Publication Information

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2002, 2024, 2047, 2051, 2064, 2128, 2235, 2263, 2271, 2315, 2357, 2418, 2428, 2436, 2452, 2461, 2471, 2565, 2589, 2653, 2659, 2688, 2845, 2869, 2907, 2913, 2947, 3056, 3099, 3108, 3123, 3142, 3148, 3154, 3158, 3176, 3181, 3209, 3315, 3499, 3508, 3533, 3538, 3545, 3580], 'mature': [49, 218, 631, 3096], 'nervous': [50, 167, 219, 336, 562, 920, 3101], 'system.': [51, 168, 220, 337], 'Here': [52, 221, 878], 'we': [53, 222, 667, 723, 801, 879, 1030, 1434, 1684, 1877, 2000, 2285, 2843, 3138, 3166], 'report': [54, 223, 880], 'that': [55, 78, 224, 247, 493, 725, 881, 1035, 1203, 1288, 1503, 1652, 1667, 1675, 1857, 2262, 2275, 2287, 2527, 2546, 2698, 2920, 2943, 2964, 3011, 3061, 3141, 3179, 3193, 3518], 'MAPK': [57, 86, 89, 110, 132, 152, 226, 255, 258, 279, 301, 321, 643, 674, 727, 770, 788, 870, 885, 911, 1131, 1175, 1429, 1462, 1476, 1489, 1518, 1539, 1661, 1679, 1859, 1989, 2264, 2935, 2948, 3026, 3042, 3063, 3077, 3109, 3143, 3170, 3294, 3502, 3549], 'is': [59, 228, 539, 621, 732, 1521, 1861, 2240, 2266, 2722, 2838, 2927, 2950, 2963, 3064, 3119, 3145, 3190], 'required': [60, 229, 2666, 2839], 'hippocampal': [62, 231, 677, 929, 936, 1870, 3184], 'long': [63, 232, 352, 402, 678, 3185], 'term': [64, 233, 353, 403, 679, 3186], 'potentiation': [65, 234, 680, 1790, 2115], '(LTP),': [66, 235, 681], 'robust': [68, 237], 'widely': [70, 239, 683], 'form': [72, 241, 685, 2278], 'synaptic': [74, 159, 243, 328, 650, 687, 926, 2280, 2298, 2534, 3152, 3376, 3541], 'plasticity.': [75, 244], 'We': [76, 245, 633, 1452, 2645, 3019, 3555, 3582], 'observed': [77, 246, 1696, 1710, 1792, 2117, 2449, 2469, 3044], 'PD': [79, 118, 248, 287, 806, 1046, 1096, 1118, 1127, 1139, 1302, 1329, 1349, 1367, 1459, 1470, 1593, 1613, 1622, 1632, 1641, 1668, 1676, 1785, 1819, 2005, 2019, 2111, 2153, 2162, 2212, 2238, 2291, 2306, 2337, 2346, 2381, 2431, 2478, 2494, 2516, 2528, 2547, 2560, 2656, 2674, 2699, 2848, 2874, 2886, 2900, 2925, 3563], '098059,': [80, 119, 249, 288, 1460, 1594, 1786, 2112], 'selective': [82, 251], 'inhibitor': [83, 252, 862, 1439, 1592, 1691], 'cascade,': [87, 256], 'blocked': [88, 257, 2166, 2184, 2427], 'activation': [90, 259, 476, 484, 789, 867, 1176, 1430, 1463, 1662, 1680, 1990, 2837, 2945, 3027, 3503], 'response': [92, 261, 390, 440, 1210], 'to': [93, 103, 262, 272, 482, 636, 794, 865, 1079, 1147, 1151, 1195, 1230, 1313, 1533, 1759, 1836, 1986, 2054, 2227, 2439, 2682, 2724, 2959, 3016, 3218, 3284], 'direct': [94, 263], 'stimulation': [95, 264, 1249, 1283, 1655, 2442], 'NMDA': [98, 267, 1152, 1394, 1529, 1653, 2352, 2372, 2419, 2536, 3201], 'receptor': [99, 268, 475, 1654, 2365, 2593, 3202], 'well': [101, 270, 1480, 1602, 3191, 3282], 'LTP-inducing': [104, 273, 876, 1657, 1881], 'stimuli.': [105, 274, 877], 'Furthermore,': [106, 275], 'inhibition': [107, 276, 882, 1891, 2998], 'markedly': [112, 281, 2022], 'attenuated': [113, 282, 2023], 'induction': [115, 284, 736, 779, 792, 890, 1160, 1238, 1337, 1865, 2013, 2032, 2273, 2705, 2871, 2915, 3182, 3199, 3303, 3506, 3526], 'LTP.': [117, 286, 3554], 'had': [121, 290, 1167, 2293, 2348, 2888, 2903], 'no': [122, 291, 1168, 2294, 2349, 2889, 2904, 3001], 'effect': [123, 292, 1125, 1169, 1327, 1688, 2003, 2236, 2295, 2350, 2654, 2846, 2890, 2905, 3002], 'on': [124, 293, 498, 1170, 1331, 1692, 2007, 2242, 2658, 2850, 2891, 3003], 'expression': [126, 295, 893, 2727, 2772, 2893, 2908, 3070, 3092, 3464], 'established': [128, 297, 1674, 2851, 3192], 'LTP,': [129, 298, 351, 401], 'was': [134, 303, 1048, 1193, 1204, 1307, 1316, 1375, 1397, 1609, 1700, 1743, 1791, 1805, 2039, 2116, 2131, 2861, 2876, 3043], 'not': [135, 304, 892, 1376, 1701, 1962, 2203, 2327, 2385, 2434, 2531, 2563, 2686, 2695, 2702, 2951, 3065, 3088], 'persistently': [136, 305, 2768, 2972, 3004, 3012, 3066], 'activated': [137, 306, 733, 1507, 2769, 2973, 3005, 3013, 3067], 'during': [138, 307, 734, 790, 872, 1431, 2470, 2770, 3029, 3068, 3553], 'LTP': [139, 308, 738, 778, 791, 895, 1237, 1332, 1432, 1693, 1695, 