Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W184388943', 'doi': 'https://doi.org/10.1007/978-0-387-89520-8_3', 'title': 'Targeting TNF for Treatment of Cancer and Autoimmunity', 'display_name': 'Targeting TNF for Treatment of Cancer and Autoimmunity', 'publication_year': 2009, 'publication_date': '2009-01-01', 'ids': {'openalex': 'https://openalex.org/W184388943', 'doi': 'https://doi.org/10.1007/978-0-387-89520-8_3', 'mag': '184388943', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19760065'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/978-0-387-89520-8_3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S43790123', 'display_name': 'Advances in experimental medicine and biology', 'issn_l': '0065-2598', 'issn': ['0065-2598', '2214-8019'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'book series'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'book-chapter', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034304968', 'display_name': 'Gautam Sethi', 'orcid': 'https://orcid.org/0000-0002-8677-8475'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gautam Sethi', 'raw_affiliation_strings': ['Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Unit 143, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA.'], 'affiliations': [{'raw_affiliation_string': 'Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Unit 143, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA.', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037193058', 'display_name': 'Bokyung Sung', 'orcid': 'https://orcid.org/0009-0001-2423-3613'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Bokyung Sung', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038274221', 'display_name': 'Ajaikumar B. Kunnumakkara', 'orcid': 'https://orcid.org/0000-0001-9121-6816'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ajaikumar B Kunnumakkara', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048675624', 'display_name': 'Bharat Aggarwal', 'orcid': 'https://orcid.org/0000-0003-3534-2898'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Bharat B Aggarwal', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.081, 'has_fulltext': False, 'cited_by_count': 112, 'citation_normalized_percentile': {'value': 0.819572, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': None, 'issue': None, 'first_page': '37', 'last_page': '51'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12817', 'display_name': 'Pharmacological Effects of Licorice Roots', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12817', 'display_name': 'Pharmacological Effects of Licorice Roots', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11503', 'display_name': 'Role of STAT3 in Cancer Inflammation and Immunity', 'score': 0.9947, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10469', 'display_name': 'Reciprocal Development of TH17 and Treg Cells', 'score': 0.9947, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proinflammatory-cytokine', 'display_name': 'Proinflammatory cytokine', 'score': 0.53817767}, {'id': 'https://openalex.org/keywords/cancer', 'display_name': 'Cancer', 'score': 0.520533}, {'id': 'https://openalex.org/keywords/tumor-microenvironment', 'display_name': 'Tumor Microenvironment', 'score': 0.505244}], 'concepts': [{'id': 'https://openalex.org/C2777226972', 'wikidata': 'https://www.wikidata.org/wiki/Q415343', 'display_name': 'Etanercept', 'level': 3, 'score': 0.83955574}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8161473}, {'id': 'https://openalex.org/C2780132546', 'wikidata': 'https://www.wikidata.org/wiki/Q348260', 'display_name': 'Adalimumab', 'level': 3, 'score': 0.7583766}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.751391}, {'id': 'https://openalex.org/C2777138892', 'wikidata': 'https://www.wikidata.org/wiki/Q415264', 'display_name': 'Infliximab', 'level': 3, 'score': 0.69346565}, {'id': 'https://openalex.org/C2777575956', 'wikidata': 