Publication Information

{'id': 'https://openalex.org/W172080573', 'doi': 'https://doi.org/10.1042/bj3030015', 'title': 'Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase', 'display_name': 'Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase', 'publication_year': 1994, 'publication_date': '1994-10-01', 'ids': {'openalex': 'https://openalex.org/W172080573', 'doi': 'https://doi.org/10.1042/bj3030015', 'mag': '172080573', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7945234', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1137549'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj3030015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc1137549?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5026207697', 'display_name': 'Gavin I. Welsh', 'orcid': 'https://orcid.org/0000-0002-2148-6658'}, 'institutions': [{'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'G I Welsh', 'raw_affiliation_strings': ['* Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, U.K.'], 'affiliations': [{'raw_affiliation_string': '* Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, U.K.', 'institution_ids': ['https://openalex.org/I36234482']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111416289', 'display_name': 'Emily J. Foulstone', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'E J Foulstone', 'raw_affiliation_strings': ['* Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, U.K.'], 'affiliations': [{'raw_affiliation_string': '* Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, U.K.', 'institution_ids': ['https://openalex.org/I36234482']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100818073', 'display_name': 'Susan Young', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'S W Young', 'raw_affiliation_strings': ['* Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, U.K.'], 'affiliations': [{'raw_affiliation_string': '* Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, U.K.', 'institution_ids': ['https://openalex.org/I36234482']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108611654', 'display_name': 'JM Tavaré', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'J M Tavaré', 'raw_affiliation_strings': ['* Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, U.K.'], 'affiliations': [{'raw_affiliation_string': '* Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, U.K.', 'institution_ids': ['https://openalex.org/I36234482']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5030513468', 'display_name': 'Christopher G. Proud', 'orcid': 'https://orcid.org/0000-0003-0704-6442'}, 'institutions': [{'id': 'https://openalex.org/I36234482', 'display_name': 'University of Bristol', 'ror': 'https://ror.org/0524sp257', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I36234482']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'C G Proud', 'raw_affiliation_strings': ['* Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, U.K.'], 'affiliations': [{'raw_affiliation_string': '* Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, U.K.', 'institution_ids': ['https://openalex.org/I36234482']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 12.558, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 204, 'citation_normalized_percentile': {'value': 0.887742, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '303', 'issue': '1', 'first_page': '15', 'last_page': '20'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt/β-catenin signaling in development and cancer', 'score': 0.9881, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10929', 'display_name': 'Wnt/β-catenin signaling in development and cancer', 'score': 0.9881, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9841, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9816, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/wortmannin', 'display_name': 'Wortmannin', 'score': 0.90790695}, {'id': 'https://openalex.org/keywords/cyclin-dependent-kinase-9', 'display_name': 'Cyclin-dependent kinase 9', 'score': 0.6110917}, {'id': 'https://openalex.org/keywords/ask1', 'display_name': 'ASK1', 'score': 0.5933688}, {'id': 'https://openalex.org/keywords/map2k7', 'display_name': 'MAP2K7', 'score': 0.43855906}], 'concepts': [{'id': 'https://openalex.org/C2778308172', 'wikidata': 'https://www.wikidata.org/wiki/Q423565', 'display_name': 'Wortmannin', 'level': 4, 'score': 0.90790695}, {'id': 'https://openalex.org/C182996813', 'wikidata': 'https://www.wikidata.org/wiki/Q910847', 'display_name': 'GSK-3', 'level': 3, 'score': 0.6539106}, {'id': 'https://openalex.org/C137361374', 'wikidata': 'https://www.wikidata.org/wiki/Q6714442', 