Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1809990660', 'doi': 'https://doi.org/10.18632/oncotarget.2942', 'title': 'γ-H2AX promotes hepatocellular carcinoma angiogenesis via EGFR/HIF-1α/VEGF pathways under hypoxic condition', 'display_name': 'γ-H2AX promotes hepatocellular carcinoma angiogenesis via EGFR/HIF-1α/VEGF pathways under hypoxic condition', 'publication_year': 2014, 'publication_date': '2014-12-10', 'ids': {'openalex': 'https://openalex.org/W1809990660', 'doi': 'https://doi.org/10.18632/oncotarget.2942', 'mag': '1809990660', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25537504', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4385844'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2942', 'pdf_url': 'https://www.oncotarget.com/article/2942/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/2942/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101982803', 'display_name': 'Heng Xiao', 'orcid': 'https://orcid.org/0000-0002-8384-4027'}, 'institutions': [{'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Heng Xiao', 'raw_affiliation_strings': ['Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, HangZhou, China', 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, HangZhou, China', 'institution_ids': ['https://openalex.org/I76130692']}, {'raw_affiliation_string': 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033800422', 'display_name': 'Rongliang Tong', 'orcid': 'https://orcid.org/0000-0002-4364-7950'}, 'institutions': [{'id': 'https://openalex.org/I4210166576', 'display_name': 'First Affiliated Hospital Zhejiang University', 'ror': 'https://ror.org/05m1p5x56', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166576']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Rongliang Tong', 'raw_affiliation_strings': ['Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'institution_ids': ['https://openalex.org/I4210166576']}, {'raw_affiliation_string': 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004737802', 'display_name': 'Chaofeng Ding', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210166576', 'display_name': 'First Affiliated Hospital Zhejiang University', 'ror': 'https://ror.org/05m1p5x56', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166576']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chaofeng Ding', 'raw_affiliation_strings': ['Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'institution_ids': ['https://openalex.org/I4210166576']}, {'raw_affiliation_string': 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113226556', 'display_name': 'Zhen Lv', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210166576', 'display_name': 'First Affiliated Hospital Zhejiang University', 'ror': 'https://ror.org/05m1p5x56', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166576']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhen Lv', 'raw_affiliation_strings': ['Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'institution_ids': ['https://openalex.org/I4210166576']}, {'raw_affiliation_string': 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019164166', 'display_name': 'Chengli Du', 'orcid': 'https://orcid.org/0000-0002-0128-9606'}, 'institutions': [{'id': 'https://openalex.org/I4210166576', 'display_name': 'First Affiliated Hospital Zhejiang University', 'ror': 'https://ror.org/05m1p5x56', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166576']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chengli Du', 'raw_affiliation_strings': ['Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'institution_ids': ['https://openalex.org/I4210166576']}, {'raw_affiliation_string': 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091904857', 'display_name': 'Chuanhui Peng', 'orcid': 'https://orcid.org/0000-0002-0800-1417'}, 'institutions': [{'id': 'https://openalex.org/I4210166576', 'display_name': 'First Affiliated Hospital Zhejiang University', 'ror': 'https://ror.org/05m1p5x56', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166576']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chuanhui Peng', 'raw_affiliation_strings': ['Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'institution_ids': ['https://openalex.org/I4210166576']}, {'raw_affiliation_string': 