'https://www.wikidata.org/wiki/Q187255', 'display_name': 'Rheumatoid arthritis', 'level': 2, 'score': 0.6704757}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.6359096}, {'id': 'https://openalex.org/C2780564577', 'wikidata': 'https://www.wikidata.org/wiki/Q179945', 'display_name': 'Psoriasis', 'level': 2, 'score': 0.6187575}, {'id': 'https://openalex.org/C2776260265', 'wikidata': 'https://www.wikidata.org/wiki/Q511097', 'display_name': 'Psoriatic arthritis', 'level': 3, 'score': 0.55872416}, {'id': 'https://openalex.org/C164027704', 'wikidata': 'https://www.wikidata.org/wiki/Q3491837', 'display_name': 'Proinflammatory cytokine', 'level': 3, 'score': 0.53817767}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.5267063}, {'id': 'https://openalex.org/C2778260677', 'wikidata': 'https://www.wikidata.org/wiki/Q917447', 'display_name': 'Inflammatory bowel disease', 'level': 3, 'score': 0.4925216}, {'id': 'https://openalex.org/C2777077863', 'wikidata': 'https://www.wikidata.org/wiki/Q170990', 'display_name': 'Arthritis', 'level': 2, 'score': 0.47011462}, {'id': 'https://openalex.org/C2780130043', 'wikidata': 'https://www.wikidata.org/wiki/Q192360', 'display_name': 'Autoimmunity', 'level': 3, 'score': 0.4381064}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.2564612}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.2042709}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.16087094}], 'mesh': [{'descriptor_ui': 'D015551', 'descriptor_name': 'Autoimmunity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000079424', 'descriptor_name': 'Tumor Necrosis Factor Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000068879', 'descriptor_name': 'Adalimumab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000068800', 'descriptor_name': 'Etanercept', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000069285', 'descriptor_name': 'Infliximab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018124', 'descriptor_name': 'Receptors, Tumor Necrosis Factor', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D018124', 'descriptor_name': 'Receptors, Tumor Necrosis Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048069', 'descriptor_name': 'Tumor Necrosis Factors', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D048069', 'descriptor_name': 'Tumor Necrosis Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/978-0-387-89520-8_3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S43790123', 'display_name': 'Advances in experimental medicine and biology', 'issn_l': '0065-2598', 'issn': ['0065-2598', '2214-8019'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'book series'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19760065', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.73, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 163, 'referenced_works': ['https://openalex.org/W111447099', 'https://openalex.org/W1205185852', 'https://openalex.org/W122439204', 'https://openalex.org/W1271773534', 'https://openalex.org/W13260057', 'https://openalex.org/W132781887', 'https://openalex.org/W1512707729', 'https://openalex.org/W1534181850', 'https://openalex.org/W1534360145', 'https://openalex.org/W1578136312', 'https://openalex.org/W1581194495', 'https://openalex.org/W1585093254', 'https://openalex.org/W1593060795', 'https://openalex.org/W1616910822', 'https://openalex.org/W1637051416', 'https://openalex.org/W1645358757', 'https://openalex.org/W1657715719', 'https://openalex.org/W1658971169', 'https://openalex.org/W1763490035', 'https://openalex.org/W1765237838', 'https://openalex.org/W1784066454', 'https://openalex.org/W1828812390', 'https://openalex.org/W1852416791', 'https://openalex.org/W1897551156', 'https://openalex.org/W196227857', 'https://openalex.org/W1964162947', 'https://openalex.org/W1965616728', 'https://openalex.org/W1970208491', 'https://openalex.org/W1970336778', 'https://openalex.org/W1970718569', 'https://openalex.org/W1973893754', 