Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2160394750', 'doi': 'https://doi.org/10.1093/molehr/gan040', 'title': 'HCG up-regulates hypoxia inducible factor-1 alpha in luteinized granulosa cells: implications for the hormonal regulation of vascular endothelial growth factor A in the human corpus luteum', 'display_name': 'HCG up-regulates hypoxia inducible factor-1 alpha in luteinized granulosa cells: implications for the hormonal regulation of vascular endothelial growth factor A in the human corpus luteum', 'publication_year': 2008, 'publication_date': '2008-06-30', 'ids': {'openalex': 'https://openalex.org/W2160394750', 'doi': 'https://doi.org/10.1093/molehr/gan040', 'mag': '2160394750', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18591213'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/molehr/gan040', 'pdf_url': 'https://academic.oup.com/molehr/article-pdf/14/8/455/6204648/gan040.pdf', 'source': {'id': 'https://openalex.org/S4210190516', 'display_name': 'Molecular Human Reproduction', 'issn_l': '1360-9947', 'issn': ['1360-9947', '1460-2407'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/molehr/article-pdf/14/8/455/6204648/gan040.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051684442', 'display_name': 'Sander van den Driesche', 'orcid': 'https://orcid.org/0000-0002-8092-6588'}, 'institutions': [{'id': 'https://openalex.org/I4210116174', 'display_name': 'MRC Centre for Reproductive Health', 'ror': 'https://ror.org/02f4tsf92', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I4210116174', 'https://openalex.org/I90344618', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I4210164624', 'display_name': "The Queen's Medical Research Institute", 'ror': 'https://ror.org/059zxg644', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210164624', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'S. van den Driesche', 'raw_affiliation_strings': ["Obstetrics and Gynaecology, Department of Reproductive and Developmental Sciences, The Queen's Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK", "Present address: MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK"], 'affiliations': [{'raw_affiliation_string': "Present address: MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK", 'institution_ids': ['https://openalex.org/I4210116174', 'https://openalex.org/I4210164624']}, {'raw_affiliation_string': "Obstetrics and Gynaecology, Department of Reproductive and Developmental Sciences, The Queen's Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK", 'institution_ids': ['https://openalex.org/I4210116174', 'https://openalex.org/I4210164624', 'https://openalex.org/I98677209']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052153931', 'display_name': 'Michelle Myers', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210164624', 'display_name': "The Queen's Medical Research Institute", 'ror': 'https://ror.org/059zxg644', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210164624', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I4210116174', 'display_name': 'MRC Centre for Reproductive Health', 'ror': 'https://ror.org/02f4tsf92', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I4210116174', 'https://openalex.org/I90344618', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'M. Myers', 'raw_affiliation_strings': ["Obstetrics and Gynaecology, Department of Reproductive and Developmental Sciences, The Queen's Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK", 'Present address: Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, UK'], 'affiliations': [{'raw_affiliation_string': "Obstetrics and Gynaecology, Department of Reproductive and Developmental Sciences, The Queen's Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK", 'institution_ids': ['https://openalex.org/I4210164624', 'https://openalex.org/I98677209', 'https://openalex.org/I4210116174']}, {'raw_affiliation_string': 'Present address: Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, UK', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039311787', 'display_name': 'Eva Gay', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210116174', 'display_name': 'MRC Centre for Reproductive Health', 'ror': 'https://ror.org/02f4tsf92', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I4210116174', 'https://openalex.org/I90344618', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I4210164624', 'display_name': "The Queen's Medical Research Institute", 'ror': 'https://ror.org/059zxg644', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210164624', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'E. Gay', 'raw_affiliation_strings': ["Obstetrics and Gynaecology, Department of Reproductive and Developmental Sciences, The Queen's Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK"], 'affiliations': [{'raw_affiliation_string': "Obstetrics and Gynaecology, Department of Reproductive and