Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2180517827', 'doi': 'https://doi.org/10.1152/ajpheart.2000.279.4.h1748', 'title': 'Novel characteristics of a misprocessed mutant HERG channel linked to hereditary long QT syndrome', 'display_name': 'Novel characteristics of a misprocessed mutant HERG channel linked to hereditary long QT syndrome', 'publication_year': 2000, 'publication_date': '2000-10-01', 'ids': {'openalex': 'https://openalex.org/W2180517827', 'doi': 'https://doi.org/10.1152/ajpheart.2000.279.4.h1748', 'mag': '2180517827', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11009462'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpheart.2000.279.4.h1748', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S87338489', 'display_name': 'AJP Heart and Circulatory Physiology', 'issn_l': '0363-6135', 'issn': ['0363-6135', '1522-1539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'http://ajpheart.physiology.org/content/ajpheart/279/4/H1748.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030990489', 'display_name': 'Eckhard Ficker', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Eckhard Ficker', 'raw_affiliation_strings': ['Rammelkamp Center for Education and Research,'], 'affiliations': [{'raw_affiliation_string': 'Rammelkamp Center for Education and Research,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034122208', 'display_name': 'Dierk Thomas', 'orcid': 'https://orcid.org/0000-0002-5687-7843'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Dierk Thomas', 'raw_affiliation_strings': ['Rammelkamp Center for Education and Research,'], 'affiliations': [{'raw_affiliation_string': 'Rammelkamp Center for Education and Research,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103565688', 'display_name': 'Prakash C. Viswanathan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Prakash C. Viswanathan', 'raw_affiliation_strings': ['Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio 44109; and'], 'affiliations': [{'raw_affiliation_string': 'Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio 44109; and', 'institution_ids': ['https://openalex.org/I58956616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057585429', 'display_name': 'Adrienne T. Dennis', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Adrienne T. Dennis', 'raw_affiliation_strings': ['Rammelkamp Center for Education and Research,'], 'affiliations': [{'raw_affiliation_string': 'Rammelkamp Center for Education and Research,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008966758', 'display_name': 'Silvia G. Priori', 'orcid': 'https://orcid.org/0000-0001-6877-0288'}, 'institutions': [{'id': 'https://openalex.org/I4210105320', 'display_name': 'Fondazione Salvatore Maugeri', 'ror': 'https://ror.org/01e8tvg28', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210105320', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Silvia G. Priori', 'raw_affiliation_strings': ['Molecular Cardiology Laboratories, Fondazione Salvatore Maugeri and'], 'affiliations': [{'raw_affiliation_string': 'Molecular Cardiology Laboratories, Fondazione Salvatore Maugeri and', 'institution_ids': ['https://openalex.org/I4210105320']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021196395', 'display_name': 'Carlo Napolitano', 'orcid': 'https://orcid.org/0000-0002-7643-4628'}, 'institutions': [{'id': 'https://openalex.org/I4210105320', 'display_name': 'Fondazione Salvatore Maugeri', 'ror': 'https://ror.org/01e8tvg28', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210105320', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Carlo Napolitano', 'raw_affiliation_strings': ['Molecular Cardiology Laboratories, Fondazione Salvatore Maugeri and'], 'affiliations': [{'raw_affiliation_string': 'Molecular Cardiology Laboratories, Fondazione Salvatore Maugeri and', 'institution_ids': ['https://openalex.org/I4210105320']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010776107', 'display_name': 'Mirella Memmi', 'orcid': 'https://orcid.org/0000-0003-4006-5661'}, 'institutions': [{'id': 'https://openalex.org/I4210105320', 'display_name': 'Fondazione Salvatore Maugeri', 'ror': 'https://ror.org/01e8tvg28', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210105320', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Mirella Memmi', 'raw_affiliation_strings': ['Molecular Cardiology Laboratories, Fondazione Salvatore Maugeri and'], 'affiliations': [{'raw_affiliation_string': 'Molecular Cardiology Laboratories, Fondazione Salvatore Maugeri and', 'institution_ids': ['https://openalex.org/I4210105320']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054850346', 'display_name': 'Barbara A. Wible', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Barbara A. Wible', 'raw_affiliation_strings': ['Biochemistry and'], 'affiliations': [{'raw_affiliation_string': 'Biochemistry and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001410007', 'display_name': 'Elizabeth S. Kaufman', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Elizabeth S. Kaufman', 'raw_affiliation_strings': ['Heart and Vascular Research Center, and'], 