1709, 1742, 1868, 1955, 1963, 1982, 1998, 2008, 2027, 2038, 2243, 2668, 2704, 2717, 2726, 2771, 2841, 2852, 2860, 2892, 2910, 2954, 3017, 3030, 3048, 3069, 3198, 3505, 3525], 'expression.': [140, 309, 2955, 3018, 3031], 'Our': [141, 310, 899], 'observations': [142, 311, 900, 2650], 'provide': [143, 312, 901], 'first': [145, 314, 1453], 'demonstration': [146, 315], 'role': [149, 318, 671, 908, 1996, 3523], 'activity-dependent': [156, 325, 647, 923, 3149], 'modification': [157, 326], 'connections': [160, 329, 651, 3542], 'between': [161, 330, 652, 3045], 'neurons': [162, 331, 558, 915, 3097, 3515], 'adult': [165, 334, 918], 'mammalian': [166, 335, 919], '1The': [343], 'abbreviations': [344, 394], 'used': [345, 395], 'are:': [346, 396], 'MAPK,': [347, 397], 'kinase;': [350, 387, 400, 437], 'potentiation;': [354, 404], 'NMDA,N-methyl-d-aspartate;': [355, 405], 'PKC,': [356, 406, 2577, 2671], 'C;': [359, 409, 3074], 'PKA,': [360, 410, 2578, 2670], 'A;': [363, 413], 'CaMKII,': [364, 414, 2969], 'calcium/calmodulin-dependent': [365, 415], 'II;': [368, 418], 'pEPSP,': [369, 419, 1294], 'population': [370, 420, 1198], 'excitatory': [371, 421, 1199], 'postsynaptic': [372, 422, 1200, 3205, 3225], 'potential;': [373, 423], 'ACSF,': [374, 424, 1343], 'artificial': [375, 425, 1055], 'cerebrospinal': [376, 426, 1056], 'fluid;': [377, 427], 'HFS,': [378, 428], 'high': [379, 429, 2440, 2551], 'frequency': [380, 430, 2441], 'stimulation;': [381, 431], 'APT,': [382, 432], 'anti-phosphotyrosine;': [383, 433], 'd,lAPV,d,l-2-amino-5-phosphonovalerate;': [384, 434], 'MEK,': [385, 435, 489, 864, 1441, 2556], 'MAPK/ERK': [386, 436], 'CREB,': [388, 438], 'cAMP': [389, 439], 'element': [391, 441], 'binding': [392, 442], 'protein.1The': [393], 'protein.': [443], 'classically': [447], 'critical': [451, 1862, 3173, 3522, 3577], 'involved': [454, 3146], 'transformation': [457], 'events': [458, 3196], 'such': [459, 2575, 2587, 3468], 'cell': [461, 547], 'proliferation': [462], 'determination.': [464], 'Such': [465], 'work': [466], 'delineated': [468], 'by': [471, 1399, 2256, 2651, 2706, 3023], 'growth': [473, 2591], 'factor': [474, 2592], 'initiates': [477], 'complex': [479], 'leading': [481, 3155], 'Ras,': [486], 'Raf,': [487], 'dual-specific': [491, 1443], 'activates': [494], 'via': [496, 2974], 'phosphorylations': [497, 2975], 'both': [499, 2246, 2763, 3134, 3222], 'threonine': [500], 'tyrosine': [502, 1038, 1490, 2585, 2936], 'residues': [503], '(reviewed': [504, 689, 3471], 'Refs.': [506, 691], '1Seger': [507], 'R.': [508, 2729], 'Krebs': [509], 'E.G.': [510], 'FASEB': [511], 'J.': [512, 524, 603, 749, 843, 957, 1002, 2629, 2779, 2820, 2988, 3234, 3424, 3449, 3483, 3590], '1995;': [513, 825, 846, 2611, 2632], '9:': [514], '726-735Crossref': [515], 'PubMed': [516, 533, 591, 612, 700, 717, 760, 828, 854, 968, 1013, 1908, 1924, 1949, 2614, 2640, 2738, 2757, 2788, 2807, 2829, 2993, 3243, 3274, 3340, 3354, 3371, 3407, 3435, 3455, 3492], 'Scopus': [517, 592, 613, 701, 718, 761, 829, 855, 969, 1014, 1909, 1925, 1950, 2615, 2641, 2739, 2758, 2808, 3244, 3275, 3341, 3355, 3372, 3408, 3436, 3456, 3493], '(3175)': [518], 'Google': [519, 534, 594, 615, 703, 720, 763, 831, 857, 971, 1016, 1911, 1927, 1952, 2617, 2643, 2741, 2760, 2789, 2810, 2830, 2994, 3246, 3277, 3343, 3357, 3374, 3410, 3438, 3458, 3495], 'Scholar': [520, 704], '2Davis': [522], 'R.J.': [523, 3332], 'Biol.': [525, 750, 844, 958, 1003, 2630, 2780, 2821, 3425, 3451], 'Chem.': [526, 751, 845, 959, 1004, 2631, 2781, 2822, 3426], '1993;': [527, 609, 697, 1905, 1921, 2804, 2823, 3240, 3334], '268:': [528, 2824], '14553-14556Abstract': [529], 'Full': [530, 588, 755, 757, 849, 851, 963, 965, 1008, 1010, 2635, 2637, 2785, 2826, 3337, 3430, 3432], 'Text': [531, 589, 756, 758, 850, 852, 964, 966, 1009, 1011, 2636, 2638, 2786, 2827, 3338, 3431, 3433], 'PDF': [532, 590, 759, 853, 967, 1012, 2639, 2787, 2828, 3339, 3434], 'Scholar).': [535, 616, 721, 764, 972, 1017, 2644, 2831, 2995, 3496], 'Although': [536], 'typically': [540, 1213], 'context': [544], 