Publication Information

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3729, 3731, 3841, 3852, 3872, 3881, 3893, 3949, 3997, 4028, 4081, 4169, 4186, 4220, 4237, 4244, 4253, 4262, 4360, 4379, 4411, 4437, 4496, 4499, 4520, 4669, 4705, 4714, 4723, 4732, 4917, 4954, 5081, 5115, 5121, 5242, 5307, 5313, 5417, 5433, 5475, 5480, 5583, 5664, 5677], 'channel': [28, 117, 129, 138, 168, 257, 269, 278, 411, 432, 2840, 2913, 2942, 3056, 3074, 3269, 3333, 3388, 3574, 3714, 3747, 3874, 3883, 4172, 4191, 4203, 4239, 4381, 4503, 4665, 4725, 4733, 4878, 4893, 4961, 5082, 5245, 5309, 5318, 5599, 5610, 5632, 5648], 'dysfunction': [29, 169, 4879, 5649], 'caused': [30, 59, 123, 170, 199, 263, 5470], 'by': [31, 42, 124, 171, 182, 264, 540, 1082, 1101, 1242, 1248, 1265, 1397, 1796, 1864, 1881, 1904, 2076, 2126, 2944, 3178, 3239, 3856, 3904, 4084, 4090, 4265, 4532, 4884, 4924, 5104, 5127, 5395], 'LQT-2': [32, 38, 120, 172, 178, 260, 736, 910, 1012, 1065, 1074, 1221, 1234, 1749, 2280, 3085, 3654, 3902, 4159, 4367, 4639, 4854, 4881, 5065, 5250, 5374, 5397, 5419, 5651, 5679], 'mutations.': [33, 173, 3963], 'Wild': [34, 174, 1108, 1924, 2150, 2439, 2975, 4200], 'type': [35, 85, 175, 225, 1009, 1109, 1746, 1925, 2151, 2413, 2440, 2612, 2634, 2651, 2701, 2735, 2749, 2775, 2802, 2838, 2976, 3023, 3083, 3191, 3291, 3466, 3481, 3519, 3650, 3671, 3898, 3931, 4092, 4201, 4901, 5117, 5149, 5167, 5423, 5487, 5529, 5543, 5559, 5618], 'mutations': [39, 55, 76, 90, 121, 179, 195, 216, 230, 261, 731, 911, 1075, 3014, 3032, 3973, 4160, 4369, 4408, 4415, 4482, 4640, 4666, 4855, 4891, 4947, 5066, 5398, 5420, 5537, 5592, 5607, 5629, 5654], 'were': [40, 80, 180, 220, 1080, 1113, 1125, 1175, 1184, 1240, 1493, 1558, 1610, 1637, 1672, 1688, 1752, 1813, 1826, 1930, 1952, 1976, 1998, 2102, 2110, 2156, 2169, 2205, 2229, 2572, 2617, 2656, 2681, 2752, 2797, 3098, 3173, 3352, 3955, 5393], 'studied': [41, 181, 914, 1176, 3889, 4193], 'stable': [43, 183, 1226], 'transient': [45, 185, 1170, 2432], 'expression': [46, 186, 2408, 3080, 4198], 'HEK': [48, 188, 1122, 1172, 1418, 1427, 1467, 2401, 2521, 2844, 3908, 3918], '293': [49, 189, 1123, 1173, 1419, 1428, 1468, 2402, 2522, 2845, 3909, 3919], 'cells.': [50, 190, 1476, 1490, 2403, 2427, 2974, 3910], 'found': [52, 192, 3716], 'that': [53, 112, 193, 252, 1019, 1407, 2717, 2732, 2818, 2836, 2864, 2900, 2915, 3008, 3020, 3065, 3121, 3221, 3258, 3276, 3308, 3360, 3396, 3562, 3576, 3619, 3726, 3862, 3877, 3979, 4004, 4126, 4157, 4315, 4327, 4365, 4375, 4440, 4485, 4518, 4572, 4895, 4969, 5006, 5037, 5053, 5063, 5114, 5262, 5294, 5466, 5518, 5612, 5634], 'some': [54, 194, 959, 1020, 4158, 4366, 4686, 5064, 5418, 5591, 5606, 5628], '(Y611H': [56, 196], 'V822M)': [58, 198], 'defects': [60, 200, 3330, 4166, 4374, 4769, 5584, 5597], 'biosynthetic': [62, 202], 'processing': [63, 203, 972, 1003, 1040, 3017, 3070, 3385, 4165, 4373, 4677, 4768, 5071], 'channels': [66, 206, 532, 704, 1066, 2399, 2595, 3234, 3363, 4333, 4393, 4443, 4488, 4672, 4971, 5094, 5261, 5328, 5619], 'protein': [69, 209, 971, 975, 1002, 1192, 1253, 1271, 1293, 1300, 1346, 1358, 1413, 1454, 1486, 1631, 1845, 2079, 2105, 2123, 2841, 2958, 2989, 3016, 3037, 3045, 3069, 3110, 3312, 3511, 3527, 3623, 3673, 3715, 3805, 3834, 3875, 3884, 3895, 4017, 4035, 4142, 4164, 4173, 4192, 4204, 4256, 4305, 4318, 4355, 4372, 4382, 4504, 4649, 4676, 4726, 4921, 5022, 5055, 5070, 5246, 5402, 5484, 5561], 'retained': [70, 210, 4009, 4395, 4490, 4590, 4657, 5601], 'endoplasmic': [73, 213, 723, 3408], 'reticulum.': [74, 214], 'Other': [75, 215, 1034], '(I593R': [77, 217], 'G628S)': [79, 219], 'processed': [81, 221, 1026, 4897, 5539, 5614], 'similarly': [82, 222, 4898, 5540, 5615], 'wild': [84, 224, 725, 1008, 1745, 2412, 2611, 2633, 2650, 2700, 2734, 2748, 2774, 2801, 2837, 2968, 3022, 3082, 3093, 3190, 3290, 3465, 3480, 3518, 3649, 3670, 3897, 3930, 4091, 4138, 4900, 5116, 5148, 5166, 5422, 5486, 5528, 5542, 5558, 5617], 'protein,': [87, 227, 4903], 'but': [88, 104, 228, 244, 1041, 2596, 3630, 5620], 'these': [89, 229, 1131, 2396, 3361, 4441, 4512, 4664, 4905, 4970, 5536, 5656], 'did': [91, 231, 1450, 2955], 'not': [92, 232, 985, 1025, 1043, 1422, 1451, 1471, 2586, 2624, 2956, 3365, 3816, 4449, 4460, 4509, 5058, 5569, 5622], 'produce': [93, 233], 'functional': [94, 234, 1005, 1045, 2407, 2594, 3329, 4331, 4671, 4910, 5073, 5260], 'channels.': [95, 235, 1015, 1219, 2614, 3025, 4912, 5405, 5545], 'In': [96, 236, 988, 1208, 1445, 2588, 2928, 3026, 3242, 3372, 3474, 3926, 3964, 4134, 4869, 4978, 5489, 5576], 'contrast,': [97, 237, 2589, 3027, 3243, 3475, 3965, 4135], 'T474I': [99, 239, 2591, 2602, 2636, 2654, 2703, 2724, 2751, 2777, 2795, 2830, 5076, 5151], 'mutation': [100, 240, 354, 1098, 2592, 2603, 2655, 2725, 2796, 3865, 4087, 4458, 4701, 4719, 5009, 5040, 5077, 5085, 5163, 5184, 5251, 5469], 'expressed': [101, 241, 1336, 2395, 2593, 2842, 2987, 3033, 3749], 'current': [103, 243, 433, 448, 547, 930, 2442, 2510, 2518, 2705, 2721, 2745, 2791, 2803, 2824, 3323, 5088, 5109, 5160, 5172, 5435], 'altered': [106, 137, 246, 277, 2598, 5090], 'gating': [107, 247, 2599, 4962, 5091, 5319], 'properties.': [108, 248, 2600, 5092], 'These': [109, 249, 1051, 3005, 3253, 3557, 3695, 3859, 4154, 4414, 4946, 5291, 5459, 5637], 'findings': [110, 250, 1017, 1052, 3006, 3348, 3558, 3696, 3860, 4155, 5638], 'suggest': [111, 251, 3007, 4156, 4484, 5052, 5293], 'loss': [114, 254], 'function': [118, 258], 'is': [122, 262, 285, 353, 963, 3117, 3280, 3324, 3503, 3566, 3580, 3601, 3739, 3885, 3937, 3980, 3992, 4018, 4113, 4143, 4205, 4224, 4306, 4319, 4364, 4459, 4508, 4515, 4530, 4673, 4702, 5011, 5031, 5375, 5425, 5522, 5568, 5572], 'multiple': [125, 265, 967], 'including': [127, 267, 969], 'abnormal': [128, 268, 974], 'processing,': [130, 270], 'generation': [132, 272], 'nonfunctional': [134, 274], 'channels,': [135, 275, 1046, 2416, 2938, 3087, 4697, 5414], 'gating.': [139, 279], 'The': [280, 904, 1072, 1291, 1303, 1342, 1355, 1388, 1584, 1669, 1685, 1790, 1811, 1823, 1890, 1900, 2099, 2108, 2116, 2167, 2601, 2678, 2742, 2952, 3047, 3319, 3598, 3721, 4303, 4313, 4404, 4456, 4472, 4494, 4887, 4913, 4932, 