Title: [Inhibition of the expression of Epstein-Barr virus antigens in vitro by Chinese medicine compound "Dongxia wan"].
Abstract: To investigate the effect of Chinese medicine "Dongxia wan" on the expression of Epstein-Barr virus (EBV) antigens in vitro.Cell culture and indirect immunoenzyme methods were used.When Raji and B95-8 cells were cultured with 20-80 microg/'ml of "Dongxia wan", the expression of EBV early antigen (EBV-EA) and EBV capsid antigen (EBV-VCA) induced by croton oil and n-butyric acid and the natural expression of EBV-VCA were all inhibited significantly. The inhibition rates were 19.3% - 49.84%, 34.63% - 45.61% and 21.67% - 47.78%, respectively. When Raji and B95-8 cells were pretreated with "Dongxia wan" the expression of EBV-EA and EBV-VCA were also inhibited obviously.Chinese medicine "Dongxia wan" can inhibit the expression of EBV antigens in target cells, it may be used to the prevention and treatment of EBV related diseases.
Publication Year: 2000
Publication Date: 2000-06-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 2
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