'mitotic': [546], 'regulation,': [548], 'its': [549], 'components': [550], 'actually': [552], 'most': [553], 'developed': [561, 3100], 'system': [563, 3102], '(3Boulton': [564], 'T.G.': [565], 'Nye': [566], 'S.H.': [567], 'Robbins': [568], 'D.J.': [569], 'Ip': [570], 'N.Y.': [571], 'Radziejewska': [572], 'E.': [573, 1901, 2774, 2792, 2817], 'Morgenbesser': [574], 'S.D.': [575], 'DePinho': [576], 'R.A.': [577], 'Panayotatos': [578], 'N.': [579], 'Cobb': [580], 'M.H.': [581], 'Yancopoulos': [582], 'G.D.': [583, 3362], 'Cell.': [584, 3333], '1991;': [585, 2782, 3452], '65:': [586], '663-675Abstract': [587], '(1473)': [593], 'Scholar,': [595, 832, 1912, 2618, 2742, 2790, 2811, 3247, 3344, 3358, 3411], '4Fiore': [596], 'R.S.': [597, 2983, 3228], 'Bayer': [598, 3229], 'V.E.': [599, 3230], 'Pelech': [600, 3231, 3258, 3391], 'S.L.': [601, 3232, 3259, 3392], 'Posada': [602, 3233], 'Cooper': [604, 3235], 'J.A.': [605, 3236], 'Baraban': [606, 2986, 3237], 'J.M.': [607, 2987, 3238], 'Neuroscience.': [608, 3239], '55:': [610, 3241], '463-472Crossref': [611, 3242], '(147)': [614, 3245], 'At': [617, 3115], 'present,': [618, 3116], 'little': [620, 3118], 'known': [622, 3120, 3509], 'about': [623, 1214], 'physiologic': [625, 785, 1426, 3127], 'roles': [626, 3128], 'neurons.': [632, 3132], 'have': [634, 668, 802, 2544, 3000, 3139, 3167], 'begun': [635], 'investigate': [637], 'possible': [639, 3297], 'involvement': [640], 'modulation': [648, 3150, 3441], 'putative': [655, 3307], 'mechanism': [656], 'neuronal': [659, 3159], 'basis': [660, 3160], 'learning': [662], 'memory.': [664], 'In': [665, 1026, 1322, 1586, 1779, 1873, 2034, 2107, 2282, 2856, 3164, 3497], 'particular,': [666, 3165], 'examined': [669, 2001, 2844], 'plasticity': [688], '5Bliss': [692], 'T.V.P.': [693, 3348], 'Collingridge': [694], 'G.L.': [695], 'Nature.': [696, 2734, 3367], '361:': [698], '31-39Crossref': [699], '(9396)': [702], '6Roberson': [706], 'E.D.': [707], 'English': [708], 'J.D.': [709, 711, 746, 748, 954, 956, 999, 1001, 1903, 2778, 2796], 'Sweatt': [710, 747, 955, 1000, 1902, 2777, 2795], 'Learn.': [712], 'Mem.': [713], '1996;': [714, 752, 960, 1005, 3271, 3404, 3427, 3489], '3:': [715], '1-24Crossref': [716], '(97)': [719], 'Recently,': [722], 'reported': [724], 'p42': [726, 1130, 1174, 1475, 1488, 1517, 1538, 1660, 2934, 3025, 3041, 3062, 3076, 3169], '(extracellular': [728], 'signal-regulated': [729, 1041], '2)': [731, 1263], 'area': [740, 782, 897, 975, 1189, 1465, 1664, 1682, 1871, 2854], 'CA1': [741, 976, 1466, 1665], 'hippocampus': [744], '(7English': [745, 953, 998], '271:': [753, 961, 1006, 3428], '24329-24332Abstract': [754, 962, 1007], '(493)': [762, 970, 1015], 'Though': [765], 'observation': [767], 'identifies': [768], 'potential': [774, 1201], 'component': [775, 2269, 3174], 'cascades': [780, 2274, 3178], 'CA1,': [783, 1190, 1683], 'necessity': [786, 3500], 'remains': [793, 3008], 'be': [795, 2971, 3219, 3544], 'established.': [796], 'To': [797, 1423, 1984, 2832], 'address': [798], 'question,': [800], 'utilized': [803, 1032, 3552], 'compound': [805], '098059': [807, 1047, 1097, 1128, 1140, 1303, 1350, 1368, 1471, 1614, 1633, 1669, 1677, 2006, 2020, 2154, 2163, 2239, 2292, 2307, 2338, 2347, 2382, 2432, 2529, 2548, 2561, 2657, 2675, 2700, 2849, 2875, 2887, 2901, 2926, 3564], '(8Dudley': [808, 2594], 'D.T.': [809, 840, 2595, 2626], 'Pang': [810, 2596], 'L.': [811, 2597, 2815], 'Decker': [812, 2598], 'S.J.': [813, 2599], 'Bridges': [814, 2600], 'A.J.': [815, 2601, 3263, 3396], 'Saltiel': [816, 841, 2602, 2627, 3559], 'A.R.': [817, 842, 2603, 2628], 'Proc.': [818, 2604, 2747, 2797, 3264, 3397], 'Natl.': [819, 2605, 2748, 2798, 3265, 3398], 'Acad.': [820, 2606, 2749, 2799, 3266, 3399], 'Sci.': [821, 2607, 2750, 2800, 3267, 3400], 'U.': [822, 2608, 2751, 2801, 3268, 3401], 'S.': [823, 2609, 2752, 2802, 3269, 3402], 'A.': [824, 836, 2610, 2622, 2753, 2803, 3270, 3330, 3403, 3448], '92:': [826, 2612], '7686-7689Crossref': [827, 2613], '(2582)': [830, 2616], '9Alessi': [833, 2619], 'D.R.': [834, 2620], 'Cuenda': [835, 