Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1954999733', 'doi': 'https://doi.org/10.1128/mcb.17.7.3977', 'title': 'Heterodimeric Interaction between Retinoid X Receptor α and Orphan Nuclear Receptor OR1 Reveals Dimerization-Induced Activation as a Novel Mechanism of Nuclear Receptor Activation', 'display_name': 'Heterodimeric Interaction between Retinoid X Receptor α and Orphan Nuclear Receptor OR1 Reveals Dimerization-Induced Activation as a Novel Mechanism of Nuclear Receptor Activation', 'publication_year': 1997, 'publication_date': '1997-07-01', 'ids': {'openalex': 'https://openalex.org/W1954999733', 'doi': 'https://doi.org/10.1128/mcb.17.7.3977', 'mag': '1954999733', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9199332', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/232250'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.17.7.3977', 'pdf_url': 'https://mcb.asm.org/content/mcb/17/7/3977.full.pdf', 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://mcb.asm.org/content/mcb/17/7/3977.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5017241012', 'display_name': 'Franziska F. Wiebel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Franziska F. Wiebel', 'raw_affiliation_strings': ['Department of Biosciences at Novum, Karolinska Institute, S-141 57 Huddinge, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Biosciences at Novum, Karolinska Institute, S-141 57 Huddinge, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085801141', 'display_name': 'Jan-Ακε Gustafsson', 'orcid': 'https://orcid.org/0000-0002-1472-1373'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Jan-Åke Gustafsson', 'raw_affiliation_strings': ['Department of Medical Nutrition, Karolinska Institute, F-60 Novum, S-141 86 Huddinge, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Nutrition, Karolinska Institute, F-60 Novum, S-141 86 Huddinge, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.03, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 54, 'citation_normalized_percentile': {'value': 0.728175, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '17', 'issue': '7', 'first_page': '3977', 'last_page': '3986'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13991', 'display_name': 'Nuclear Receptors and Signaling', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/retinoid-x-receptor', 'display_name': 'Retinoid X receptor', 'score': 0.8706571}, {'id': 'https://openalex.org/keywords/small-heterodimer-partner', 'display_name': 'Small heterodimer partner', 'score': 0.5993129}, {'id': 'https://openalex.org/keywords/thyroid-hormone-receptor', 'display_name': 'Thyroid hormone receptor', 'score': 0.5038263}], 'concepts': [{'id': 'https://openalex.org/C128821507', 'wikidata': 'https://www.wikidata.org/wiki/Q3454518', 'display_name': 'Retinoid X receptor', 'level': 5, 'score': 0.8706571}, {'id': 'https://openalex.org/C63932345', 'wikidata': 'https://www.wikidata.org/wiki/Q422500', 'display_name': 'Nuclear receptor', 'level': 4, 'score': 0.86491746}, {'id': 'https://openalex.org/C68484354', 'wikidata': 'https://www.wikidata.org/wiki/Q17516011', 'display_name': 'Retinoid X receptor alpha', 'level': 5, 'score': 0.7899673}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.65203327}, {'id': 'https://openalex.org/C183481951', 'wikidata': 'https://www.wikidata.org/wiki/Q15312971', 'display_name': 'Small heterodimer partner', 'level': 5, 'score': 0.5993129}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5757264}, {'id': 'https://openalex.org/C195598365', 'wikidata': 'https://www.wikidata.org/wiki/Q14914583', 'display_name': 'Nuclear receptor coactivator 1', 'level': 5, 'score': 0.54222894}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.5243124}, {'id': 