'display_name': 'MAP kinase kinase kinase', 'level': 4, 'score': 0.64608765}, {'id': 'https://openalex.org/C90934575', 'wikidata': 'https://www.wikidata.org/wiki/Q6593810', 'display_name': 'Mitogen-activated protein kinase kinase', 'level': 4, 'score': 0.6227596}, {'id': 'https://openalex.org/C59143045', 'wikidata': 'https://www.wikidata.org/wiki/Q15314942', 'display_name': 'Cyclin-dependent kinase 9', 'level': 5, 'score': 0.6110917}, {'id': 'https://openalex.org/C124160383', 'wikidata': 'https://www.wikidata.org/wiki/Q14914383', 'display_name': 'ASK1', 'level': 5, 'score': 0.5933688}, {'id': 'https://openalex.org/C192118531', 'wikidata': 'https://www.wikidata.org/wiki/Q86360001', 'display_name': 'Glycogen synthase', 'level': 3, 'score': 0.56394815}, {'id': 'https://openalex.org/C82495950', 'wikidata': 'https://www.wikidata.org/wiki/Q14911732', 'display_name': 'Cyclin-dependent kinase 2', 'level': 4, 'score': 0.53380495}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.4844363}, {'id': 'https://openalex.org/C112446052', 'wikidata': 'https://www.wikidata.org/wiki/Q422579', 'display_name': 'Insulin receptor', 'level': 4, 'score': 0.4719343}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.44435638}, {'id': 'https://openalex.org/C159479382', 'wikidata': 'https://www.wikidata.org/wiki/Q18030801', 'display_name': 'MAP2K7', 'level': 5, 'score': 0.43855906}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.41477734}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.39029655}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.37090343}, {'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.37021318}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.36258364}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3484823}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.29720396}, {'id': 'https://openalex.org/C2780610907', 'wikidata': 'https://www.wikidata.org/wiki/Q2273248', 'display_name': 'Phosphatidylinositol', 'level': 3, 'score': 0.2746585}, {'id': 'https://openalex.org/C2777391703', 'wikidata': 'https://www.wikidata.org/wiki/Q1053470', 'display_name': 'Insulin resistance', 'level': 3, 'score': 0.06163922}], 'mesh': [{'descriptor_ui': 'D000730', 'descriptor_name': 'Androstadienes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017871', 'descriptor_name': 'Calcium-Calmodulin-Dependent Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007329', 'descriptor_name': 'Insulin Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011972', 'descriptor_name': 'Receptor, Insulin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000730', 'descriptor_name': 'Androstadienes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001769', 'descriptor_name': 'Blood', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016466', 'descriptor_name': 'CHO Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017871', 'descriptor_name': 'Calcium-Calmodulin-Dependent Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003470', 'descriptor_name': 'Culture Media', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D038362', 'descriptor_name': 'Glycogen Synthase Kinase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D038341', 'descriptor_name': 'Glycogen Synthase Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020662', 'descriptor_name': 'Guanine Nucleotide Exchange Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007329', 'descriptor_name': 'Insulin Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011972', 'descriptor_name': 'Receptor, Insulin', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D011972', 'descriptor_name': 'Receptor, Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013755', 'descriptor_name': 'Tetradecanoylphorbol Acetate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013755', 'descriptor_name': 'Tetradecanoylphorbol Acetate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077191', 'descriptor_name': 'Wortmannin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj3030015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1137549', 'pdf_url': 'https://europepmc.org/articles/pmc1137549?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1137549', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7945234', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1137549', 'pdf_url': 'https://europepmc.org/articles/pmc1137549?