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'abstract_inverted_index': {'CKD-MBDに関わる因子のうちで,': [0], '最も生命予後と関係の深い因子である,': [1], 'リンの調整系が判明したのは最近のことである.': [2], 'fibroblast': [3], 'growth': [4], 'factor': [5], '23': [6], '(FGF23)': [7], 'は骨細胞より分泌されるが,': [8], 'KlothoとFGF受容体の複合体に結合すると,': [9], '近位尿細管でのナトリウム-リン共輸送体': [10], '(NaPi-Ⅱ)': [11], 'の発現が抑制され,': [12], 'リンの再吸収が低下する.': [13], 'また,': [14, 24], '活性型ビタミンD': [15], '[1,25(OH)2D]': [16], '産生を抑制し,': [17], '腸管からのリン再吸収を抑制する.': [18], 'KlothoはCKDの早期から発現が低下し始めるが,': [19], '動物実験などから腎保護作用を有することが確かめられている.': [20], 'FGF23もCKD早期から上昇を認めるが,': [21], '透析患者のみならず,': [22], '保存期CKD患者の予後とも関係が深い.': [23], 'FGF23は予後予測因子というだけでなく,': [25], '予後不良因子として,': [26], 'FGF23自体が左室肥大をきたすことも指摘されており,': [27], 'そのメカニズムも解明されつつある.': [28], 'さらには,': [29], '肥大心自体もFGF23を産生することが判明している.': [30]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2902331921', 'counts_by_year': [], 'updated_date': '2024-08-26T21:19:17.724083', 'created_date': '2018-12-11'}