Publication Information

{'id': 'https://openalex.org/W1602386597', 'doi': 'https://doi.org/10.1096/fasebj.12.13.1301', 'title': 'Tissue‐specific effects of<i>in vivo</i>adenosine receptor blockade on glucose uptake in Zucker rats', 'display_name': 'Tissue‐specific effects of<i>in vivo</i>adenosine receptor blockade on glucose uptake in Zucker rats', 'publication_year': 1998, 'publication_date': '1998-10-01', 'ids': {'openalex': 'https://openalex.org/W1602386597', 'doi': 'https://doi.org/10.1096/fasebj.12.13.1301', 'mag': '1602386597', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9761773'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fasebj.12.13.1301', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109226006', 'display_name': 'George H. Crist', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I130769515', 'display_name': 'Pennsylvania State University', 'ror': 'https://ror.org/04p491231', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130769515']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'George H. Crist', 'raw_affiliation_strings': ['Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 0850,'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 0850,', 'institution_ids': ['https://openalex.org/I130769515']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110955805', 'display_name': 'Baiyang Xu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I130769515', 'display_name': 'Pennsylvania State University', 'ror': 'https://ror.org/04p491231', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130769515']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Baiyang Xu', 'raw_affiliation_strings': ['Department of Cellular and Molecular Physiology The Pennsylvania State University College of Medicine Hershey Pennsylvania 17033-0850 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular and Molecular Physiology The Pennsylvania State University College of Medicine Hershey Pennsylvania 17033-0850 USA', 'institution_ids': ['https://openalex.org/I130769515']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001128846', 'display_name': 'Kathryn F. LaNoue', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I130769515', 'display_name': 'Pennsylvania State University', 'ror': 'https://ror.org/04p491231', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130769515']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kathryn F. Lanoue', 'raw_affiliation_strings': ['Department of Cellular and Molecular Physiology The Pennsylvania State University College of Medicine Hershey Pennsylvania 17033-0850 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular and Molecular Physiology The Pennsylvania State University College of Medicine Hershey Pennsylvania 17033-0850 USA', 'institution_ids': ['https://openalex.org/I130769515']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5073807348', 'display_name': 'Charles H. Lang', 'orcid': 'https://orcid.org/0000-0002-3260-7363'}, 'institutions': [{'id': 'https://openalex.org/I130769515', 'display_name': 'Pennsylvania State University', 'ror': 'https://ror.org/04p491231', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130769515']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Charles H. Lang', 'raw_affiliation_strings': ['Department of Cellular and Molecular Physiology The Pennsylvania State University College of Medicine Hershey Pennsylvania 17033-0850 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular and Molecular Physiology The Pennsylvania State University College of Medicine Hershey Pennsylvania 17033-0850 USA', 'institution_ids': ['https://openalex.org/I130769515']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.903, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 74, 'citation_normalized_percentile': {'value': 0.865815, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '12', 'issue': '13', 'first_page': '1301', 'last_page': '1308'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11193', 'display_name': 'Adenosine and Purinergic Signaling', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/carbohydrate-metabolism', 'display_name': 'Carbohydrate Metabolism', 'score': 0.5337786}, {'id': 'https://openalex.org/keywords/glucose-clamp-technique', 'display_name': 'Glucose clamp technique', 'score': 0.5309296}], 'concepts': [{'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.90604955}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.88298523}, {'id': 