Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1841037392', 'doi': 'https://doi.org/10.1016/j.bbamcr.2015.07.018', 'title': "In situ Fourier transform infrared analysis of live cells' response to doxorubicin", 'display_name': "In situ Fourier transform infrared analysis of live cells' response to doxorubicin", 'publication_year': 2015, 'publication_date': '2015-07-29', 'ids': {'openalex': 'https://openalex.org/W1841037392', 'doi': 'https://doi.org/10.1016/j.bbamcr.2015.07.018', 'mag': '1841037392', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26231933'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.bbamcr.2015.07.018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210226410', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Molecular Cell Research', 'issn_l': '0167-4889', 'issn': ['0167-4889', '1879-2596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.bbamcr.2015.07.018', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089693172', 'display_name': 'Pedro L. Falé', 'orcid': 'https://orcid.org/0000-0002-4644-7655'}, 'institutions': [{'id': 'https://openalex.org/I183935753', 'display_name': "King's College London", 'ror': 'https://ror.org/0220mzb33', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I183935753']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Pedro L. Fale', 'raw_affiliation_strings': ["Institute of Pharmaceutical Science, King's College London, SE1 9NH, UK"], 'affiliations': [{'raw_affiliation_string': "Institute of Pharmaceutical Science, King's College London, SE1 9NH, UK", 'institution_ids': ['https://openalex.org/I183935753']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038085552', 'display_name': 'Ali Altharawi', 'orcid': 'https://orcid.org/0000-0002-6491-6611'}, 'institutions': [{'id': 'https://openalex.org/I183935753', 'display_name': "King's College London", 'ror': 'https://ror.org/0220mzb33', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I183935753']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ali Altharawi', 'raw_affiliation_strings': ["Institute of Pharmaceutical Science, King's College London, SE1 9NH, UK"], 'affiliations': [{'raw_affiliation_string': "Institute of Pharmaceutical Science, King's College London, SE1 9NH, UK", 'institution_ids': ['https://openalex.org/I183935753']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067760811', 'display_name': 'K. L. Andrew Chan', 'orcid': 'https://orcid.org/0000-0002-1137-4599'}, 'institutions': [{'id': 'https://openalex.org/I183935753', 'display_name': "King's College London", 'ror': 'https://ror.org/0220mzb33', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I183935753']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'K.L. Andrew Chan', 'raw_affiliation_strings': ["Institute of Pharmaceutical Science, King's College London, SE1 9NH, UK"], 'affiliations': [{'raw_affiliation_string': "Institute of Pharmaceutical Science, King's College London, SE1 9NH, UK", 'institution_ids': ['https://openalex.org/I183935753']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3380, 'currency': 'USD', 'value_usd': 3380, 'provenance': 'doaj'}, 'apc_paid': {'value': 3227, 'currency': 'EUR', 'value_usd': 3480, 'provenance': 'openapc'}, 'fwci': 1.863, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 55, 'citation_normalized_percentile': {'value': 0.999584, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '1853', 'issue': '10', 'first_page': '2640', 'last_page': '2648'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11324', 'display_name': 'Spectroscopy Techniques in Biomedical and Chemical Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1304', 'display_name': 'Biophysics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11324', 'display_name': 'Spectroscopy Techniques in Biomedical and Chemical Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1304', 'display_name': 'Biophysics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10640', 'display_name': 'Spectroscopy and Chemometric Analyses', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1602', 'display_name': 'Analytical Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T13539', 