2621], 'Cohen': [837, 2623], 'P.': [838, 1942, 2624, 3261, 3394], 'Dudley': [839, 2625], '270:': [847, 2633], '27489-27494Abstract': [848, 2634], '(3242)': [856, 2642], 'Scholar),': [858, 1928, 2761, 3375, 3439, 3459, 3479], 'recently': [860, 1437], 'described': [861, 952, 996, 1438], 'block': [866], 'delivery': [874, 3054], 'greatly': [887], 'attenuates': [888], 'but': [891, 1961], 'CA1.': [898, 1872, 2855], 'an': [902, 1033, 1256, 1296, 1393, 1501, 1978, 1992, 2267, 2361], 'initial': [903, 1323, 1753, 1875, 2048, 2253, 2312, 2397, 2472], 'insight': [904], 'into': [905, 1054], 'physiological': [907], 'system:': [921], 'regulation': [924, 3378, 3461], 'strength.': [927], 'For': [928, 1092, 1120, 1179, 1385], 'slice': [930], 'preparation,': [931], 'pharmacology,': [932], 'electrophysiology,': [934], 'transverse': [935], 'slices': [937, 1133, 1402, 1699, 1712, 1780, 1821, 2082, 2087, 2108, 2148, 2157, 2214, 2220, 2480, 2867], '(400': [938], 'μm)': [939, 2684], 'from': [940, 1708, 1825, 1832, 2218, 2225, 2387, 2680], '4–8': [941], 'week': [942], 'old': [943], 'male': [944], 'Sprague-Dawley': [945], 'rats': [946], 'were': [947, 993, 1104, 1134, 1223, 1240, 1351, 1361, 1381, 1498, 1822, 2202, 2207, 2215, 2317, 2331, 2384, 2448], 'prepared': [948, 1352], 'maintained': [950, 1105, 1317], 'Drug': [973], 'application,': [974], 'subregion': [977], 'microdissection,': [978], 'tissue': [979], 'sonication,': [980], 'fractionation': [981], 'soluble': [983], 'extracts,': [984], 'Western': [985], 'blotting,': [986], 'densitometric': [988], 'analysis': [989, 1122, 1515], 'phosphotyrosine': [991, 1477, 1540, 1598, 3036, 3078], 'immunoreactivity': [992, 1478, 1520, 1541, 1599, 3039], 'conducted': [994], 'previously': [997, 2714], 'All': [1018], 'data': [1019, 1380, 1650, 1855, 2075, 2142, 2201], 'means': [1023], '±': [1024, 1547, 1553, 1569, 1575, 1617, 1625, 1636, 1644, 1728, 1735, 1761, 1807, 2056, 2095, 2102, 2133, 2180, 2198, 2319, 2392, 2400, 2484, 2490, 2497, 2505, 2512, 2519, 3081], 'S.E.': [1025], 'present': [1028], 'studies,': [1029, 1876], 'also': [1031, 1362, 2021, 2332, 2902, 3583], 'antibody': [1034, 1502], 'selectively': [1036, 1504], 'recognizes': [1037, 1505], 'phosphorylated': [1039], 'kinases': [1042, 2574, 2586, 2665, 2693, 2713], '(New': [1043], 'England': [1044], 'Biolabs).': [1045], 'dissolved': [1049], 'Me2SO': [1051, 1088, 1100, 1143, 1165, 1306, 1544, 1566, 1719], 'diluted': [1053], 'fluid': [1057], '(ACSF;': [1058], 'mm': [1060, 1414, 1417], '125': [1061], 'NaCl,': [1062], '2.5': [1063, 2303], 'KCl,': [1064], '1.25': [1065], 'NaH2PO4,': [1066], '25': [1067], 'NaHCO3,': [1068], '10d-glucose,': [1069], '2': [1070, 1072, 1775, 1813, 2071, 2226], 'CaCl2,': [1071, 1415], 'MgCl2,': [1073, 1418], 'saturated': [1074], 'with': [1075, 1255, 1295, 1334, 1371, 1403, 1409, 1714, 1751, 1782, 1957, 1965, 2010, 2029, 2046, 2110, 2150, 2159, 2245, 2334, 2897, 2912], '95%': [1076], 'O2/5%': [1077], 'CO2)': [1078], 'give': [1080], 'desired': [1082], 'final': [1083, 1087, 2065], 'concentration': [1084, 1089], '(with': [1085], '0.33%).': [1091], 'drug': [1093, 1716, 2085], 'application': [1094, 1153, 2289, 2308, 2383, 2923], '(either': [1095], 'or': [1098, 1141, 1157, 1172, 1304, 1346, 1530, 1656, 1994, 2460, 2539, 3037, 3126], '0.33%': [1099, 1142, 1164, 1305, 1344, 1718, 1732, 2099], 'alone),': [1101], 'ACSF': [1102, 1406], 'solutions': [1103, 1340], '32': [1108], '°C': [1109], 'water': [1110], 'bath': [1111], '(to': [1112], 'assure': [1113], 'complete': [1115, 2930], 'solubility': [1116], '098059).': [1119], 'upon': [1129, 2296, 2351, 2906], 'activation,': [1132], 'preincubated': [1135], '50': [1137, 1365, 1783, 2160, 2182, 2422, 2467, 2558], 'μm': [1138, 1348, 1366, 1421, 1784, 2152, 2161, 2336, 2380, 2559], '45': [1145, 3051], 'min': [1146, 1229, 1273, 1767, 1838, 2062, 2229, 2883, 3052], '1': [1148, 1215, 1310, 1493, 1510, 2341, 2376, 2681, 2879], 'h': [1149, 1311, 2304, 2342, 2377, 2880], 'prior': [1150, 1312], '(100': [1154, 2164], 'μm,': [1155], '4′)': [1156], 'HFS': [1158, 