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1486631729', 'https://openalex.org/W1496316111', 'https://openalex.org/W1505315584', 'https://openalex.org/W1528752221', 'https://openalex.org/W1531537331', 'https://openalex.org/W1534965462', 'https://openalex.org/W1550703182', 'https://openalex.org/W1572009433', 'https://openalex.org/W1583950528', 'https://openalex.org/W1593810032', 'https://openalex.org/W1712871378', 'https://openalex.org/W1742701470', 'https://openalex.org/W1758789982', 'https://openalex.org/W1818313483', 'https://openalex.org/W1832251486', 'https://openalex.org/W1874223625', 'https://openalex.org/W1908612571', 'https://openalex.org/W1974328588', 'https://openalex.org/W1977182622', 'https://openalex.org/W1978798502', 'https://openalex.org/W1983055247', 'https://openalex.org/W1991760443', 'https://openalex.org/W1995862772', 'https://openalex.org/W1996882707', 'https://openalex.org/W2020200674', 'https://openalex.org/W2024839583', 'https://openalex.org/W2031610264', 'https://openalex.org/W2041102071', 'https://openalex.org/W2044301435', 'https://openalex.org/W2044693162', 'https://openalex.org/W2048127269', 'https://openalex.org/W2069132844', 'https://openalex.org/W2078011486', 'https://openalex.org/W2083433543', 'https://openalex.org/W2093621392', 'https://openalex.org/W2101168569', 'https://openalex.org/W2105717889', 'https://openalex.org/W2117669008', 'https://openalex.org/W2126440278', 'https://openalex.org/W2128635872', 'https://openalex.org/W2161316513', 'https://openalex.org/W2416516295', 'https://openalex.org/W259495519', 'https://openalex.org/W76057369'], 'related_works': ['https://openalex.org/W7135663', 'https://openalex.org/W4255520261', 'https://openalex.org/W2162824132', 'https://openalex.org/W2145966802', 'https://openalex.org/W2122407726', 'https://openalex.org/W2053685014', 'https://openalex.org/W2034580062', 'https://openalex.org/W2031154171', 'https://openalex.org/W2008360372', 'https://openalex.org/W1581952739'], 'abstract_inverted_index': {'We': [0, 25], 'have': [1], 'previously': [2], 'shown': [3], 'that': [4, 28, 68, 123, 140, 156, 195, 209], 'insulin': [5, 21, 91, 116, 212], 'causes': [6], 'inactivation': [7, 36, 58, 222], 'of': [8, 37, 59, 83, 89, 103, 167, 188, 223], 'glycogen': [9], 'synthase': [10], 'kinase-3': [11], '(GSK-3)': [12], 'in': [13, 40, 44, 146, 173], 'Chinese': [14], 'hamster': [15], 'ovary': [16], 'cells': [17, 42], 'over-expressing': [18], 'the': [19, 45, 57, 69, 87, 101, 147, 165, 186, 221], 'human': [20], 'receptor': [22], '(CHO.T': [23], 'cells).': [24], 'now': [26], 'show': [27], 'serum': [29, 63, 93], 'and': [30, 43, 92, 97, 110, 117, 134, 138], 'phorbol': [31, 65, 192, 196, 226], 'ester': [32], 'also': [33, 98], 'cause': [34], 'rapid': [35], 'GSK-3,': [38], 'both': [39, 90, 104], 'CHO.T': [41], 'nontransfected': [46], 'parental': [47], 'cell': [48], 'line,': [49], 'CHO.K1': [50], 'cells.': [51], 'Rapamycin': [52], 'was': [53], 'without': [54], 'effect': [55, 184, 219], 'on': [56, 94, 185, 220], 'GSK-3': [60, 95, 124, 157, 224], 'by': [61, 128, 177, 191, 202, 211, 225], 'insulin,': [62], 'or': [64, 205, 213], 'ester,': [66, 193], 'indicating': [67, 194], 'p70': [70], 'S6': [71, 106, 136], 'kinase': [72, 107, 114, 133, 137, 149, 190, 201], 'pathway': [73], 'is': [74, 126], 'not': [75], 'involved.': [76], 'In': [77], 'contrast,': [78], 'wortmannin,': [79], 'a': [80, 129, 182, 203], 'potent': [81], 'inhibitor': [82], 'phosphatidylinositol': [84], '3-kinase,': [85], 'blocked': [86], 'effects': [88], 'activity,': [96], 'substantially': [99], 'reduced': [100], 'activation': [102, 187], 'p90': [105, 135], '(by': [108, 115], 'insulin)': [109], 'mitogen-activated': [111], 'protein': [112], '(MAP)': [113], 'serum).': [118], 'These': [119], 'findings': [120], 'imply': [121], '(i)': [122], 'activity': [125], 'regulated': [127, 176], 'cascade': [130], 'involving': [131], 'MAP': [132, 148, 189, 200], '(ii)': [139], 'wortmannin': [141], 'affects': [142], 'an': [143, 160], 'early': [144], 'step': [145], 'pathway.': [150], 'One': [151], 'can': [152], 'infer': [153], 'from': [154], 'this': [155, 231], 'may': [158, 198], 'be': [159], 'important': [161], 'regulatory': [162], 'enzyme': [163], 'for': [164, 230], 'control': [166], 'several': [168], 'biosynthetic': [169], 'pathways,': [170], 'key': [171], 'enzymes': [172], 'which': [174], 'are': [175, 232], 'GSK-3-mediated': [178], 'phosphorylation.': [179], 'Wortmannin': [180, 215], 'had': [181, 216], 'smaller': [183], 'esters': [197], 'stimulate': [199], 'different': [204], 'additional': [206], 'mechanism': [207], 'to': [208], 'employed': [210], 'serum.': [214], 'very': [217], 'little': [218], 'ester:': [227], 'possible': [228], 'reasons': [229], 'discussed.': [233]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W172080573', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-11T03:29:00.891393', 'created_date': '2016-06-24'}