'affiliations': [{'raw_affiliation_string': 'Heart and Vascular Research Center, and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034748018', 'display_name': 'Sudha K. Iyengar', 'orcid': 'https://orcid.org/0000-0001-7488-250X'}, 'institutions': [{'id': 'https://openalex.org/I1299218025', 'display_name': 'MetroHealth', 'ror': 'https://ror.org/0377srw41', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1299218025']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sudha Iyengar', 'raw_affiliation_strings': ['Department of Epidemiology and Biostatistics, MetroHealth Campus, Departments of'], 'affiliations': [{'raw_affiliation_string': 'Department of Epidemiology and Biostatistics, MetroHealth Campus, Departments of', 'institution_ids': ['https://openalex.org/I1299218025']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013224321', 'display_name': 'Peter J. Schwartz', 'orcid': 'https://orcid.org/0000-0003-0367-1048'}, 'institutions': [{'id': 'https://openalex.org/I25217355', 'display_name': 'University of Pavia', 'ror': 'https://ror.org/00s6t1f81', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I25217355']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Peter J. Schwartz', 'raw_affiliation_strings': ['Department of Cardiology, University of Pavia, Policlinico San Matteo, Istituto di Ricovero e Cura a Carattere Scientifico, 27100 Pavia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, University of Pavia, Policlinico San Matteo, Istituto di Ricovero e Cura a Carattere Scientifico, 27100 Pavia, Italy', 'institution_ids': ['https://openalex.org/I25217355']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034297723', 'display_name': 'Yoram Rudy', 'orcid': 'https://orcid.org/0000-0001-7561-4371'}, 'institutions': [{'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yoram Rudy', 'raw_affiliation_strings': ['Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio 44109; and'], 'affiliations': [{'raw_affiliation_string': 'Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio 44109; and', 'institution_ids': ['https://openalex.org/I58956616']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5086423794', 'display_name': 'Arthur Brown', 'orcid': 'https://orcid.org/0000-0002-8725-3195'}, 'institutions': [{'id': 'https://openalex.org/I4210150971', 'display_name': 'Institute of Molecular Biology and Biophysics', 'ror': 'https://ror.org/051f11n17', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I1313323035', 'https://openalex.org/I4210110862', 'https://openalex.org/I4210150971']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Arthur M. Brown', 'raw_affiliation_strings': ['Physiology and Biophysics,'], 'affiliations': [{'raw_affiliation_string': 'Physiology and Biophysics,', 'institution_ids': ['https://openalex.org/I4210150971']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.179, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 109, 'citation_normalized_percentile': {'value': 0.999905, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '279', 'issue': '4', 'first_page': 'H1748', 'last_page': 'H1756'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10217', 'display_name': 'Cardiac electrophysiology and arrhythmias', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10882', 'display_name': 'Cardiomyopathy and Myosin Studies', 'score': 0.9872, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/herg', 'display_name': 'hERG', 'score': 0.98977685}, {'id': 'https://openalex.org/keywords/short-qt-syndrome', 'display_name': 'Short QT syndrome', 'score': 0.6636325}, {'id': 'https://openalex.org/keywords/ventricular-action-potential', 'display_name': 'Ventricular action potential', 'score': 0.5458127}, {'id': 'https://openalex.org/keywords/sudden-death', 'display_name': 'Sudden Death', 'score': 0.535853}, {'id': 'https://openalex.org/keywords/cardiac-action-potential', 'display_name': 'Cardiac action potential', 'score': 0.48319542}], 'concepts': [{'id': 'https://openalex.org/C2779362680', 'wikidata': 'https://www.wikidata.org/wiki/Q905000', 'display_name': 'hERG', 'level': 3, 'score': 0.98977685}, {'id': 'https://openalex.org/C2779703243', 'wikidata': 'https://www.wikidata.org/wiki/Q653924', 'display_name': 'Long QT syndrome', 'level': 3, 'score': 0.82216877}, {'id': 'https://openalex.org/C118441451', 'wikidata': 'https://www.wikidata.org/wiki/Q12074763', 'display_name': 'QT interval', 'level': 2, 'score': 0.7517382}, {'id': 'https://openalex.org/C2779578097', 'wikidata': 'https://www.wikidata.org/wiki/Q1484058', 'display_name': 'Short QT syndrome', 'level': 4, 'score': 0.6636325}, {'id': 'https://openalex.org/C83743174', 'wikidata': 'https://www.wikidata.org/wiki/Q423778', 'display_name': 'Potassium channel', 'level': 2, 'score': 0.6151373}, {'id': 'https://openalex.org/C75563809', 'wikidata': 'https://www.wikidata.org/wiki/Q2656896', 'display_name': 'Missense mutation', 'level': 4, 'score': 0.6091836}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.60490024}, {'id': 'https://openalex.org/C146403970', 'wikidata': 'https://www.wikidata.org/wiki/Q205729', 'display_name': 