1531, 1564, 1630, 1658, 2458, 3058], '(strong': [1159], 'paradigm,': [1161, 3059], 'see': [1162], 'below).': [1163], 'alone': [1166], 'NMDA-': [1171, 1483, 1605], 'HFS-mediated': [1173, 1485, 1607, 2540], '(not': [1177, 2343, 2917], 'shown).': [1178, 2344, 2918], 'field': [1181], 'recordings': [1182], 'Schaffer': [1185], 'collateral': [1186], 'synapses': [1187], 'stimulus': [1191, 1253, 1286], 'intensity': [1192, 1287], 'adjusted': [1194], 'elicit': [1196], '(pEPSP)': [1202], 'approximately': [1205], '25%': [1206], 'maximum': [1209], '(initial': [1211], 'slope': [1212, 1721, 1754, 1804, 2049, 2130, 2173, 2191, 2313], 'mV/ms),': [1216], 'responses': [1218, 1811, 1827, 2137, 2254, 2323, 2374, 2438], '(obtained': [1219], 'at': [1220, 1226, 1250, 1284, 1704, 2123, 2174, 2192, 2677], '0.05': [1221, 2409], 'Hz)': [1222], 'monitored': [1224], 'least': [1227], '15': [1228], 'ensure': [1231], 'stable': [1233, 1741, 1867, 2037, 2859], 'base': [1234, 2395, 2403], 'line.': [1235], 'Two': [1236], 'paradigms': [1239, 1960, 1967], 'employed:': [1241], '1)': [1242], 'modest:': [1243], 'two': [1244, 1278], 'trains': [1245, 1279], '1-s,': [1247, 1281], '100-Hz': [1248, 1282], 'test': [1252, 1424], 'intensity,': [1254], 'intertrain': [1257, 1297], 'interval': [1258, 1298], '20': [1260, 1300, 1420, 1835, 2569], 's;': [1261], 'strong:': [1264], 'three': [1265, 2084, 2156, 2186, 2188, 2664, 2711], 'sets': [1266, 1970, 2016], 'tetani,': [1268], 'each': [1269, 1829], 'set': [1270, 1887], 'spaced': [1271], '10': [1272, 1557], 'apart': [1274], 'consisting': [1276, 1883], 'generated': [1289], '75%': [1290], 'maximal': [1293], 's.': [1301], 'applied': [1308, 2339, 2877], 'tetanization': [1314], 'throughout': [1318], 'recording': [1320, 1357], 'period.': [1321], 'experiments': [1324, 1387], 'testing': [1325, 2652], '098095': [1330], 'elicited': [1333, 1744, 2009, 2040, 2244, 2355, 2862, 2911], 'strong': [1336, 2012, 2249, 3057], 'protocol,': [1338, 2872], '30-ml': [1339], 'normal': [1342, 2252], 'Me2SO,': [1345], '100': [1347, 1546, 1568, 2151, 2335, 2379, 2483, 2504], 'recycled': [1354], 'chambers.': [1358], 'Similar': [1359, 1496, 2329], 'results': [1360, 1497, 2330, 2525, 2941], 'obtained': [1363, 1499, 2333], 'using': [1364, 1500, 2868], '(which,': [1369], 'all': [1372, 1597, 2222], 'other': [1373], 'experiments,': [1374, 2284, 2858], 'recycled),': [1377], 'these': [1379, 1649, 2200, 2524, 2649, 2691, 2710, 2857, 2898, 3112, 3287, 3302, 3566], 'pooled': [1382, 2077, 2144], 'noted.': [1384], 'control': [1386, 1698, 1749, 1826, 2035, 2081, 2219, 2283, 3046], 'illustrated': [1388], 'Fig.': [1390, 1774, 2070], '3': [1391, 2444], 'B,': [1392], 'receptor-mediated': [1395, 2353, 2373, 2537], 'pEPSP': [1396, 1757, 1803, 2052, 2129, 2172, 2190, 2316], 'isolated': [1398], 'perfusing': [1400], 'modified': [1405], '(as': [1407], 'described,': [1408], 'following': [1411, 1768, 2063, 2375, 3053], 'exceptions:': [1412], '4': [1413], '0': [1416], '6-cyano-7-nitroquinoxaline-2,3-dione).': [1422], 'significance': [1427], 'induction,': [1433, 1999], 'employed': [1435, 1878], 'responsible': [1446], 'phosphorylating': [1448], 'activating': [1450], 'MAPKs.': [1451], 'determined': [1454, 1686], 'whether': [1455, 1988, 2834], 'MEK': [1457, 1591, 2836, 2997], 'inhibitor,': [1458], 'blocks': [1461, 1670, 1678, 1954], 'hippocampus.': [1469], 'completely': [1472, 2424], 'abolished': [1473], 'basal': [1474, 2297, 2533, 2933], 'increase': [1486, 1536], 'phosphorylation': [1491, 2937], '(Fig.': [1492, 1509, 1812, 2443, 2938, 3071], 'A,APT': [1494], 'Western).': [1495, 1513], 'phosphorylated,': [1506], 'A,': [1511, 1776, 1814], 'α-PMAPK': [1512], 'Quantitative': [1514], 'APT': [1519], 'shown': [1522], 'Fig.1': [1524], 'B.': [1525, 3446], 'Application': [1526, 2412], 'either': [1528, 2451, 3035, 3122], 'led': [1532], 'significant': [1535], '(NMDA': [1542, 1611], 'application:': [1543, 1565, 1612, 1631], 'alone,': [1545, 1567, 1615, 1634], '13;': [1548, 1570], 'n=': [1549, 1571, 1646, 1730, 2097], '8;': [1550], 