Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4282924888', 'doi': 'https://doi.org/10.3390/ijms23126637', 'title': 'Beta-Site Amyloid Precursor Protein-Cleaving Enzyme Inhibition Partly Restores Sevoflurane-Induced Deficits on Synaptic Plasticity and Spine Loss', 'display_name': 'Beta-Site Amyloid Precursor Protein-Cleaving Enzyme Inhibition Partly Restores Sevoflurane-Induced Deficits on Synaptic Plasticity and Spine Loss', 'publication_year': 2022, 'publication_date': '2022-06-14', 'ids': {'openalex': 'https://openalex.org/W4282924888', 'doi': 'https://doi.org/10.3390/ijms23126637', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35743082'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms23126637', 'pdf_url': 'https://www.mdpi.com/1422-0067/23/12/6637/pdf?version=1655209885', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/1422-0067/23/12/6637/pdf?version=1655209885', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100673276', 'display_name': 'Xingxing Wang', 'orcid': 'https://orcid.org/0000-0001-7497-5001'}, 'institutions': [{'id': 'https://openalex.org/I2802619606', 'display_name': 'Klinikum rechts der Isar', 'ror': 'https://ror.org/04jc43x05', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802619606', 'https://openalex.org/I62916508']}, {'id': 'https://openalex.org/I62916508', 'display_name': 'Technical University of Munich', 'ror': 'https://ror.org/02kkvpp62', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I62916508']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Xingxing Wang', 'raw_affiliation_strings': ['Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany', 'institution_ids': ['https://openalex.org/I2802619606', 'https://openalex.org/I62916508']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066353065', 'display_name': 'Qinfang Shi', 'orcid': 'https://orcid.org/0000-0003-2375-4596'}, 'institutions': [{'id': 'https://openalex.org/I2802619606', 'display_name': 'Klinikum rechts der Isar', 'ror': 'https://ror.org/04jc43x05', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802619606', 'https://openalex.org/I62916508']}, {'id': 'https://openalex.org/I62916508', 'display_name': 'Technical University of Munich', 'ror': 'https://ror.org/02kkvpp62', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I62916508']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Qinfang Shi', 'raw_affiliation_strings': ['Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany', 'institution_ids': ['https://openalex.org/I2802619606', 'https://openalex.org/I62916508']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002661804', 'display_name': 'Arpit Kumar Pradhan', 'orcid': 'https://orcid.org/0000-0003-4047-7615'}, 'institutions': [{'id': 'https://openalex.org/I2802619606', 'display_name': 'Klinikum rechts der Isar', 'ror': 'https://ror.org/04jc43x05', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802619606', 'https://openalex.org/I62916508']}, {'id': 'https://openalex.org/I62916508', 'display_name': 'Technical University of Munich', 'ror': 'https://ror.org/02kkvpp62', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I62916508']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Arpit Kumar Pradhan', 'raw_affiliation_strings': ['Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany', 'institution_ids': ['https://openalex.org/I2802619606', 'https://openalex.org/I62916508']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087218038', 'display_name': 'Laura Ziegon', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I62916508', 'display_name': 'Technical University of Munich', 'ror': 'https://ror.org/02kkvpp62', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I62916508']}, {'id': 'https://openalex.org/I2802619606', 'display_name': 'Klinikum rechts der Isar', 'ror': 'https://ror.org/04jc43x05', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802619606', 'https://openalex.org/I62916508']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Laura Ziegon', 'raw_affiliation_strings': ['Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany', 