'Repolarization', 'level': 3, 'score': 0.57456726}, {'id': 'https://openalex.org/C47423411', 'wikidata': 'https://www.wikidata.org/wiki/Q7920311', 'display_name': 'Ventricular action potential', 'level': 4, 'score': 0.5458127}, {'id': 'https://openalex.org/C2993353509', 'wikidata': 'https://www.wikidata.org/wiki/Q411867', 'display_name': 'Sudden death', 'level': 2, 'score': 0.535853}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.49571717}, {'id': 'https://openalex.org/C79743260', 'wikidata': 'https://www.wikidata.org/wiki/Q2882301', 'display_name': 'Cardiac action potential', 'level': 4, 'score': 0.48319542}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.44118837}, {'id': 'https://openalex.org/C2775935837', 'wikidata': 'https://www.wikidata.org/wiki/Q202837', 'display_name': 'Sudden cardiac death', 'level': 2, 'score': 0.42630062}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41233164}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3830865}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3513441}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34151453}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.33291692}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.32282385}, {'id': 'https://openalex.org/C185263204', 'wikidata': 'https://www.wikidata.org/wiki/Q1154774', 'display_name': 'Electrophysiology', 'level': 2, 'score': 0.23222122}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.15151352}], 'mesh': [{'descriptor_ui': 'D027682', 'descriptor_name': 'Cation Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008133', 'descriptor_name': 'Long QT Syndrome', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020125', 'descriptor_name': 'Mutation, Missense', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015221', 'descriptor_name': 'Potassium Channels', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D024642', 'descriptor_name': 'Potassium Channels, Voltage-Gated', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000200', 'descriptor_name': 'Action Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000200', 'descriptor_name': 'Action Potentials', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003198', 'descriptor_name': 'Computer Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072237', 'descriptor_name': 'ERG1 Potassium Channel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004553', 'descriptor_name': 'Electric Conductivity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051638', 'descriptor_name': 'Ether-A-Go-Go Potassium Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005990', 'descriptor_name': 'Glycerol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005990', 'descriptor_name': 'Glycerol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008133', 'descriptor_name': 'Long QT Syndrome', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D008133', 'descriptor_name': 'Long QT Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008955', 'descriptor_name': 'Models, Cardiovascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020125', 'descriptor_name': 'Mutation, Missense', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D020125', 'descriptor_name': 'Mutation, Missense', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009865', 'descriptor_name': 'Oocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018408', 'descriptor_name': 'Patch-Clamp Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015221', 'descriptor_name': 'Potassium Channels', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015221', 'descriptor_name': 'Potassium Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013696', 'descriptor_name': 'Temperature', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071230', 'descriptor_name': 'Transcriptional Regulator ERG', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014982', 'descriptor_name': 'Xenopus laevis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpheart.2000.279.4.h1748', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S87338489', 'display_name': 'AJP Heart and Circulatory Physiology', 'issn_l': '0363-6135', 'issn': ['0363-6135', '1522-1539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.970.1558', 'pdf_url': 'http://ajpheart.physiology.org/content/ajpheart/279/4/H1748.full.pdf', 'source': {'id': 'https://openalex.org/S4306400349', 'display_name': 'CiteSeer X (The Pennsylvania State University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I130769515', 'host_organization_name': 'Pennsylvania State University', 'host_organization_lineage': ['https://openalex.org/I130769515'], 'host_organization_lineage_names': ['Pennsylvania State University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11009462', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.970.1558', 'pdf_url': 'http://ajpheart.physiology.org/content/ajpheart/279/4/H1748.full.pdf', 'source': {'id': 'https://openalex.org/S4306400349', 'display_name': 'CiteSeer X (The Pennsylvania State University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I130769515', 'host_organization_name': 'Pennsylvania State University', 