'display_name': 'thermodynamics and calorimetric analyses', 'score': 0.9721, 'subfield': {'id': 'https://openalex.org/subfields/1606', 'display_name': 'Physical and Theoretical Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hela', 'display_name': 'HeLa', 'score': 0.7135456}, {'id': 'https://openalex.org/keywords/attenuated-total-reflection', 'display_name': 'Attenuated total reflection', 'score': 0.42165184}], 'concepts': [{'id': 'https://openalex.org/C2781303535', 'wikidata': 'https://www.wikidata.org/wiki/Q18936', 'display_name': 'Doxorubicin', 'level': 3, 'score': 0.76138186}, {'id': 'https://openalex.org/C2777366897', 'wikidata': 'https://www.wikidata.org/wiki/Q847482', 'display_name': 'HeLa', 'level': 3, 'score': 0.7135456}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.6042594}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.4768154}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.46572608}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46127722}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.43084598}, {'id': 'https://openalex.org/C49102809', 'wikidata': 'https://www.wikidata.org/wiki/Q300035', 'display_name': 'Attenuated total reflection', 'level': 3, 'score': 0.42165184}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.39739317}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.34593147}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29505908}, {'id': 'https://openalex.org/C153642686', 'wikidata': 'https://www.wikidata.org/wiki/Q70906', 'display_name': 'Infrared spectroscopy', 'level': 2, 'score': 0.2577722}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2372855}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.07834718}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000903', 'descriptor_name': 'Antibiotics, Antineoplastic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000903', 'descriptor_name': 'Antibiotics, Antineoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018938', 'descriptor_name': 'Caco-2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017550', 'descriptor_name': 'Spectroscopy, Fourier Transform Infrared', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.bbamcr.2015.07.018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210226410', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Molecular Cell Research', 'issn_l': '0167-4889', 'issn': ['0167-4889', '1879-2596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26231933', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.bbamcr.2015.07.018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210226410', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Molecular Cell Research', 'issn_l': '0167-4889', 'issn': ['0167-4889', '1879-2596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.74, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 49, 'referenced_works': ['https://openalex.org/W1555873096', 'https://openalex.org/W195624623', 'https://openalex.org/W1966231888', 'https://openalex.org/W1969190266', 'https://openalex.org/W1978752676', 'https://openalex.org/W1983763758', 'https://openalex.org/W1988806072', 'https://openalex.org/W1989661168', 'https://openalex.org/W1992157385', 'https://openalex.org/W1994455753', 'https://openalex.org/W1997521244', 'https://openalex.org/W1998569977', 'https://openalex.org/W2000905486', 'https://openalex.org/W2000936809', 'https://openalex.org/W2001759342', 'https://openalex.org/W2005526537', 'https://openalex.org/W2010891854', 'https://openalex.org/W2011055829', 'https://openalex.org/W2011480306', 'https://openalex.org/W2013016134', 'https://openalex.org/W2015707434', 'https://openalex.org/W2016342028', 'https://openalex.org/W2022620844', 'https://openalex.org/W2037540104', 'https://openalex.org/W2038774948', 'https://openalex.org/W2047021635', 'https://openalex.org/W2047325480', 'https://openalex.org/W2055683699', 'https://openalex.org/W2064359917', 'https://openalex.org/W2065055290', 'https://openalex.org/W2070884546', 'https://openalex.org/W2071620654', 'https://openalex.org/W2075173321', 'https://openalex.org/W2075747125', 