Publication Information

{'id': 'https://openalex.org/W1847600382', 'doi': 'https://doi.org/10.18632/oncotarget.3299', 'title': '2D-DIGE proteomic analysis identifies new potential therapeutic targets for adrenocortical carcinoma', 'display_name': '2D-DIGE proteomic analysis identifies new potential therapeutic targets for adrenocortical carcinoma', 'publication_year': 2015, 'publication_date': '2015-01-21', 'ids': {'openalex': 'https://openalex.org/W1847600382', 'doi': 'https://doi.org/10.18632/oncotarget.3299', 'mag': '1847600382', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25691058', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4467395'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3299', 'pdf_url': 'https://www.oncotarget.com/article/3299/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/3299/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046902215', 'display_name': 'G Poli', 'orcid': 'https://orcid.org/0000-0001-9949-0422'}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giada Poli', 'raw_affiliation_strings': ['Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.', 'institution_ids': ['https://openalex.org/I45084792']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049128949', 'display_name': 'E. Ceni', 'orcid': 'https://orcid.org/0000-0003-2156-3964'}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Elisabetta Ceni', 'raw_affiliation_strings': ['Gastroenterology Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Gastroenterology Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.', 'institution_ids': ['https://openalex.org/I45084792']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012946154', 'display_name': 'Roberta Armignacco', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Roberta Armignacco', 'raw_affiliation_strings': ['Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.', 'institution_ids': ['https://openalex.org/I45084792']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032951456', 'display_name': 'Tonino Ercolino', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210115393', 'display_name': 'Azienda Ospedaliero-Universitaria Careggi', 'ror': 'https://ror.org/02crev113', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115393']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Tonino Ercolino', 'raw_affiliation_strings': ['Endocrinology Unit, Careggi Hospital, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Endocrinology Unit, Careggi Hospital, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.', 'institution_ids': ['https://openalex.org/I4210115393']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058896363', 'display_name': 'Letizia Canu', 'orcid': 'https://orcid.org/0000-0003-4995-8108'}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Letizia Canu', 'raw_affiliation_strings': ['Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.', 'institution_ids': ['https://openalex.org/I45084792']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055870977', 'display_name': 'Gianna Baroni', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gianna Baroni', 'raw_affiliation_strings': ['Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy'], 'affiliations': [{'raw_affiliation_string': 'Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy', 'institution_ids': ['https://openalex.org/I45084792']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072623709', 'display_name': 'Gabriella Nesi', 'orcid': 'https://orcid.org/0000-0002-2614-944X'}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gabriella Nesi', 'raw_affiliation_strings': ['Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy'], 'affiliations': [{'raw_affiliation_string': 'Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy', 'institution_ids': ['https://openalex.org/I45084792']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027938455', 'display_name': 'Andrea Galli', 'orcid': 'https://orcid.org/0000-0001-5416-6290'}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Andrea Galli', 'raw_affiliation_strings': ['Gastroenterology Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Gastroenterology Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.', 