Title: Chapter 5 The regulation of lipoprotein metabolism
Abstract: This chapter discusses the overall regulation of lipoprotein metabolism within the circulation and focuses on the interrelationships among the catabolic pathways of the different lipoproteins. The major function of these lipoproteins is the transport of energy-rich triglyceride from the intestine and the liver to sites of storage and utilization. The two major classes in this group are the chylomicrons and very low-density lipoproteins (VLDL). The proportion of triglyceride is higher in chylomicrons than in VLDL and there are important differences in apoprotein composition. A characteristic difference between the two triglyceride-rich lipoproteins is in the nature of the obligatory structural apoprotein, (apo)B. The intravascular catabolism of VLDL is regulated, at least initially, along similar lines to that of chylomicrons. There is early transfer of apoC and apoE from high-density lipoproteins (HDL) that controls the rates at which delipidation and removal take place. Remodeling of VLDL remnants is also required and involves the transfer of unwanted surface lipid and protein to HDL and exchange of core lipids between VLDL and HDL.
Publication Year: 1987
Publication Date: 1987-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 5
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