Adalimumab induction and maintenance therapy for patients with ulcerative colitis previously treated with infliximab

Name: Work Video:
Duration: 3 min 30 s
Carlos Taxonera; Javier Torralba Estellés; I. Fernández-Blanco; Olga Merino; Ignacio Marín‐Jiménez; Manuel Barreiro–de Acosta; Cristina Morales Saro; Valle García-Sánchez; Elena Gento; Guillermo Bastida; Javier P. Gisbert; Isabel Vera; Pilar Martínez-Montiel; Sara García-Morán; M. C. Sánchez; Juan L. Mendoza
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1930, 1940, 1987, 1999, 2032, 2041, 2084, 2107, 2115, 2136, 2155, 2206, 2218, 2227, 2230, 2235, 2238, 2250, 2285, 2300, 2305, 2313, 2349, 2357, 2378, 2446, 2461, 2678, 2796, 2803, 2954, 2959, 3101, 3113, 3126, 3258, 3330, 3338, 3477, 3493, 3503, 3518, 3551, 3577, 3693, 3748, 3771, 3799, 3845, 3852, 3872, 3882, 3894, 3922, 3934, 3940, 3943, 3955, 3970, 4017, 4062, 4068, 4104, 4115, 4128, 4165, 4192, 4200, 4216, 4234, 4265, 4339, 4358, 4432, 4435, 4476, 4490, 4511, 4534, 4560, 4574, 4600, 4604, 4609, 4621, 4654, 4685, 4691, 4703, 4714, 4717, 4761, 4803, 4820, 4871, 4882, 4909, 4949, 5037, 5041, 5065, 5090, 5100, 5106, 5109, 5114, 5117, 5137, 5142, 5148, 5179, 5187, 5191, 5228, 5232, 5439, 5551, 5716, 5826, 5989, 6003], 'Wiley': [577, 5532, 5641, 5683, 5869, 5908, 6190], 'Online': [578, 5533, 5642, 5684, 5870, 5909, 6191], 'Library': [579], 'UseShareable': [584], 'LinkUse': [585], 'link': [587], 'a': [591, 606, 735, 836, 908, 922, 1038, 1072, 1104, 1267, 1360, 1476, 1658, 1667, 1677, 1685, 1712, 2181, 2187, 2322, 2675, 2707, 2715, 2737, 2823, 3192, 3212, 3585, 3651, 3673, 3676, 3822, 3867, 3897, 3998, 4041, 4161, 4284, 4391, 4398, 4454, 4506, 4548, 4554, 4789, 4862, 4886, 4891, 4897, 4924, 4977, 5002, 5031, 5076, 5083, 5103, 5346, 5631, 5712, 5791, 6180], 'article': [596], 'your': [598], 'friends': [599], 'colleagues.': [601], 'Learn': [602], 'more.Copy': [603], 'URL': [604], 'Share': [605], 'linkShare': [607], 'onFacebookTwitterLinked': [608], 'InRedditWechat': [609], 'Abstract': [610], 'Aliment': [611, 5525, 5634, 5862, 5901, 6183], 'Pharmacol': [612, 5526, 5635, 5863, 5902, 6184], 'Ther': [613, 5527, 5636, 5864, 5903, 6185], '2011;': [614], '33:': [615], '340–348': [616], 'Summary': [617, 1144], 'Background': [618], 'The': [619, 680, 1015, 1253, 1302, 1322, 1369, 1455, 1473, 1503, 1532, 1552, 1582, 1641, 1783, 1835, 1847, 1874, 1906, 1944, 2007, 2037, 2063, 2100, 2240, 2268, 2353, 2364, 2644, 2800, 2975, 3207, 3242, 3264, 3304, 3400, 3423, 3446, 3541, 3634, 3885, 3987, 4140, 4169, 4221, 4239, 4414, 4523, 4695, 4795, 4941, 5048, 5093], 'long-term': [620, 639, 1022, 1558, 3607, 3707, 4133, 4501, 4655, 4950, 6177], 'efficacy': [621, 971, 990, 1027, 2853, 3961, 3971, 4240, 4512, 4656, 5554, 5855], 'adalimumab': [623, 642, 660, 687, 973, 986, 1031, 1067, 1128, 1264, 1318, 1481, 1504, 1561, 1863, 1879, 1927, 2003, 2035, 2045, 2053, 2209, 2232, 2344, 2768, 2777, 2830, 2845, 3204, 3256, 3269, 3324, 3342, 3364, 3382, 3484, 3501, 3523, 3546, 3627, 3657, 3681, 3743, 3860, 3892, 3973, 4005, 4038, 4136, 4166, 4257, 4287, 4369, 4514, 4579, 4605, 4660, 4689, 4701, 4732, 4768, 4975, 4993, 5079, 5196, 5620, 5659, 5888, 6174], 'in': [624, 643, 713, 726, 776, 808, 820, 839, 856, 861, 867, 872, 887, 944, 974, 991, 1012, 1034, 1043, 1068, 1085, 1130, 1142, 1187, 1211, 1266, 1271, 1274, 1277, 1283, 1316, 1349, 1408, 1419, 1514, 1521, 1545, 1661, 1671, 1687, 1728, 1746, 1937, 2083, 2114, 2186, 2249, 2273, 2312, 2321, 2333, 2348, 2361, 2409, 2445, 2460, 2649, 2666, 2677, 2795, 2901, 3025, 3081, 3220, 3239, 3316, 3550, 3561, 3595, 3735, 3747, 3770, 3893, 3901, 3918, 3921, 3939, 3950, 3962, 3974, 4007, 4012, 4031, 4053, 4103, 4137, 4176, 4186, 4215, 4249, 4261, 4270, 4384, 4411, 4419, 4449, 4475, 4494, 4515, 4537, 4552, 4568, 4573, 4620, 4628, 4661, 4792, 4849, 4856, 4865, 4927, 4948, 4958, 4981, 4994, 5036, 5089, 5147, 5200, 5208, 5227, 5377, 5434, 5522, 5557, 5660, 5783, 5814, 5818, 5847, 5856, 5898, 5923, 5963, 6002, 6216], 'is': [629, 803, 850, 865, 880, 935, 1468, 3916, 3945, 3954, 3989, 3997, 4422, 4526, 4547, 4566, 4802, 4824, 4841, 5082], 'not': [630, 854, 930, 1207, 1249, 1446, 2059, 3946, 4003, 4441, 4456, 4473, 4527, 4572, 4642, 4648, 4728, 4825, 4836, 5132, 5167], 'well': [631, 769, 1010, 4047, 5198], 'known.': [632], 'Aim': [633], 'To': [634, 1184, 4353], 'evaluate': [635, 2247], 'short-': [637, 1020], 'outcomes': [640, 5035], 'infliximab.': [650, 667, 1052, 2637, 2643, 3912, 4336, 5469, 5675, 6122], 'Methods': [651], 'Patients': [652, 785, 892, 1601, 1720, 3667, 4206, 5217], 'active': [654, 1197, 1217, 2661, 4520, 5967], 'were': [657, 673, 697, 760, 1083, 1095, 1119, 1156, 1193, 1206, 1248, 1388, 1445, 1512, 1535, 1602, 1727, 1736, 1759, 1768, 1833, 2010, 2058, 2081, 2104, 2128, 2152, 2184, 2203, 2215, 2259, 2310, 2331, 2346, 2454, 2731, 2751, 2847, 3022, 3334, 3354, 3371, 3434, 3470, 3486, 3842, 4173, 4195, 4301, 4308, 4407, 4472, 4540, 4615, 4632, 4722, 4736, 4772, 5131], 'after': [661, 1076, 3084, 3859, 4179, 4500, 6035, 6057, 6084, 6114, 6143], 'failure': [662, 1077, 4855, 6025, 6056], 'other': [664, 1079, 2850, 2946, 3298, 3542, 4821, 4905], 'therapies': [665, 1080, 1825], 'including': [666, 1081, 1430, 1828, 1869, 1966, 2049, 3911, 4677, 4881, 4908, 4962, 5665], 'Short-term': [668, 2854, 2904], 'clinical': [669, 722, 755, 774, 787, 1023, 1569, 1606, 1648, 1723, 1729, 1741, 1748, 2026, 2167, 2182, 2855, 2861, 2878, 2891, 2905, 2911, 2921, 2925, 3073, 3120, 3138, 3155, 3170, 3453, 3462, 3615, 3699, 3756, 3779, 4119, 4147, 4170, 4412, 4451, 5149, 5206, 5220, 5430, 5725, 5932, 5961], 'response': [670, 705, 756, 775, 788, 871, 903, 961, 1004, 1365, 1607, 1649, 1654, 1724, 1742, 1965, 2027, 2091, 2168, 2862, 2879, 2912, 2922, 2926, 2957, 3074, 3087, 3121, 3139, 3156, 3171, 3215, 3219, 3454, 3463, 3590, 3616, 3646, 3700, 3716, 3757, 3780, 4006, 4120, 4163, 4171, 4182, 4285, 4345, 4350, 4595, 4630, 4899, 5026, 5057, 5069, 5077, 