Title: 444 PREVALENCE, RISK FACTORS AND OUTCOME OF FIBROSING CHOLESTATIC HEPATITIS IN VIRAL CIRRHOSIS LIVER TRANSPLANT RECIPIENTS AT A REFERENCE CENTER FROM 2001–2008
Abstract: Results: HCC was the primary indication in 266 (36.9%) transplants: 251 HCC known at listing and 15 found during the waiting time.In 264 HCC was associated with cirrhosis: HCV-related in 130 (49%), HBV in 54 (20.5%),HCV+HBV+HDV in 29 (11%), alcohol-related in 31 (11.7%) and cryptogenic in 17 (6.4%).At listing 52 (20.7%) patients were classified as T1, 174 (69.3%) as T2 and 25 (10%) as T3.Corresponding median unadjusted MELD scores were 13 (range 6-27), 11 (6-32) and 10 (6-24).At transplant 55 (20.7%) were classified as T1, 176 (66.2%) as T2 and 22 (8.3%) as T3.Corresponding unadjusted MELD scores were 12 (6-31), 11 (6-40) and 12 (6-22).Median HCC-adjusted MELD was 22 (6-40, T1), 22 (6-40, T2) and 22 (7-40, T3).Median waiting time before transplant was 4.5 months (0-40) in HCC-T1, 4 (0-55) in T2, 3 (0-32) in T3, and 20 months (1-71) in HCC found incidentally.Down-staging was performed in 17 (33%) HCC-T1, 74 (42%) HCC-T2 and 15 (60%) HCC.Age of donors grafted to patients with or without HCC was 57 (16-97) vs 54 (12-86) years; cold-ischemia time was 7.2 (2.6-16) and 7.6 (2.6-15); and donors deceased for trauma were 24.8% and 29.3%, respectively (n.s). Conclusion:Patients transplanted for HCC in Italy are receiving high priority regardless of HCC-stage and severity of underlying liver disease and are given grafts of average quality.Most receive down-staging procedures while waiting.These findings may be helpful at the national level to implement the current allocation policy.
Publication Year: 2009
Publication Date: 2009-04-01
Language: en
Type: article
Indexed In: ['crossref']
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