Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1842002390', 'doi': 'https://doi.org/10.1111/j.1346-8138.2011.01483.x', 'title': 'Antimicrobial peptides in the pathogenesis of psoriasis', 'display_name': 'Antimicrobial peptides in the pathogenesis of psoriasis', 'publication_year': 2012, 'publication_date': '2012-02-21', 'ids': {'openalex': 'https://openalex.org/W1842002390', 'doi': 'https://doi.org/10.1111/j.1346-8138.2011.01483.x', 'mag': '1842002390', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22352846', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3527011'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1346-8138.2011.01483.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1346-8138.2011.01483.x', 'source': {'id': 'https://openalex.org/S143887118', 'display_name': 'The Journal of Dermatology', 'issn_l': '0385-2407', 'issn': ['0385-2407', '1346-8138'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1346-8138.2011.01483.x', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5037804730', 'display_name': 'Shin Morizane', 'orcid': 'https://orcid.org/0000-0003-1374-065X'}, 'institutions': [{'id': 'https://openalex.org/I163770644', 'display_name': 'Okayama University', 'ror': 'https://ror.org/02pc6pc55', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I163770644']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shin MORIZANE', 'raw_affiliation_strings': ['Department of Dermatology; Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences; Okayama Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology; Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences; Okayama Japan', 'institution_ids': ['https://openalex.org/I163770644']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5055585390', 'display_name': 'Richard L. Gallo', 'orcid': 'https://orcid.org/0000-0002-1401-7861'}, 'institutions': [{'id': 'https://openalex.org/I4210099595', 'display_name': 'VA San Diego Healthcare System', 'ror': 'https://ror.org/00znqwq11', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210099595', 'https://openalex.org/I4210138663']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard L. GALLO', 'raw_affiliation_strings': ['Division of Dermatology, Department of Medicine, University of California, and VA San Diego Healthcare System, San Diego, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Dermatology, Department of Medicine, University of California, and VA San Diego Healthcare System, San Diego, California, USA', 'institution_ids': ['https://openalex.org/I4210099595']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.363, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 206, 'citation_normalized_percentile': {'value': 0.703833, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '39', 'issue': '3', 'first_page': '225', 'last_page': '230'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11103', 'display_name': 'Antimicrobial Peptides and Activities', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11103', 'display_name': 'Antimicrobial Peptides and Activities', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 0.9932, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10371', 'display_name': 'Immune Response and Inflammation', 'score': 0.9883, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cathelicidin', 'display_name': 'Cathelicidin', 'score': 0.95304215}, {'id': 'https://openalex.org/keywords/pathogenesis', 'display_name': 'Pathogenesis', 'score': 0.62732846}], 'concepts': [{'id': 'https://openalex.org/C2777379352', 'wikidata': 'https://www.wikidata.org/wiki/Q24739493', 'display_name': 'Cathelicidin', 'level': 4, 'score': 0.95304215}, {'id': 'https://openalex.org/C540938839', 'wikidata': 'https://www.wikidata.org/wiki/Q1201508', 'display_name': 'Antimicrobial peptides', 'level': 3, 'score': 0.9169524}, {'id': 'https://openalex.org/C2780564577', 'wikidata': 'https://www.wikidata.org/wiki/Q179945', 'display_name': 'Psoriasis', 'level': 2, 'score': 0.8782738}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.6335548}, {'id': 'https://openalex.org/C2780942790', 'wikidata': 'https://www.wikidata.org/wiki/Q372016', 'display_name': 'Pathogenesis', 'level': 2, 'score': 0.62732846}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.57207876}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.52916074}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.48169598}, {'id': 'https://openalex.org/C4937899', 'wikidata': 