Title: Electrocorticographic and electrochordographic study of the convulsions induced by cardiazol
Abstract: 1. Changes elicited by the administration of convulsant doses of Cardiazol upon cortical and spinal rhythms have been investigated in chloralosed and curarized dogs and cats, by means of simultaneous recording with electrodes directly on cortex and in spinal cord. 2. In animals with intact C.N.S., Cardiazol evokes characteristic cortical changes of a convulsive type, while analogous and synchronous but slightly different modifications have been observed in records from the grey matter of the anterior horns of the spinal cord. 3. In animals with C.N.S. severed through a mesencephalic transection Cardiazol does not alter the spinal activity, even though inducing the typical convulsive changes in the cortex. 4. It is suggested that the changes in spinal activity are evoked by efferent impulses from suprabulbar centres, while a direct action of the drug upon the spinal neurons can probably be excluded, at least with the doses employed. 5. The results obtained, following administration of other drugs stimulating the C.N.S., in animals previously treated with convulsant doses of Cardiazol. confirm the susceptibility of the spinal neurons to react to pharmacological stimuli, even under anaestesia and curatization, and suggest a simple hypothesis of the elective site of action and upon the synergism of the drug themselves.
Publication Year: 1950
Publication Date: 1950-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 43
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