'Me2SO/NMDA,': [1551], '290': [1552], '38;': [1554], 'n': [1555, 1577, 1619, 1627, 1638, 1737, 2104, 2405, 2507, 3085], '=': [1556, 1578, 1620, 1628, 1639, 1723, 1738, 1772, 1799, 1834, 2068, 2090, 2105, 2125, 2139, 2176, 2194, 2325, 2406, 2486, 2492, 2499, 2508, 2514, 2521, 3086], '(p': [1558, 1580], '<': [1559, 1581, 1847, 1852], '0.01,': [1560], "Student's": [1561, 1583], 't': [1562, 1584, 1833, 2124, 2175, 2193], 'test);': [1563], '6;': [1572, 1579, 1626, 1731, 2098, 2487, 2509, 3087], 'Me2SO/HFS,': [1573], '159': [1574], '20;': [1576], '0.05,': [1582], 'test)).': [1585], 'presence': [1588, 2358], 'essentially': [1596], '(basal': [1600], 'increases)': [1608], 'eliminated': [1610], '6': [1616], '12;': [1618], '7;': [1621], '098059/NMDA,': [1623], '16': [1624], '9;': [1629, 2069], '9': [1635, 1643], '3;': [1637, 1640, 1645], '098059/HFS,': [1642], '3).': [1647, 2106], 'Together,': [1648], 'demonstrate': [1651, 2526], 'elicits': [1659], 'activation.': [1672], 'Having': [1673], 'next': [1685], 'induction.': [1694, 1983, 2718], 'significantly': [1702, 1823, 2204, 2216], 'any': [1705, 2708], 'time': [1706, 1830, 2223], 'point': [1707, 1831], 'treated': [1713, 1781, 2109, 2149, 2158], 'vehicle,': [1717], '(pEPSP': [1720, 2088], 'att': [1722, 1798, 2089], '90': [1724, 1766, 1800, 1837], 'min,': [1725, 1801, 1841, 1850, 2092, 2127, 2178, 2196], 'control:': [1726, 2093], '173': [1727, 1760], '9%,': [1729], 'Me2SO:': [1733, 2100, 2488, 2510], '174': [1734], '11%,': [1736], '4).': [1739], 'Overall,': [1740, 2523], 'nine': [1746, 2042, 2044, 2119], 'ten': [1748, 2121], 'slices,': [1750, 2036, 2045], 'potentiated': [1758, 2053], '7%': [1762, 1808], 'pre-tetanus': [1764, 2059], 'levels,': [1765, 2060], 'tetanus': [1770, 2066, 2473], '(n': [1771, 2067, 2138, 2324], '10;': [1773], 'closed': [1777], 'circles).': [1778, 1816, 2073], 'decaying': [1789, 2114, 2259], 'six': [1794, 1796, 2080, 2168, 2864, 2866], 'slices;': [1797, 2122, 2171, 2189], '116': [1806], 'base-line': [1810, 2136, 2322, 2388], 'open': [1815], 'Responses': [1817, 2210], '098059-treated': [1820, 2213, 2479], '(time': [1839], '0–18': [1840], 'p': [1842, 1851], '>': [1843, 2408], '0.05;': [1844, 1848], '20–46': [1845], 'min,p': [1846], '48–90': [1849], '0.01.)': [1853], 'These': [1854, 2074, 2141, 2940], 'suggest': [1856, 2942, 3296, 3517], 'our': [1874], 'modest': [1880, 1959, 2247, 2870], 'paradigm': [1882, 2916], 'single': [1886], 'tetani.': [1889, 2018], 'certain': [1893], 'enzymes': [1894], '(e.g.': [1895, 1968, 3310, 3379, 3442, 3465], 'nitric-oxide': [1896], 'synthase': [1897], '(10Chetkovich': [1898], 'D.M.': [1899], 'Klann': [1900], 'Neuroreport.': [1904], '4:': [1906], '919-922Crossref': [1907], '(115)': [1910], '11Haley': [1913], 'J.E.': [1914], 'Malen': [1915], 'P.L.': [1916, 1940], 'Chapman': [1917], 'P.F.': [1918], 'Neurosci.': [1919, 2989, 3349], 'Lett.': [1920, 3350], '160:': [1922], '85-88Crossref': [1923], '(91)': [1926], 'fyn': [1929], 'knockout': [1931], 'mice': [1932], '(12Grant': [1933], 'S.G.N.': [1934], "O'Dell": [1935], 'T.J.': [1936], 'Karl': [1937], 'K.A.': [1938], 'Stein': [1939], 'Soriano': [1941], 'Kandel': [1943], 'E.R.': [1944], 'Science.': [1945, 3475, 3488], '1992;': [1946, 2754, 3476], '258:': [1947], '1903-1910Crossref': [1948], '(957)': [1951], 'Scholar))': [1953], 'induced': [1956, 1964, 2028], 'similar': [1958, 2241], 'stronger': [1966, 2031, 2914], 'multiple': [1969, 2015], 'tetani),': [1972], 'suggesting': [1973, 2697], 'modulatory': [1975, 1995], 'rather': [1976], 'than': [1977], 'obligatory': [1979, 1993, 2268], 'function': [1980, 3106, 3534], 'begin': [1985], 'determine': [1987, 2833], 'plays': [1991], 'protocol:': [2014], 'magnitude': [2025], 'protocol.': [2033], '226': [2055], '12%': [2057], '60': [2061, 2091, 2126, 2177, 2195, 2228], 'B,closed': [2072], 'averages': [2078, 2145], 'vehicle-treated': [2086], '228': [2094], '7%,': [2096], '224': [2101], '38%,': [2103], '132': [2132, 2179, 2197], '13%': [2134], '10).': [2140], 'seven': [2147, 2170], 'μm:': [2165, 2183], '19%;': [2181], '7%;': [2199], 