'https://openalex.org/C2777866211', 'wikidata': 'https://www.wikidata.org/wiki/Q5572349', 'display_name': 'Glucose uptake', 'level': 3, 'score': 0.69007385}, {'id': 'https://openalex.org/C171089720', 'wikidata': 'https://www.wikidata.org/wiki/Q193583', 'display_name': 'Adipose tissue', 'level': 2, 'score': 0.68413997}, {'id': 'https://openalex.org/C161573976', 'wikidata': 'https://www.wikidata.org/wiki/Q420277', 'display_name': 'Glucose transporter', 'level': 3, 'score': 0.54775345}, {'id': 'https://openalex.org/C17093226', 'wikidata': 'https://www.wikidata.org/wiki/Q2734081', 'display_name': 'Carbohydrate metabolism', 'level': 2, 'score': 0.5337786}, {'id': 'https://openalex.org/C2778808658', 'wikidata': 'https://www.wikidata.org/wiki/Q2975183', 'display_name': 'Glucose clamp technique', 'level': 5, 'score': 0.5309296}, {'id': 'https://openalex.org/C2776991684', 'wikidata': 'https://www.wikidata.org/wiki/Q190012', 'display_name': 'Adenosine', 'level': 2, 'score': 0.50078845}, {'id': 'https://openalex.org/C2777391703', 'wikidata': 'https://www.wikidata.org/wiki/Q1053470', 'display_name': 'Insulin resistance', 'level': 3, 'score': 0.47295707}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46672833}, {'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.45888788}, {'id': 'https://openalex.org/C2780352109', 'wikidata': 'https://www.wikidata.org/wiki/Q728309', 'display_name': 'Pancreatic hormone', 'level': 4, 'score': 0.26727498}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.24430087}], 'mesh': [{'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007333', 'descriptor_name': 'Insulin Resistance', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009765', 'descriptor_name': 'Obesity', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D058915', 'descriptor_name': 'Purinergic P1 Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014970', 'descriptor_name': 'Xanthines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000273', 'descriptor_name': 'Adipose Tissue', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000273', 'descriptor_name': 'Adipose Tissue', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001693', 'descriptor_name': 'Biological Transport, Active', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001693', 'descriptor_name': 'Biological Transport, Active', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D003847', 'descriptor_name': 'Deoxyglucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003847', 'descriptor_name': 'Deoxyglucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006946', 'descriptor_name': 'Hyperinsulinism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006946', 'descriptor_name': 'Hyperinsulinism', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007333', 'descriptor_name': 'Insulin Resistance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009765', 'descriptor_name': 'Obesity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009765', 'descriptor_name': 'Obesity', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009928', 'descriptor_name': 'Organ Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011924', 'descriptor_name': 'Rats, Zucker', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014970', 'descriptor_name': 'Xanthines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fasebj.12.13.1301', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9761773', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.53, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1486029121', 'https://openalex.org/W1535611266', 'https://openalex.org/W1544933262', 'https://openalex.org/W1599097515', 'https://openalex.org/W1605488382', 'https://openalex.org/W1764140709', 'https://openalex.org/W1888512598', 'https://openalex.org/W1969997616', 'https://openalex.org/W1978029732', 'https://openalex.org/W1982178858', 'https://openalex.org/W2011631192', 'https://openalex.org/W2022801078', 'https://openalex.org/W2053200285', 'https://openalex.org/W2055447291', 'https://openalex.org/W2060313221', 'https://openalex.org/W2065739432', 'https://openalex.org/W2066932627', 'https://openalex.org/W2067057146', 'https://openalex.org/W2070336067', 'https://openalex.org/W2079690870', 'https://openalex.org/W2085073307', 'https://openalex.org/W2085950922', 'https://openalex.org/W2087881873', 'https://openalex.org/W2088746083', 'https://openalex.org/W2113114932', 