5075, 5093, 5390, 5653], 'syndrome': [284, 352, 366, 983], 'a': [286, 408, 908, 1134, 1288, 1298, 1328, 1368, 1874, 2027, 2172, 2233, 2258, 2515, 2642, 2854, 2859, 2920, 2991, 3066, 3118, 3412, 3581, 3609, 3678, 3689, 3810, 3819, 3984, 4121, 4149, 4187, 4195, 4217, 4241, 4349, 4476, 4533, 4864, 4979, 5042, 5156, 5490], 'disorder': [287], 'delayed': [290, 445], 'cardiac': [291, 457, 553, 710], 'repolarization': [292, 460], 'prolonged': [294], 'electrocardiographic': [295], 'intervals': [297], 'development': [300], 'ventricular': [302], 'arrhythmias': [303, 554], '(torsades': [304], 'de': [305], 'pointes)': [306], 'sudden': [308], 'death': [309], '(1Moss': [310], 'A.J.': [311], 'Schwartz': [312, 852], 'P.J.': [313, 853, 4832], 'Crampton': [314], 'R.S.': [315, 5223], 'Tzivoni': [316], 'D.': [317, 664, 874, 1374, 5231, 5355, 5692], 'Locati': [318], 'E.H.': [319], 'MacCluer': [320], 'J.': [321, 334, 517, 587, 602, 656, 686, 798, 1155, 1520, 1547, 1655, 1725, 2046, 2348, 2471, 2494, 2541, 2563, 2884, 3149, 3543, 3758, 4056, 4289, 4744, 4998, 5234, 5509, 5701], 'Hall': [322], 'W.J.': [323], 'Weitkamp': [324], 'L.': [325, 4986, 5497], 'Vincent': [326, 389, 744, 2294], 'G.M.': [327, 390, 745, 2295], 'Garson': [328], 'Jr.,': [329], 'A.': [330, 422, 621, 668, 826, 945, 1537, 2376, 4540, 4556, 4625, 5205, 5282, 5343, 5450, 5689], 'Robinson': [331], 'J.L.': [332, 4789], 'Benhorin': [333], 'Choi': [335, 4987, 5498], 'S.': [336, 421, 648, 816, 944, 2366, 2486, 2555, 3760, 4746, 5204, 5281, 5342, 5449], 'Circulation.': [337, 609, 776, 835, 858, 877, 2326, 2385], '1991;': [338], '84:': [339], '1136-1144Crossref': [340], 'PubMed': [341, 402, 426, 480, 497, 526, 567, 596, 613, 642, 676, 757, 780, 804, 839, 899, 949, 1164, 1529, 1552, 1664, 1734, 1914, 2055, 2135, 2307, 2330, 2354, 2389, 2480, 2550, 2893, 3154, 3446, 3552, 3776, 3795, 4045, 4062, 4073, 4298, 4548, 4564, 4613, 4632, 4762, 4846, 5209, 5239, 5286, 5347, 5369, 5454], 'Scopus': [342, 403, 427, 481, 498, 527, 568, 597, 614, 643, 677, 758, 781, 805, 840, 863, 900, 950, 1165, 1530, 1553, 1665, 1735, 1915, 2056, 2136, 2308, 2331, 2355, 2390, 2481, 2551, 2894, 3155, 3447, 3553, 3777, 3796, 4046, 4063, 4074, 4299, 4549, 4565, 4614, 4633, 4763, 4794, 4820, 4847, 5210, 5287, 5348, 5370, 5455], '(844)': [343], 'Google': [344, 405, 429, 483, 500, 529, 570, 599, 616, 627, 645, 661, 679, 760, 783, 807, 842, 865, 882, 902, 952, 1167, 1532, 1555, 1667, 1737, 1917, 2058, 2138, 2310, 2333, 2357, 2392, 2483, 2499, 2553, 2568, 2896, 3157, 3449, 3555, 3779, 3798, 4048, 4065, 4076, 4301, 4551, 4567, 4616, 4635, 4765, 4796, 4822, 4849, 5212, 5240, 5289, 5350, 5372, 5457], 'Scholar).': [345, 406, 430, 530, 701, 903, 953, 1168, 1387, 1556, 1668, 1738, 2059, 2500, 2569, 2897, 3158, 3450, 3556, 3799, 4077, 4302, 4568, 4636, 4766, 4850, 5290, 5373, 5458], 'One': [346], 'cause': [347, 4645, 5563], 'humanether-a-go-go-related': [357], 'gene': [358], '(HERG)': [359], 'producing': [360], '1The': [368], 'abbreviations': [369], 'are:': [371], 'LQT-2human': [372], 'QTPBSphosphate-buffered': [377], 'salineEndo': [378], 'Hendoglycosidase': [379], 'HERendoplasmic': [380], 'reticulumWTwild': [381], 'type.': [382, 726], '(2Curran': [383, 738, 2288], 'M.E.': [384, 470, 632, 739, 934, 2289, 5271, 5439], 'Splawski': [385, 740, 2290], 'I.': [386, 741, 2291, 4621], 'Timothy': [387, 742, 2292, 5700], 'K.W.': [388, 743, 2293], 'Green': [391, 746, 2296], 'E.D.': [392, 747, 788, 2297, 2338], 'Keating': [393, 471, 633, 748, 937, 2298, 5274, 5442], 'M.T.': [394, 472, 634, 749, 938, 2299, 5275, 5443], 'Cell.': [395, 473, 750, 2300, 3439, 3769, 4604, 4628, 4755], '1995;': [396, 474, 494, 564, 751, 2301, 3792, 4561, 4840, 5344], '80:': [397, 752, 2302], '795-803Abstract': [398, 753, 2303], 'Full': [399, 477, 521, 523, 591, 593, 754, 1159, 1161, 1524, 1526, 1659, 1661, 1729, 1731, 2050, 2052, 2304, 2475, 2477, 2545, 2547, 2888, 2890, 3443, 3547, 3549, 3773, 4293, 4295, 4608, 4610, 4759, 4843, 5364, 5366], 'Text': [400, 478, 522, 524, 592, 594, 755, 1160, 1162, 1525, 1527, 1660, 1662, 1730, 1732, 2051, 2053, 2305, 2476, 2478, 2546, 2548, 2889, 2891, 3444, 3548, 3550, 3774, 4294, 4296, 4609, 4611, 4760, 4844, 5365, 5367], 'PDF': [401, 479, 525, 595, 756, 1163, 1528, 1663, 1733, 2054, 2306, 2479, 2549, 2892, 3445, 3551, 3775, 4297, 4612, 4761, 4845, 5368], '(1996)': [404, 759, 2309], 'HERGencodes': [407], 'voltage-gated': [409, 4189, 4866, 5326], 'potassium': [410], '(3Warmke': [412, 5195], 'J.W.': [413, 488, 558, 5196], 'Ganetzky': [414, 489, 559, 5197], 'B.': [415, 490, 507, 560, 577, 606, 872, 1145, 1510, 1541, 1645, 1715, 2036, 2461, 2531, 2874, 3533, 4279, 4990, 5198, 5501], 'Proc.': [416, 939, 5199, 5276, 5337, 5444], 'Natl.': [417, 940, 5200, 5277, 5338, 5445], 'Acad.': [418, 941, 5201, 5278, 5339, 5446], 'Sci.': [419, 942, 4839, 5202, 5279, 5340, 5447], 'U.': [420, 943, 5203, 5280, 5341, 5448], '1994;': [423, 5206], '91:': [424, 5207], '3438-3442Crossref': [425, 5208], '(866)': [428, 5211], 'has': [434, 984, 4678, 5185, 5321], 'been': [435, 733, 913, 921, 986, 4679, 4772, 5186, 5322], 'shown': [436, 922, 1076, 2266, 2435, 2455, 2834, 2948, 3182, 3452, 3665, 3912, 4467, 4773, 4883, 5132, 5462, 5517, 5532], 'have': [438, 705, 732, 912, 920, 2833, 4770, 5004, 5068, 5461, 5516, 5623], 'properties': [439, 906, 1006], 'similar': [440, 3018, 3504, 5112, 5564], 'rapidly': [443, 3886, 4402], 'activating': [444], 'rectifier': [446], 'K+': [447, 4867, 5327], '(IKr),': [449], 'it': [451, 2736, 2963, 3814, 4232], 'plays': [452], 'an': [453, 535, 708, 1206, 1706, 2998, 3975, 4682, 5376], 'important': [454, 536, 709, 4358, 4683, 4776], 'role': [455, 5312], 'action': [458, 549], 'potential': [459, 550], 'mammalian': [463, 3751, 4197], 'heart': [464], '(4Sanguinetti': [465], 'M.C.': [466, 486, 556, 636, 932, 5269, 5437], 'Jiang': [467], 'C.': [468, 849, 4554, 4812, 5136, 5697], 'Curran': [469, 631, 933, 5270, 5438], '81:': [475], '299-307Abstract': [476], '(2152)': [482], 'Scholar,': [484, 501, 571, 600, 617, 628, 646, 662, 680, 761, 784, 808, 843, 866, 883, 1533, 2311, 2334, 2358, 2484, 3780, 4049, 4066, 4552, 4617, 