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101670837', 'display_name': 'Shaobing Cheng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210166576', 'display_name': 'First Affiliated Hospital Zhejiang University', 'ror': 'https://ror.org/05m1p5x56', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166576']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shaobing Cheng', 'raw_affiliation_strings': ['Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'institution_ids': ['https://openalex.org/I4210166576']}, {'raw_affiliation_string': 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100405593', 'display_name': 'Haiyang Xie', 'orcid': 'https://orcid.org/0000-0002-6913-9284'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Haiyang Xie', 'raw_affiliation_strings': ['Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100776835', 'display_name': 'Lin Zhou', 'orcid': 'https://orcid.org/0000-0001-5884-9961'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lin Zhou', 'raw_affiliation_strings': ['Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China.'], 'affiliations': [{'raw_affiliation_string': 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029600413', 'display_name': 'Jian Wu', 'orcid': 'https://orcid.org/0000-0002-6325-0766'}, 'institutions': [{'id': 'https://openalex.org/I4210166576', 'display_name': 'First Affiliated Hospital Zhejiang University', 'ror': 'https://ror.org/05m1p5x56', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166576']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jian Wu', 'raw_affiliation_strings': ['Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China', 'institution_ids': []}, {'raw_affiliation_string': 'Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'institution_ids': ['https://openalex.org/I4210166576']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100654810', 'display_name': 'Shusen Zheng', 'orcid': 'https://orcid.org/0000-0003-1459-8261'}, 'institutions': [{'id': 'https://openalex.org/I4210166576', 'display_name': 'First Affiliated Hospital Zhejiang University', 'ror': 'https://ror.org/05m1p5x56', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166576']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shusen Zheng', 'raw_affiliation_strings': ['Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.', 'institution_ids': ['https://openalex.org/I4210166576']}, {'raw_affiliation_string': 'Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.375, 'has_fulltext': False, 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.864275, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '6', 'issue': '4', 'first_page': '2180', 'last_page': '2192'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hypoxia', 'display_name': 'Hypoxia', 'score': 0.6430097}, {'id': 'https://openalex.org/keywords/hypoxia-inducible-factors', 'display_name': 'Hypoxia-Inducible Factors', 'score': 0.42642912}, {'id': 'https://openalex.org/keywords/hif1a', 'display_name': 'HIF1A', 'score': 0.42552504}], 'concepts': [{'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.8109999}, {'id': 'https://openalex.org/C2778019345', 'wikidata': 'https://www.wikidata.org/wiki/Q1148337', 'display_name': 'Hepatocellular carcinoma', 'level': 2, 'score': 0.7954024}, {'id': 'https://openalex.org/C167734588', 'wikidata': 'https://www.wikidata.org/wiki/Q4356503', 'display_name': 'VEGF receptors', 'level': 2, 'score': 0.6500185}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6498935}, {'id': 'https://openalex.org/C7836513', 'wikidata': 'https://www.wikidata.org/wiki/Q1641506', 'display_name': 'Hypoxia (environmental)', 'level': 3, 'score': 0.6430097}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6076659}, {'id': 'https://openalex.org/C2777546739', 'wikidata': 'https://www.wikidata.org/wiki/Q33525', 'display_name': 'Carcinoma', 'level': 2, 'score': 0.47975978}, {'id': 'https://openalex.org/C146285616', 'wikidata': 'https://www.wikidata.org/wiki/Q7916455', 'display_name': 'Vascular endothelial growth factor A', 'level': 4, 'score': 0.42843378}, {'id': 'https://openalex.org/C160450060', 'wikidata': 'https://www.wikidata.org/wiki/Q104598479', 'display_name': 'Hypoxia-inducible factors', 'level': 3, 'score': 0.42642912}, {'id': 'https://openalex.org/C31194975', 