'institution_ids': ['https://openalex.org/I62916508', 'https://openalex.org/I2802619606']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103201335', 'display_name': 'Martin Schlegel', 'orcid': 'https://orcid.org/0000-0001-7054-9566'}, 'institutions': [{'id': 'https://openalex.org/I62916508', 'display_name': 'Technical University of Munich', 'ror': 'https://ror.org/02kkvpp62', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I62916508']}, {'id': 'https://openalex.org/I2802619606', 'display_name': 'Klinikum rechts der Isar', 'ror': 'https://ror.org/04jc43x05', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802619606', 'https://openalex.org/I62916508']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Martin Schlegel', 'raw_affiliation_strings': ['Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany', 'institution_ids': ['https://openalex.org/I62916508', 'https://openalex.org/I2802619606']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057517491', 'display_name': 'Gerhard Rammes', 'orcid': 'https://orcid.org/0000-0002-1698-4257'}, 'institutions': [{'id': 'https://openalex.org/I62916508', 'display_name': 'Technical University of Munich', 'ror': 'https://ror.org/02kkvpp62', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I62916508']}, {'id': 'https://openalex.org/I2802619606', 'display_name': 'Klinikum rechts der Isar', 'ror': 'https://ror.org/04jc43x05', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802619606', 'https://openalex.org/I62916508']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Gerhard Rammes', 'raw_affiliation_strings': ['Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Intensive Care Medicine, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany', 'institution_ids': ['https://openalex.org/I62916508', 'https://openalex.org/I2802619606']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5057517491'], 'corresponding_institution_ids': ['https://openalex.org/I62916508', 'https://openalex.org/I2802619606'], 'apc_list': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'apc_paid': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'fwci': 0.247, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.483462, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 62, 'max': 72}, 'biblio': {'volume': '23', 'issue': '12', 'first_page': '6637', 'last_page': '6637'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12963', 'display_name': 'Neurotoxic Effects of Anesthetic Agents on Brain Development', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12963', 'display_name': 'Neurotoxic Effects of Anesthetic Agents on Brain Development', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10867', 'display_name': 'Management of Delirium in Critical Care Patients', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2706', 'display_name': 'Critical Care and Intensive Care Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/synaptic-plasticity', 'display_name': 'Synaptic Plasticity', 'score': 0.50755}], 'concepts': [{'id': 'https://openalex.org/C25274449', 'wikidata': 'https://www.wikidata.org/wiki/Q1805481', 'display_name': 'Long-term potentiation', 'level': 3, 'score': 0.9464209}, {'id': 'https://openalex.org/C174884520', 'wikidata': 'https://www.wikidata.org/wiki/Q902079', 'display_name': 'Dendritic spine', 'level': 3, 'score': 0.8817575}, {'id': 'https://openalex.org/C98229152', 'wikidata': 'https://www.wikidata.org/wiki/Q1551556', 'display_name': 'Synaptic plasticity', 'level': 3, 'score': 0.7814567}, {'id': 'https://openalex.org/C148762608', 'wikidata': 'https://www.wikidata.org/wiki/Q3748185', 'display_name': 'Hippocampal formation', 'level': 2, 'score': 0.7252754}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.7110792}, {'id': 'https://openalex.org/C2781161787', 'wikidata': 'https://www.wikidata.org/wiki/Q48360', 'display_name': 'Hippocampus', 'level': 2, 'score': 0.61281526}, {'id': 'https://openalex.org/C127445978', 'wikidata': 'https://www.wikidata.org/wiki/Q187181', 'display_name': 'Synapse', 'level': 2, 'score': 0.46439606}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.44908565}, {'id': 