5351], '5Trudeau': [485], 'Warmke': [487, 557], 'Robertson': [491, 512, 561, 582, 1150, 1515, 1650, 1720, 2041, 2466, 2536, 2879, 3538, 4284], 'G.A.': [492, 513, 562, 583, 1151, 1516, 1651, 1721, 2042, 2467, 2537, 2880, 3539, 3764, 4285, 4750], 'Science.': [493, 563, 4069, 4790], '269:': [495, 565], '92-95Crossref': [496, 566], '(1099)': [499, 569], '6Zhou': [502, 572], 'Z.': [503, 509, 573, 579, 650, 684, 1141, 1147, 1506, 1512, 1641, 1647, 1711, 1717, 2032, 2038, 2457, 2463, 2488, 2527, 2533, 2557, 2870, 2876, 3529, 3535, 4275, 4281, 5227], 'Gong': [504, 574, 651, 1142, 1507, 1642, 1712, 2033, 2458, 2489, 2528, 2558, 2871, 3530, 4276], 'Q.': [505, 575, 652, 1143, 1508, 1643, 1713, 2034, 2459, 2490, 2529, 2559, 2872, 3531, 4277], 'Ye': [506, 576, 1144, 1509, 1644, 1714, 2035, 2460, 2530, 2873, 3532, 4278], 'Fan': [508, 578, 1146, 1511, 1646, 1716, 2037, 2462, 2532, 2875, 3534, 4280], 'Makielski': [510, 580, 1148, 1513, 1648, 1718, 2039, 2464, 2534, 2877, 3536, 4282], 'J.C.': [511, 581, 1149, 1514, 1649, 1719, 2040, 2465, 2535, 2878, 3537, 4283], 'January': [514, 584, 653, 1152, 1517, 1652, 1722, 2043, 2468, 2491, 2538, 2560, 2881, 3540, 4286], 'C.T.': [515, 585, 654, 682, 1153, 1518, 1653, 1723, 2044, 2469, 2492, 2539, 2561, 2882, 3541, 3782, 4287], 'Biophys.': [516, 586, 1154, 1519, 1654, 1724, 2045, 2470, 2540, 2883, 3542, 4288, 4997, 5508], '1998;': [518, 588, 896, 1156, 1521, 1656, 1726, 2047, 2472, 2542, 2885, 3544, 4290, 4999, 5510], '74:': [519, 589, 1157, 1522, 1657, 1727, 2048, 2473, 2543, 2886, 3545, 4291], '230-241Abstract': [520, 590, 1158, 1523, 1658, 1728, 2049, 2474, 2544, 2887, 3546, 4292], '(627)': [528, 598, 1166, 1531, 1666, 1736, 2057, 2482, 2552, 2895, 3554, 4300], 'also': [534, 1479, 2230, 2767, 2816, 3301, 3591, 3724, 4771, 4935, 5010, 5032, 5257, 5320, 5515], 'target': [537], 'for': [538, 958, 980, 1060, 1186, 1627, 1787, 1828, 1866, 1897, 1921, 1932, 2065, 2161, 2632, 2649, 2733, 2747, 2772, 2793, 2822, 2828, 2935, 3594, 3700, 3824, 4136, 4480, 4863, 4876, 5145, 5161, 5179, 5585, 5646, 5703], 'block': [539], 'many': [541], 'drugs,': [542], 'suppression': [544, 5432, 5474, 5567], 'causes': [548, 3071, 4712, 5041], 'prolongation': [551], '(5Trudeau': [555], '7Kiehn': [601], 'Lacerda': [603], 'A.E.': [604, 3768, 4754], 'Wible': [605], 'Brown': [607, 669], 'A.M.': [608, 670, 4053], '1996;': [610, 624, 639, 777, 801, 946, 2327, 2351, 5283, 5361, 5451], '94:': [611], '2572-2579Crossref': [612], '(187)': [615], '8Snyders': [618], 'D.J.': [619], 'Chaudhary': [620], 'Mol.': [622, 4626], 'Pharmacol.': [623], '49:': [625], '949-955PubMed': [626], '9Spector': [629], 'P.': [630, 870, 889], 'Sanguinetti': [635], 'Circ.': [637], 'Res.': [638], '78:': [640], '499-503Crossref': [641], '(274)': [644], '10Mohammad': [647, 2485], 'Zhou': [649, 683, 2487, 2556], 'Am.': [655, 797, 2347, 2493, 2562], 'Physiol.': [657, 1548, 2495, 2564], '1997;': [658, 673, 836, 859, 878, 2386, 2496, 2565, 4070, 4605, 4629, 4817, 5236], '273:': [659, 2497, 2566], 'H2534-H2538PubMed': [660, 2498, 2567], '11Rampe': [663], 'Roy': [665], 'M.L.': [666], 'Dennis': [667], 'FEBS': [671], 'Lett.': [672], '417:': [674], '28-32Crossref': [675], '(282)': [678], '12January': [681], 'Liebman': [685], 'Electrocardiology': [687], "'96:": [688], 'From': [689], 'Cell': [691, 4057, 4543, 4559], 'Body': [694], 'Surface.': [695], 'World': [696], 'Scientific': [697], 'Inc.,': [698], 'Singapore1997:': [699], '231-240Google': [700], 'Therefore,': [702, 4339], 'emerged': [706], 'as': [707, 1137, 1205, 1301, 1502, 1618, 2453, 2641, 2947, 2978, 2980, 3677, 3809, 4211, 4348, 4466, 4681, 5131, 5403, 5551], 'ion': [711, 4190, 4911, 4964], 'channel.': [712, 1033, 2927, 3588, 4868], 'phosphate-buffered': [719], 'saline': [720], 'endoglycosidase': [721, 1835], 'H': [722, 1836, 3378, 3391, 3472, 3487, 3605], 'reticulum': [724, 3409], 'More': [727, 5668], 'than': [728], '30': [729, 1788, 1840, 1849], 'identified': [734, 1247, 4419, 4510], 'patients': [737], '13Benson': [762, 2312], 'D.W.': [763, 2313, 3762, 4748, 4992, 4994, 5503, 5505], 'MacRae': [764, 2314], 'C.A.': [765, 786, 885, 2315, 2336], 'Vesely': [766, 789, 886, 2316, 2339], 'M.R.': [767, 790, 868, 887, 2317, 2340], 'Walsh': [768, 787, 2318, 2337], 'E.P.': [769, 2319], 'Seidman': [770, 772, 2320, 2322], 'J.G.': [771, 2321], 'C.E.': [773, 2323], 'Satler': [774, 2324], 'A.S.': [775, 2325], '93:': [778, 947, 2328, 5284, 5452], '1791-1795Crossref': [779, 2329], '(76)': [782, 2332], '14Satler': [785, 2335], 'Plummer': [791, 2341], 'M.H.': [792, 2342], 'Ginsburg': [793, 890, 2343], 'G.S.': [794, 891, 2344], 'Jacob': [795, 2345], 'H.J.': [796, 2346], 'Med.': [799, 2349], 'Genet.': [800, 895, 2350, 4816], '65:': [802, 2352], '27-35Crossref': [803, 2353], '(56)': [806, 2356], '15Tanaka': [809, 2359], 'T.': [810, 828, 2360, 2378], 'Nagai': [811, 2361], 'R.': [812, 2362, 5330], 'Tomoike': [813, 2363], 'H.': [814, 830, 1889, 2364, 2380, 3143, 3147, 4068], 'Takata': [815, 2365], 'Yano': [817, 2367], 'K.': [818, 820, 2368, 2370, 4455], 'Yabuta': [819, 2369], 'Haneda': [821, 2371], 'N.': [822, 2372, 3139], 'Nakano': [823, 2373], 'O.': [824, 851, 2374], 'Shibata': [825, 2375], 'Sawayama': [827, 2377], 'Kasai': [829, 2379], 'Yazaki': [831, 2381], 'Y.': [832, 834, 2382, 2384, 3786], 'Nakamura': [833, 2383], '95:': [837, 2387], '565-567Crossref': [838, 2388], '(106)': [841, 2391], '16Priori': [844], 'S.G.': [845], 'Matteo': [846], 'P.S.': [847, 936, 5273, 5441], 'Napolitano': [848], 'Civile': [850], 'Paganini': [854], 'V.': [855], 'Casari': [856], 'G.': [857], '96': [860, 879], '(abstr.):': [861, 880, 5001, 5512], 'I-212Crossref': [862], '(158)': [864], '17Vesely': [867], 'Duggal': [869, 888], 'London': [871], 'Wattanasirichaigoon': [873], 'Beggs': [875, 892], 'A.H.': [876, 893], 'I-56PubMed': [881], '18Satler': [884], 'Hum.': [894], '102:': [897], '265-272Crossref': [898], '(52)': [901], 'electrophysiological': [905, 5624], 'few': [909], 'Xenopus': [916, 5464], 'oocytes,': [917], 'where': [918, 4231, 4399, 4424], 'they': [919, 1048, 3426, 4400, 4425, 4655], 'result': [924, 4161, 4370, 4958, 5428, 5593, 5608, 5630, 5660], 