5159, 5207, 5221, 5246, 5431, 5591, 5628, 5671, 5933], 'remission': [672, 723, 943, 1708, 1730, 2093, 2892, 2914, 2928, 4417, 5120, 5433, 5962], 'assessed': [674, 698, 1603, 1623, 1891, 4510], 'at': [675, 706, 757, 763, 789, 1096, 1113, 1470, 1486, 1492, 1507, 1608, 1615, 1624, 1650, 1693, 1731, 1754, 1794, 1797, 1826, 1865, 1882, 1951, 1978, 2020, 2028, 2072, 2169, 2339, 2406, 2419, 2608, 2734, 2831, 2840, 2863, 2870, 2880, 2893, 2915, 2929, 2986, 2994, 3011, 3030, 3056, 3075, 3122, 3131, 3140, 3151, 3157, 3165, 3172, 3184, 3257, 3278, 3337, 3357, 3365, 3413, 3436, 3455, 3464, 3473, 3489, 3502, 3535, 3592, 3599, 3617, 3647, 3670, 3701, 3717, 3758, 3781, 4121, 4204, 4209, 4288, 4596, 4690, 4739, 4769, 5027, 5058, 5072, 5134, 5222, 5934], 'weeks': [676, 707, 1493, 1508, 1609, 1625, 1732, 1755, 1779, 1798, 1883, 1952, 2602, 2685, 2815, 2894, 2916, 2938, 2969, 3031, 3057, 3197, 3231, 3249, 3311, 3430, 3437, 3536, 4122, 4619, 4627], '4': [677, 708, 965, 1610, 1618, 1627, 1733, 1756, 1780, 1799, 2170, 2812, 2895, 2917, 2939, 2996, 3032, 3058, 3594, 4123, 5451], '12.': [679, 1652, 1782, 1801, 2919, 3124, 3142, 3159, 3457, 4598, 5060], 'proportion': [681, 690, 1784, 1857, 1893, 2907, 4942], 'who': [684, 693, 753, 953, 996, 1048, 1094, 1721, 1726, 1773, 1860, 1921, 2070, 2117, 3071, 3226, 3333, 3353, 3361, 3380, 3460, 3480, 3521, 3875, 4300, 4331, 4366, 4759, 4945, 5045, 5051, 5157, 5218, 5243], 'continued': [685, 743, 1861, 3254, 3362, 3499, 4687, 4766], 'on': [686, 744, 1201, 1526, 1549, 1567, 1862, 1878, 3167, 3255, 3268, 3323, 3335, 3363, 3383, 3500, 3597, 3626, 3668, 3742, 4132, 4207, 4325, 4489, 4688, 4737, 4763, 4767, 4876, 5550], 'remained': [694], 'colectomy': [695, 761, 793, 1776, 1909, 1948, 2964, 3228, 3397, 3404, 3427, 3450, 3471, 3487, 3534, 3549, 3568, 3727, 3766, 3877, 4806, 4823, 4938, 4947, 5003, 5053, 5071, 5087, 5226], 'free': [696, 762, 3472, 3488], 'over': [699, 794, 1562, 1851, 4112], 'long': [701, 764, 796, 1564, 1853, 1995, 2207, 2462, 3366, 3474, 3490, 3552, 4219, 4704, 4770, 5038, 5073, 5091, 5229, 5552], 'term.': [702, 765, 797, 2463, 3475, 3491, 4220, 5074, 5092, 5230], 'Results': [703, 2297], 'Clinical': [704, 1378, 1653, 1707, 2852, 5025, 6206], 'was': [711, 724, 768, 1280, 1297, 1343, 1356, 1371, 1414, 1584, 1622, 1644, 1655, 1709, 1792, 1804, 1822, 1845, 1855, 1880, 1899, 1910, 1934, 1949, 2095, 2162, 2224, 2244, 2271, 2282, 2370, 2382, 2653, 2980, 3078, 3211, 3247, 3271, 3309, 3405, 3428, 3584, 3704, 3720, 3864, 4075, 4100, 4428, 4440, 4581, 4706, 4711, 4951, 5030, 5197], 'achieved': [712, 754, 2877, 3072, 3137, 3461, 5219], '16': [714, 2480, 2566, 2650, 3429, 4323, 5875], '(53%)': [715], '18': [717, 1098, 2867, 5948], '(60%)': [718, 2869], 'patients,': [719, 732, 2532, 5112], 'respectively,': [720], 'obtained': [725, 1298], '(10%)': [728, 2885], '8': [730, 2577, 3177, 5572], '(27%)': [731, 4396], 'respectively.': [733, 1750, 2898, 3286, 3422, 3445, 3540, 4638], 'After': [734], 'mean': [736, 2137, 2365, 2379, 2485, 2517, 2524, 2738, 2976, 3026], '48': [737, 3196], 'weeks’': [738], 'follow-up,': [739, 4096], '15': [740, 2624, 2749, 3162, 3179, 3200, 5837], '(50%)': [742, 2750, 3202, 3532, 5022], 'adalimumab.': [745, 3393, 4071, 4094, 4352, 4754, 4913, 5047, 5258], 'Six': [746, 3394, 3789], '(20%)': [748], 'required': [749, 1194, 3291, 3878, 4081, 5023], 'colectomy.': [750, 1943, 2006, 4108, 5024], 'All': [751, 1059, 1117, 2079, 2336, 2401, 2638, 2657, 2820, 3351, 3377, 3458], 'week': [758, 790, 1651, 1843, 1992, 2029, 2808, 2832, 2841, 2864, 2871, 2947, 2966, 2995, 3012, 3076, 3123, 3141, 3152, 3158, 3173, 3299, 3358, 3456, 3465, 3494, 3593, 3618, 3648, 3702, 3718, 3759, 3782, 4152, 4289, 4389, 4478, 4597, 5028, 5059, 5223], 'Conclusions': [766], 'tolerated': [770, 5199], 'induced': [772, 3993, 5204], 'durable': [773, 5205], 'many': [777, 5209], 'otherwise': [780, 5212], 'medically': [781, 5213], 'refractory': [782, 2771, 3814, 3906, 4305, 4363, 5214, 6146], 'colitis.': [784, 1199, 2400, 2773, 4014, 4794, 4818, 5216, 5498, 5524, 5969, 6062, 6090, 6148], 'achieving': [786, 3698], 'avoided': [792, 3548, 4937, 5225], 'Introduction': [798], 'Tumour': [799, 3913], 'necrosis': [800, 3914], 'factor-α': [801], '(TNF)': [802], 'an': [804, 851, 1257, 1698, 2664, 2700, 2836, 3384, 3588, 3621, 3723, 4959, 5594, 5699, 5857], 'important': [805], 'cytokine': [806, 849, 3938], 'involved': [807], 'pathogenesis': [810, 841, 3941], 'inflammatory': [812, 5154, 5707, 6219], 'bowel': [813, 5155, 5708, 6220], 'disease.': [814, 3952, 5379, 5404, 5559, 5757, 6221], 'Although': [815], 'role': [817, 838, 3935], 'TNF': [819, 833, 3957], 'has': [823, 3982], 'been': [824, 978, 2415, 2791, 3983], 'subject': [825, 4235], 'debate,': [827], 'several': [828], 'studies': [829, 4052, 4471, 4919], 'shown': [831, 2175], 'that': [832, 846, 985, 1149, 3612, 3642, 3697, 3990, 4089, 4276, 4567, 4608, 4781, 4813, 4954, 4972, 5238], 'does': [834, 5166], 'play': [835], 'key': [837], 'disease,': [844, 1973, 2785, 3530, 5017], 'targeting': [847], 'effective': [852, 866, 936, 4787], 'only': [855, 3956, 4101, 4359, 4673], 'Crohn’s': [857, 947, 3951, 4009, 4034, 4231, 4273, 4298, 5378, 5403, 5437, 5464, 5558, 5756, 5784, 5822, 5850, 5892, 6150], 'disease1-4': [858], 'but': [859, 1448, 3547, 3933, 4571], 'also': [860, 1911, 1935, 4616], 'colitis.5': [863], 'Infliximab': [864, 3953, 5124, 5398, 5490], 'inducing': [868, 940], 'maintaining': [870, 942, 4247], 'moderate-to-severe': [875], 'colitis,6': [877], 'although': [878], 'it': [879, 4439, 4710, 5165], 'immunogenic': [881], 'repeated': [883], 'infusions': [884, 2594], 'can': [885, 4810], 'result': [886, 909], 'development': [889, 1168], 'antibodies.': [891], 'positive': [893], 'antibodies': [895, 3992, 5130], 'are': [898, 2359, 4023, 4357, 4613, 4641, 4670, 4835, 5099, 5249], 'likely': [900], 'lose': [902, 5158], 'or': [904, 914, 952, 962, 1005, 1174, 1178, 1222, 1228, 1237, 1244, 1460, 1541, 