'https://openalex.org/C2781453256', 'wikidata': 'https://www.wikidata.org/wiki/Q419394', 'display_name': 'Sevoflurane', 'level': 2, 'score': 0.44686502}, {'id': 'https://openalex.org/C205383261', 'wikidata': 'https://www.wikidata.org/wiki/Q7392570', 'display_name': 'SPINE (molecular biology)', 'level': 2, 'score': 0.4249281}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.3903769}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3397044}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.27637076}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.23433238}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.18431643}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000777', 'descriptor_name': 'Anesthetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016229', 'descriptor_name': 'Amyloid beta-Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016564', 'descriptor_name': 'Amyloid beta-Protein Precursor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000777', 'descriptor_name': 'Anesthetics', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049229', 'descriptor_name': 'Dendritic Spines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049229', 'descriptor_name': 'Dendritic Spines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000075983', 'descriptor_name': 'Nectins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000075983', 'descriptor_name': 'Nectins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009473', 'descriptor_name': 'Neuronal Plasticity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077149', 'descriptor_name': 'Sevoflurane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077149', 'descriptor_name': 'Sevoflurane', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014978', 'descriptor_name': 'Xenon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014978', 'descriptor_name': 'Xenon', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014978', 'descriptor_name': 'Xenon', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms23126637', 'pdf_url': 'https://www.mdpi.com/1422-0067/23/12/6637/pdf?version=1655209885', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223703', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35743082', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/ijms23126637', 'pdf_url': 'https://www.mdpi.com/1422-0067/23/12/6637/pdf?version=1655209885', 'source': {'id': 'https://openalex.org/S10623703', 'display_name': 'International Journal of Molecular Sciences', 'issn_l': '1422-0067', 'issn': ['1422-0067', '1661-6596'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 64, 'referenced_works': ['https://openalex.org/W1511180457', 'https://openalex.org/W1520284233', 'https://openalex.org/W1577778731', 'https://openalex.org/W1601830790', 'https://openalex.org/W1927567505', 'https://openalex.org/W1968900405', 'https://openalex.org/W1972567838', 'https://openalex.org/W1973977212', 'https://openalex.org/W1974067040', 'https://openalex.org/W1976034037', 'https://openalex.org/W1976810156', 'https://openalex.org/W1979990721', 'https://openalex.org/W1981842342', 'https://openalex.org/W1986317165', 'https://openalex.org/W1989718404', 'https://openalex.org/W1994372868', 'https://openalex.org/W1995886761', 'https://openalex.org/W2003422666', 'https://openalex.org/W2007495000', 'https://openalex.org/W2008299878', 'https://openalex.org/W2011209444', 'https://openalex.org/W2016928060', 'https://openalex.org/W2030550029', 'https://openalex.org/W2039478530', 'https://openalex.org/W2042955975', 'https://openalex.org/W2048620382', 'https://openalex.org/W2056414888', 'https://openalex.org/W2061192893', 'https://openalex.org/W2063738878', 'https://openalex.org/W2069252300', 'https://openalex.org/W2071545866', 'https://openalex.org/W2072781119', 'https://openalex.org/W2077189922', 'https://openalex.org/W2089994977', 'https://openalex.org/W2098092575', 'https://openalex.org/W2100557509', 'https://openalex.org/W2100569554', 'https://openalex.org/W2101750224', 'https://openalex.org/W2104898383', 'https://openalex.org/W2109809796', 