'reduced': [926, 3491], 'or': [927, 1047, 1128, 1275, 1425, 1777, 1926, 2152, 4651, 4963, 4974, 5214, 5298], 'absent': [928], '(19Sanguinetti': [931, 5268, 5436], 'Spector': [935, 5272, 5440], '2208-2212Crossref': [948, 5285, 5453], '(392)': [951, 5288, 5456], 'Although': [954, 5107], 'basis': [957, 979], 'diseases': [962, 4830], 'known': [964, 5570], 'involve': [966], 'defective': [970, 4960], 'function,': [976, 2644], 'studied.': [987], 'present': [990, 2525, 4362, 5144, 5387, 5391], 'work,': [991], 'we': [992, 1223, 2270, 2417, 2939, 3375, 3657, 4023, 4249, 4967], 'intracellular': [1001, 1273, 3383, 3989, 4152, 4163, 4478, 5054, 5193, 5595], 'five': [1011, 2278, 2972, 3901], 'mutant': [1013, 1021, 1035, 1064, 1111, 1235, 1927, 2153, 2397, 2415, 2637, 2704, 2937, 3086, 3299, 3311, 3362, 3621, 3655, 3804, 3833, 4006, 4016, 4128, 4170, 4392, 4442, 4487, 4501, 4920, 5021, 5385, 5483, 5521], 'Our': [1016, 4177, 4851], 'show': [1018, 3725, 3861, 4439, 4860, 4936], 'proteins': [1023, 1037, 1671, 1825, 2943, 2966, 3172, 3405, 3421, 3748, 4007, 4030, 4329, 4523, 4578, 4588, 4894, 4906, 5408, 5600, 5611, 5633], 'mature': [1029, 2908, 3264, 3570, 3737, 3870, 4235, 4464], 'form': [1030, 1044, 2909, 2923, 3053, 3265, 3283, 3571, 3584, 3680, 3691, 3734, 3738, 3823, 3871, 3880, 4215, 4236, 4330, 4909, 5412], 'undergo': [1038, 3015, 3427, 3641, 4384, 4595], 'normal': [1039, 1069, 4385, 5061, 5383], 'do': [1042, 5621], 'gate': [1049, 5263, 5635], 'abnormally.': [1050, 5636], 'provide': [1053, 3559, 3697, 4179, 5639], 'new': [1054, 1289, 4180, 5640], 'information': [1055, 5641], 'about': [1056, 3498, 3614, 4182, 4245, 5128, 5642], 'failure': [1062, 3072, 4378, 4731], 'generate': [1068, 1364, 2277, 3868, 4426, 4892], 'current.': [1071, 5168], 'Table': [1078, 2268], 'I': [1079], 'generated': [1081, 1296], 'site-directed': [1083, 2272], 'mutagenesis': [1084, 1092, 2273], 'using': [1085, 1104, 1133, 1297, 1349, 1367, 1499, 1834, 2431, 3661], 'Altered': [1087], 'Site': [1088], 'II': [1089], 'vitro': [1091], 'system': [1093], '(Promega,': [1094], 'Madison,': [1095, 1324], 'WI).': [1096], 'Each': [1097], 'was': [1099, 1196, 1263, 1295, 1317, 1335, 1347, 1359, 1395, 1433, 1439, 1625, 1703, 1794, 1846, 1871, 1892, 1902, 1972, 2074, 2087, 2093, 2119, 2255, 2511, 2524, 2726, 2737, 2825, 2904, 2919, 3193, 3208, 3247, 3300, 3341, 3468, 3483, 3490, 3674, 3685, 3806, 3815, 5111, 5124, 5143, 5155], 'verified': [1100], 'DNA': [1102, 1106], 'sequencing': [1103], 'automatic': [1105], 'sequencer.': [1107], 'cDNAs': [1112], 'subcloned': [1114, 1318], 'into': [1115, 1319, 1361, 3315, 4309, 5015], 'pcDNA3': [1116], 'vector': [1117, 1322], '(Invitrogen,': [1118], 'Carlsbad,': [1119], 'CA),': [1120], 'cells': [1124, 1174, 1183, 1216, 1420, 1469, 1751, 1812, 1929, 1975, 1997, 2155, 2168, 2204, 2228, 2523, 2577, 2622, 2846, 3089, 3164, 3752, 3920, 3927, 3941, 3966, 4082], 'transfected': [1126, 1182, 1237, 2426, 2576, 2621, 3091, 3907, 3928, 3967, 4083], 'transiently': [1127, 1181, 2423], 'stably': [1129, 1236, 2425, 2575, 2620, 3090], 'constructs': [1132], 'lipofectamine': [1135], 'method': [1136, 1370], 'described': [1138, 1503, 1639], 'previously': [1139, 1504, 1638, 2454, 2835], '(6Zhou': [1140, 1505, 1640, 1710, 2031, 2456, 2526, 2869, 3528, 4274], 'After': [1169, 1965, 2060], 'transfection,': [1171], 'at': [1177, 1612, 1696, 1784, 1894, 2062, 2068, 2095, 2164, 2195, 2449, 2605, 2708, 2728, 2739, 2779, 2808, 2994, 3002, 3039, 4707, 5096, 5173, 5264], '48': [1178], 'h.': [1179, 1899, 3830, 3858], 'When': [1180, 2639], 'patch': [1187, 2419], 'clamp': [1188, 2420, 2429], 'experiments,': [1189, 1210, 2227, 5535], 'green': [1190, 1213, 4100], 'fluorescent': [1191, 1214], 'cDNA': [1193, 1200, 1304], '(1': [1194], 'μg)': [1195, 1202], 'co-transfected': [1197], '(5': [1201], 'serve': [1204], 'indicator.': [1207], 'our': [1209, 3160, 4885, 5035, 5534, 5578, 5682], '>90%': [1211], 'protein-positive': [1215], 'express': [1217], 'For': [1220, 1739, 1832, 2223, 2501, 3335, 3800, 4095, 4690], 'mutants,': [1222, 4873], 'established': [1224], 'four': [1225], 'cell': [1227, 1238, 1261, 1497, 1843, 2072, 3078, 3113, 3369, 4336, 4389, 4729, 4929, 4942, 5028], 'lines': [1228, 1239, 4436], '(T474I,': [1229], 'I593R,': [1230, 2283, 2503, 2581, 2983, 3011, 3960], 'Y611H,': [1231, 2284, 2504, 2582, 3095, 3336, 3802], 'G628S).': [1233], 'selected': [1241, 1264], 'their': [1243, 3943], 'G418': [1244, 1267], 'resistance': [1245], 'presence': [1250], 'on': [1254, 1455, 2422, 2851, 3111, 4344, 4420, 5026, 5047], 'Western': [1255, 1398, 1404, 1456, 1634, 1829, 2852, 2945, 3179, 3455, 3718, 3999, 4345, 4421, 5048], 'blot.': [1256, 1457, 3180, 5049], 'A': [1257, 1376, 5311], 'mock-transfected': [1258, 1424, 1473, 1489, 2960, 3917], '(pcDNA3': [1259], 'vector)': [1260], 'line': [1262], 'its': [1266, 4928, 4944, 5180], 'resistance.Table': [1268], 'ILQT-2': [1269], 'mutationsMutationHERG': [1270], 'domainT474IS2–S3': [1272], 'loop': [1274, 5194, 5301], 'S2I593RS5': [1276], 'pore': [1277, 1279, 4952], 'regionY611HS5': [1278], 'regionG628SPore': [1280], 'regionV822MCyclic': [1281], 'nucleotide': [1282], 'binding': [1283], 'domain': [1284, 5219], 'Open': [1285], 'table': [1286], 'tab': [1290], 'antibody': [1294, 1366, 1394, 1410, 1438, 1702, 2214, 2235, 2248, 2954], 'fusion': [1299, 1331, 1345, 1357, 1443], 'antigen.': [1302], 'fragment': [1305], 'encoding': [1308], '181': [1309], 'amino': [1310, 3134], 'acid': [1311], 'residues': [1312], 'from': [1313, 2121, 3228, 3495, 4259, 4524], 'carboxyl': [1315], 'terminus': [1316], 'pET-32a': [1321], '(Novagen,': [1323], 'WI)': [1325], 'make': [1327], 'histidine-tagged': [1329, 1343], 'thioredoxin-HERG': [1330, 1344], 'construct.': [1332], 'This': [1333, 3207, 3358, 3501, 3617, 3987, 4112, 4569, 4718, 5050, 5084, 5169, 5183], 'construct': [1334], 'inEscherichia': [1337], 'coli': [1338], 'AD494(DE3)pLysS': [1339], 'strain': [1340], '(Novagen).': [1341, 1354], 'purified': [1348, 1356], 'His-Bind': [1351], 'Buffer': [1352], 'Kit': [1353], 'injected': [1360], 'rabbits': [1362], 'polyclonal': [1365, 1392], 'standard': [1369], '(21Harlow': [1371], 