Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1891779952', 'doi': 'https://doi.org/10.1016/j.bbrc.2015.10.018', 'title': 'Soluble αKlotho as a candidate for the biomarker of aging', 'display_name': 'Soluble αKlotho as a candidate for the biomarker of aging', 'publication_year': 2015, 'publication_date': '2015-10-22', 'ids': {'openalex': 'https://openalex.org/W1891779952', 'doi': 'https://doi.org/10.1016/j.bbrc.2015.10.018', 'mag': '1891779952', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26462468'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbrc.2015.10.018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5088959554', 'display_name': 'Daisuke Koyama', 'orcid': 'https://orcid.org/0000-0002-6971-180X'}, 'institutions': [{'id': 'https://openalex.org/I146500386', 'display_name': 'Jichi Medical University', 'ror': 'https://ror.org/010hz0g26', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146500386']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Daisuke Koyama', 'raw_affiliation_strings': ['Department of Internal Medicine, Fukushima Prefectural Miyashita Hospital, 1150 Minajiri, Mishima, Fukushima 969-7511, Japan', 'Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan', 'institution_ids': ['https://openalex.org/I146500386']}, {'raw_affiliation_string': 'Department of Internal Medicine, Fukushima Prefectural Miyashita Hospital, 1150 Minajiri, Mishima, Fukushima 969-7511, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012449153', 'display_name': 'Yu Sato', 'orcid': 'https://orcid.org/0000-0003-1084-6475'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yu Sato', 'raw_affiliation_strings': ['Department of Internal Medicine, Fukushima Prefectural Miyashita Hospital, 1150 Minajiri, Mishima, Fukushima 969-7511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Fukushima Prefectural Miyashita Hospital, 1150 Minajiri, Mishima, Fukushima 969-7511, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009502775', 'display_name': 'Masato Aizawa', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masato Aizawa', 'raw_affiliation_strings': ['Department of Internal Medicine, Fukushima Prefectural Miyashita Hospital, 1150 Minajiri, Mishima, Fukushima 969-7511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Fukushima Prefectural Miyashita Hospital, 1150 Minajiri, Mishima, Fukushima 969-7511, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052797780', 'display_name': 'Takumi Maki', 'orcid': 'https://orcid.org/0009-0005-8757-6030'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takumi Maki', 'raw_affiliation_strings': ['Department of Internal Medicine, Fukushima Prefectural Miyashita Hospital, 1150 Minajiri, Mishima, Fukushima 969-7511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Fukushima Prefectural Miyashita Hospital, 1150 Minajiri, Mishima, Fukushima 969-7511, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077262683', 'display_name': 'Masaki Kurosawa', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masaki Kurosawa', 'raw_affiliation_strings': ['Department of Internal Medicine, Fukushima Prefectural Miyashita Hospital, 1150 Minajiri, Mishima, Fukushima 969-7511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Fukushima Prefectural Miyashita Hospital, 1150 Minajiri, Mishima, Fukushima 969-7511, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090201226', 'display_name': 'Makoto Kuro‐o', 'orcid': 'https://orcid.org/0000-0003-0018-7269'}, 'institutions': [{'id': 'https://openalex.org/I146500386', 'display_name': 'Jichi Medical University', 'ror': 'https://ror.org/010hz0g26', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146500386']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Makoto Kuro-o', 'raw_affiliation_strings': ['Division of Anti-aging Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Anti-aging Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan', 'institution_ids': ['https://openalex.org/I146500386']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5051683488', 'display_name': 'Yusuke Furukawa', 'orcid': 'https://orcid.org/0000-0002-7249-6418'}, 'institutions': [{'id': 'https://openalex.org/I146500386', 'display_name': 'Jichi Medical University', 'ror': 'https://ror.org/010hz0g26', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146500386']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Yusuke Furukawa', 'raw_affiliation_strings': ['Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan', 'institution_ids': ['https://openalex.org/I146500386']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5051683488'], 'corresponding_institution_ids': ['https://openalex.org/I146500386'], 'apc_list': {'value': 2770, 'currency': 'USD', 'value_usd': 2770, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.851, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 39, 'citation_normalized_percentile': {'value': 0.824474, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '467', 'issue': '4', 'first_page': '1019', 'last_page': '1025'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10516', 