'https://openalex.org/W2110053335', 'https://openalex.org/W2129085204', 'https://openalex.org/W2131938020', 'https://openalex.org/W2143716353', 'https://openalex.org/W2154228706', 'https://openalex.org/W2179672615', 'https://openalex.org/W2462465517', 'https://openalex.org/W2524203551', 'https://openalex.org/W2564588209', 'https://openalex.org/W2585261722', 'https://openalex.org/W2597471487', 'https://openalex.org/W2599851926', 'https://openalex.org/W2607491924', 'https://openalex.org/W2608003033', 'https://openalex.org/W2751763851', 'https://openalex.org/W2758031603', 'https://openalex.org/W2762599792', 'https://openalex.org/W2769786813', 'https://openalex.org/W2786122097', 'https://openalex.org/W2901540835', 'https://openalex.org/W2930646899', 'https://openalex.org/W2944268986', 'https://openalex.org/W3028643474', 'https://openalex.org/W3165640899'], 'related_works': ['https://openalex.org/W4317935580', 'https://openalex.org/W3132088562', 'https://openalex.org/W2528820646', 'https://openalex.org/W2169505641', 'https://openalex.org/W2151123745', 'https://openalex.org/W2136747326', 'https://openalex.org/W2120160245', 'https://openalex.org/W2089161864', 'https://openalex.org/W1996493542', 'https://openalex.org/W1989838035'], 'abstract_inverted_index': {'Evidence': [0], 'indicates': [1], 'that': [2, 157], 'inhalative': [3, 30], 'anesthetics': [4, 31], 'enhance': [5], 'the': [6, 27, 62, 111, 175, 179, 182], 'β-site': [7], 'amyloid': [8, 16], 'precursor': [9], 'protein': [10], '(APP)-cleaving': [11], 'enzyme': [12], '(BACE)': [13], 'activity,': [14], 'increase': [15], 'beta': [17], '1-42': [18], '(Aβ1–42)': [19], 'aggregation,': [20], 'and': [21, 37, 78, 89, 103, 107, 119, 128, 163], 'modulate': [22], 'dendritic': [23, 34, 69, 90, 189], 'spine': [24, 35, 70, 105, 121, 126, 139, 190], 'dynamics.': [25], 'However,': [26], 'mechanisms': [28], 'of': [29, 61, 178], 'on': [32, 87], 'hippocampal': [33, 46, 97], 'plasticity': [36], 'BACE-dependent': [38], 'APP': [39, 72], 'processing': [40], 'remain': [41], 'unclear.': [42], 'In': [43], 'this': [44], 'study,': [45], 'slices': [47], 'were': [48, 82, 92], 'incubated': [49], 'with': [50, 165], 'equipotent': [51], 'isoflurane': [52], '(iso),': [53], 'sevoflurane': [54], '(sevo),': [55], 'or': [56, 142], 'xenon': [57], '(Xe)': [58], 'with/without': [59], 'pretreatment': [60], 'BACE': [63, 146, 161], 'inhibitor': [64], 'LY2886721': [65], '(LY).': [66], 'Thereafter,': [67], 'CA1': [68, 112, 176], 'density,': [71, 140], 'processing-related': [73], 'molecule': [74], 'expressions,': [75], 'nectin-3': [76, 85, 108], 'levels,': [77], 'long-term': [79], 'potentiation': [80], '(LTP)': [81], 'tested.': [83], 'The': [84], 'downregulation': [86], 'LTP': [88, 118], 'spines': [91], 'evaluated.': [93], 'Sevo': [94], 'treatment': [95, 124], 'increased': [96], 'mouse': [98], 'Aβ1–42': [99], '(mAβ1–42),': [100], 'abolished': [101], 'CA1-LTP,': [102], 'decreased': [104, 125], 'density': [106, 127], 'expressions': [109], 'in': [110, 174], 'region.': [113], 'Furthermore,': [114], 'CA1-nectin-3': [115], 'knockdown': [116], 'blocked': [117, 133], 'reduced': [120], 'density.': [122], 'Iso': [123], 'attenuated': [129], 'LTP.': [130], 'Although': [131], 'Xe': [132, 185], 'LTP,': [134], 'it': [135], 'did': [136], 'not': [137, 187], 'affect': [138], 'mAβ1–42,': [141], 'nectin-3.': [143], 'Finally,': [144], 'antagonizing': [145], 'activity': [147, 162], 'partly': [148, 159], 'restored': [149], 'sevo-induced': [150], 'deficits.': [151], 'Taken': [152], 'together,': [153], 'our': [154], 'study': [155], 'suggests': [156], 'sevo': [158], 'elevates': [160], 'interferes': [164], 'synaptic': [166, 172], 'remodeling,': [167], 'whereas': [168], 'iso': [169], 'mildly': [170], 'modulates': [171], 'changes': [173], 'region': [177], 'hippocampus.': [180], 'On': [181], 'other': [183], 'hand,': [184], 'does': [186], 'alternate': [188], 'remodeling.': [191]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4282924888', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2024-09-08T22:10:16.586770', 'created_date': '2022-06-16'}