'E.': [1372, 1539, 4808], 'Lane': [1373], 'Antibodies:': [1375], 'Laboratory': [1377], 'Manual.': [1378], 'Cold': [1379, 1383], 'Spring': [1380, 1384], 'Harbor': [1381], 'Laboratory,': [1382], 'Harbor,': [1385], 'NY1988Google': [1386], 'specificity': [1389], 'anti-HERG': [1393], 'tested': [1396], 'blot,': [1399, 2853], 'immunohistochemical,': [1400], 'immunoprecipitation': [1402, 2006, 2114], 'assays.': [1403], 'blot': [1405, 1635, 1830, 2946, 3456, 3719, 4000, 4346, 4422], 'showed': [1406, 1480, 2443, 3608, 3921], 'recognized': [1411, 2964, 4517, 4680], 'bands': [1414, 1487, 3217, 3711, 3845], 'only': [1415, 1464, 2514, 3034, 4316, 4427, 4573], 'HERG-transfected': [1417, 1466, 1928, 2154], 'untransfected': [1426, 1475], 'cells,': [1429, 1744, 2961], 'this': [1431, 4412, 4861], 'reaction': [1432, 1901], 'inhibited': [1434], 'when': [1435, 3742], 'preincubated': [1440], 'protein.': [1444, 3334, 3389, 3419, 3951, 5488, 5530], 'addition,': [1446], 'preimmune': [1447], 'rabbit': [1448], 'serum': [1449, 1949], 'recognize': [1452, 2957], 'Immunofluorescence': [1458, 2253], 'experiments': [1459, 1478, 1609, 1833, 3660, 4001, 4474, 4914, 4934, 5036], 'demonstrated': [1460], 'positive': [1461, 2451, 2781, 5139, 5175], 'fluorescence': [1462, 2260], 'staining': [1463, 2226, 2254, 3935, 3977, 4027, 4938], 'Immunoprecipitation': [1477], 'absence': [1482, 3048], 'detectable': [1484, 3923], 'Membrane': [1491, 1630, 3171], 'currents': [1492, 2778], 'recorded': [1494], 'whole': [1496], 'configuration': [1498], 'suction': [1500], 'pipettes': [1501], '22Hamill': [1534], 'O.P.': [1535], 'Marty': [1536], 'Neher': [1538], 'Sakmann': [1540], 'Sigworth': [1542], 'F.J.': [1543], 'Pflug.': [1544], 'Arch.': [1545], 'Eur.': [1546, 3148], '1981;': [1549], '391:': [1550], '85-100Crossref': [1551], '(15145)': [1554], 'Cells': [1557, 1951], 'superfused': [1559], 'HEPES-buffered': [1561], 'Tyrode': [1562], 'solution': [1563, 1587], 'containing': [1564, 1763, 1803, 1858, 1946, 1959, 2013, 2174], '(in': [1565], 'mm)': [1566], '137': [1567], 'NaCl,': [1568, 1769, 2016], '4': [1569, 2069, 2096, 2196, 3590], 'KCl,': [1570, 1591], '1.8': [1571], 'CaCl2,': [1572], '1': [1573, 1592, 1933, 1966, 2627, 2694, 5135], 'MgCl2,': [1574, 1594], '10': [1575, 1578, 1601, 1764], 'glucose,': [1576], 'HEPES': [1579, 1603], '(pH': [1580, 1604, 1774, 1856], '7.4': [1581], 'NaOH).': [1583], 'internal': [1585], 'pipette': [1586], 'contained': [1588], '130': [1589], 'mm': [1590, 1593, 1596, 1599, 1602, 1765, 1768, 1772, 1805, 1879, 1987, 2009, 2015], '5': [1595, 1598, 2066], 'EGTA,': [1597], 'MgATP,': [1600], '7.2': [1605], 'KOH).': [1607], 'All': [1608], 'performed': [1611, 2271, 2418, 3658, 4024], '22–23': [1613], '°C.': [1614], 'Data': [1615], 'presented': [1617], 'mean': [1619], '±': [1620, 2658, 2667, 2683, 2687, 2754, 2758], 'S.E.': [1621], "Student's": [1622], 't': [1623], 'test': [1624], 'statistical': [1628], 'analysis.': [1629, 1831], 'preparation': [1632], 'procedures': [1636], 'membrane': [1670, 1824, 1844, 3274, 3746, 4738], 'subjected': [1673, 2140], 'SDS-polyacrylamide': [1675, 2143], 'gel': [1676, 2144], 'electrophoresis': [1677], 'then': [1679, 1814, 1953, 2088, 2187, 3174, 3631, 4225, 4307], 'electrophoretically': [1680], 'transferred': [1681], 'onto': [1682], 'nitrocellulose': [1683, 1686], 'membranes.': [1684], 'membranes': [1687], 'incubated': [1689, 1757, 1893, 1954, 2094, 2188, 2206, 2231], 'antiserum': [1693, 2084, 2192], '(1:20,000': [1694], 'dilution)': [1695, 2086, 2194], 'room': [1697, 2165], 'temperature': [1698], 'overnight,': [1699], 'detected': [1704, 5025], 'ECL': [1707], 'detection': [1708], 'kit': [1709], 'proteinase': [1740, 1781, 1791, 3101, 3168, 3197, 3250, 3304, 3344, 3350, 4324, 4454, 4925], 'K': [1741, 1782, 1792, 3102, 3116, 3169, 3198, 3251, 3305, 3345, 3351, 4325, 4926], 'treatment': [1742, 3199, 3488, 3516, 3606], 'HERG-': [1747], 'mutant-transfected': [1750, 2973], 'washed': [1753, 1817, 1977, 1999, 2111, 2220], 'PBS': [1755, 1802, 2185], '2': [1759, 1771, 1867, 1922, 1986], 'ml': [1760, 1799], 'buffer': [1762, 1855, 1907, 2007, 2128, 2173], 'HEPES,': [1766], '150': [1767, 2014], 'CaCl2': [1773], '7.4)': [1775], 'without': [1778, 3042, 4597], '200': [1779], 'μg/ml': [1780], '(Sigma)': [1783], '37': [1785, 1895], '°C': [1786, 1896, 2097, 2197], 'min.': [1789, 1868, 1923], 'activity': [1793], 'stopped': [1795, 1903], 'adding': [1797, 1905], '1.3': [1798], 'ice-cold': [1801, 1821], '6': [1804], 'phenylmethylsulfonyl': [1806], 'fluoride': [1807, 1870], '25': [1809], 'mmEDTA.': [1810], 'harvested': [1815], 'three': [1818, 5581], 'times': [1819, 3826], 'PBS.': [1822, 2222], 'isolated': [1827, 2103, 3175], '(Endo': [1837], 'H)': [1838], 'treatment,': [1839, 3306], 'μg': [1841], 'dissolved': [1847], 'μl': [1850, 2004], '50': [1852], 'mmsodium': [1853], 'citrate': [1854], '5.5)': [1857], '15': [1859, 1885], 'mmβ-mercaptoethanol': [1860], '0.12%': [1862], 'SDS': [1863], 'boiling': [1865, 1920], 'Phenylmethylsulfonyl': [1869], 'added': [1872, 3398], 'final': [1875], 'concentration': [1876], '0.5': [1878], 'followed': [1880], 'addition': [1883, 4261, 4870], 'milliunits': [1886], 'Endo': [1888, 3377, 3390, 3433, 3471, 3486, 3604], 'mixture': [1891, 2030, 2092], '24': [1898, 3829, 3857], 'sample': [1906, 2127], '(23Laemmli': [1908, 2129], 'U.K.': [1909, 2130], 'Nature.': [1910, 2131, 4041], '1970;': [1911, 2132], '227:': [1912, 2133], '680-685Crossref': [1913, 2134], '(207208)': [1916, 2137], 'Scholar)': [1918, 2393, 5003, 5213, 5241, 5514], 'starved': [1931], 'h': [1934, 1967], 'serum-free': [1936], "Dulbecco's": [1937, 1981], 'modified': [1938, 1982, 4226], "Eagle's": [1939, 1983], 'medium': [1940, 1958, 1971, 1984], 'lacking': [1941], 'methionine': [1942, 1989], 'cysteine': [1944], '0.25%': [1947], 'bovine': [1948], 'albumin.': [1950], 'same': [1957, 4109], '[35S]methionine': [1960], '[35S]cysteine': [1962], '(400': [1963], 'μci/ml).': [1964], 'labeling,': [1969], 'removed,': [1973], 'chased': [1979], 'unlabeled': [1988], 'cysteine.': [1991], 'At': [1992, 5137], 'different': [1993, 5657, 5662], 'time': [1994], 'intervals,': [1995], 