1666, 1697, 1705, 1718, 1725, 1743, 1781, 1809, 1975, 2017, 2120, 2142, 2157, 2427, 2674, 2686, 2760, 2923, 2927, 3216, 4011, 4080, 4098, 4246, 4404, 4699, 4727, 4747, 5189, 5248, 5589, 5626, 5672, 5752, 6121, 6175], 'become': [905], 'intolerant': [906, 2694, 5250], 'as': [907, 1009, 1011, 1124, 1362, 1657, 1711, 1806, 2135, 2442, 2778, 3524, 3722, 3947, 3949, 4046, 4048, 4149, 4151, 4303, 4370, 4424, 4719, 4788, 5294, 5331], 'acute': [911, 1173, 2701], 'infusion': [912, 1335, 1342, 1841, 1990, 2574, 2702, 2806], 'reactions': [913, 917, 2057], 'delayed': [915, 1175, 2708], 'hypersensitivity': [916, 1176, 2579, 2709], 'drug.7': [920], 'Adalimumab,': [921], 'fully': [923], 'human': [924, 5128, 6212], 'anti-TNF': [925, 951, 1138, 4228, 4516, 5000, 5175], 'monoclonal': [926], 'antibody,': [927, 4001], 'which': [928, 3996, 4553, 4846], 'do': [929], 'immunogenicity': [932, 5549], 'infliximab,': [934, 2553, 3995, 4544], 'safe': [938], 'disease': [948, 1110, 1969, 2014, 2380, 2514, 2662, 3391, 3944, 4010, 4035, 4232, 4274, 4299, 5156, 5465, 5785, 5851], 'naïve': [949, 4998], 'responded': [955, 998, 4334, 4558], 'then': [959, 1002, 1499], 'lost': [960, 1003, 1364, 5245, 5590, 5627], 'became': [963, 1006, 2693], 'intolerant.3,': [964], 'No': [966, 3715, 3966, 4072, 4084], 'controlled': [967, 1240, 3967, 4029], 'study': [968, 1017, 1254, 1583, 1867, 2077, 2314, 3853, 3887, 3968, 4269, 4421, 4509, 4524, 4622, 4646, 4676, 4801, 4961, 4991, 5098, 5233, 5657], 'assessing': [969, 3969, 4653], 'published': [979, 3984, 4675], 'date.': [981, 3986], 'Preliminary': [982], 'evidence': [983, 4145, 5140], 'suggests': [984], 'may': [987, 5253], 'limited': [989, 2096], 'intolerant,8,': [1007], '9': [1008, 2505, 5608], 'infliximab-naïve': [1013], 'patients.10': [1014], 'present': [1016, 3886], 'describes': [1018, 3888], 'experience': [1024, 3890, 5897], 'regarding': [1025], 'safety': [1029, 1203, 2038, 2085, 4242, 4658, 5853], 'when': [1032, 2277, 4467, 4611], 'administered': [1033, 1265, 1415, 1513, 1536], 'context': [1036, 1070, 3895], 'multicentre': [1039, 4267, 4508], 'compassionate': [1040, 1073, 1189, 1268, 1319, 2306, 3898, 4436], 'use': [1041, 1074, 1135, 1190, 1269, 1320, 1817, 1977, 2019, 2307, 2538, 3899, 4201, 4437, 4911], 'program': [1042, 1075, 1213, 1270, 1279, 2308], 'had': [1049, 1103, 1216, 1774, 2392, 2403, 2414, 2437, 2640, 2660, 2790, 3620, 3650, 3828, 4332, 5001], 'received': [1051, 1475, 2071, 2338, 2404, 2425, 2439, 2642, 2758, 2767, 2776, 2822, 3381, 3522, 4368], 'Materials': [1053], 'methods': [1055], 'Selection': [1056], 'consecutive': [1060], 'enrolled': [1084, 1186, 2311], 'study.': [1087, 5138, 5596, 5828, 5861], 'Eligible': [1088], 'included': [1090, 1324, 2040, 2067, 2082, 2185, 2332, 2347, 3083, 4178, 4329, 5010], 'men': [1091], 'women': [1093], 'least': [1097, 1114, 1616, 1694, 2073, 2340, 2420], 'years': [1099, 2372, 2384], 'age': [1101, 2366], 'diagnosis': [1105], 'duration': [1111, 1916, 2381, 2600, 4043], '6': [1115, 2684, 2798, 2971, 3965, 5511], 'months.': [1116, 2799], 'regulatory': [1125], 'approval': [1126], 'requires': [1133], 'previous': [1134, 1225, 1233, 2797, 3098], 'agent': [1139, 1821, 2423, 2755], 'already': [1140], 'accepted': [1141], 'Product': [1146], 'Characteristics': [1147, 2298], 'treatment': [1150, 1443, 1898, 2119, 4502, 4750, 4902, 5373, 5889, 6115], 'indication.': [1151], 'Reasons': [1152], 'discontinuation': [1155, 1332, 1444, 2560, 2648, 3210, 3246, 3800], 'considered': [1157, 1737, 1936, 3843, 4076, 4408], 'investigators': [1160, 1303, 1553, 3846, 4129], 'could': [1162, 1571, 4090], 'include': [1163, 4649, 4847], 'loss': [1164, 2654, 3085, 3217, 4180, 5669], 'response,': [1166, 2563], 'intolerance': [1170, 3099, 4190, 5588, 5625, 5673], '(due': [1171], 'reactions),': [1177], 'primary': [1179, 1642, 1848, 2721, 3115, 4279, 4541], 'nonresponse': [1180, 2722], 'drug.': [1183, 1368, 4193], 'be': [1185, 1484, 1572, 1745, 3848, 4078, 4091, 4158, 4259, 4382, 4410, 4786, 4811], 'program,': [1191], 'Based': [1200, 4324], 'recommendations,': [1204], 'eligible': [1208], 'inclusion': [1210, 1311, 2609], 'if': [1214], 'they': [1215], 'infection,': [1218], 'untreated': [1220], 'tuberculosis': [1221], 'concurrent': [1223], 'tuberculosis,': [1224], 'demyelinating': [1226], 'disorders': [1227], 'malignancies,': [1229], 'severe': [1230, 2450, 2782, 3388, 3527, 5014], 'heart': [1231], 'failure,': [1232], 'colectomy,': [1234], 'toxic': [1235], 'megacolon,': [1236], 'any': [1238, 1819, 5163], 'poorly': [1239], 'medical': [1241, 3909, 4906], 'condition.': [1242], 'Pregnant': [1243], 'breastfeeding': [1245], 'female': [1246, 4866], 'eligible.': [1250], 'Study': [1251, 5748], 'design': [1252], 'consisted': [1255], 'uncontrolled,': [1258], 'open-label': [1259, 4266, 4293, 4960, 4990, 5595, 5858], 'retrospective': [1260], 'case': [1261, 5164], 'series': [1262, 4030, 4499, 4539, 5009], 'centres': [1273, 1516], 'Inclusion': [1276], 'carried': [1281, 1769, 2111, 3002, 3019, 3065, 4429], 'out': [1282, 3091, 3104, 3144], 'accordance': [1284], 'regulations': [1287], 'Spanish': [1290, 1393], 'Ministry': [1291], 'Health.': [1293], 'Written': [1294], 'informed': [1295], 'consent': [1296], 'from': [1299, 1637, 2226, 2811, 2942, 3294, 4264, 4917, 5255, 5345, 5825], 'all': [1300, 2068, 4457, 4757], 'patients.': [1301, 3241], 'prepared': [1304], 'reports': [1305, 1323], 'justifying': [1306], 'request': [1308], 'each': [1313, 1350, 1424, 1471, 1490, 1546, 1866, 2274, 2334], 'individual': [1314], 'patient': [1315, 1361, 1550, 2713, 3804, 3811, 3818, 3827, 4386, 4877], 'program.': [1321], 'reason': [1326, 1980, 2022, 2645, 3208], 'discontinuation.': [1329, 4733], 'Before': [1330], 'due': [1333, 2780], 'reaction,': [1336, 2575, 2580, 2703, 2710], 'premedication': [1337], 'slowing': [1339], 'attempted': [1344], 'according': [1345, 1811, 4198], 'protocol': [1348], 'centre.': [1351, 1425, 1472, 2335], 'Escalation': [1352], 'dose': [1355, 