'thus': [2208, 3281], 'combined).': [2209], 'points': [2224], '(p<': [2230], '0.01': [2231], 'each).': [2233, 2411], '(i.e.': [2251], 'followed': [2255], 'slowly': [2258], 'potentiation)': [2260], 'subserve': [2276], 'potentiation.': [2281, 3187], 'found': [2286, 3140], 'prolonged': [2288], 'transmission': [2299], '(Fig.3': [2300, 2370], 'A).': [2301, 2895], 'Following': [2302], '(50': [2309], 'μm),': [2310, 2423], 'average': [2311], '87': [2318], '10%': [2320], '3,': [2326], 'significant).': [2328, 3089], 'Similarly,': [2345], 'pEPSPs': [2354], '6-cyano-7-nitroquinoxaline-2,3-dione,': [2360], 'antagonist': [2362, 2416], 'non-NMDA': [2364], 'subtypes': [2366], 'glutamate': [2368], 'receptors': [2369], 'B).': [2371], 'levels': [2389, 3028], '(amplitude:': [2390], '99': [2391], '2%': [2393], 'line;': [2396, 2404], 'slope:': [2398], '94': [2399], '4%': [2401], '3;p': [2407], 'competitive': [2415], 'receptor,d,l-2-amino-5-phosphonovalerate': [2420], '(d,l-APV,': [2421], 'reversibly': [2426], 'pEPSP.': [2429], 'Finally,': [2430, 3188], 'did': [2433, 2562, 2685], 'alter': [2435, 2564], 'depolarization': [2437, 2454, 2463], 'C).': [2445], 'No': [2446, 3032], 'differences': [2447], 'total': [2453], '(integral': [2455], 'over': [2456, 2465, 2568], 'entire': [2457], 'response)': [2459], 'steady-state': [2462], '(average': [2464], 'last': [2466], 'ms)': [2468], 'control,': [2475], 'Me2SO-': [2476], '(Integral:': [2481], '(control:': [2482, 2503], '6.5%,n': [2485], '88': [2489, 2511], '12%,n': [2491], '4;': [2493, 2515], '098059:': [2495, 2517], '100.5': [2496], '13.5%,n': [2498], '6).': [2500], 'Steady-state': [2501], 'depolarization:': [2502], '7.8%,': [2506], '14%,n': [2513], '97.4': [2518], '11.7%,n': [2520], '6)).': [2522], 'does': [2530, 2701], 'affect': [2532, 2687], 'transmission,': [2535], 'responses,': [2538], 'depolarization.': [2541], 'Previous': [2542], 'reports': [2543], 'demonstrated': [2545], 'shows': [2549], 'degree': [2552], 'selectivity': [2554], 'because': [2557], 'activity': [2566, 2660, 2689, 2721], 'kinases,': [2571], 'including': [2572], 'serine/threonine': [2573], 'c-Raf,': [2579], 'c-Jun': [2581], 'N-terminal': [2582], 'epidermal': [2590], 'replicated': [2646], 'extended': [2648], 'vitro': [2662], 'induction:': [2669], 'CaMKII.': [2673], '(used': [2676], 'concentrations': [2678], 'ranging': [2679], '300': [2683], '(data': [2694], 'shown),': [2696], 'attenuate': [2703], 'inhibiting': [2707], 'implicated': [2715], 'Ongoing': [2719], 'thought': [2723], 'underlie': [2725, 3180], '(13Malinow': [2728], 'Madison': [2730], 'D.V.': [2731], 'Tsien': [2732], 'R.W.': [2733], '1988;': [2735], '335:': [2736], '820-824Crossref': [2737], '(444)': [2740], '14Wang': [2743], 'J.H.': [2744, 3346], 'Feng': [2745], 'D.P.': [2746], '89:': [2755], '2576-2580Crossref': [2756], '(145)': [2759], 'PKC': [2764, 2967], 'CaMKII': [2766], '(15Klann': [2773], 'Chen': [2775, 2793], 'S.-J.': [2776, 2794], '266:': [2783], '24253-24256Abstract': [2784], '16Klann': [2791], '90:': [2805], '8337-8341Crossref': [2806], '(153)': [2809], '17Fukunaga': [2812], 'K.': [2813, 3360, 3417, 3421], 'Stoppini': [2814], 'Miyamoto': [2816], 'Muller': [2818], 'D.': [2819], '7863-7867Abstract': [2825], 'ongoing': [2835, 2944], 'expression,': [2842], 'beginning': [2881], '30': [2882], 'after': [2884], 'tetanization.': [2885], '(Fig.4': [2894], 'Consistent': [2896], 'observations,': [2899], 'Note': [2919], '1-h': [2922], 'sufficient': [2928], 'reversal': [2931], '1).': [2939], 'necessary': [2952], 'One': [2956], 'important': [2957, 3194, 3529], 'caveat': [2958], 'conclusion,': [2961], 'MAPKs,': [2965, 3006], 'like': [2966], 'can': [2970], '(18Murphy': [2976], 'T.H.': [2977], 'Blatter': [2978], 'L.A.': [2979], 'Bhat': [2980], 'R.V.': [2981], 'Fiore': [2982], 'Wier': [2984], 'W.G.': [2985], '1994;': [2990, 3368], '14:': [2991], '1320-1331Crossref': [2992], 'Because': [2996], 'would': [2999], 'it': [3007, 3189], 'possibility': [3010], 'contribute': [3015], 'tested': [3020], 'hypothesis': [3022], 'examining': [3024], 