'institution_ids': ['https://openalex.org/I45084792']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032995631', 'display_name': 'Massimo Mannelli', 'orcid': 'https://orcid.org/0000-0002-8001-9857'}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}, {'id': 'https://openalex.org/I4210123523', 'display_name': 'Tumour Institute of Tuscany', 'ror': 'https://ror.org/028e6y556', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210123523']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Massimo Mannelli', 'raw_affiliation_strings': ['Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.', 'Istituto Toscano Tumori, Florence, Italy'], 'affiliations': [{'raw_affiliation_string': 'Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.', 'institution_ids': ['https://openalex.org/I45084792']}, {'raw_affiliation_string': 'Istituto Toscano Tumori, Florence, Italy', 'institution_ids': ['https://openalex.org/I4210123523']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016806501', 'display_name': 'Michaela Luconi', 'orcid': 'https://orcid.org/0000-0001-5186-064X'}, 'institutions': [{'id': 'https://openalex.org/I45084792', 'display_name': 'University of Florence', 'ror': 'https://ror.org/04jr1s763', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45084792']}, {'id': 'https://openalex.org/I4210123523', 'display_name': 'Tumour Institute of Tuscany', 'ror': 'https://ror.org/028e6y556', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210123523']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Michaela Luconi', 'raw_affiliation_strings': ['Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.', 'Istituto Toscano Tumori, Florence, Italy'], 'affiliations': [{'raw_affiliation_string': 'Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.', 'institution_ids': ['https://openalex.org/I45084792']}, {'raw_affiliation_string': 'Istituto Toscano Tumori, Florence, Italy', 'institution_ids': ['https://openalex.org/I4210123523']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.236, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 30, 'citation_normalized_percentile': {'value': 0.926802, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '6', 'issue': '8', 'first_page': '5695', 'last_page': '5706'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11054', 'display_name': 'Adrenal and Paraganglionic Tumors', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11054', 'display_name': 'Adrenal and Paraganglionic Tumors', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11839', 'display_name': 'Hormonal Regulation and Hypertension', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/adrenocortical-adenoma', 'display_name': 'Adrenocortical adenoma', 'score': 0.5004585}], 'concepts': [{'id': 'https://openalex.org/C2781399356', 'wikidata': 'https://www.wikidata.org/wiki/Q918285', 'display_name': 'Adrenocortical carcinoma', 'level': 2, 'score': 0.82011306}, {'id': 'https://openalex.org/C2777977426', 'wikidata': 'https://www.wikidata.org/wiki/Q19065', 'display_name': 'Adrenal cortex', 'level': 2, 'score': 0.6364665}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5185595}, {'id': 'https://openalex.org/C2778674399', 'wikidata': 'https://www.wikidata.org/wiki/Q4684749', 'display_name': 'Adrenocortical adenoma', 'level': 3, 'score': 0.5004585}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.46029127}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4512545}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.4043905}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3302031}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.28320628}, {'id': 'https://openalex.org/C2777428134', 'wikidata': 'https://www.wikidata.org/wiki/Q272741', 'display_name': 'Adenoma', 'level': 2, 'score': 0.13265699}], 'mesh': [{'descriptor_ui': 'D000306', 'descriptor_name': 'Adrenal Cortex Neoplasms', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D018268', 'descriptor_name': 'Adrenocortical Carcinoma', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D057825', 'descriptor_name': 'Two-Dimensional Difference Gel Electrophoresis', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000306', 'descriptor_name': 'Adrenal Cortex Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000306', 