1482, 2075, 2233, 2342, 2740, 2825, 2839, 2935, 3292, 4580, 4586, 5188], 'mandatory': [1357], 'before': [1358, 1901, 2965, 4592, 5177], 'considering': [1359, 5178], 'having': [1363], 'indication': [1370], 'initially': [1372], 'evaluated': [1373], 'Departments': [1376], 'different': [1382, 4601, 4617], 'hospital': [1383, 1421, 4082], 'centres,': [1384], 'requests': [1387], 'likewise': [1389], 'submitted': [1390], 'Medicines': [1394], 'Agency': [1395], 'evaluation': [1397, 4427], 'final': [1399, 1678], 'approval.': [1400], 'Following': [1401], 'approval,': [1402], 'medication': [1404], '(adalimumab': [1405], '40': [1406, 1957, 2943, 2949, 3284, 3295, 3301, 3418, 3514, 4589], 'mg': [1407, 2828, 2838, 2944, 2950, 3296, 3302, 3515, 4590], '0.8': [1409], 'mL;': [1410], 'Humira,': [1411], 'Abbott': [1412], 'Laboratories)': [1413], 'pharmacy': [1422, 1488], 'Administration': [1426], 'drug,': [1429], 'initial': [1432, 2090, 4344], 'dose,': [1434], 'need': [1436, 1907, 1941, 2033, 4804], 'intensification': [1438], 'timing': [1441], 'pre-established,': [1447], 'rather': [1449], 'left': [1450, 4712], 'investigators′': [1453], 'discretion.': [1454], 'decision': [1456, 4696], 'either': [1458, 4008, 5185], 'continue': [1459, 4698], 'interrupt': [1461, 4700], 'immunosuppressant': [1462, 3168, 3183, 4226], 'corticosteroid': [1465, 1897, 3375, 4776], 'tapering': [1466], 'schedule': [1467], 'determined': [1469, 1793], 'prescription': [1477], 'planned': [1480], 'dispensed': [1485], 'centre': [1491, 1593, 5860], '0,': [1494, 1626], '2': [1495, 1501, 1511, 2591, 3230, 4532, 5389], '4,': [1497, 1884, 1953, 2429, 2865, 3279, 3414], 'every': [1500, 1617, 2849, 2945, 3297], 'weeks.': [1502, 1619, 2173, 2882, 2931], 'doses': [1506, 1534, 2726, 2846, 2961, 5081], '0': [1509, 1638, 1704, 1717, 1844, 2809, 2833, 3153, 3359, 4405], 'specialised': [1518, 1543], 'personnel,': [1519], 'who,': [1520], 'turn,': [1522], 'instructed': [1523], 'self-administration': [1527], 'via': [1528], 'subcutaneous': [1530], 'route.': [1531], 'subsequent': [1533], 'themselves,': [1540], 'personnel': [1544], 'centre,': [1547], 'depending': [1548, 1566], 'preference.': [1551], 'based': [1554], 'their': [1555, 2197], 'decisions': [1556], 'about': [1557], 'continuation': [1559, 4134], 'term,': [1565, 1996, 2208, 5039], 'whether': [1568, 4726], 'benefit': [1570, 5254], 'expected': [1573], 'assuming': [1575], 'absence': [1577], 'relevant': [1579, 4797], 'side': [1580], 'effects.': [1581], 'approved': [1585], 'Ethics': [1588], 'Committee': [1589], 'leading': [1592, 2051, 4127], '(Hospital': [1594], 'Spain).': [1597], 'Outcomes': [1598], 'measurements': [1600, 5146], 'short-term': [1605, 1964, 3581, 4118, 4349, 5068], '12,': [1612, 1885, 1954, 2030, 2897, 3106, 3174, 3280, 3415, 4125, 4390], 'thereafter,': [1614], 'Disease': [1620], 'activity': [1621], 'using': [1630, 2106, 2154, 2217, 2261, 2284], 'partial': [1632, 1663, 1673, 1679, 1713, 2977, 3027, 4141, 4399], 'Mayo': [1633, 1664, 1674, 1680, 1714, 1752, 2522, 2978, 3028, 4142, 4400, 4491], 'score': [1634, 1665, 1675, 1681, 1702, 1715, 2979, 3029, 4143, 4401], '(scores': [1635], 'ranging': [1636], '9).': [1640], 'endpoint': [1643], 'defined': [1656, 1710, 1805], 'three-point': [1659], 'decrease': [1660, 1668, 2676], '≥50%': [1670], '≤2,': [1683], 'drop': [1686], 'rectal': [1689, 1700], 'bleeding': [1690, 1701], 'subscore': [1691], 'one': [1695, 2074, 2341, 2421, 2712, 3000, 3803, 3810, 4312, 4674], 'point': [1696, 2408], 'absolute': [1699], '1.': [1706, 1719, 2363, 2465], 'showed': [1722, 2720, 2860, 2890, 3119, 3154, 3451, 3611, 3672, 3696, 4117, 4275, 4283, 4348, 4920], 'show': [1739], 'sustained': [1740, 1747], 'remission,': [1749, 4321], 'Partial': [1751, 2521], 'scores': [1753], 'compared': [1760, 2153, 3175], 'baseline': [1763, 1795, 2354, 2987, 3166, 3600, 3671, 4210], 'score.': [1764], 'Last': [1765], 'observed': [1766, 4483], 'data': [1767, 3018, 3064, 4916], 'forward': [1770], 'undergone': [1775], 'prior': [1777, 4189, 5668], 'C-reactive': [1788, 2528, 3044, 3052], 'protein': [1789, 2529, 3045, 3053], '≥5': [1790, 2530, 3046, 3054], 'mg/L': [1791, 3055], 'Ulcerative': [1802, 5723], 'extensive,': [1807], 'left-sided': [1808, 2399], 'proctitis': [1810], 'Montreal': [1814, 5718], 'classification.11': [1815], 'Previous': [1816], 'immunosuppressive': [1820, 1831, 1976, 2018, 2422, 2627, 2754], 'recorded.': [1823, 1846, 2060], 'Concurrent': [1824], 'baseline,': [1827, 1979, 2021, 2735, 3039, 3132, 4740], 'corticosteroids': [1829, 1974, 2016, 2405, 2733, 3130, 3150, 3336, 3356, 4203, 4738, 4764], 'agents,': [1832], 'assessed.': [1834], 'interval': [1836, 1985, 2679, 2801], 'between': [1837, 1926, 1986, 2315, 2802, 2937, 3751, 3774], 'last': [1839, 1871, 1903, 1931, 1988, 2804, 3259, 3504, 4692], 'outcome': [1849, 4798, 5618, 6142], 'parameter': [1850], 'term': [1854, 3367, 3553, 4705, 4771, 5553], 'visit,': [1868, 3506], 'follow-up': [1872, 1904, 1932, 2101, 3194, 3260, 3505, 4461, 4693, 4831, 4979, 6178], 'visit.': [1873, 1905, 4694], 'probability': [1875, 1945, 3265, 3320, 3401, 3565, 3623, 3739, 3763], 'remaining': [1877, 3267, 3625], 'analysed': [1881, 1950, 1961, 1998, 2105, 2225], '20,': [1886, 1955, 3281, 3416], '30': [1887, 2474, 2556, 3282, 4535], '40.': [1889], 'We': [1890, 1960, 3575, 4154], 'whose': [1896], 'discontinued': [1900, 1922, 2118, 3203, 3346, 3392, 3545, 4748, 5046], 'recorded': [1912, 4063], 'during': [1913, 3325, 3349, 3569, 3744, 3767, 4751, 4807, 4939], 'entire': [1915], 'follow-up.': [1918, 3350, 4480, 4808, 4940], 'For': [1919], 'adalimumab,': [1923, 4782], 'period': [1925, 4980], 'withdrawal': [1928, 2004, 2210, 3658, 3682], 'visit': [1933, 3261], 'terms': [1938], 'avoiding': [1947, 3403, 3567, 3765], '30,': [1956, 3417], '60.': [1959, 6127], 'predictors': [1962, 2165], 'age,': [1967, 2012], 'gender,': [1968, 2013, 2477], 'duration,': [1970, 2015], 'extent': [1971], 'discontinuation,': [1983, 