Title: Significance of expressions of Ki67 and P16 in adrenocortical tumor tissue
Abstract: Objective To study the relationship between Ki67、P16 and adrenocortical tumors by combining assays of expressions of Ki67 and P16 in adrenocortical tumor. Methods The labeling indexes (LI) of Ki67 and P16 were detected by immunohistochemical staining in 6 cases of adrenocortical carcinoma, 39 cases of adrenocortical adenoma and 9 cases of normal adrenocortical tissue beside the tumor. Results The highest expression of Ki67 and the lowest expressions of P16 were found in adrenocortical carcinoma. There existed negative correlation between the expressions of Ki67 and P16 (r=-0.67, P0.05). There was significant difference in the LI of Ki67 and P16betweenadrenocorticalcarcinomaandadrenocorticaladenoma (both P0.01), with LI cutpoints of 4% and 12% respectively. Conclusion The LI of Ki67 above 4% and LI of P16 below 12% may indicate adrenocortical carcinoma. It is suggested that combined detections of Ki67 and P16 may have reference significance in the differentiation of adrencortical adenoma!from adrencortical carcinoma.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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