'lysed': [2001], '500': [2003], '(50': [2008], 'Tris-HCl,': [2010], 'pH': [2011], '8.0': [2012], '1%': [2017, 2020], 'Triton': [2018, 2179], 'X-100,': [2019, 2180], 'sodium': [2021], 'deoxycholate,': [2022], '0.1%': [2024], 'SDS)': [2025], 'protease': [2028, 3120], 'inhibitor': [2029], 'centrifugation': [2061], '14,000': [2063], 'rpm': [2064], 'min': [2067, 2163], '°C,': [2070], 'lysate': [2073], 'precleared': [2075], 'incubation': [2077], 'A-agarose': [2080, 2106, 2124], 'beads': [2081, 2125], '(Pierce).': [2082], '(1:100': [2085], 'added,': [2089], 'overnight.': [2098, 2198], 'antigen-antibody': [2100], 'complexes': [2101], 'beads.': [2107], 'immunoprecipitates': [2109], 'buffer.': [2115], 'bound': [2117], 'antigen': [2118], 'eluted': [2120], 'Scholar),': [2139, 4797, 4823], '7.5%': [2142], 'electrophoresis,': [2145], 'visualized': [2147], 'autoradiography.': [2149], 'fixed': [2157], '4%': [2159], 'paraformaldehyde': [2160], '20': [2162, 5129], 'temperature.': [2166], 'blocked': [2170], '5%': [2175], 'goat': [2176, 2210, 2244], 'serum,': [2177], '0.2%': [2178], '0.05%': [2182], 'azide': [2183], '(1:3000': [2193], 'Following': [2199], 'washing': [2200], 'PBS,': [2202], 'fluorescein': [2208], 'isothiocyanate-conjugated': [2209], 'anti-rabbit': [2211], 'IgG': [2212, 2246], 'secondary': [2213, 2247], '(Jackson,': [2215, 2249], 'West': [2216, 2250], 'Grove,': [2217, 2251], 'PA)': [2218], 'double': [2224, 4025], 'immunofluorescence': [2225, 3924, 3934, 3953, 3976, 4026, 4937], 'monoclonal': [2234], 'BiP': [2237, 4036, 4103, 4131, 4147], '(Stressgen,': [2238], 'Victoria,': [2239], 'Canada)': [2240], 'Texas': [2242], 'Red-conjugated': [2243], 'anti-mouse': [2245], 'PA).': [2252], 'viewed': [2256], 'Nikon': [2259], 'microscope': [2261], '(Nikon,': [2262], 'Tokyo,': [2263], 'Japan).': [2264], 'As': [2265, 3181, 3451, 3664, 3911, 4248, 5531], 'I,': [2269], 'reported': [2279, 5323], 'mutations,': [2281, 2986], 'T474I,': [2282, 2982, 3010, 3959], 'G628S,': [2285, 2505], 'V822M': [2287, 3031, 3061, 3356, 3972, 4407, 4643, 5554], 'To': [2404, 3076, 3644, 4011], 'studies': [2421, 5671], 'Patch': [2428], 'recordings': [2430], 'transfection': [2433], 'Fig.': [2437, 2626, 2693, 2811, 2950, 3184, 3373, 3459, 3589, 3667, 3914, 5134], '1.': [2438], 'voltage-dependent': [2444], 'activation': [2445, 2630, 2647], 'inward': [2447, 2770, 5141], 'rectification': [2448, 2771, 5142], 'more': [2450, 2606, 2780, 3981, 4150, 5097, 5138, 5174, 5265], 'voltages': [2452, 2608, 2648, 5099, 5176, 5267], 'mutants': [2502, 2580, 3062, 3903, 5549, 5587], 'V822M,': [2507], 'no': [2508, 3922], 'recorded;': [2512], 'rather,': [2513], 'small': [2516], 'amplitude': [2517, 2804, 5110], 'endogenous': [2519], 'Scholar,10Mohammad': [2554], 'Similar': [2570, 2615, 3288, 3347, 3952], 'results': [2571, 2616, 3254, 3996, 4080, 4178, 4258, 4852, 5258, 5292, 5392], 'obtained': [2573, 2618, 3353, 3956, 5394], 'G628S': [2584, 2985, 3013, 3097, 3298, 3310, 3962, 4890, 4919, 5468, 5482], '(data': [2585, 2623], 'shown).': [2587, 2625], 'activated': [2604], 'negative': [2607, 5098, 5266, 5431, 5473, 5566], 'compared': [2609, 2799, 3743, 5164], 'Bshows': [2628], 'curves': [2631], 'currents.': [2638], 'fit': [2640], 'Boltzmann': [2643], 'half-maximal': [2646], '−15.9': [2657], '1.1': [2659], 'mV': [2660, 2669, 2730, 2789, 5130], '(n': [2661, 2670], '=': [2662, 2671], '17': [2663], 'cells)': [2664], '−43.2': [2666], '1.2': [2668], '16': [2672], 'cells),': [2673], 'respectively': [2674, 2689, 2761], '(p': [2675, 2690, 2762, 2805], '<': [2676, 2806], '0.05).': [2677, 2692, 2764], 'slope': [2679], 'factors': [2680], '7.6': [2682], '0.3': [2684], '6.8': [2686], '0.6,': [2688], '>': [2691, 2763], 'C': [2695, 2766, 3225], 'shows': [2696, 2716, 2768, 2817, 3592, 4003, 4079, 4120, 4148], 'theI-V': [2697, 5122], 'plots': [2698], 'density': [2706, 4780], 'measured': [2707], 'end': [2710], 'depolarizing': [2713], 'step.': [2714], 'It': [2715, 4223, 4514, 5030], 'maximal': [2719, 2743], 'outward': [2720, 2744, 5159], 'reached': [2727, 2738], '−20': [2729], '0': [2740], 'mV.': [2741], 'densities': [2746], '34.7': [2753], '4.0': [2755], '26.6': [2757], '5.6': [2759], 'pA/pF,': [2760], 'Fig.1': [2765], 'marked': [2769, 5471], 'both': [2773, 2865, 4481, 5069, 5146, 5382], 'voltages,': [2782, 5140], 'voltage': [2786, 2821, 5305], 'range': [2787], '0–60': [2788], 'amplitudes': [2792], 'decreased': [2798, 3610], '0.05': [2807], 'each': [2809], 'voltage).': [2810], '1,': [2812], 'B': [2813], 'C,': [2815], 'threshold': [2820], 'eliciting': [2823], 'shifted': [2826, 5102, 5125], 'negatively': [2827, 5103, 5126], 'mutation.': [2831, 3357, 3597], 'consists': [2847], 'two': [2849, 2988], 'forms': [2850], '135-kDa': [2855, 3245, 3578, 3599, 3811, 3854], '(lower)': [2856], 'band': [2857, 2903, 2918, 2993, 3001, 3038, 3188, 3246, 3261, 3279, 3295, 3340, 3463, 3478, 3502, 3512, 3565, 3579, 3600, 3855, 4342, 5046], '155-kDa': [2860, 3564, 3710, 4304, 4317, 4328, 4341], '(upper)': [2861], 'band,': [2862], 'species': [2866], 'involveN-linked': [2867], 'glycosylation': [2868, 3401, 3626], 'proposed': [2899, 5187], 'upper': [2902, 2999, 3044, 3187, 3230, 3260, 3294, 3462, 5045], 'complexly': [2906, 3051, 3568], 'glycosylated,': [2907, 3569], 'lower': [2917, 2992, 3036, 3214, 3278, 3339, 3477, 4430], 'core-glycosylated,': [2921], 'precursor': [2922, 3282, 3583, 3679, 3702, 3733, 4214, 4433], 'order': [2929], 'accounting': [2934], 'dysfunctional': [2936], 'analyzed': [2940, 3177], '2.': [2951], 'whereas': [2962, 4146], 'type-transfected': [2969, 4139], 'all': [2971], 'HERG,': [2977, 3292, 3932, 4955], 'well': [2979, 4516], 'bands,': [2990], '135': [2995, 3040, 3496, 3682, 4221], 'kDa': [2996, 3041, 3220], 'broad': [3000], '155': [3003, 3693, 4246], 'kDa.': [3004, 3500, 3616, 3694, 4222, 4247], 'Y611H': [3029, 3059, 3596, 3620, 3864, 3970, 4086, 4097, 4405, 4457, 4641, 5552], 'band.': [3046, 3206, 3231, 4434], 'glycosylated': [3052], 'strongly': [3063], 'suggests': [3064, 3359, 3618, 4326], 'defect': [3067], 'maturation.': [3075, 4356], 'surface': [3079, 3273, 3317, 3370, 4337, 4930], 'intact': [3088, 3166], 