'wikidata': 'https://www.wikidata.org/wiki/Q20970095', 'display_name': 'HIF1A', 'level': 3, 'score': 0.42552504}, {'id': 'https://openalex.org/C2778271429', 'wikidata': 'https://www.wikidata.org/wiki/Q1281049', 'display_name': 'Neovascularization', 'level': 3, 'score': 0.42438474}, {'id': 'https://openalex.org/C2777025900', 'wikidata': 'https://www.wikidata.org/wiki/Q29725', 'display_name': 'Vascular endothelial growth factor', 'level': 3, 'score': 0.37118787}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.34652337}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.3014207}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22821346}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.1483042}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0656313}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C540031477', 'wikidata': 'https://www.wikidata.org/wiki/Q629', 'display_name': 'Oxygen', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051795', 'descriptor_name': 'Hypoxia-Inducible Factor 1, alpha Subunit', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000098', 'qualifier_name': 'blood supply', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015687', 'descriptor_name': 'Cell Hypoxia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056945', 'descriptor_name': 'Hep G2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051795', 'descriptor_name': 'Hypoxia-Inducible Factor 1, alpha Subunit', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051795', 'descriptor_name': 'Hypoxia-Inducible Factor 1, alpha Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053208', 'descriptor_name': 'Kaplan-Meier Estimate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000098', 'qualifier_name': 'blood supply', 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016031', 'descriptor_name': 'Liver Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016513', 'descriptor_name': 'Mice, SCID', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018613', 'descriptor_name': 'Microscopy, Confocal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059467', 'descriptor_name': 'Transcriptome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014183', 'descriptor_name': 'Transplantation, Heterologous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2942', 'pdf_url': 'https://www.oncotarget.com/article/2942/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4385844', 'pdf_url': 'https://europepmc.org/articles/pmc4385844?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385844', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25537504', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.2942', 'pdf_url': 'https://www.oncotarget.com/article/2942/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.71}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1859756055', 'https://openalex.org/W1968366677', 'https://openalex.org/W1971095820', 'https://openalex.org/W1977517636', 'https://openalex.org/W1977798765', 'https://openalex.org/W1979898371', 'https://openalex.org/W1984795881', 'https://openalex.org/W1987662957', 'https://openalex.org/W1994649209', 'https://openalex.org/W1997192714', 'https://openalex.org/W1997796798', 'https://openalex.org/W2000088760', 'https://openalex.org/W2009127419', 'https://openalex.org/W2012834220', 'https://openalex.org/W2016440796', 'https://openalex.org/W2022109171', 'https://openalex.org/W2037373653', 'https://openalex.org/W2044151404', 'https://openalex.org/W2052181005', 'https://openalex.org/W2056731507', 'https://openalex.org/W2064434163', 'https://openalex.org/W2064760132', 'https://openalex.org/W2065666952', 'https://openalex.org/W2066062780', 'https://openalex.org/W2074849180', 'https://openalex.org/W2079986242', 'https://openalex.org/W2084650284', 'https://openalex.org/W2090296094', 'https://openalex.org/W2106787323', 'https://openalex.org/W2116443070', 'https://openalex.org/W2128680272', 'https://openalex.org/W2141173616', 'https://openalex.org/W2144026946', 'https://openalex.org/W2148346100', 'https://openalex.org/W2151411596', 'https://openalex.org/W2168041959', 'https://openalex.org/W2170948814', 'https://openalex.org/W3143765497', 'https://openalex.org/W4238328529'], 'related_works': ['https://openalex.org/W4251360078', 