Developmental Sciences, The Queen's Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK", 'institution_ids': ['https://openalex.org/I4210116174', 'https://openalex.org/I4210164624', 'https://openalex.org/I98677209']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022777994', 'display_name': 'K.J. Thong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210116174', 'display_name': 'MRC Centre for Reproductive Health', 'ror': 'https://ror.org/02f4tsf92', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I4210116174', 'https://openalex.org/I90344618', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I4210164624', 'display_name': "The Queen's Medical Research Institute", 'ror': 'https://ror.org/059zxg644', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210164624', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'K. J. Thong', 'raw_affiliation_strings': ["Obstetrics and Gynaecology, Department of Reproductive and Developmental Sciences, The Queen's Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK"], 'affiliations': [{'raw_affiliation_string': "Obstetrics and Gynaecology, Department of Reproductive and Developmental Sciences, The Queen's Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK", 'institution_ids': ['https://openalex.org/I4210116174', 'https://openalex.org/I4210164624', 'https://openalex.org/I98677209']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5034446157', 'display_name': 'W. Colin Duncan', 'orcid': 'https://orcid.org/0000-0002-7170-5740'}, 'institutions': [{'id': 'https://openalex.org/I4210116174', 'display_name': 'MRC Centre for Reproductive Health', 'ror': 'https://ror.org/02f4tsf92', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I4210116174', 'https://openalex.org/I90344618', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I4210164624', 'display_name': "The Queen's Medical Research Institute", 'ror': 'https://ror.org/059zxg644', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210164624', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'W. C. Duncan', 'raw_affiliation_strings': ["Obstetrics and Gynaecology, Department of Reproductive and Developmental Sciences, The Queen's Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK"], 'affiliations': [{'raw_affiliation_string': "Obstetrics and Gynaecology, Department of Reproductive and Developmental Sciences, The Queen's Medical Research Institute, Centre for Reproductive Biology, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK", 'institution_ids': ['https://openalex.org/I4210116174', 'https://openalex.org/I4210164624', 'https://openalex.org/I98677209']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5051684442'], 'corresponding_institution_ids': ['https://openalex.org/I4210116174', 'https://openalex.org/I4210164624', 'https://openalex.org/I98677209'], 'apc_list': {'value': 3638, 'currency': 'EUR', 'value_usd': 3923, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.657, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 92, 'citation_normalized_percentile': {'value': 0.94134, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '14', 'issue': '8', 'first_page': '455', 'last_page': '464'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10631', 'display_name': 'Metabolic Reprogramming in Cancer Biology', 'score': 0.9914, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10631', 'display_name': 'Metabolic Reprogramming in Cancer Biology', 'score': 0.9914, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10748', 'display_name': 'Insulin-like Growth Factors in Health and Disease', 'score': 0.99, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10584', 'display_name': 'Reproductive Health in Dairy Cattle', 'score': 0.9859, 'subfield': {'id': 'https://openalex.org/subfields/1102', 'display_name': 'Agronomy and Crop Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hif1a', 'display_name': 'HIF1A', 'score': 0.8888641}, {'id': 'https://openalex.org/keywords/growth-hormone', 'display_name': 'Growth Hormone', 'score': 0.495095}, {'id': 'https://openalex.org/keywords/hypoxia-inducible-factors', 'display_name': 'Hypoxia-inducible factors', 'score': 0.44674337}], 'concepts': [{'id': 'https://openalex.org/C31194975', 'wikidata': 'https://www.wikidata.org/wiki/Q20970095', 'display_name': 'HIF1A', 'level': 3, 'score': 0.8888641}, {'id': 'https://openalex.org/C2776608385', 'wikidata': 'https://www.wikidata.org/wiki/Q749637', 'display_name': 'Corpus luteum', 'level': 3, 'score': 0.7907431}, {'id': 'https://openalex.org/C146285616', 'wikidata': 'https://www.wikidata.org/wiki/Q7916455', 'display_name': 'Vascular endothelial growth factor A', 'level': 4, 'score': 0.7653793}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6671239}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.66593075}, {'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.63236153}, {'id': 'https://openalex.org/C2777025900', 