2025], '0.': [1993], 'At': [1994, 3038, 4388], 'we': [1997, 4328, 4482], 'predictive': [2000], 'factors': [2001, 3574, 3578], 'following': [2008], 'variables': [2009, 2103, 2151], 'included:': [2011], 'escalation.': [2036], 'analysis': [2039, 2062, 2088, 2178, 3640, 5894], 'ability': [2042], 'tolerate': [2044], 'adverse': [2047, 3237, 3792, 3795, 4018, 4064, 4073], 'events': [2048, 3238, 3796], 'those': [2050, 3096, 4026, 4187, 4447, 4469, 5666], 'withdrawal.': [2054, 3861], 'Injection': [2055], 'site': [2056], 'Statistical': [2061, 2087], 'intention-to-treat': [2064, 2350], '(ITT)': [2065, 2351], 'population': [2066, 2369, 4525, 4551], 'treatment.': [2078, 3376, 3816, 4777], 'analysis.': [2086, 2191, 2267], 'rates': [2094, 2214, 2254, 4172, 4631, 4640], 'descriptive': [2098], 'statistics.': [2099], 'quantitative': [2102], 'LOCF': [2108], '(last': [2109], 'observation': [2110], 'forward)': [2112, 3003], 'technique': [2113], 'suffered': [2121, 2699, 3805, 3833], 'events.': [2122, 3793], 'Paired': [2123], 'parametric': [2124], 'nonparametric': [2126], 'tests': [2127], 'used': [2129, 2245, 2607, 4418], 'compare': [2131], 'continuous': [2132], 'variables,': [2133], 'expressed': [2134], '±': [2138], 'standard': [2139], 'deviation': [2140], '(s.d.)': [2141, 2486, 2518, 2525, 2596, 2603, 2618], 'median': [2143, 3193, 3243, 3305, 3424], 'interquartile': [2145], 'range': [2146], '(IQR)': [2147], '(P25–P75),': [2148], 'whereas': [2149, 2748], 'categorical': [2150], 'chi-squared': [2156], 'Fisher': [2158], 'tests.': [2159], 'Logistic': [2160], 'regression': [2161, 2190, 2266, 3639], 'performed': [2163, 2283, 3435, 4474], 'Variables': [2174], 'univariate': [2177], 'exert': [2180], 'influence': [2183], 'multivariate': [2188], 'logistic': [2189], 'Adjusted': [2192, 2253], 'odds': [2193], 'ratios': [2194, 2255], '(adjORs)': [2195], '95%': [2198, 3661, 3685], 'confidence': [2199], 'intervals': [2200], '(95%': [2201], 'CI)': [2202], 'calculated.': [2204], 'In': [2205, 4109, 4291, 4680, 4931, 5162, 5194], 'colectomy-free': [2212, 3708], 'survival': [2213, 2251, 2265, 3609, 3638, 3694, 3709, 3749, 3772], 'estimated': [2216], 'Kaplan–Meier': [2219, 3327, 3571], 'method.': [2220, 3328, 3572], 'Time': [2221], 'event': [2223], 'date': [2228, 2236], 'first': [2231, 3341, 4561], 'event.': [2239], 'Breslow': [2241], 'exact': [2242, 3786], 'test': [2243, 2276], 'differences': [2248, 3024, 3746, 3769, 4197], 'curves.': [2252], '(hazard': [2256], 'ratios,': [2257], 'HR)': [2258], 'calculated': [2260], 'Cox': [2262, 3635], 'proportional': [2263, 3636], 'hazard': [2264, 3637], 'null': [2269], 'hypothesis': [2270, 3988], 'rejected': [2272], 'statistical': [2275, 2292], 'P': [2278, 3603, 3629, 3664, 3688, 3730], '<': [2279, 2998, 3015, 3630, 3711], '0.05.': [2280], 'Analysis': [2281], 'spss': [2286], '15.0': [2288], '(Chicago,': [2289], 'IL,': [2290], 'USA)': [2291], 'package': [2293], 'Microsoft': [2295], 'Windows.': [2296], 'Thirty': [2302], 'entered': [2304, 4320, 4760], 'September': [2316], '2006': [2317], 'March': [2319], '2009': [2320], 'total': [2323, 4392, 4814], 'centres.': [2326], 'One': [2327, 3817, 3826, 3862], 'six': [2329, 3447, 3873, 4105, 4319, 5049], 'population.': [2352], 'characteristics': [2355, 2467], 'summarised': [2360], 'Table': [2362, 2464], '40.5': [2371, 2487], '(range': [2373, 2385, 2744, 2982, 2990, 3007], '18–70;': [2374], 's.d.': [2375, 2387, 2746, 2984, 2992, 3009], '±14.5),': [2376], '6.7': [2383, 2519], '2–17;': [2386], '±3.7).': [2388], 'Twenty-one': [2389], '(70%)': [2391], 'extensive': [2393], 'colitis,': [2395, 2452, 3932], 'nine': [2397], '(30%)': [2398], 'some': [2407, 2753], 'time.': [2410], 'Twenty-six': [2411, 2765], '(86.7%)': [2413], '(25': [2424], 'azathioprine': [2426, 2759], 'mercaptopurine;': [2428, 2632, 2761], 'methotrexate;': [2430], '2,': [2432, 2763], 'mycophenolate': [2433, 2634], 'mofetil).': [2434], 'Seven': [2435, 2932, 4583], 'intravenous': [2440, 2783, 3389, 3528, 5015], 'ciclosporin': [2441, 2794], 'rescue': [2443, 4371], 'management': [2447, 4374, 5150], 'corticosteroid-refractory': [2449, 2784, 3390, 5016], 'subsequently': [2455, 2962], 'thiopurinic': [2458], 'agents': [2459, 4229], 'Baseline': [2466], 'Variable': [2470], 'Patients,': [2471], 'n': [2472, 2478, 2492, 2497, 2503, 2508, 2533, 2554, 2564, 2569, 2576, 2581, 2585, 2589], '(%)': [2473, 2479, 2493, 2498, 2504, 2509, 2534, 2543, 2548, 2555, 2565, 2570, 2590, 2612, 2623], '(100)': [2475, 2557], 'Male': [2476], '(53.3)': [2481, 2567], 'Age': [2482], '–': [2483, 2515, 2601, 2616, 4880, 4889, 5852], 'years,': [2484, 2516], '(±14.5)': [2488], 'Smoker': [2489], 'status': [2490], 'Nonsmoker,': [2491], '27': [2494], '(90.0)': [2495], 'Smoker,': [2496], '(10.0)': [2500], 'Extension': [2501], 'Left-sided,': [2502], '(30.0)': [2506], 'Extensive,': [2507], '21': [2510, 6048], '(70.0)': [2511], 'Duration': [2512], '(±3.7)': [2520], 'score,': [2523], '6.5': [2526, 2981], '(±1.5)': [2527], 'mg/L,': [2531], '25': [2535, 3040, 6160], '(83)': [2536], 'Prior': [2537], 'IMM': [2540, 2621], '(AZA/MP/MTX/MYC)': [2541], '–n': [2542, 2547, 2595, 2611, 2622], '26': [2544, 6196], '(86.7)': [2545], 'Ciclosporin': [2546], '7': [2549, 5538], '(23.3)': [2550], 'Reason': [2558], 'Loss': [2561], 'Intolerance,': [2568], '(40.0)': [2572], 'Acute': [2573], 'Delayed': [2578], 'Lupus-like': [2583], 'syndrome,': [2584], '1': [2586, 4403, 5359], 'Primary': [2587], 'nonresponder,': [2588], '(6.7)': [2592], 'IFX': [2593, 2599], '7.6': [2597], '(±4.8)': [2598], '41.3': [2604], '(±33.2)': [2605], 'Drugs': [2606], 'Steroids': [2610, 2615], '19': [2613, 3135, 3248, 3331, 5978], '(63.3)': [2614], 'mg/day': [2617, 2743], '34.2': [2619, 2742], '(±17.4)': [2620], '(50.0)': [2625], 'IMM,': [2626], 'agent;': [2628], 'AZA,': [2629], 'azathioprine;': [2630], 'MP,': [2631], 'MYC,': [2633], 'mofetil;': [2635], 'IFX,': [2636], '(53.3%)': [2652, 2859, 3181], 'response.': [2656, 2856, 