'https://openalex.org/W4247038846', 'https://openalex.org/W4245725519', 'https://openalex.org/W4241716718', 'https://openalex.org/W4233046059', 'https://openalex.org/W4232585526', 'https://openalex.org/W2942378958', 'https://openalex.org/W2160394750', 'https://openalex.org/W2130070461', 'https://openalex.org/W1894268419'], 'abstract_inverted_index': {'//': [0, 89, 93], 'Heng': [1], 'Xiao': [2], '1,2,*': [3, 7], ',': [4, 8, 12, 16, 20, 24, 28, 32, 36], 'Rongliang': [5], 'Tong': [6], 'Chaofeng': [9], 'Ding': [10], '1,2': [11, 15, 19, 23, 27, 39, 43], 'Zhen': [13], 'Lv': [14], 'Chengli': [17], 'Du': [18], 'Chuanhui': [21], 'Peng': [22], 'Shaobing': [25], 'Cheng': [26], 'Haiyang': [29], 'Xie': [30], '2': [31, 35, 64], 'Lin': [33], 'Zhou': [34], 'Jian': [37, 86], 'Wu': [38], 'and': [40, 48, 159, 198, 217, 219, 247, 268, 286], 'Shusen': [41, 90], 'Zheng': [42], '1': [44], 'Division': [45], 'of': [46, 52, 60, 67, 72, 137, 171, 178, 221, 228, 234, 266, 273, 282], 'Hepatobiliary': [47], 'Pancreatic': [49], 'Surgery,': [50, 53], 'Department': [51], 'First': [54], 'Affiliated': [55], 'Hospital,': [56], 'Zhejiang': [57], 'University': [58], 'School': [59], 'Medicine,': [61], 'Hangzhou,': [62, 75], 'China': [63, 76], 'Key': [65], 'Lab': [66], 'Combined': [68, 244], 'Multi-Organ': [69], 'Transplantation,': [70], 'Ministry': [71], 'Public': [73], 'Health,': [74], '*': [77], 'These': [78], 'authors': [79], 'contributed': [80], 'equally': [81], 'to': [82, 210], 'this': [83], 'work': [84], 'Correspondence:': [85], 'Wu,': [87], 'email:': [88, 92], 'Zheng,': [91], 'Keywords': [94], ':': [95, 117, 122, 127], 'hepatocellular': [96], 'carcinoma': [97, 133], '(HCC),': [98], 'γ-H2AX,': [99, 245], 'angiogenesis,': [100], 'vascular': [101, 194], 'endothelial': [102], 'growth': [103, 108], 'factor': [104, 109, 113], '(': [105], 'VEGF),': [106], 'epidermal': [107], 'receptor(EGFR),': [110], 'hypoxia': [111], 'inducible': [112], '1α': [114], '(HIF-1α)': [115], 'Received': [116], 'August': [118], '23,': [119], '2014': [120, 125, 130], 'Accepted': [121], 'December': [123, 128], '09,': [124], 'Published': [126], '10,': [129], 'Abstract': [131], 'Hepatocellular': [132], '(HCC)': [134], 'is': [135, 155, 189, 262, 275], 'one': [136], 'the': [138, 168, 176, 231, 280], 'most': [139], 'deadly': [140], 'cancers.': [141], 'Using': [142], 'mRNA': [143], 'microarray': [144], 'analysis,': [145], 'we': [146], 'found': [147], 'that': [148, 162, 183, 260], 'H2AX': [149, 164], 'decreased': [150], 'under': [151, 241], 'hypoxic': [152, 242], 'conditions.': [153, 243], 'Hypoxia': [154], 'an': [156], 'important': [157], 'physiological': [158], 'pathological': [160], 'stress': [161], 'induces': [163], 'phosphorylation': [165], '(γ-H2AX),': [166], 'but': [167], 'regulatory': [169], 'mechanism': [170, 227], 'γ-H2AX': [172, 185, 206, 229, 261, 269], 'remains': [173], 'elusive': [174], 'in': [175, 187, 215, 223, 279], 'progress': [177], 'HCC.': [179], 'We': [180], 'report': [181], 'here': [182], 'increased': [184], 'expression': [186, 214], 'HCC': [188, 222, 235, 254, 267, 283], 'associated': [190, 263], 'with': [191, 264], 'tumor': [192], 'size,': [193], 'invasion,': [195], 'TNM': [196], 'stage': [197], 'reduced': [199], 'survival': [200], 'rate': [201], 'after': [202, 255, 284], 'liver': [203], 'transplantation': [204], '(LT).': [205], 'knockdown': [207], 'was': [208], 'able': [209], 'effectively': [211], 'inhibit': [212], 'VEGF': [213], 'vitro': [216], 'tumorigenicity': [218], 'angiogenesis': [220, 265], 'vivo': [224], '.': [225], 'The': [226], 'on': [230], 'angiogenic': [232], 'activity': [233], 'might': [236], 'go': [237], 'through': [238], 'EGFR/HIF-1α/VEGF': [239], 'pathways': [240], 'HIF-1α': [246], 'EGFR': [248], 'has': [249], 'better': [250], 'prognostic': [251], 'value': [252], 'for': [253], 'LT.': [256], 'This': [257], 'study': [258], 'suggests': [259], 'or': [270], 'a': [271, 276, 287], 'combination': [272], 'γ-H2AX/EGFR/HIF-1α': [274], 'novel': [277], 'marker': [278], 'prognosis': [281], 'LT': [285], 'potential': [288], 'therapeutic': [289], 'target.': [290]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1809990660', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2024-12-24T16:21:38.526673', 'created_date': '2016-06-24'}