'display_name': 'Parathyroid Disorders and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2727', 'display_name': 'Nephrology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10516', 'display_name': 'Parathyroid Disorders and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2727', 'display_name': 'Nephrology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11928', 'display_name': 'Genetic Syndromes and Imprinting', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11412', 'display_name': 'Genetic and Kidney Cyst Diseases', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/klotho', 'display_name': 'Klotho', 'score': 0.9021691}], 'concepts': [{'id': 'https://openalex.org/C9832595', 'wikidata': 'https://www.wikidata.org/wiki/Q414050', 'display_name': 'Klotho', 'level': 3, 'score': 0.9021691}, {'id': 'https://openalex.org/C114276007', 'wikidata': 'https://www.wikidata.org/wiki/Q14897899', 'display_name': 'Fibroblast growth factor 23', 'level': 4, 'score': 0.6707892}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6373002}, {'id': 'https://openalex.org/C159641895', 'wikidata': 'https://www.wikidata.org/wiki/Q108377937', 'display_name': 'Renal function', 'level': 2, 'score': 0.6199383}, {'id': 'https://openalex.org/C2778653478', 'wikidata': 'https://www.wikidata.org/wiki/Q1054718', 'display_name': 'Kidney disease', 'level': 2, 'score': 0.59088546}, {'id': 'https://openalex.org/C2781208988', 'wikidata': 'https://www.wikidata.org/wiki/Q202476', 'display_name': 'Parathyroid hormone', 'level': 3, 'score': 0.5661678}, {'id': 'https://openalex.org/C2781197716', 'wikidata': 'https://www.wikidata.org/wiki/Q864574', 'display_name': 'Biomarker', 'level': 2, 'score': 0.554376}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4918661}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.42009535}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.33121502}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.2111786}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18147731}, {'id': 'https://openalex.org/C519063684', 'wikidata': 'https://www.wikidata.org/wiki/Q706', 'display_name': 'Calcium', 'level': 2, 'score': 0.10802829}], 'mesh': [{'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005966', 'descriptor_name': 'Glucuronidase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000375', 'descriptor_name': 'Aging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000089703', 'descriptor_name': 'Fibroblast Growth Factor-23', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005966', 'descriptor_name': 'Glucuronidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000090265', 'descriptor_name': 'Klotho Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012995', 'descriptor_name': 'Solubility', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbrc.2015.10.018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26462468', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.65}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1970204106', 'https://openalex.org/W1970719549', 'https://openalex.org/W1977645780', 'https://openalex.org/W1980991502', 'https://openalex.org/W1983527841', 'https://openalex.org/W1984789653', 'https://openalex.org/W1989025333', 'https://openalex.org/W1993621156', 'https://openalex.org/W2018913177', 'https://openalex.org/W2023316153', 'https://openalex.org/W2034546193', 'https://openalex.org/W2040542461', 'https://openalex.org/W2045867494', 'https://openalex.org/W2049229440', 'https://openalex.org/W2049720707', 'https://openalex.org/W2052109036', 'https://openalex.org/W2069528022', 'https://openalex.org/W2070126973', 'https://openalex.org/W2073300231', 'https://openalex.org/W2076708929', 'https://openalex.org/W2092823666', 'https://openalex.org/W2094148720', 'https://openalex.org/W2094551185', 'https://openalex.org/W2106711282', 'https://openalex.org/W2111447328', 'https://openalex.org/W2111899789', 'https://openalex.org/W2113275211', 'https://openalex.org/W2114360920', 'https://openalex.org/W2117104852', 'https://openalex.org/W2120129493', 'https://openalex.org/W2121960517', 'https://openalex.org/W2123069635', 'https://openalex.org/W2132141431', 'https://openalex.org/W2134584253', 'https://openalex.org/W2137720344', 'https://openalex.org/W2140942817', 'https://openalex.org/W2144787350', 'https://openalex.org/W2152189242', 'https://openalex.org/W2154614385', 'https://openalex.org/W2159733103', 'https://openalex.org/W2164533721', 'https://openalex.org/W2170534823', 'https://openalex.org/W2172122530'], 'related_works': ['https://openalex.org/W77211318', 'https://openalex.org/W4388773448', 'https://openalex.org/W2902331921', 'https://openalex.org/W2496875861', 'https://openalex.org/W2415947158', 'https://openalex.org/W222523100', 'https://openalex.org/W2193223877', 'https://openalex.org/W2042208523', 'https://openalex.org/W2004167485', 'https://openalex.org/W1966074338'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1891779952', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2024-12-16T05:34:50.163821', 'created_date': '2016-06-24'}