'https://openalex.org/W2080030546', 'https://openalex.org/W2082646095', 'https://openalex.org/W2105817351', 'https://openalex.org/W2114886598', 'https://openalex.org/W2114918609', 'https://openalex.org/W2123077206', 'https://openalex.org/W2123879929', 'https://openalex.org/W2125938961', 'https://openalex.org/W2130055497', 'https://openalex.org/W2153808980', 'https://openalex.org/W2169615419', 'https://openalex.org/W2169909600', 'https://openalex.org/W2171664179', 'https://openalex.org/W2258757901', 'https://openalex.org/W33580557'], 'related_works': ['https://openalex.org/W3203146466', 'https://openalex.org/W2898604066', 'https://openalex.org/W2414906240', 'https://openalex.org/W2374053201', 'https://openalex.org/W2373307992', 'https://openalex.org/W2363151046', 'https://openalex.org/W2357943637', 'https://openalex.org/W2355183202', 'https://openalex.org/W2319590788', 'https://openalex.org/W1989845301'], 'abstract_inverted_index': {'The': [0, 162], 'study': [1], 'of': [2, 5, 12, 19, 25, 30, 58, 80, 116, 121, 131, 204, 206, 212, 214, 239], 'the': [3, 17, 28, 45, 56, 78, 83, 112, 122, 132, 152, 171, 176, 202, 207, 210, 215], 'response': [4], 'cancer': [6, 26, 33, 61], 'cells': [7, 96, 123, 178], 'to': [8, 16, 22, 35, 41, 54, 63, 73, 82, 149, 160, 184, 201, 218, 250], 'chemotherapy': [9, 36, 84], 'drugs': [10, 21], 'is': [11, 221], 'high': [13], 'importance': [14], 'due': [15], 'specificity': [18], 'some': [20, 31], 'certain': [23], 'types': [24, 34], 'and': [27, 43, 47, 72, 94, 99, 119, 165, 190, 209, 235], 'resistance': [29, 81, 159, 213], 'specific': [32], 'drugs.': [37], 'Our': [38], 'aim': [39], 'was': [40, 109, 135], 'develop': [42], 'apply': [44], 'label-free': [46], 'non-destructive': [48, 234], 'Fourier': [49], 'transform': [50], 'infrared': [51], '(FTIR)': [52], 'method': [53, 224], 'determine': [55, 150], 'sensitivity': [57], 'three': [59, 153], 'different': [60, 70, 158], 'cell-lines': [62], 'a': [64, 222], 'common': [65], 'anti-cancer': [66], 'drug': [67, 85, 208], 'doxorubicin': [68, 108], 'at': [69, 111], 'concentrations': [71], 'demonstrate': [74], 'that': [75, 151, 197, 225], 'information': [76], 'about': [77], 'mechanism': [79, 211], 'can': [86], 'be': [87, 199], 'extracted': [88], 'from': [89], 'spectral': [90], 'data.': [91], 'HeLa,': [92], 'PC3,': [93], 'Caco-2': [95], 'were': [97, 124], 'seeded': [98], 'grown': [100], 'on': [101], 'an': [102], 'attenuated': [103], 'total': [104], 'reflection': [105], '(ATR)': [106], 'crystal,': [107], 'applied': [110], 'clinically': [113], 'significant': [114], 'concentration': [115], '0.1-20': [117], 'μM,': [118], 'spectra': [120, 164], 'collected': [125], 'hourly': [126], 'over': [127], '20': [128], 'h.': [129], 'Analysis': [130], 'amide': [133], 'bands': [134], 'correlated': [136], 'with': [137, 145], 'cell': [138, 154, 216], 'viability,': [139], 'which': [140], 'had': [141, 156], 'been': [142], 'cross': [143], 'validated': [144], 'MTT': [146], 'assays,': [147], 'allowing': [148], 'lines': [155, 217], 'significantly': [157], 'doxorubicin.': [161, 219], 'difference': [163], 'principal': [166], 'component': [167], 'analysis': [168, 238], '(PCA)': [169], 'highlighted': [170], 'subtle': [172], 'chemical': [173, 240], 'changes': [174, 196, 241], 'in': [175, 236, 242], 'living': [177], 'under': [179], 'treatment.': [180], 'Spectral': [181], 'regions': [182], 'assigned': [183], 'nucleic': [185], 'acids': [186], '(mainly': [187, 192], '1085': [188], 'cm(-1))': [189, 194], 'carbohydrates': [191], '1024': [193], 'showed': [195], 'could': [198], 'related': [200], 'mode': [203], 'action': [205], 'This': [220], 'cost-effective': [223], 'does': [226], 'not': [227], 'require': [228], 'bioassay': [229], 'reagents': [230], 'but': [231], 'allows': [232], 'label-free,': [233], 'situ': [237], 'live': [243], 'cells,': [244], 'using': [245], 'standard': [246], 'FTIR': [247], 'equipment': [248], 'adapted': [249], 'ATR': [251], 'measurements.': [252]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1841037392', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2024-12-17T12:14:04.853586', 'created_date': '2016-06-24'}