'https://openalex.org/C758759', 'wikidata': 'https://www.wikidata.org/wiki/Q18031337', 'display_name': 'Retinoid X receptor beta', 'level': 5, 'score': 0.51228017}, {'id': 'https://openalex.org/C109115496', 'wikidata': 'https://www.wikidata.org/wiki/Q2539644', 'display_name': 'Thyroid hormone receptor', 'level': 3, 'score': 0.5038263}, {'id': 'https://openalex.org/C71931279', 'wikidata': 'https://www.wikidata.org/wiki/Q21163354', 'display_name': 'Nuclear receptor co-repressor 1', 'level': 5, 'score': 0.49918532}, {'id': 'https://openalex.org/C162253465', 'wikidata': 'https://www.wikidata.org/wiki/Q18031338', 'display_name': 'Retinoid X receptor gamma', 'level': 5, 'score': 0.47602776}, {'id': 'https://openalex.org/C120197328', 'wikidata': 'https://www.wikidata.org/wiki/Q2838685', 'display_name': 'Retinoic acid receptor', 'level': 4, 'score': 0.4444395}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.43269444}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.40067792}, {'id': 'https://openalex.org/C2781121885', 'wikidata': 'https://www.wikidata.org/wiki/Q425517', 'display_name': 'Retinoic acid', 'level': 3, 'score': 0.36500347}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06048417}], 'mesh': [{'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D018168', 'descriptor_name': 'Receptors, Retinoic Acid', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015533', 'descriptor_name': 'Transcriptional Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019556', 'descriptor_name': 'COS Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D019281', 'descriptor_name': 'Dimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018168', 'descriptor_name': 'Receptors, Retinoic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047488', 'descriptor_name': 'Retinoid X Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016415', 'descriptor_name': 'Sequence Alignment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.17.7.3977', 'pdf_url': 'https://mcb.asm.org/content/mcb/17/7/3977.full.pdf', 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC232250', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9199332', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.17.7.3977', 'pdf_url': 'https://mcb.asm.org/content/mcb/17/7/3977.full.pdf', 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 63, 'referenced_works': ['https://openalex.org/W1545280767', 'https://openalex.org/W1566912406', 'https://openalex.org/W1569540889', 'https://openalex.org/W1592769976', 'https://openalex.org/W1602722523', 'https://openalex.org/W1723187988', 'https://openalex.org/W1780126526', 'https://openalex.org/W1884402625', 'https://openalex.org/W1968370020', 'https://openalex.org/W1970316586', 'https://openalex.org/W1975070287', 'https://openalex.org/W1979761686', 'https://openalex.org/W1981939829', 'https://openalex.org/W1985865142', 'https://openalex.org/W1990613292', 'https://openalex.org/W1990939350', 'https://openalex.org/W1995754186', 'https://openalex.org/W1996168740', 'https://openalex.org/W2000077941', 'https://openalex.org/W2003877378', 'https://openalex.org/W2003928686', 'https://openalex.org/W2006602286', 'https://openalex.org/W2007822628', 'https://openalex.org/W2013378362', 'https://openalex.org/W2017719948', 'https://openalex.org/W2019535432', 'https://openalex.org/W2028483852', 'https://openalex.org/W2030207960', 'https://openalex.org/W2042901562', 'https://openalex.org/W2050145162', 'https://openalex.org/W2057050252', 'https://openalex.org/W2059207612', 'https://openalex.org/W2060868921', 'https://openalex.org/W2068113812', 'https://openalex.org/W2069532898', 'https://openalex.org/W2070136069', 'https://openalex.org/W2081070477', 'https://openalex.org/W2081732968', 