'https://www.wikidata.org/wiki/Q68541106', 'display_name': 'Antimicrobial', 'level': 2, 'score': 0.40681916}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3218968}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.28973642}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.11022529}], 'mesh': [{'descriptor_ui': 'D054804', 'descriptor_name': 'Cathelicidins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D011565', 'descriptor_name': 'Psoriasis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023181', 'descriptor_name': 'Antimicrobial Cationic Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054804', 'descriptor_name': 'Cathelicidins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D054804', 'descriptor_name': 'Cathelicidins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002762', 'descriptor_name': 'Cholecalciferol', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D002762', 'descriptor_name': 'Cholecalciferol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002762', 'descriptor_name': 'Cholecalciferol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023082', 'descriptor_name': 'Defensins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D023082', 'descriptor_name': 'Defensins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D023082', 'descriptor_name': 'Defensins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011565', 'descriptor_name': 'Psoriasis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011565', 'descriptor_name': 'Psoriasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009418', 'descriptor_name': 'S100 Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009418', 'descriptor_name': 'S100 Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D009418', 'descriptor_name': 'S100 Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1346-8138.2011.01483.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1346-8138.2011.01483.x', 'source': {'id': 'https://openalex.org/S143887118', 'display_name': 'The Journal of Dermatology', 'issn_l': '0385-2407', 'issn': ['0385-2407', '1346-8138'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3527011', 'pdf_url': 'https://europepmc.org/articles/pmc3527011?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527011', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22352846', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1346-8138.2011.01483.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1346-8138.2011.01483.x', 'source': {'id': 'https://openalex.org/S143887118', 'display_name': 'The Journal of Dermatology', 'issn_l': '0385-2407', 'issn': ['0385-2407', '1346-8138'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.63}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 81, 'referenced_works': ['https://openalex.org/W1514540900', 'https://openalex.org/W1522866020', 'https://openalex.org/W1523788432', 'https://openalex.org/W1571292455', 'https://openalex.org/W1587261904', 'https://openalex.org/W1676840812', 'https://openalex.org/W1714831240', 'https://openalex.org/W1720483047', 'https://openalex.org/W1898779455', 'https://openalex.org/W1906440469', 'https://openalex.org/W1909667061', 'https://openalex.org/W1969824915', 'https://openalex.org/W1970189777', 'https://openalex.org/W1973049554', 'https://openalex.org/W1974905498', 'https://openalex.org/W1978194636', 'https://openalex.org/W1979258089', 'https://openalex.org/W1979962636', 'https://openalex.org/W1981525140', 'https://openalex.org/W1983280412', 'https://openalex.org/W1987287925', 'https://openalex.org/W1990576293', 'https://openalex.org/W1990903687', 'https://openalex.org/W1991765113', 'https://openalex.org/W2003164428', 'https://openalex.org/W2005032514', 'https://openalex.org/W2009067699', 'https://openalex.org/W2010757272', 'https://openalex.org/W2012077729', 'https://openalex.org/W2017434692', 'https://openalex.org/W2017987372', 'https://openalex.org/W2020799333', 'https://openalex.org/W2025374951', 'https://openalex.org/W2029331076', 'https://openalex.org/W2035053917', 'https://openalex.org/W2036765310', 'https://openalex.org/W2038279559', 'https://openalex.org/W2050207472', 'https://openalex.org/W2059683060', 'https://openalex.org/W2064512362', 'https://openalex.org/W2066723587', 'https://openalex.org/W2067520762', 'https://openalex.org/W2068886573', 'https://openalex.org/W2071343804', 'https://openalex.org/W2074062652', 'https://openalex.org/W2074753880', 'https://openalex.org/W2078967227', 'https://openalex.org/W2079260693', 