3582], 'them': [2659, 2789, 3510, 5021], 'despite': [2663], 'increase': [2665], 'dosage': [2668], '10': [2670, 3133, 3310, 4058, 5647], 'mg/kg': [2671], '(eight': [2672, 2688], 'patients)': [2673], 'administration': [2682], 'fewer': [2687], 'patients).': [2689], 'Twelve': [2690], '(40%)': [2692], 'infliximab:': [2696, 5593, 5630, 6176], 'eight': [2697, 2887, 3485, 4394], 'three': [2704, 3017, 3063, 3508, 4317], 'experienced': [2706, 3791], 'developed': [2714, 3169, 3812, 3819, 4086], 'lupus-like': [2716], 'syndrome.': [2717], 'Two': [2718, 3794], '(6.7%).': [2727], 'Nineteen': [2728, 4734], '(63.3%)': [2730], 'receiving': [2732, 2752], 'prednisone': [2739], '10–60;': [2745], '±17.4),': [2747], '(13': [2756], 'methotrexate).': [2764], 'out-patient': [2770], 'Four': [2774], 'in-patients': [2779, 3525, 5012], 'none': [2787, 5063], 'ranged': [2810], '52': [2814], '(median': [2816], '6,': [2817, 3439], 'IQR': [2818], '4–11).': [2819], 'loading': [2824], '160': [2827], 'followed': [2834], '80': [2837], '2.': [2842], 'Subsequent': [2843], '40-mg': [2844], 'given': [2848], 'week.': [2851], 'Sixteen': [2857], '(Figure': [2873, 3205, 3262, 3398, 3632, 3713], '1).': [2874], 'Thirteen': [2875, 3048], 'both': [2881, 2930], 'Three': [2883, 2952], '(26.7%)': [2889], 'Figure': [2899, 3314, 3559, 3733], '1Open': [2900], 'figure': [2902, 3317, 3562, 3736], 'viewerPowerPoint': [2903, 3318, 3563, 3737], 'response:': [2906], 'Sustained': [2920], 'remission:': [2924], 'underwent': [2934, 2963, 3533, 3876, 4459, 4585], 'escalation': [2936, 3293, 3308, 3482, 3512, 4577, 4587], 'weekly.': [2951, 3303, 3516], 'without': [2956, 3149, 3182, 3755, 3778, 5121], '(at': [2968], '3,': [2970, 3438], '7,': [2973, 3440], 'respectively).': [2974, 3067, 3558], '4–9;': [2983], '±1.5)': [2985], 'vs.': [2988, 3005], '3.6': [2989], '0–9;': [2991, 3008], '±2.1)': [2993], '(P': [2997, 3014, 3035, 3108, 3186, 3710], '0.001;': [2999, 3016], 'datum': [3001], '3.03': [3006], '±2.4)': [3010], 'forward).': [3020], 'There': [3021, 3583, 4194], 'no': [3023, 3452, 3645, 4196, 4343, 4425, 4720], '=': [3036, 3109, 3187, 3369, 3468, 3604, 3665, 3689, 3731], '0.130).': [3037], '(83%)': [3042], 'presented': [3043, 3051, 4397], 'mg/L.': [3047], '(43%)': [3050], '(one': [3061], 'forward,': [3066], 'Proportion': [3068], 'broadly': [3079, 4174, 4633], 'similar': [3080, 4024, 4042, 4175, 4528, 4952, 4978], '(10': [3090], '16,': [3093], '62.5%)': [3094], 'drug': [3102, 4791], '(8': [3103, 4618], '66.6%)': [3107], '0.999).': [3110], 'Neither': [3111, 4337], 'two': [3114, 3240, 3531, 3543, 4050, 4060, 4292, 4340, 4495, 5019, 5926, 5935], 'nonresponders': [3116, 4280, 4542, 5820], 'Among': [3125, 3476, 3492], '(52.6%)': [3136], 'Eight': [3143], '11': [3146, 3478, 5689], '(72.7%)': [3148], 'Ten': [3160], '(66.6%)': [3164], 'entry': [3185, 5135], 'N.S.).': [3188], 'Long-term': [3189, 5617, 6055, 6141], 'outcomes.': [3190], 'During': [3191, 4095], '(IQR': [3198, 3250, 3312, 3431], '16–104),': [3199], '2).': [3206, 3263], 'lack': [3213, 5101], '13': [3221, 3344, 4238, 4678, 4982, 5770], '(including': [3223], 'five': [3224], 'needed': [3227, 3396, 3481, 3511, 4946, 5052, 5070], 'within': [3229], 'being': [3233, 4304], 'withdrawn)': [3234], 'serious': [3236, 4079, 4087], 'time': [3244, 3306, 3339, 3425, 4610], '12–32).': [3251], 'Fifteen': [3252], '96.7%,': [3272, 3406], '90%,': [3273, 3407, 3408], '71%,': [3274], '63%': [3275], '50%': [3277, 4113], 'weeks,': [3285, 3421, 3557], 'Eleven': [3287], 'overall': [3289], '(36.7%)': [3290], '8–23).': [3313], '2Open': [3315], 'Cumulative': [3319, 3564, 3738, 3762, 6024], 'continuing': [3322, 3741], 'follow-up:': [3326, 3570, 3745, 3768], 'Of': [3329, 3517], 'administration,': [3343], '(68%)': [3345], 'these': [3347, 4138, 4326, 4356, 4744, 5145], 'drugs': [3348], 'taking': [3355], '(n': [3368, 3467], '7)': [3370], 'able': [3372, 4773], 'stop': [3374, 4775], 'four': [3378, 3519, 4314, 5011], 'in-patient': [3385], 'basis': [3386], '3).': [3399], '83.3%,': [3409], '83.3%': [3410], '80%': [3412, 4934], '60': [3420], '5.2–40.5).': [3432], 'Colectomies': [3433], '25,': [3441], '32': [3442], '66,': [3444], '18)': [3469], 'responders,': [3496], 'steroid-refractory': [3529], '32,': [3539], '(36': [3554], '62': [3556], '3Open': [3560], 'Predictive': [3573], 'explored': [3576, 4383], 'associated': [3579, 3705, 4843], 'trend': [3586], 'towards': [3587, 3675], 'increased': [3589, 3622, 3919], 'rate': [3591, 3655, 3679, 5004, 5042, 6026, 6112], 'immunomodulators': [3598, 3669, 4208, 4248], '(OR': [3601], '0.2,': [3602], '0.063).': [3605], 'Regarding': [3606], 'outcomes,': [3608], 'curves': [3610, 3695, 3750, 3773], '(Breslow': [3628, 3785], '0.001)': [3631, 3712], '4a).': [3633], 'indicated': [3641], 'significantly': [3652], 'higher': [3653], 'adjusted': [3654, 3678], '(HR': [3659, 3683, 3728], '7.27,': [3660], 'CI': [3662, 3686], '2.32–22.75;': [3663], '0.001).': [3666, 3732], 'tendency': [3674], 'reduced': [3677, 4746], '0.392,': [3684], '0.124–1.238;': [3687], '0.100).': [3690], 'Evaluation': [3691], '4b).': [3714], 'identified': [3721], 'independent': [3724], 'predictor': [3725, 5032, 5085], 'undefined;': [3729], '4Open': [3734], '(top).': [3761], '(bottom)': [3784], 'test).': [3787], 'Safety': [3788], 'led': [3797, 4066], 'adalimumab:': [3802, 4311], 'exacerbation': [3806], 'psoriasis': [3808], 'cough': [3813, 3856], 'fatigue': [3820], 'mild': [3823], 'skin': [3824], 'rash.': [3825], 'transient': [3829], 'fever': [3830], 'another': [3832, 5174], 'arthralgia.': [3834], 'Exacerbation': [3835], 'psoriasis,': [3837], 'fever,': [3838], 'arthralgia': [3839], 'rash': [3841], 'probably': [3849], 'related': [3850, 4092, 4159], 'medication.': [3854], 'Refractory': [3855], 'subsided': [3857], 'shortly': [3858], 'woman': [3863], 'diagnosed': [3865], 'dermoid': [3868], 'ovarian': [3869], 'cyst.': [3870], 'Only': [3871, 4059, 4531], 'hospitalisation': [3879], 'perform': [3881], 