hypertriglyceridemia.Finally,': [1609], 'ponder': [1614], 'potential': [1616], 'humans.': [1623], 'Gpihbp1−/−': [1625, 1743], 'mouse,': [1626], 'develops': [1628], 'even': [1631], 'low-fat': [1634, 1735], 'diet,10': [1635], 'exhibits': [1636], 'small': [1637], 'macrophage-rich': [1638], 'streak': [1640], 'lesions': [1641, 1662, 1732], 'aortic': [1646, 1660], 'sinus': [1647, 1661], 'coronary': [1649], '11': [1652], '12': [1654], 'months': [1655, 1665], '22': [1664], 'age.26': [1667], 'GPIHBP1-deficiency': [1672, 1710], 'probably': [1674], 'caused': [1675], 'chylomicrons/VLDL,': [1682], 'exacerbate': [1685], 'generation': [1697], 'proatherogenic': [1699], 'lipid': [1700], 'products.': [1701], 'clear,': [1704], 'weak': [1714], 'LDL': [1719, 2224], 'receptor-deficiency': [1720], 'ApoE-deficiency': [1722], 'mouse': [1724], 'models,': [1725], 'develop': [1727], 'complex': [1730, 2412], 'advanced': [1731, 1752], 'when': [1733], 'fed': [1734], 'diets': [1736], 'ages': [1739], 'mice.The': [1744], 'colleagues13': [1749], 'undoubtedly': [1751], 'our': [1753], 'understanding': [1754, 1774], 'likely': [1763], 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