'difference': [3033], 'phospho-MAPK': [3038], 'samples': [3049], 'taken': [3050], 'indicating': [3060], '4,B': [3072], 'normalized': [3075], 'immunoreactivity:': [3079], '114': [3080], '20%': [3082], 'control;': [3084], 'abundant': [3091], 'specialized': [3105], 'cells.': [3114], 'regarding': [3121], 'regulatory': [3124], 'mechanisms': [3125], 'Using': [3133], 'electrophysiology': [3135], 'biochemistry,': [3137], 'strength,': [3153], 'candidate': [3156], 'information': [3162], 'storage.': [3163], 'identified': [3168], 'early': [3195, 3288], 'include': [3200], 'stimulation,': [3203], 'subsequent': [3204], 'calcium': [3206], 'influx,': [3207], 'initiation': [3210], 'several': [3212, 3293], 'cascades.': [3215, 3527], 'appear': [3217], 'localized': [3220], 'presynaptic': [3223], 'structures': [3226], '(4Fiore': [3227], '19Jovanovic': [3248], 'J.N.': [3249, 3382], 'Benfenati': [3250, 3383], 'F.': [3251, 3384], 'Siow': [3252, 3385], 'Y.L.': [3253, 3386], 'Sihra': [3254, 3387], 'T.S.': [3255, 3388], 'Sanghera': [3256, 3389], 'J.S.': [3257, 3390], 'Greengard': [3260, 3393], 'Czernik': [3262, 3395], '93:': [3272, 3405], '3679-3683Crossref': [3273, 3406], '(355)': [3276, 3409], 'Scholar)': [3278], 'positioned': [3283], 'participate': [3285], 'events.': [3289], 'Interestingly,': [3290], 'consideration': [3291], 'substrates': [3295, 3550], 'cascades:': [3304], 'generation': [3305], 'retrograde': [3308], 'messengers': [3309], 'cytosolic': [3311], 'phospholipase': [3312], 'A2': [3313], 'formation': [3316], 'arachadonic': [3318], 'acid/platelet-activating': [3319], 'factor)': [3320], '(20Lin': [3321], 'L.-L.': [3322], 'Wartmann': [3323], 'M.': [3324, 3413, 3415], 'Lin': [3325], 'A.Y.': [3326], 'Knopf': [3327], 'J.L.': [3328], 'Seth': [3329], 'Davis': [3331], '72:': [3335], '269-278Abstract': [3336], '(1643)': [3342], '21Williams': [3345], 'Bliss': [3347], '1989;': [3351], '107:': [3352], '301-306Crossref': [3353], '(84)': [3356], '22Kato': [3359], 'Clark': [3361], 'Bazan': [3363], 'N.G.': [3364], 'Zorumski': [3365], 'C.F.': [3366], '367:': [3369], '175-179Crossref': [3370], '(224)': [3373], 'vesicle': [3377], 'synapsin)': [3380], '(19Jovanovic': [3381], '23Matsubara': [3412], 'Kusubata': [3414], 'Ishiguro': [3416], 'Uchida': [3418], 'T.': [3419], 'Titani': [3420], 'Taniguchi': [3422], 'H.': [3423], '21108-21113Abstract': [3429], '(212)': [3437], 'cytoskeletal': [3440], 'MAP2': [3443], 'protein)': [3444], '(24Brugg': [3445], 'Matus': [3447], 'Cell': [3450], '114:': [3453], '735-743Crossref': [3454], '(177)': [3457], 'gene': [3463], 'transcription': [3466], 'factors': [3467], 'Elk-1)': [3470], 'Ref.25Roberts': [3473], 'T.M.': [3474], '360:': [3477], '534-535Google': [3478], 'CREB': [3481], '(26Xing': [3482], 'Ginty': [3484], 'D.D.': [3485], 'Greenberg': [3486], 'M.E.': [3487], '273:': [3490], '959-963Crossref': [3491], '(1079)': [3494], 'short,': [3498], 'localization': [3510], 'strongly': [3516], 'play': [3520], 'An': [3528], 'step': [3530], 'understanding': [3532], 'strengthening': [3539], 'will': [3543], 'determination': [3546], 'thank': [3556, 3584], 'Dr.': [3557], 'Alan': [3558], 'generously': [3561], 'providing': [3562], 'studies': [3567], 'Erik': [3569], 'Roberson,': [3570], 'Coleen': [3571], 'Atkins,': [3572], 'Anne': [3574], 'Anderson': [3575], 'readings': [3578], 'manuscript.': [3581], 'Richard': [3585], 'Dickason,': [3586], 'David': [3587], 'Leopold,': [3588], 'William': [3589], 'Martin,': [3591], 'Mark': [3593], 'Jacobs': [3594], 'useful': [3596], 'discussions.': [3597]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1964486755', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 19}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 15}, {'year': 2018, 'cited_by_count': 22}, {'year': 2017, 'cited_by_count': 26}, {'year': 2016, 'cited_by_count': 19}, {'year': 2015, 'cited_by_count': 27}, {'year': 2014, 'cited_by_count': 27}, {'year': 2013, 'cited_by_count': 31}, {'year': 2012, 'cited_by_count': 26}], 'updated_date': '2024-12-19T16:12:01.578556', 'created_date': '2016-06-24'}