'procedure.': [3883], 'Discussion': [3884], 'programme': [3900], 'conventional': [3908, 4901], 'treatment,': [3910], 'factor': [3915], 'found': [3917], 'concentrations': [3920, 6215], 'blood,': [3923], 'stools': [3924], 'colonic': [3926], 'mucosa': [3927], 'evident': [3948], 'antagonist': [3958], 'offering': [3959], 'confirmed': [3960], 'colitis.5,': [3964], 'pre-existing': [3991], 'hybrid': [3999], 'human-murine': [4000], 'would': [4002], 'affect': [4004], 'As': [4015, 4453], 'regards': [4016], 'effects': [4019, 4065], 'profile,': [4020], 'results': [4022, 4243, 4779, 5236, 5824], 'large': [4028, 4385], 'follow-up,3': [4045], 'uncontrolled': [4051], 'colitis.9,': [4057], 'suspension': [4069], 'effect': [4074, 4926], 'admission.': [4083], 'infections': [4088], 'admission': [4097], 'surgery': [4099, 4875], 'necessary': [4102], 'undergoing': [4107], 'study,': [4111, 4570, 4576, 4933], 'thus': [4126], 'decided': [4131], 'subjects.': [4139], 'provided': [4144], 'improvement': [4148], 'early': [4150], '4.': [4153], 'consider': [4155], 'rapid': [4162], 'doses.': [4168], 'baseline.': [4205], 'tended': [4211], 'respond': [4213], 'better': [4214, 5034], 'short': [4217], 'potential': [4222, 4872], 'impact': [4223, 4873], 'combining': [4225], 'remains': [4233], 'debate.12,': [4237], 'adding': [4245], 'should': [4258], 'studied': [4260], 'depth.': [4262], 'Data': [4263, 4652], 'CARE': [4268, 5827], '36%': [4277], '26.14': [4290], 'single-centre': [4294, 5632, 6181], 'studies,': [4295], 'classified': [4302], 'respectively.15,': [4322], 'data,': [4327], 'never': [4333], 'showing': [4342], 'knowledge,': [4355], 'therapy.': [4372], 'This': [4373], 'option': [4375], 'must': [4381], 'series.': [4387], 'remission.': [4413], 'definition': [4415, 5118], 'weak': [4423], 'endoscopic': [4426, 4460, 4470, 4492, 4650, 5122], 'out.': [4430], 'Given': [4431], 'nature': [4433], 'programme,': [4438], 'possible': [4442], 'pre-establish': [4444], 'explorations': [4445], 'outside': [4446], 'contemplated': [4448], 'routine': [4450], 'practice.': [4452], 'result,': [4455], 'assess': [4463], 'mucosal': [4464, 4485, 5929], 'healing': [4465, 4486, 5930], 'and,': [4466], 'performed,': [4468], 'same': [4477], 'Nevertheless,': [4481], 'complete': [4484], '(0': [4487], 'points': [4488], 'subscore)': [4493], 'adalimumab.17': [4504], 'Recently,': [4505], 'placebo-controlled': [4507], 'naive': [4517], 'colitis.18': [4522], 'ours.': [4530], 'so': [4545], 'selected': [4550], 'majority': [4555], 'anti-TNF.': [4562], 'Another': [4563], 'main': [4564, 5094], 'difference': [4565], 'Reinisch': [4575, 4624, 5742, 5804, 5949], 'permitted.': [4582], 'weekly': [4591], 'assessment': [4593], 'Despite': [4599, 5231], 'populations,': [4603], 'dosing': [4606, 5192], 'assessments': [4612], 'made': [4614], 'ours)': [4629], 'similar:': [4634], '54.6%18': [4635], '60%,': [4637], 'Remission': [4639], 'comparable': [4643], 'because': [4644], 'did': [4647], 'assessment.': [4651, 5123], 'limited,': [4671], 'patients.9': [4679], 'series,': [4682], 'half': [4683], 'clearly': [4707], 'subjective,': [4708], 'i.e.': [4709], 'discretion': [4715], 'investigator': [4718], 'criteria': [4721], 'prespecified': [4723], 'determine': [4725], 'proceed': [4730], '68%': [4742], 'subjects': [4745], 'such': [4749], 'More': [4755, 5061], 'remarkably,': [4756], 'trial': [4762], 'These': [4778, 4868], 'suggest': [4780, 5237], 'like': [4783], 'infliximab,5': [4784], 'might': [4785], 'corticosteroid-sparing': [4790], 'most': [4796], 'It': [4809], 'argued': [4812], 'proctocolectomy': [4815, 6059], 'heals': [4816], 'On': [4819], 'hand,': [4822], 'risk': [4826], 'free:': [4827], 'require': [4829], 'frequent': [4830], 'procedures': [4832], 'complications': [4834, 4869, 5886, 5993], 'uncommon.19': [4837], 'An': [4838], 'ileoanal': [4839], 'pouch': [4840, 4854], 'frequently': [4842], 'complications,': [4845], 'pouchitis': [4848], 'approximately': [4850], '40%': [4851], 'patients,20': [4853], 'around': [4857], '8%': [4858], 'patients,21': [4860], 'marked': [4863], 'reduction': [4864], 'fertility.22': [4867], 'body': [4878], 'image': [4879], 'possibility': [4883], 'requiring': [4885], 'permanent': [4887], 'ileostomy': [4888], 'lead': [4890], 'considerable': [4892], 'number': [4893], 'poor': [4898], 'demand': [4904], 'therapies,': [4907], 'off-label': [4910], 'Post': [4914], 'hoc': [4915], 'ACT': [4918], 'colectomy-sparing': [4925], 'out-patients.23': [4930], 'reported': [4955, 4973], '121': [4963], 'out-patients': [4964, 4983], '(17%': [4965], 'subjected': [4966, 4985], 'colectomy),24': [4968], 'lower': [4970], 'than': [4971], '(46%': [4984], 'colectomy).9': [4987], 'A': [4988], 'recent': [4989], '15%': [5006], '(3/20).25': [5007], 'Our': [5008], 'diminishing': [5040], 'failed': [5054], 'achieve': [5056], 'importantly,': [5062], 'Thus,': [5075], 'potent': [5084], 'avoidance': [5088], 'limitations': [5095], 'control': [5104], 'group,': [5105], 'heterogeneity': [5107], 'weakness': [5115], 'trough': [5125], 'levels': [5126], 'antichimeric': [5129], 'measured': [5133], 'Recent': [5139], 'underscores': [5141], 'importance': [5143], 'infliximab.26': [5161], 'seem': [5168], 'reasonable': [5169], 'switch': [5171], 'prematurely': [5172], 'compound': [5176], 'optimisation': [5180], 'increasing': [5186], 'decreasing': [5190], 'interval.': [5193], 'conclusion,': [5195], 'cohort': [5202], 'limitations,': [5234], 'switching': [5256], 'Acknowledgements': [5259], 'Declaration': [5260, 5353], 'personal': [5262], 'interests:': [5263, 5356], 'served': [5293, 5330], 'speakers,': [5295, 5332], 'consultants': [5296, 5333], 'advisory': [5298, 5335], 'board': [5299, 5336], 'members': [5300, 5337], 'Abbott.': [5302], 'Schering': [5339, 5349], 'Plough-MSD.': [5341], 'benefited': [5344], 'grant': [5347], 'Plough': [5351], 'funding': [5355], 'None.': [5357], 'References': [5358], 'Rutgeerts': [5360, 5422, 5454, 5482, 6105], 'P,': [5361, 5423, 5455, 