'wikidata': 'https://www.wikidata.org/wiki/Q29725', 'display_name': 'Vascular endothelial growth factor', 'level': 3, 'score': 0.6203265}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6198289}, {'id': 'https://openalex.org/C143228043', 'wikidata': 'https://www.wikidata.org/wiki/Q2363481', 'display_name': 'Luteal phase', 'level': 3, 'score': 0.59089446}, {'id': 'https://openalex.org/C160450060', 'wikidata': 'https://www.wikidata.org/wiki/Q104598479', 'display_name': 'Hypoxia-inducible factors', 'level': 3, 'score': 0.44674337}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.26134032}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.21573031}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.15925622}, {'id': 'https://openalex.org/C167734588', 'wikidata': 'https://www.wikidata.org/wiki/Q4356503', 'display_name': 'VEGF receptors', 'level': 2, 'score': 0.059889317}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.05883643}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D006063', 'descriptor_name': 'Chorionic Gonadotropin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D006107', 'descriptor_name': 'Granulosa Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D051795', 'descriptor_name': 'Hypoxia-Inducible Factor 1, alpha Subunit', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003994', 'descriptor_name': 'Bucladesine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003994', 'descriptor_name': 'Bucladesine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015687', 'descriptor_name': 'Cell Hypoxia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006063', 'descriptor_name': 'Chorionic Gonadotropin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003338', 'descriptor_name': 'Corpus Luteum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003338', 'descriptor_name': 'Corpus Luteum', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D003338', 'descriptor_name': 'Corpus Luteum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003338', 'descriptor_name': 'Corpus Luteum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006107', 'descriptor_name': 'Granulosa Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006107', 'descriptor_name': 'Granulosa Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D006107', 'descriptor_name': 'Granulosa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051795', 'descriptor_name': 'Hypoxia-Inducible Factor 1, alpha Subunit', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051795', 'descriptor_name': 'Hypoxia-Inducible Factor 1, alpha Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011374', 'descriptor_name': 'Progesterone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011374', 'descriptor_name': 'Progesterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/molehr/gan040', 'pdf_url': 'https://academic.oup.com/molehr/article-pdf/14/8/455/6204648/gan040.pdf', 'source': {'id': 'https://openalex.org/S4210190516', 'display_name': 'Molecular Human Reproduction', 'issn_l': '1360-9947', 'issn': ['1360-9947', '1460-2407'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18591213', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/molehr/gan040', 'pdf_url': 'https://academic.oup.com/molehr/article-pdf/14/8/455/6204648/gan040.pdf', 'source': {'id': 'https://openalex.org/S4210190516', 'display_name': 'Molecular Human Reproduction', 'issn_l': '1360-9947', 'issn': ['1360-9947', '1460-2407'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 84, 'referenced_works': ['https://openalex.org/W148216960', 'https://openalex.org/W1535466351', 'https://openalex.org/W1583026873', 'https://openalex.org/W1940154096', 'https://openalex.org/W1951089905', 'https://openalex.org/W196112143', 'https://openalex.org/W1963596842', 'https://openalex.org/W1963938932', 'https://openalex.org/W1967216944', 'https://openalex.org/W1979826225', 'https://openalex.org/W1992181680', 'https://openalex.org/W1992435888', 'https://openalex.org/W1993102795', 'https://openalex.org/W1994574743', 'https://openalex.org/W1994791024', 'https://openalex.org/W2004348481', 'https://openalex.org/W2011375682', 'https://openalex.org/W2015054574', 'https://openalex.org/W2015344488', 'https://openalex.org/W2019759067', 'https://openalex.org/W2019931546', 'https://openalex.org/W2023054545', 'https://openalex.org/W2026831351', 'https://openalex.org/W2029193079', 'https://openalex.org/W2030768294', 'https://openalex.org/W2031456134', 'https://openalex.org/W2036751011', 'https://openalex.org/W2040334560', 'https://openalex.org/W2042745449', 'https://openalex.org/W2044175411', 'https://openalex.org/W2057366643', 'https://openalex.org/W2062153969', 'https://openalex.org/W2062404599', 'https://openalex.org/W2063716341', 'https://openalex.org/W2066429427', 'https://openalex.org/W2066565504', 'https://openalex.org/W2072540967', 'https://openalex.org/W2076057346', 'https://openalex.org/W2086889235', 