'host_organization_lineage': ['https://openalex.org/I130769515'], 'host_organization_lineage_names': ['Pennsylvania State University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.47, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1498681083', 'https://openalex.org/W1583128097', 'https://openalex.org/W1588246354', 'https://openalex.org/W1963890550', 'https://openalex.org/W1964565849', 'https://openalex.org/W1968098810', 'https://openalex.org/W1970377240', 'https://openalex.org/W1971993744', 'https://openalex.org/W1981098216', 'https://openalex.org/W1989746014', 'https://openalex.org/W1991696056', 'https://openalex.org/W2004964064', 'https://openalex.org/W2019973925', 'https://openalex.org/W2031630236', 'https://openalex.org/W2032258216', 'https://openalex.org/W2034934027', 'https://openalex.org/W2044326283', 'https://openalex.org/W2045626047', 'https://openalex.org/W2045689507', 'https://openalex.org/W2048796422', 'https://openalex.org/W2059217828', 'https://openalex.org/W2073727172', 'https://openalex.org/W2079234445', 'https://openalex.org/W2088143209', 'https://openalex.org/W2097042367', 'https://openalex.org/W2121217634', 'https://openalex.org/W2125391335', 'https://openalex.org/W2126688997', 'https://openalex.org/W2132561989', 'https://openalex.org/W2135820955', 'https://openalex.org/W2156048327', 'https://openalex.org/W2338941399', 'https://openalex.org/W2526704564', 'https://openalex.org/W2986121682'], 'related_works': ['https://openalex.org/W72878334', 'https://openalex.org/W2434468260', 'https://openalex.org/W2388475879', 'https://openalex.org/W2180517827', 'https://openalex.org/W2159561758', 'https://openalex.org/W2125553912', 'https://openalex.org/W2107628842', 'https://openalex.org/W2040918531', 'https://openalex.org/W2010980296', 'https://openalex.org/W1997071795'], 'abstract_inverted_index': {'Hereditary': [0], 'long': [1, 117], 'QT': [2, 13, 108, 118], 'syndrome': [3], '(hLQTS)': [4], 'is': [5], 'a': [6, 52, 65, 104, 180, 190, 208], 'heterogeneous': [7], 'genetic': [8], 'disease': [9, 63], 'characterized': [10], 'by': [11, 125, 175], 'prolonged': [12], 'interval': [14, 109], 'in': [15, 25, 64, 77, 113, 196], 'the': [16, 26, 33, 42, 62, 72, 89, 99, 116, 129, 136, 166, 231], 'electrocardiogram,': [17], 'recurrent': [18], 'syncope,': [19], 'and': [20, 40, 158, 220], 'sudden': [21], 'cardiac': [22, 27, 100], 'death.': [23], 'Mutations': [24], 'potassium': [28], 'channel': [29], 'HERG': [30, 57, 184, 187, 214], '(KCNH2)': [31], 'are': [32], 'second': [34], 'most': [35], 'common': [36], 'form': [37], 'of': [38, 67, 98, 139, 183, 193, 200, 203, 234], 'hLQTS': [39], 'reduce': [41], 'delayed': [43], 'rectifier': [44], 'K(+)': [45], 'currents,': [46], 'thereby': [47], 'prolonging': [48], 'repolarization.': [49], 'We': [50, 146], 'studied': [51], 'novel': [53], 'COOH-terminal': [54], 'missense': [55], 'mutation,': [56], 'R752W,': [58], 'which': [59], 'segregated': [60], 'with': [61], 'family': [66], '101': [68], 'genotyped': [69], 'individuals.': [70], 'When': [71], 'mutant': [73, 130], 'cRNA': [74], 'was': [75, 123, 132, 143, 152], 'expressed': [76], 'Xenopus': [78], 'oocytes': [79], 'it': [80], 'produced': [81], 'enhanced': [82], 'rather': [83, 95], 'than': [84, 96], 'reduced': [85], 'currents.': [86], 'Simulations': [87], 'using': [88], 'Luo-Rudy': [90], 'model': [91], 'predicted': [92], 'minimal': [93], 'shortening': [94], 'prolongation': [97], 'action': [101], 'potential.': [102], 'Consequently,': [103], 'normal': [105], 'or': [106, 178], 'shortened': [107], 'would': [110], 'be': [111, 173, 218, 228], 'expected': [112], 'contrast': [114], 'to': [115, 135, 165, 227, 230], 'observed': [119], 'clinically.': [120], 'This': [121], 'anomaly': [122], 'resolved': [124], 'our': [126], 'observation': [127], 'that': [128, 148, 159, 207, 221], 'protein': [131], 'not': [133, 172, 217], 'delivered': [134, 164], 'plasma': [137, 167], 'membrane': [138], 'mammalian': [140], 'cells': [141], 'but': [142], 'retained': [144], 'intracellularly.': [145], 'found': [147], 'this': [149], 'trafficking': [150, 170, 194, 215, 235], 'defect': [151], 'corrected': [153], 'at': [154], 'lower': [155], 'incubation': [156], 'temperatures': [157], 'functional': [160], 'channels': [161, 205], 'were': [162], 'now': [163], 'membrane.': [168], 'However,': [169], 'could': [171], 'restored': [174], 'chemical': [176], 'chaperones': [177], 'E-4031,': [179], 'specific': [181], 'blocker': [182], 'channels.': [185], 'Therefore,': [186], 'R752W': [188], 'represents': [189], 'new': [191], 'class': [192], 'mutants': [195], 'hLQTS.': [197], 'The': [198], 'occurrence': [199], 'different': [201, 222, 232], 'classes': [202, 233], 'misprocessed': [204], 'suggests': [206], 'unified': [209], 'therapeutic': [210], 'approach': [211], 'for': [212], 'altering': [213], 'will': [216, 225], 'possible': [219], 'treatment': [223], 'modalities': [224], 'have': [226], 'matched': [229], 'mutants.': [236]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2180517827', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-24T13:17:36.883951', 'created_date': '2016-06-24'}