5483, 6021, 6075, 6106], 'Feagan': [5362, 5486, 6107], 'BG,': [5363, 5487, 6108], 'Lichtenstein': [5364], 'GR,': [5365], 'et': [5366, 5396, 5424, 5458, 5488, 5545, 5615, 5654, 5696, 5744, 5778, 5810, 5844, 5882, 5955, 6080, 6109, 6139, 6167, 6204], 'al.': [5367, 5397, 5425, 5459, 5489, 5546, 5616, 5655, 5697, 5745, 5779, 5811, 5845, 5883, 5956, 6081, 6110, 6140, 6168, 6205], 'Comparison': [5368], 'scheduled': [5370, 5788], 'episodic': [5372], 'strategies': [5374], 'Gastroenterology': [5380, 5442, 5794, 5970, 6123], '2004;': [5381, 5409, 6094], '126:': [5382], '402–': [5383], '13.': [5384], 'CrossrefCASPubMedWeb': [5385, 5413, 5447, 5507, 5568, 5604, 5766, 5799, 6128, 6229], 'Science®Google': [5387, 5415, 5449, 5479, 5509, 5536, 5570, 5606, 5645, 5687, 5768, 5801, 5873, 5912, 5946, 6015, 6046, 6071, 6100, 6130, 6158, 6194, 6231], 'Scholar': [5388, 5416, 5450, 5480, 5510, 5537, 5571, 5607, 5646, 5688, 5736, 5769, 5802, 5836, 5874, 5913, 5947, 5977, 6016, 6047, 6072, 6101, 6131, 6159, 6195, 6232], 'Sands': [5390], 'BE,': [5391], 'Anderson': [5392], 'FH,': [5393], 'Bernstein': [5394], 'CN,': [5395], 'fistulizing': [5402], 'N': [5405, 5499, 5560, 5758], 'Engl': [5406, 5500, 5759], 'J': [5407, 5501, 5562, 5598, 5728, 5760, 5830, 5938, 6007, 6149, 6223], 'Med': [5408, 5472, 5502, 5563, 5761], '350:': [5410], '876–': [5411], '85.': [5412], 'Colombel': [5418, 5738], 'FJ,': [5419], 'Sandborn': [5420, 5452, 5484, 5740, 5951, 5985, 6103], 'WJ,': [5421, 5453, 5485, 5741, 5952, 6104], 'disease:': [5438, 5709, 5823, 5893], 'CHARM': [5440], 'trial.': [5441, 5793], '2007;': [5443, 5473, 5528, 5600, 5865], '132:': [5444], '52–': [5445], '65.': [5446], 'Ems': [5456], 'R,': [5457, 5807], 'Ann': [5470, 6063], 'Intern': [5471], '146:': [5474], '829–': [5475], '38.': [5476], 'CrossrefPubMedWeb': [5477, 5944, 6013, 6044, 6069, 6098, 6156], '5': [5481], '2005;': [5503, 5730], '353:': [5504], '2462–': [5505], '76.': [5506], 'JP,': [5513], 'Gonzalez-Lama': [5514], 'Y,': [5515], 'Maté': [5516], 'Systematic': [5518], 'review:': [5519], '25:': [5529, 5866], '19–': [5530], '37.': [5531], 'LibraryCASPubMedWeb': [5534, 5643, 5685, 5871, 5910, 6192], 'Baert': [5539], 'F,': [5540], 'Norman': [5541], 'M,': [5542, 5917, 6134], 'Vermeire': [5543], 'S,': [5544, 5841, 6136], 'Influence': [5547], 'Eng': [5561], '2003;': [5564, 6065], '348:': [5565], '601–': [5566], '8.': [5567, 5798, 6189], 'Peyrin-Biroulet': [5573], 'L,': [5574, 5881], 'Laclotte': [5575, 5611], 'C,': [5576, 5612, 5775, 6077], 'Roblin': [5577], 'X,': [5578], 'Bigard': [5579], 'MA.': [5580], 'World': [5597, 5719, 5937], 'Gastroenterol': [5599, 5729, 5831, 5939, 6008, 6224], '13:': [5601], '2328–': [5602], '32.': [5603], 'Oussalah': [5609], 'A,': [5610, 5879, 5919, 6019, 6079], 'Chevaux': [5613], 'JB,': [5614], 'experience.': [5633], '2008;': [5637, 5795, 5832, 6009, 6152], '28:': [5638], '966–': [5639], '72.': [5640], 'Afif': [5648, 6197], 'W,': [5649, 5743, 5805, 5950, 6198], 'Leighton': [5650], 'JA,': [5651], 'Hanauer': [5652], 'SB,': [5653], 'Open-label': [5656], 'Inflamm': [5676], 'Bowel': [5677], 'Dis': [5678, 6037, 6091], '2009;': [5679, 5904, 5940, 6124], '15:': [5680, 5941], '1302–': [5681], '7.': [5682], 'Silverberg': [5690], 'MS,': [5691], 'Satsangi': [5692], 'J,': [5693, 5839, 5843], 'Ahmad': [5694], 'T,': [5695], 'Toward': [5698], 'integrated': [5700], 'clinical,': [5701], 'molecular': [5702], 'serological': [5704], 'classification': [5705], 'Report': [5710], 'Working': [5713], 'Party': [5714], '2005': [5717], 'Congress': [5720], 'Gastroenterology.': [5722], 'classification.': [5726], 'Can': [5727], '19(Suppl.': [5731], 'A):': [5732], '9A–': [5733], '13A.': [5734], 'Google': [5735, 5835], 'JF,': [5739], ',': [5746], 'SONIC': [5747], 'Group.': [5749], 'Infliximab,': [5750], 'azathioprine,': [5751], 'combination': [5753], '2010;': [5762, 5971, 6186, 6225], '362:': [5763], '1383–': [5764], '95.': [5765], 'Van': [5771], 'Assche': [5772], 'G,': [5773, 5777], 'Magdelaine-Beuzelin': [5774], 'D’Haens': [5776], 'Withdrawal': [5780], 'immunosuppression': [5782], 'maintenance:': [5790], 'randomized': [5792], '134:': [5796], '1861–': [5797], '14': [5803], 'Lofberg': [5806], 'Louis': [5808], 'E,': [5809], 'effectiveness': [5813], 'TNF-antagonist-naive': [5815], 'Am': [5829, 6006, 6222], '103:': [5833, 6010], 'A1068.': [5834], 'Seiderer': [5838], 'Brand': [5840], 'Dambacher': [5842], 'single': [5859], '787–': [5867], '96.': [5868], 'Ho': [5876], 'GT,': [5877], 'Mowat': [5878], 'Potts': [5880], 'Efficacy': [5884], 'medically-refractory': [5891], 'nationwide': [5896], 'Scotland': [5899], '(2004-2008).': [5900], '29:': [5905], '527–': [5906], '34.': [5907, 6068], '17': [5914], 'Lorenzo': [5918], 'Dominguez-Muñoz': [5920], 'JE.': [5921], 'colitis:': [5925], 'cases': [5927], 'years.': [5936], '3814–': [5942], '6.': [5943], 'Hommes': [5953], 'DW,': [5954], 'moderately': [5964], 'severely': [5966], '138(Suppl.': [5972], '1):': [5973], 'S-114–': [5974], '5.': [5975], 'CrossrefGoogle': [5976], 'Loftus': [5979, 6199], 'EV,': [5980], 'Delgado': [5981], 'DJ,': [5982], 'Friedman': [5983], 'HS,': [5984], 'WJ.': [5986], 'Colectomy': [5987, 6111], 'incidence': [5990], 'postsurgical': [5992], 'among': [5994], 'private': [5999], 'health': [6000], 'insurance': [6001], 'United': [6004], 'States.': [6005], '1737–': [6011], '45.': [6012], '20': [6017], 'Lepisto': [6018], 'Luukkonen': [6020], 'Jarvinen': [6022], 'HJ.': [6023], 'ileal': [6028, 6085], 'pouch-anal': [6029], 'anastomosis': [6030, 6087], 'quality': [6032], 'life': [6034], 'failure.': [6036], 'Colon': [6038, 6092], 'Rectum': [6039, 6093], '2002;': [6040], '45:': [6041], '1289–': [6042], '94.': [6043], 'Tulchinsky': [6049], 'H,': [6050, 6138], 'Hawley': [6051], 'PR,': [6052], 'Nicholls': [6053], 'restorative': [6058], 'Surg': [6064], '238:': [6066], '229–': [6067], '22': [6073], 'Johnson': [6074], 'Richard': 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