'https://openalex.org/W1974759996', 'https://openalex.org/W1974956454', 'https://openalex.org/W1975161308', 'https://openalex.org/W1976007204', 'https://openalex.org/W1978174408', 'https://openalex.org/W1978350019', 'https://openalex.org/W1979595147', 'https://openalex.org/W1980773490', 'https://openalex.org/W1980901730', 'https://openalex.org/W1985763670', 'https://openalex.org/W1986098328', 'https://openalex.org/W1987738489', 'https://openalex.org/W1988417956', 'https://openalex.org/W1989483724', 'https://openalex.org/W1989783048', 'https://openalex.org/W1989923712', 'https://openalex.org/W1989925698', 'https://openalex.org/W1991868611', 'https://openalex.org/W1993735050', 'https://openalex.org/W1994665445', 'https://openalex.org/W1995625289', 'https://openalex.org/W1995935750', 'https://openalex.org/W1996486158', 'https://openalex.org/W1996794055', 'https://openalex.org/W1997794396', 'https://openalex.org/W1998073646', 'https://openalex.org/W1999246265', 'https://openalex.org/W1999981141', 'https://openalex.org/W2001872777', 'https://openalex.org/W2004212929', 'https://openalex.org/W2004465286', 'https://openalex.org/W2006831045', 'https://openalex.org/W2009160702', 'https://openalex.org/W2012766110', 'https://openalex.org/W2014850908', 'https://openalex.org/W2014965141', 'https://openalex.org/W2016537283', 'https://openalex.org/W2016652483', 'https://openalex.org/W2017443683', 'https://openalex.org/W2019641244', 'https://openalex.org/W2027454708', 'https://openalex.org/W2028547258', 'https://openalex.org/W2028910347', 'https://openalex.org/W2031327262', 'https://openalex.org/W2033634651', 'https://openalex.org/W2036614725', 'https://openalex.org/W2036974395', 'https://openalex.org/W2038243504', 'https://openalex.org/W2041466047', 'https://openalex.org/W2043548025', 'https://openalex.org/W2045248497', 'https://openalex.org/W2046628605', 'https://openalex.org/W2049927686', 'https://openalex.org/W2050828232', 'https://openalex.org/W2054696173', 'https://openalex.org/W2055278445', 'https://openalex.org/W2056191911', 'https://openalex.org/W2056864249', 'https://openalex.org/W2056958245', 'https://openalex.org/W2056994847', 'https://openalex.org/W2061600342', 'https://openalex.org/W2062333398', 'https://openalex.org/W2062395623', 'https://openalex.org/W2062773281', 'https://openalex.org/W2064320561', 'https://openalex.org/W2070324001', 'https://openalex.org/W2072037483', 'https://openalex.org/W2072380594', 'https://openalex.org/W2073299175', 'https://openalex.org/W2074438676', 'https://openalex.org/W2075300112', 'https://openalex.org/W2076816261', 'https://openalex.org/W2079190230', 'https://openalex.org/W2079641066', 'https://openalex.org/W2079863993', 'https://openalex.org/W2080147816', 'https://openalex.org/W2081367726', 'https://openalex.org/W2086860754', 'https://openalex.org/W20888715', 'https://openalex.org/W2090169008', 'https://openalex.org/W2090439142', 'https://openalex.org/W2091419870', 'https://openalex.org/W2094600008', 'https://openalex.org/W2095013915', 'https://openalex.org/W2099029129', 'https://openalex.org/W2099341150', 'https://openalex.org/W2100078626', 'https://openalex.org/W2101580628', 'https://openalex.org/W2103901688', 'https://openalex.org/W2107917306', 'https://openalex.org/W2114313100', 'https://openalex.org/W2115556861', 'https://openalex.org/W2116032799', 'https://openalex.org/W2117576131', 'https://openalex.org/W2120633856', 'https://openalex.org/W2122026176', 'https://openalex.org/W2123806340', 'https://openalex.org/W2124202816', 'https://openalex.org/W2124418207', 'https://openalex.org/W2128380182', 'https://openalex.org/W2131847864', 'https://openalex.org/W2135271960', 'https://openalex.org/W2142239033', 'https://openalex.org/W2144152742', 'https://openalex.org/W2144420811', 'https://openalex.org/W2146786154', 'https://openalex.org/W2149140447', 'https://openalex.org/W2149544286', 'https://openalex.org/W2151365647', 'https://openalex.org/W2153045866', 