'type,': [3094], 'exposed': [3099], 'digest': [3104], 'extracellular': [3106, 3240], 'domains': [3107], 'surface.': [3114, 4390, 5029], 'Proteinase': [3115], 'serine': [3119], 'cleaves': [3122], 'peptide': [3123], 'bonds': [3124], 'adjacent': [3125, 5299], 'carboxylic': [3128], 'group': [3129], 'aliphatic': [3131], 'aromatic': [3133], 'acids': [3135], '(24Ebeling': [3136], 'W.': [3137, 5221], 'Hennrich': [3138], 'Klockow': [3140], 'M.': [3141, 4040, 4988, 5336, 5499], 'Metz': [3142], 'Orth': [3144], 'H.D.': [3145], 'Lang': [3146], 'Biochem.': [3150, 4838], '1974;': [3151], '47:': [3152], '91-97Crossref': [3153], '(492)': [3156], 'Under': [3159], 'experimental': [3161], 'conditions,': [3162], 'remained': [3165], 'after': [3167], 'treatment.': [3170, 3252, 3346], '3,': [3185], 'sensitive': [3194, 3236, 3302, 3484, 3602, 4320, 4450], 'complete': [3202, 3850], 'disappearance': [3203, 3851], 'appearance': [3212, 3840], 'mass': [3216, 3494, 3507, 3612, 3822, 3844, 4219, 4243, 4432], '60–75': [3219], 'should': [3222], 'represent': [3223, 3523], 'degraded': [3224, 4659], 'terminus-containing': [3226], 'fragments': [3227], 'Thus,': [3232, 4637], 'digestion': [3238, 4923], 'proteases.': [3241], 'resistant': [3248, 3342, 3469], 'support': [3255], 'hypothesis': [3257], 'represents': [3262, 5078], 'located': [3270, 3284, 4445], 'inside': [3285], 'cell.': [3287], 'indicating': [3307, 4125], 'traffics': [3313], 'normally': [3314], 'membrane.': [3318, 3371, 4312, 4338], 'lack': [3320], 'probably': [3325], 'due': [3326], 'single': [3338, 3413, 4429], 'transported': [3366, 3635, 4308], '4,': [3374, 3460], 'further': [3381, 3560], 'biochemical': [3384], 'digests': [3392], 'high': [3393], 'mannose': [3394], 'oligosaccharides': [3395, 4264], 'during': [3399], 'core': [3400, 3625], 'newly': [3403, 4521], 'synthesized': [3404, 3676, 3808, 4207, 4522], '(ER),': [3410], 'leaving': [3411], 'GlcNAc': [3414], 'residue': [3415], 'attached': [3416], 'Once': [3420], 'reach': [3422], 'medial': [3424, 3638], 'Golgi,': [3425], 'complex': [3428, 3642, 4263, 4601], 'oligosaccharide': [3429], 'modification': [3430, 4271], 'become': [3432], 'H-resistant': [3434], '(25Dunphy': [3435], 'W.G.': [3436], 'Rothman': [3437], 'J.E.': [3438, 5233], '1985;': [3440, 4791], '42:': [3441], '13-21Abstract': [3442], '(281)': [3448], 'analyses': [3457], 'digestion.': [3473], '132': [3499, 3615], 'smaller': [3510, 3842], 'observed': [3513, 4343], 'followingN-glycosidase': [3514], 'F': [3515], 'may': [3522, 4272, 4644, 4957, 5057, 5177, 5659], 'deglycosylated': [3525], 'evidence': [3561, 3699, 4438], 'core-glycosylated': [3582, 4213], 'data': [3593, 3723, 4181, 5579], 'undergoes': [3624], 'ER': [3629, 4210, 4507, 4526, 4593], 'fails': [3632, 3866], 'be': [3634, 4775, 5024, 5059, 5189], 'Golgi': [3639, 4229, 4529, 4600], 'glycosylation.': [3643], 'biosynthesis': [3647, 4184], 'transport-deficient': [3653, 4014, 4872, 5548], 'proteins,': [3656], 'pulse-chase': [3659, 3722, 4470], 'metabolic': [3662], 'labeling.': [3663], '5,': [3668], 'initially': [3675, 3807, 4206], 'kDa,': [3683], 'which': [3684, 4119, 4711, 4956], 'gradually': [3686], 'converted': [3687, 3817, 4461], 'larger': [3690, 3820], 'direct': [3698], 'product': [3704], 'relationship': [3705], '135-': [3708], 'experiments.': [3720, 4471, 4513], 'rate': [3728], 'conversion': [3730], 'relatively': [3740], 'slow': [3741], 'other': [3745, 4269, 4827, 4874, 5325], '(26Cheng': [3753, 4739], 'S.H.': [3754, 4740], 'Gregory': [3755, 4741], 'R.J.': [3756, 4742], 'Marshall': [3757, 4743], 'Paul': [3759, 4745], 'Souza': [3761, 4747], 'White': [3763, 4749], "O'Riordan": [3765, 4751], 'C.R.': [3766, 4752], 'Smith': [3767, 4753], '1990;': [3770, 4756], '63:': [3771, 4757], '827-834Abstract': [3772, 4758], '(1423)': [3778, 4764], '27Schulteis': [3781], 'John': [3783], 'S.A.': [3784, 5353], 'Huang': [3785], 'Tang': [3787], 'C.Y.': [3788], 'Papazian': [3789, 5356], 'D.M.': [3790, 5357], 'Biochemistry.': [3791], '34:': [3793], '1725-1733Crossref': [3794], '(29)': [3797], 'form;': [3812], 'however,': [3813], 'chase': [3825], 'up': [3827], 'Rather,': [3831, 4391], 'underwent': [3835], 'progressive': [3836], 'degradation': [3837, 4596], 'nearly': [3849], 'immature': [3879], 'degraded.': [3887, 4403], 'subcellular': [3891], 'localization': [3892], 'immunostaining': [3905], 'permeabilized': [3906], '6,': [3915], 'staining.': [3925], 'pattern': [3936, 3978, 3991], 'visible': [3938], 'throughout': [3939, 4940], 'processes,': [3944], 'showing': [3945, 4915], 'widespread': [3947], 'distribution': [3948, 3990, 4479], 'patterns': [3954, 4185, 4939], 'display': [3974], 'restricted': [3982, 3988, 4106, 4151, 4477], 'perinuclear': [3985, 4110], 'region.': [3986], 'consistent': [3993], 'intracellularly.': [4010, 4446], 'whether': [4013], 'trapped': [4019], 'ER,': [4022, 4398], 'ER-resident': [4033], 'chaperone': [4034], '(28Haas': [4037], 'I.G.': [4038], 'Walb': [4039], '1983;': [4042], '306:': [4043], '387-389Crossref': [4044], '(593)': [4047], '29Huovila': [4050], 'A.P.J.': [4051], 'Eder': [4052], 'Fuller': [4054], 'S.D.': [4055], 'Biol.': [4058, 4544, 4560, 4627], '1992;': [4059], '118:': [4060], '1305-1320Crossref': [4061], '(228)': [4064], '30Riezman': [4067], '278:': [4071], '1728-1729Crossref': [4072], '(18)': [4075], 'Fig.7': [4078], '(A–D)': [4088], '(E–H).': [4094], 'mutant,': [4098], 'andred': [4102], 'immunoreactivities': [4104], 'distribution.': [4111], 'confirmed': [4114], 'superimposed': [4117], 'image,': [4118], 'uniform': [4122], 'yellow': [4123], 'color,': [4124], 'colocalized.': [4133], 'cell,': [4140], 'widely': [4144], 'distributed,': [4145], 'localization.': [4153], 'retention': [4168, 4498, 4722], 'ER.': [4176, 4493, 4581, 4662], 'human,': [4188, 4865], 'heterologous': [4196], 'system.': [4199], 'apparatus,': [4230], 'becomes': [4233], 'noted': [4250], 'previously,': [4251], 'much': [4252], 'increased': [4255], 'size': [4257], 'N-linked': [4266], 'glycosylation,': [4267], 'although': [4268], 'post-translational': [4270], 'occur': [4273], 'plasma': [4311, 4737, 5017], 'fact': [4314], 'externally': [4322, 4452], 'applied': [4323, 