'https://openalex.org/W2123869023', 'https://openalex.org/W2124232607', 'https://openalex.org/W2128702770', 'https://openalex.org/W2129316761', 'https://openalex.org/W2146845495', 'https://openalex.org/W2154935464', 'https://openalex.org/W2226762186', 'https://openalex.org/W2272992369', 'https://openalex.org/W2394646614', 'https://openalex.org/W2396197872', 'https://openalex.org/W2396635053', 'https://openalex.org/W2398262967', 'https://openalex.org/W2403693505', 'https://openalex.org/W32407373', 'https://openalex.org/W4232437917', 'https://openalex.org/W4236341500'], 'related_works': ['https://openalex.org/W4309722971', 'https://openalex.org/W4285741418', 'https://openalex.org/W4211103015', 'https://openalex.org/W2726421366', 'https://openalex.org/W2547069902', 'https://openalex.org/W2414633774', 'https://openalex.org/W2147329254', 'https://openalex.org/W2107510101', 'https://openalex.org/W1994965139', 'https://openalex.org/W1971859682'], 'abstract_inverted_index': {'Previous': [0], 'studies': [1], 'have': [2], 'shown': [3], 'that': [4, 40, 107, 220, 231], 'treatment': [5, 113, 160, 179], 'of': [6, 55, 76, 106, 126, 144, 161, 258], 'obese': [7, 33, 84, 100, 120, 146, 162, 191, 224], 'Zucker': [8, 38, 101, 121, 194, 225, 268], 'rats': [9, 39, 102, 226], 'with': [10, 45, 86], 'the': [11, 91, 124, 127], 'adenosine': [12, 234, 261], 'receptor': [13, 262], 'antagonist': [14], '1,3-dipropyl-8-(p-acrylic)': [15], 'phenyl': [16], 'xanthine': [17], '(BWA1433)': [18], 'improves': [19, 200], 'intraperitoneal': [20], 'glucose': [21, 67, 72, 77, 97, 115, 137, 151, 165, 181, 201, 205, 212, 265], 'tolerance.': [22], 'In': [23, 197], 'this': [24], 'study,': [25], 'a': [26, 238], 'euglycemic': [27, 92], 'hyperinsulinemic': [28, 93, 157], 'clamp': [29], 'was': [30, 57, 103, 130], 'performed': [31], 'on': [32, 264], '(fa/fa)': [34], 'and': [35, 142, 169, 174, 188, 192, 230], 'lean': [36, 82, 110, 154, 193], '(Fa/fa)': [37], 'had': [41, 148], 'been': [42], 'treated': [43], 'orally': [44], 'BWA1433': [46, 112, 159, 178, 199], 'or': [47, 74, 83, 87], 'vehicle': [48], 'for': [49], '1': [50], 'wk.': [51], 'A': [52], 'constant': [53], 'infusion': [54], '[3H]glucose': [56], 'initiated': [58], 'in': [59, 71, 99, 109, 119, 136, 167, 183, 190, 207, 223, 259, 267], 'fasted': [60], 'animals': [61, 85, 147, 163], 'to': [62, 132, 241], 'measure': [63], 'basal': [64], 'whole': [65, 95], 'body': [66, 96], 'kinetics.': [68], 'No': [69], 'differences': [70, 135], 'concentration': [73], 'rates': [75], 'production/disappearance': [78], 'were': [79], 'observed': [80, 108], 'between': [81], 'without': [88], 'BWA1433.': [89], 'During': [90], 'clamp,': [94, 128], 'disposal': [98, 116], 'only': [104], '22%': [105], 'animals.': [111], 'increased': [114, 164], 'by': [117, 172, 186, 203, 214], '88%': [118], 'rats.': [122, 269], 'At': [123], 'end': [125], '[14C]-2-deoxyglucose': [129], 'injected': [131], 'determine': [133], 'tissue-specific': [134, 242], 'uptake.': [138], 'Gastrocnemius,': [139], 'soleus,': [140], 'heart,': [141], 'liver': [143], 'untreated': [145], 'significantly': [149], 'lower': [150], 'uptake': [152, 166, 182, 206, 213, 266], 'than': [153], 'controls': [155], 'under': [156], 'conditions.': [158], 'gastrocnemius': [168], 'soleus': [170], 'muscles': [171], '44': [173], '47%,': [175], 'respectively.': [176, 196], 'Conversely,': [177], 'decreased': [180], 'adipose': [184, 215], 'tissue': [185, 228], '54': [187], '49%': [189], 'rats,': [195], 'summary,': [198], 'tolerance': [202], 'increasing': [204], 'skeletal': [208], 'muscle': [209], 'while': [210], 'decreasing': [211], 'tissue.': [216], 'This': [217], 'study': [218], 'suggests': [219], 'insulin': [221, 243], 'resistance': [222], 'is': [227], 'specific': [229], 'signaling': [232], 'from': [233], 'receptors': [235], 'may': [236], 'be': [237], 'factor': [239], 'contributing': [240], 'resistance.—Crist,': [244], 'G.': [245], 'H.,': [246], 'Xu,': [247], 'B.,': [248], 'La-': [249], 'Noue,': [250], 'K.': [251], 'F.,': [252], 'Lang,': [253], 'C.': [254], 'H.': [255], 'Tissue-specific': [256], 'effects': [257], 'vivo': [260], 'blockade': [263], 'FASEB': [270], 'J.': [271], '12,': [272], '1301–1308': [273], '(1998)': [274]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1602386597', 'counts_by_year': [{'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-12T11:16:38.582932', 'created_date': '2016-06-24'}