'descriptor_name': 'Adrenal Cortex Neoplasms', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D000306', 'descriptor_name': 'Adrenal Cortex Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018268', 'descriptor_name': 'Adrenocortical Carcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018268', 'descriptor_name': 'Adrenocortical Carcinoma', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D018268', 'descriptor_name': 'Adrenocortical Carcinoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002675', 'descriptor_name': 'Child, Preschool', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007223', 'descriptor_name': 'Infant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040901', 'descriptor_name': 'Proteomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040901', 'descriptor_name': 'Proteomics', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D057825', 'descriptor_name': 'Two-Dimensional Difference Gel Electrophoresis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3299', 'pdf_url': 'https://www.oncotarget.com/article/3299/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4467395', 'pdf_url': 'https://europepmc.org/articles/pmc4467395?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467395', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/2158/1007875', 'pdf_url': 'https://flore.unifi.it/bitstream/2158/1007875/2/Poli%20Ceni%20et%20al%20Oncotarget%202015.pdf', 'source': {'id': 'https://openalex.org/S4306402033', 'display_name': 'Florence Research (University of Florence)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I45084792', 'host_organization_name': 'University of Florence', 'host_organization_lineage': ['https://openalex.org/I45084792'], 'host_organization_lineage_names': ['University of Florence'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25691058', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3299', 'pdf_url': 'https://www.oncotarget.com/article/3299/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.62, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1965723377', 'https://openalex.org/W1970082459', 'https://openalex.org/W1970558444', 'https://openalex.org/W1973268693', 'https://openalex.org/W1976320655', 'https://openalex.org/W1989807503', 'https://openalex.org/W1999928675', 'https://openalex.org/W2002869675', 'https://openalex.org/W2003721774', 'https://openalex.org/W2015207840', 'https://openalex.org/W2023024480', 'https://openalex.org/W2035470074', 'https://openalex.org/W2053131896', 'https://openalex.org/W2073264397', 'https://openalex.org/W2082817623', 'https://openalex.org/W2098165008', 'https://openalex.org/W2098622295', 'https://openalex.org/W2099616702', 'https://openalex.org/W2099784905', 'https://openalex.org/W2102885350', 'https://openalex.org/W2105635119', 'https://openalex.org/W2108819945', 'https://openalex.org/W2125157555', 'https://openalex.org/W2127513469', 'https://openalex.org/W2129110988', 'https://openalex.org/W2134730633', 'https://openalex.org/W2138551378', 'https://openalex.org/W2141643459', 'https://openalex.org/W2143370279', 'https://openalex.org/W2150301509', 'https://openalex.org/W2170729108', 'https://openalex.org/W2171030481', 'https://openalex.org/W2803327664', 'https://openalex.org/W4211233876'], 'related_works': ['https://openalex.org/W4213088998', 'https://openalex.org/W2604610389', 'https://openalex.org/W2589211820', 'https://openalex.org/W2423091720', 'https://openalex.org/W2388642290', 'https://openalex.org/W2387105672', 'https://openalex.org/W2129110988', 'https://openalex.org/W2071366513', 'https://openalex.org/W2068151222', 'https://openalex.org/W1993102388'], 'abstract_inverted_index': {'//': [0, 114, 118], 'Giada': [1], 'Poli': [2], '1,*': [3], ',': [4, 8, 12, 16, 20, 24, 28, 32], 'Elisabetta': [5], 'Ceni': [6], '2,*': [7], 'Roberta': [9], 'Armignacco': [10], '1': [11, 19, 40], 'Tonino': [13], 'Ercolino': [14], '3': [15, 69], 'Letizia': [17], 'Canu': [18], 'Gianna': [21], 'Baroni': [22], '4': [23, 27, 80], 'Gabriella': [25], 'Nesi': [26], 'Andrea': [29], 'Galli': [30], '2': [31, 55], 'Massimo': [33, 115], 'Mannelli': [34], '1,5': [35, 39], 'and': [36, 46, 61, 88, 167, 198, 209, 258, 266, 330], 'Michaela': [37, 