4453], 'serves': [4347], 'useful': [4350], 'marker': [4351], 'assess': [4353], 'An': [4357], 'finding': [4359], 'disease-causing': [4368], 'lead': [4376], 'transport': [4386, 5056, 5596], 'examples': [4410], 'defect.': [4413], 'most': [4417, 4699], 'easily': [4418], 'analysis,': [4423], 'Several': [4435], 'They': [4447], 'form,': [4465], 'immunolocalization': [4473, 4933], 'confirm': [4475, 4927], 'mechanism': [4495, 4536, 4570, 4684, 4862, 5080], 'export': [4519], 'regulated': [4531], '“quality': [4534], 'control”': [4535], '(31Hurtley': [4537], 'S.M.': [4538], 'Helenius': [4539, 4555, 4624], 'Annu.': [4541], 'Rev.': [4542], '1989;': [4545], '5:': [4546], '277-307Crossref': [4547], '(778)': [4550], '32Hammond': [4553], 'Curr.': [4557], 'Opin.': [4558], '7:': [4562], '523-529Crossref': [4563], '(587)': [4566], 'ensures': [4571], 'properly': [4574], 'folded': [4575], 'assembled': [4577, 4586], 'leave': [4579], 'Misfolded,': [4582], 'unassembled,': [4583], 'incompletely': [4585], 'subunit': [4587], 'reaching': [4598], '(33Kopito': [4602], 'R.R.': [4603], '88:': [4606], '427-430Abstract': [4607], '(482)': [4615], '34Zhang': [4618], 'J-X.': [4619], 'Braakman': [4620], 'Matlack': [4622], 'K.E.S.': [4623], '8:': [4630], '1943-1954Crossref': [4631], '(171)': [4634], 'structural': [4646], 'abnormalities': [4647], 'misfolding': [4650], 'improper': [4652], 'assembly,': [4653], 'Whether': [4663, 5546], 'capable': [4668], 'forming': [4670], 'unknown.': [4674], 'Defective': [4675], 'diseases.': [4689], 'cystic': [4691, 4715], 'fibrosis': [4692, 4716], 'transmembrane': [4693], 'conductance': [4694], 'regulator': [4695], 'chloride': [4696], 'common': [4700], 'deletion': [4704], 'phenylalanine': [4706], 'position': [4708], '508': [4709], '(ΔF508),': [4710], '70%': [4713], 'cases.': [4717], 'leads': [4720], 'within': [4727], 'trafficking': [4734], 'Protein': [4767], 'low': [4779], 'lipoprotein': [4781], 'receptor': [4782], 'familial': [4784], 'hypercholesterolemia': [4785], '(35Brown': [4786], 'M.S.': [4787], 'Goldstein': [4788], '232:': [4792], '34-47Crossref': [4793], '(4362)': [4795], 'Na+/glucose': [4800], 'symporter': [4801], 'glucose-galactose': [4803], 'malabsorption': [4804], '(36Martin': [4805], 'M.G.': [4806], 'Turk': [4807], 'Lostao': [4809], 'M.P.': [4810], 'Kerner': [4811], 'Wright': [4813], 'E.M.': [4814], 'Nat.': [4815], '12:': [4818], '216-220Crossref': [4819], '(233)': [4821], 'several': [4826], '(37Thomas': [4831], 'Qu': [4833], 'B.H.': [4834], 'Pedersen': [4835], 'P.L.': [4836], 'Trends': [4837], '20:': [4841], '456-459Abstract': [4842], '(484)': [4848], 'first': [4858], 'findings.': [4886, 5684], 'I593R': [4888, 5008, 5039, 5520], 'yet': [4904], 'fail': [4907], 'sensitivity': [4916], 'location.': [4931], 'processes.': [4945], 'close': [4949], 'region': [4953, 5255, 5297, 5316], 'permeation;': [4965], 'hence,': [4966], 'conclude': [4968], 'cannot': [4972], 'open': [4973], 'conduct': [4975], 'ions': [4976], 'normally.': [4977], 'brief': [4980], 'report,': [4981, 5492], 'Nie': [4982, 5493], 'et': [4983, 5494], 'al.': [4984, 5495], '(38Nie': [4985, 5496], 'Palmer': [4989, 5500], 'Wang': [4991, 5224, 5502], 'Benson': [4993, 5504], 'Bennett': [4995, 5506], 'P.B.': [4996, 5507], '74': [5000, 5511], 'A213Google': [5002, 5513], 'suggested': [5005], 'able': [5012, 5523], 'insert': [5014], 'membrane,': [5018], 'since': [5019], 'epitope-tagged': [5020], 'can': [5023, 5555], 'interesting': [5033], 'weakly': [5043], 'stained': [5044], 'could': [5051, 5067], 'completely': [5060], 'defects.': [5074], 'another': [5079, 5249], 'dysfunction.': [5083], 'generates': [5086], 'activate': [5095], '(activation': [5100], 'V½': [5101], '27.3': [5105], 'mV).': [5106], 'maximum': [5108], 'current,': [5118, 5477], 'peak': [5120], 'plot': [5123], 'mutation,': [5152], 'there': [5154], 'reduction': [5157], 'decrease': [5170], 'account': [5178], 'QT-prolonging': [5181], 'phenotype.': [5182], 'S2-S3': [5192, 5300], 'S2': [5217, 5254, 5296, 5315], 'intramembrane': [5218], '(39Shi': [5220], 'Wymore': [5222], 'H.S.': [5225], 'Pan': [5226], 'Cohen': [5228], 'I.S.': [5229], 'Mckinnon': [5230], 'Dixon': [5232], 'Neurosci.': [5235], '17:': [5237], '9423-9432Crossref': [5238], 'putative': [5244], 'structure.': [5247], 'Interestingly,': [5248], '(N470D)': [5256], 'contribute': [5302], 'dependence': [5306], 'activation.': [5310], '(40Planells-Cases': [5329], 'Ferrer-Montiel': [5331], 'A.V.': [5332], 'Patten': [5333], 'C.D.': [5334], 'Montal': [5335], '92:': [5345], '9422-9426Crossref': [5346], '(92)': [5349], '41Seoh': [5352], 'Sigg': [5354], 'Bezanilla': [5358], 'F.': [5359], 'Neuron.': [5360], '16:': [5362], '1159-1167Abstract': [5363], '(580)': [5371], 'autosomal': [5377], 'dominant': [5378, 5430, 5472, 5565], 'inherited': [5379], 'disease': [5380], 'genes': [5386], 'patients.': [5389, 5652], 'expressing': [5396], 'wild-type': [5400], 'homomultimeric': [5404], 'Since': [5406], 'thought': [5410, 5426], 'tetrameric': [5413], 'co-expression': [5416], 'investigators': [5460], 'oocytes': [5465], 'suggesting': [5478], 'co-assembly': [5479], 'preliminary': [5491], 'co-assemble': [5525, 5556], 'such': [5550], 'presently': [5573], 'under': [5574], 'investigation.': [5575], 'summary,': [5577], 'identify': [5580], 'types': [5582], 'LQT-2:': [5589], '1)': [5590], 'ER;': [5604], '2)': [5605], 'function;': [5625], '3)': [5627], 'severities': [5663], 'LQT': [5665], 'clinical': [5666, 5670], 'phenotypes.': [5667], 'detailed': [5669], 'needed': [5673], 'permit': [5675], 'correlation': [5676], 'phenotypes': [5680], 'thank': [5686], 'Drs.': [5687], 'Gail': [5688], 'Robertson,': [5690], 'James': [5691], 'Bangs,': [5693], 'Shetuan': [5694], 'Zhang,': [5695], 'Jonathan': [5696], 'Makielski,': [5698], 'Kamp': [5702], 'helpful': [5704], 'advice': [5705], 'discussion.': [5707]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1963890550', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 17}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 16}, {'year': 2012, 'cited_by_count': 18}], 'updated_date': '2025-01-20T00:34:13.093609', 'created_date': '2016-06-24'}