'https://openalex.org/W2156502755', 'https://openalex.org/W2160882187', 'https://openalex.org/W2162373011', 'https://openalex.org/W2162440323', 'https://openalex.org/W2163478957', 'https://openalex.org/W2179525903', 'https://openalex.org/W2261566293', 'https://openalex.org/W2312313151', 'https://openalex.org/W2340084730', 'https://openalex.org/W2347335228', 'https://openalex.org/W2360667186', 'https://openalex.org/W2399611407', 'https://openalex.org/W2409336032', 'https://openalex.org/W2410563927', 'https://openalex.org/W2411512892', 'https://openalex.org/W2411770471', 'https://openalex.org/W4233561050', 'https://openalex.org/W4249235470', 'https://openalex.org/W4292198229', 'https://openalex.org/W4313347663', 'https://openalex.org/W63864630', 'https://openalex.org/W68902017'], 'related_works': ['https://openalex.org/W3149869290', 'https://openalex.org/W2980843199', 'https://openalex.org/W2809810071', 'https://openalex.org/W2755604283', 'https://openalex.org/W2318799791', 'https://openalex.org/W2236197927', 'https://openalex.org/W2162495586', 'https://openalex.org/W2116752853', 'https://openalex.org/W2075153701', 'https://openalex.org/W1588288904'], 'abstract_inverted_index': {'Tumor': [0], 'necrosis': [1], 'factor-α': [2], '(TNF-α)': [3], 'was': [4], 'first': [5], 'isolated': [6], 'two': [7], 'decades': [8], 'ago': [9], 'as': [10, 101], 'a': [11, 72], 'macrophageproduced': [12], 'protein': [13], 'that': [14, 50, 145], 'can': [15, 167], 'effectively': [16], 'kill': [17], 'tumor': [18, 59], 'cells.': [19], 'TNF-α': [20, 51, 70, 144], 'is': [21, 31, 52, 178], 'also': [22], 'an': [23], 'essential': [24], 'component': [25], 'of': [26, 54, 75, 98, 143], 'the': [27, 55, 120], 'immune': [28, 42], 'system': [29], 'and': [30, 40, 64, 93, 108, 111, 126, 136, 149, 159, 171], 'required': [32], 'for': [33, 35, 41, 119], 'hematopoiesis,': [34], 'protection': [36], 'from': [37, 156], 'bacterial': [38], 'infection': [39], 'cell-mediated': [43], 'cytotoxicity.': [44], 'Extensive': [45], 'research,': [46], 'however,': [47, 131], 'has': [48], 'revealed': [49], 'one': [53], 'major': [56], 'players': [57], 'in': [58], 'initiation,': [60], 'proliferation,': [61], 'invasion,': [62], 'angiogenesis': [63], 'metastasis.': [65], 'The': [66], 'proinflammatory': [67], 'activities': [68], 'link': [69], 'with': [71], 'wide': [73], 'variety': [74], 'autoimmune': [76], 'diseases,': [77], 'including': [78], 'psoriasis,': [79], 'inflammatory': [80, 122], 'bowel': [81, 123], 'disease,': [82, 124], 'rheumatoid': [83, 127], 'arthritis,': [84], 'systemic': [85, 87], 'sclerosis,': [86, 91], 'lupus': [88], 'erythematosus,': [89], 'multiple': [90], 'diabetes': [92], 'ankylosing': [94], 'spondylitis.': [95], 'Systemic': [96], 'inhibitors': [97], 'TNF': [99, 106, 169, 172], 'such': [100], 'etanercept': [102], '(Enbrel)': [103], '(a': [104], 'soluble': [105], 'receptor)': [107], 'infliximab': [109], '(Remicade)': [110], 'adalimumab': [112], '(Humira)': [113], '(anti-TNF': [114], 'antibodies)': [115], 'have': [116, 163], 'been': [117, 164], 'approved': [118], 'treatment': [121], 'psoriasis': [125], 'arthritis.': [128], 'These': [129], 'drugs,': [130], 'exhibit': [132], 'severe': [133], 'side': [134], 'effects': [135], 'are': [137, 146, 151], 'expensive.': [138], 'Hence': [139], 'orally': [140], 'active': [141], 'blockers': [142], 'safe,': [147], 'efficacious': [148], 'inexpensive': [150], 'urgently': [152], 'needed.': [153], 'Numerous': [154], 'products': [155], 'fruits,': [157], 'vegetable': [158], 'traditional': [160], 'medicinal': [161], 'plants': [162], 'described': [165], 'which': [166], 'suppress': [168], 'expression': [170], 'signaling': [173], 'but': [174], 'their': [175], 'clinical': [176], 'potential': [177], 'yet': [179], 'uncertain.': [180]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W184388943', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2024-09-09T06:16:31.629179', 'created_date': '2016-06-24'}