'https://openalex.org/W2084893672', 'https://openalex.org/W2085124463', 'https://openalex.org/W2097724305', 'https://openalex.org/W2101336717', 'https://openalex.org/W2102877511', 'https://openalex.org/W2110500827', 'https://openalex.org/W2112632255', 'https://openalex.org/W2113624181', 'https://openalex.org/W2117825435', 'https://openalex.org/W2128825094', 'https://openalex.org/W2129289858', 'https://openalex.org/W2129390584', 'https://openalex.org/W2132933799', 'https://openalex.org/W2135007868', 'https://openalex.org/W2141662437', 'https://openalex.org/W2143241514', 'https://openalex.org/W2146383800', 'https://openalex.org/W2147579515', 'https://openalex.org/W2157063922', 'https://openalex.org/W2160402926', 'https://openalex.org/W2172256092', 'https://openalex.org/W2406539631', 'https://openalex.org/W2868496', 'https://openalex.org/W4229958257', 'https://openalex.org/W59002756'], 'related_works': ['https://openalex.org/W4256318850', 'https://openalex.org/W4250112211', 'https://openalex.org/W2166939597', 'https://openalex.org/W2158268923', 'https://openalex.org/W2156831079', 'https://openalex.org/W2113624181', 'https://openalex.org/W2074335699', 'https://openalex.org/W2039074443', 'https://openalex.org/W2029725115', 'https://openalex.org/W2021082813'], 'abstract_inverted_index': {'OR1': [0, 29, 77, 130, 183], 'is': [1, 139], 'a': [2, 24, 134, 159, 186], 'member': [3], 'of': [4, 54, 63, 73, 87, 99, 105, 126, 145, 162, 167, 182], 'the': [5, 32, 50, 55, 61, 71, 85, 88, 95, 100, 106, 110, 124, 127, 143], 'steroid/thyroid': [6], 'hormone': [7], 'nuclear': [8, 33, 107, 174], 'receptor': [9, 34, 37, 168], 'superfamily': [10], 'which': [11, 64], 'has': [12, 41], 'been': [13, 42], 'described': [14, 43, 172], 'to': [15, 19, 44], 'mediate': [16], 'transcriptional': [17, 46, 82], 'responses': [18], 'retinoids': [20], 'and': [21, 52, 76, 84, 97, 129, 165], 'oxysterols.': [22], 'On': [23], 'DR4': [25], 'response': [26], 'element,': [27], 'an': [28], 'heterodimer': [30], 'with': [31, 150, 192], 'retinoid': [35], 'X': [36], 'alpha': [38, 75], '(RXR': [39], 'alpha)': [40], 'convey': [45], 'activation': [47, 91, 136, 157, 169, 181], 'in': [48, 94], 'both': [49], 'absence': [51, 96], 'presence': [53, 98], 'RXR': [56, 74, 101, 128, 151], 'ligand': [57], '9-cis': [58], 'retinoic': [59], 'acid,': [60], 'mechanisms': [62], 'have': [65], 'remained': [66], 'unclear.': [67], 'Here,': [68], 'we': [69, 177], 'dissect': [70], 'effects': [72], 'ligand-binding': [78, 131], 'domain': [79, 114], 'interaction': [80, 125, 149, 164], 'on': [81, 142], 'regulation': [83], 'role': [86], 'respective': [89], 'carboxy-terminal': [90], 'domains': [92, 132], '(AF-2s)': [93], 'ligand,': [102], 'employing': [103], 'chimeras': [104], 'receptors': [108], 'containing': [109], 'heterologous': [111], 'GAL4': [112], 'DNA-binding': [113], 'as': [115, 117, 158], 'well': [116], 'natural': [118], 'receptors.': [119, 175], 'The': [120], 'results': [121], 'show': [122], 'that': [123, 138, 148, 180], 'unleashes': [133], 'transcription': [135], 'potential': [137], 'mainly': [140], 'dependent': [141], 'AF-2': [144], 'OR1,': [146], 'indicating': [147], 'activates': [152], 'OR1.': [153], 'This': [154], 'defines': [155], 'dimerization-induced': [156], 'novel': [160], 'function': [161], 'heterodimeric': [163], 'mechanism': [166], 'not': [170], 'previously': [171], 'for': [173], 'Moreover,': [176], 'present': [178], 'evidence': [179], 'occurs': [184], 'by': [185], 'conformational': [187], 'change': [188], 'induced': [189], 'upon': [190], 'heterodimerization': [191], 'RXR.': [193]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1954999733', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T19:41:41.711853', 'created_date': '2016-06-24'}