'https://openalex.org/W2084951281', 'https://openalex.org/W2088391696', 'https://openalex.org/W2090042814', 'https://openalex.org/W2090306216', 'https://openalex.org/W2092663747', 'https://openalex.org/W2094029007', 'https://openalex.org/W2094036101', 'https://openalex.org/W2100446659', 'https://openalex.org/W2106449126', 'https://openalex.org/W2113810254', 'https://openalex.org/W2120886459', 'https://openalex.org/W2121580723', 'https://openalex.org/W2126162679', 'https://openalex.org/W2129946962', 'https://openalex.org/W2131493069', 'https://openalex.org/W2133657961', 'https://openalex.org/W2134617091', 'https://openalex.org/W2139008734', 'https://openalex.org/W2142461098', 'https://openalex.org/W2144974645', 'https://openalex.org/W2151566115', 'https://openalex.org/W2154379321', 'https://openalex.org/W2155379600', 'https://openalex.org/W2161214879', 'https://openalex.org/W2164880184', 'https://openalex.org/W2169758620', 'https://openalex.org/W2169759699', 'https://openalex.org/W2316692558', 'https://openalex.org/W2330865388', 'https://openalex.org/W2410493785', 'https://openalex.org/W2561759163', 'https://openalex.org/W4249483860', 'https://openalex.org/W932301977'], 'related_works': ['https://openalex.org/W3029902832', 'https://openalex.org/W2973941391', 'https://openalex.org/W2164030344', 'https://openalex.org/W2114983395', 'https://openalex.org/W1976106884', 'https://openalex.org/W1964758221', 'https://openalex.org/W1842002390', 'https://openalex.org/W1512191088', 'https://openalex.org/W1492295638', 'https://openalex.org/W1469662256'], 'abstract_inverted_index': {'One': [0], 'characteristic': [1], 'abnormality': [2], 'of': [3, 12, 64, 72, 110, 135, 141, 170], 'lesional': [4], 'skin': [5], 'in': [6, 34, 53, 58, 113, 156, 161], 'psoriasis': [7, 87, 111], 'is': [8], 'the': [9, 84, 130, 133, 142, 158, 168], 'excessive': [10], 'production': [11], 'antimicrobial': [13], 'peptides': [14, 45], 'and': [15, 28, 31, 42, 82, 88, 163], 'proteins': [16, 93], '(AMPs).': [17], 'AMPs': [18, 78, 116, 136, 155], 'typically': [19], 'are': [20, 32, 46, 61, 79, 146], 'small': [21], '(12-50': [22], 'amino': [23], 'acids),': [24], 'have': [25, 94], 'positive': [26], 'charge': [27], 'amphipathic': [29], 'structure,': [30], 'found': [33], 'all': [35], 'living': [36], 'organisms': [37], 'including': [38], 'mammals,': [39], 'insects,': [40], 'plants': [41], 'invertebrates.': [43], 'These': [44], 'best': [47], 'known': [48], 'for': [49, 154], 'their': [50], 'integral': [51], 'role': [52, 153], 'killing': [54], 'pathogenic': [55], 'microorganisms;': [56], 'however,': [57], 'vertebrates,': [59], 'they': [60], 'also': [62, 128], 'capable': [63], 'modifying': [65], 'host': [66], 'inflammatory': [67], 'responses': [68], 'by': [69], 'a': [70, 100, 108, 150], 'variety': [71], 'mechanisms.': [73], 'In': [74], 'psoriatic': [75, 122], 'lesions,': [76], 'many': [77], 'highly': [80], 'expressed,': [81], 'especially': [83], 'associations': [85], 'between': [86], 'cathelicidin,': [89], 'β-defensins': [90], 'or': [91], 'S100': [92], 'been': [95, 105, 118], 'well': [96], 'studied.': [97], 'Among': [98], 'them,': [99], 'cathelicidin': [101], 'peptide,': [102], 'LL-37,': [103], 'has': [104, 127], 'highlighted': [106], 'as': [107], 'modulator': [109], 'development': [112], 'recent': [114, 125], 'years.': [115], 'had': [117], 'thought': [119], 'to': [120, 148, 164], 'worsen': [121], 'lesions': [123], 'but': [124], 'evidence': [126], 'suggested': [129], 'possibility': [131], 'that': [132], 'induction': [134], 'expression': [137], 'might': [138], 'improve': [139, 165], 'aspects': [140], 'disease.': [143], 'Further': [144], 'investigations': [145], 'needed': [147], 'uncover': [149], 'previously': [151], 'underappreciated': [152], 'modulating': [157], 'immune': [159], 'response': [160], 'psoriasis,': [162], 'disease': [166], 'without': [167], 'risks': [169], 'systemic': [171], 'immunosuppressive': [172], 'approaches.': [173]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1842002390', 'counts_by_year': [{'year': 2024, 'cited_by_count': 16}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 23}, {'year': 2021, 'cited_by_count': 27}, {'year': 2020, 'cited_by_count': 24}, {'year': 2019, 'cited_by_count': 18}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 16}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 19}, {'year': 2013, 'cited_by_count': 9}], 'updated_date': '2025-01-01T19:36:50.095201', 'created_date': '2016-06-24'}