Title: INTRAHEPATIC CHOLESTASIS FOLLOWING LIVER TRANSPLANTATION
Abstract: Cholestasis, a term coined by physiologists to indicate decreased bile flow, is commonly used to refer to a group of histologic findings in the liver that includes portal tract and bile ductular inflammation, often accompanied by bile staining of hepatocytes and bile plugs. The term is also used to refer to liver dysfunction manifested by disproportionate increases in the serum bilirubin, serum alkaline phosphatase, and γ-glutamyl transpeptidase. This article reviews the common causes of intrahepatic cholestasis following orthotopic liver transplantation (OLT), which are listed below. The reader may wish to consult other recent reviews for additional discussion about the causes and management of extrahepatic cholestasis following OLT.14, 43, 47 Origin of intrahepatic cholestasis following liver transplantationInfections Cholangitis lentaCytomegalovirus hepatitis Infections Cholangitis lenta Cytomegalovirus hepatitis Drugs Immunosuppressive agents Antimicrobial agents Allograft rejection Humoral rejection Acute cellular rejection Chronic ductopenic rejection Fibrosing cholestatic hepatitis Hepatitis B Hepatitis C Recurrence of biliary tract disease Primary sclerosing cholangitis Primary biliary cirrhosis Intrahepatic strictures Hepatic artery thrombosis or stenosis Donor liver preservation injury ABO blood-type incompatibility
Publication Year: 1999
Publication Date: 1999-08-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 4
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