'https://openalex.org/W2091551783', 'https://openalex.org/W2094621870', 'https://openalex.org/W2095125236', 'https://openalex.org/W2096618601', 'https://openalex.org/W2102773713', 'https://openalex.org/W2106058249', 'https://openalex.org/W2106659986', 'https://openalex.org/W2112034301', 'https://openalex.org/W2116910291', 'https://openalex.org/W2117747493', 'https://openalex.org/W2120484405', 'https://openalex.org/W2120847343', 'https://openalex.org/W2121909743', 'https://openalex.org/W2122193526', 'https://openalex.org/W2126041400', 'https://openalex.org/W2143160897', 'https://openalex.org/W2143563119', 'https://openalex.org/W2145257242', 'https://openalex.org/W2145287854', 'https://openalex.org/W2147414139', 'https://openalex.org/W2148768012', 'https://openalex.org/W2150261229', 'https://openalex.org/W2151249651', 'https://openalex.org/W2153142227', 'https://openalex.org/W2160314287', 'https://openalex.org/W2163069245', 'https://openalex.org/W2168816764', 'https://openalex.org/W2170055254', 'https://openalex.org/W2172045047', 'https://openalex.org/W2296293854', 'https://openalex.org/W2419021405', 'https://openalex.org/W4231526727', 'https://openalex.org/W4231570670', 'https://openalex.org/W4232613927', 'https://openalex.org/W4235523954', 'https://openalex.org/W4235651369', 'https://openalex.org/W4236174308', 'https://openalex.org/W4241893443', 'https://openalex.org/W4242177467', 'https://openalex.org/W4242376174', 'https://openalex.org/W4246231876', 'https://openalex.org/W4246863270', 'https://openalex.org/W4247625975', 'https://openalex.org/W4248440142', 'https://openalex.org/W4250583703'], 'related_works': ['https://openalex.org/W643340119', 'https://openalex.org/W2596919727', 'https://openalex.org/W2330686657', 'https://openalex.org/W2116337251', 'https://openalex.org/W2073373208', 'https://openalex.org/W2061048993', 'https://openalex.org/W2018476437', 'https://openalex.org/W1982629628', 'https://openalex.org/W1973217960', 'https://openalex.org/W1515639876'], 'abstract_inverted_index': {'Vascular': [0], 'endothelial': [1], 'growth': [2], 'factor': [3, 38], '(VEGF)-dependent': [4], 'angiogenesis': [5], 'is': [6, 14, 18, 29, 215, 250], 'essential': [7], 'for': [8], 'normal': [9], 'luteal': [10, 57, 140, 220], 'development.': [11], 'Although': [12], 'it': [13, 28], 'believed': [15], 'that': [16, 51, 244], 'hypoxia': [17], 'the': [19, 25, 52, 65, 145, 238], 'primary': [20], 'inducer': [21], 'of': [22, 54, 67, 213, 241, 248, 255], 'VEGF,': [23], 'in': [24, 74, 79, 82, 86, 99, 111, 121, 127, 134, 219, 222, 225], 'corpus': [26, 148], 'luteum': [27, 149], 'up-regulated': [30, 89, 164], 'by': [31, 165], 'human': [32, 75, 83], 'chorionic': [33], 'gonadotrophin': [34], '(hCG).': [35], 'As': [36], 'hypoxia-inducible': [37], '(HIF)1A': [39], 'has': [40], 'been': [41], 'shown': [42], 'to': [43], 'regulate': [44, 229], 'VEGFA': [45, 58, 70, 90, 102, 120, 154, 173, 187, 203, 230, 249], 'under': [46, 196, 232], 'ligand-stimulated': [47], 'conditions,': [48], 'we': [49], 'hypothesized': [50], 'effect': [53, 66, 207], 'hCG': [55, 68, 184], 'on': [56, 69, 208], 'was': [59, 114, 137], 'mediated': [60], 'through': [61, 167], 'HIF1A.': [62, 256], 'We': [63], 'studied': [64], 'and': [71, 81, 94, 101, 106, 119, 126, 142, 158, 177, 183, 191, 224, 227, 234], 'HIF1A': [72, 95, 107, 118, 133, 159, 178, 192, 209, 214], 'expression': [73, 182, 212, 231], 'luteinized': [76], 'granulosa': [77], 'cells': [78, 136, 221], 'vitro': [80, 100, 128, 223], 'corpora': [84], 'lutea': [85], 'vivo.': [87, 112], 'HCG': [88], '(P': [91, 96, 103, 108, 123, 129, 150, 155, 160, 174, 179, 188, 193], '<': [92, 97, 104, 109, 124, 130, 151, 156, 161, 175, 180, 189, 194], '0.05)': [93, 105, 110, 181], '0.001)': [98, 157, 176, 190], 'There': [113], 'a': [115, 168], 'correlation': [116], 'between': [117], 'vivo': [122, 226], '0.005)': [125], '0.05).': [131, 152], 'Nuclear': [132], 'granulosa-lutein': [135], 'highest': [138], 'during': [139], 'formation': [141], 'absent': [143], 'from': [144], 'fully': [146], 'functional': [147], 'Both': [153], '0.01)': [162, 195], 'were': [163], 'dibutyryl-cAMP,': [166], 'PKA': [169], 'pathway.': [170], 'Hypoxia': [171], 'increased': [172, 201], 'further': [185], 'augmented': [186], 'hypoxic': [197, 235], 'conditions.': [198, 236], 'However,': [199, 237], 'progesterone': [200, 242], 'hCG-stimulated': [202], 'but': [204], 'had': [205], 'no': [206], 'expression.': [210], 'The': [211], 'therefore': [216], 'hormonally': [217], 'regulated': [218], 'may': [228], 'normoxic': [233], 'differential': [239], 'effects': [240], 'suggest': [243], 'not': [245], 'all': [246], 'regulation': [247], 'associated': [251], 'with': [252], 'an': [253], 'up-regulation': [254]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2160394750', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-09-15T08:05:16.546357', 'created_date': '2016-06-24'}