111], 'Luconi': [38], 'Endocrinology': [41, 70], 'Unit,': [42, 57, 71], 'Department': [43, 58, 85], 'of': [44, 51, 59, 65, 82, 86, 92, 169, 182, 207, 231, 309, 339], 'Experimental': [45, 60], 'Clinical': [47, 62], 'Biomedical': [48], 'Sciences,': [49], 'University': [50, 64, 91], 'Florence,': [52, 53, 66, 67, 78, 93, 94, 100], 'Italy': [54, 68, 79, 95, 101], 'Gastroenterology': [56], 'Medicine,': [63, 90], 'Careggi': [72], 'Hospital,': [73], 'Azienda': [74], 'Ospedaliera': [75], 'Universitaria': [76], 'Careggi,': [77], 'Division': [81], 'Pathological': [83], 'Anatomy,': [84], 'Surgery': [87], 'Translational': [89], '5': [96], 'Istituto': [97], 'Toscano': [98], 'Tumori,': [99], '*': [102], 'These': [103, 322], 'authors': [104], 'contributed': [105], 'equally': [106], 'to': [107, 188], 'this': [108], 'work': [109], 'Correspondence:': [110], 'Luconi,': [112], 'email:': [113, 117], 'Mannelli,': [116], 'Keywords': [119], ':': [120, 126, 131, 136], 'proteomics,': [121], 'cancer': [122], 'metabolism,': [123], 'biomarkers': [124, 329], 'Received': [125], 'December': [127], '02,': [128, 133], '2014': [129], 'Accepted': [130], 'January': [132, 137], '2015': [134, 139], 'Published': [135], '21,': [138], 'Abstract': [140], 'Adrenocortical': [141], 'carcinoma': [142, 197, 300], '(ACC)': [143], 'is': [144, 159], 'a': [145, 190, 236, 294], 'rare': [146], 'aggressive': [147], 'tumor': [148, 157], 'with': [149, 204, 284, 302], 'poor': [150], 'prognosis': [151], 'when': [152], 'metastatic': [153], 'at': [154], 'diagnosis.': [155], 'The': [156, 246], 'biology': [158], 'still': [160], 'mostly': [161, 221], 'unclear,': [162], 'justifying': [163], 'the': [164, 170, 178, 232, 240, 315], 'limited': [165], 'specificity': [166], 'efficacy': [168], 'anti-cancer': [171], 'drugs': [172], 'currently': [173], 'available.': [174], 'This': [175], 'study': [176], 'reports': [177], 'first': [179], 'proteomic': [180, 296], 'analysis': [181, 206, 227], 'ACC': [183, 265, 328], 'by': [184, 251, 280, 307], 'using': [185], 'two-dimensional-differential-in-gel-electrophoresis': [186], '(2D-DIGE)': [187], 'evaluate': [189], 'differential': [191, 247], 'protein': [192], 'expression': [193, 248], 'profile': [194, 297], 'between': [195], 'adrenocortical': [196, 244, 299], 'normal': [199, 210, 267, 285, 303], 'adrenal.': [200], 'Mass': [201], 'spectrometry,': [202], 'associated': [203], '2D-DIGE': [205], 'carcinomas': [208], 'adrenals,': [211], 'identified': [212], '22': [213], 'proteins': [214, 233, 277, 323], 'in': [215, 223, 243, 298, 320, 336], '27': [216], 'differentially': [217], 'expressed': [218, 279], '2D': [219], 'spots,': [220], 'overexpressed': [222], 'ACC.': [224, 321], 'Gene': [225], 'ontology': [226], 'revealed': [228], 'that': [229], 'most': [230], 'concurs': [234], 'towards': [235], 'metabolic': [237, 311], 'shift,': [238], 'called': [239], 'Warburg': [241, 316], 'effect,': [242], 'cancer.': [245], 'was': [249], 'validated': [250, 335], 'Western': [252], 'blot': [253], 'for': [254, 274], 'Aldehyde-dehydrogenase-6-A1,Transferrin,': [255], 'Fascin-1,Lamin': [256], 'A/C,Adenylate-cyclase-associated-protein-1': [257], 'Ferredoxin-reductase.': [259], 'Moreover,': [260], 'immunohistochemistry': [261], 'performed': [262], 'on': [263], 'paraffin-embedded': [264], 'adrenal': [268, 286, 304], 'specimens': [269], 'confirmed': [270], 'marked': [271], 'positive': [272], 'staining': [273], 'all': [275], '6': [276], 'diffusely': [278], 'neoplastic': [281], 'cells,': [282], 'compared': [283, 301], 'cortex.': [287], 'In': [288], 'conclusion,': [289], 'our': [290], 'preliminary': [291], 'findings': [292], 'reveal': [293], 'different': [295], 'cortex': [305], 'characterized': [306], 'overexpression': [308], 'mainly': [310], 'enzymes,': [312], 'thus': [313], 'suggesting': [314], 'effect': [317], 'also': [318], 'occurs': [319], 'may': [324], 'represent': [325], 'promising': [326], 'novel': [327], 'potential': [331], 'therapeutic': [332], 'targets': [333], 'if': [334], 'larger': [337], 'cohorts': [338], 'patients.': [340]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1847600382', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2025-01-13T04:20:09.148468', 'created_date': '2016-06-24'}