Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1589760452', 'doi': 'https://doi.org/10.1111/j.1365-2567.2012.03552.x', 'title': 'Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low‐density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release', 'display_name': 'Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low‐density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release', 'publication_year': 2012, 'publication_date': '2012-01-12', 'ids': {'openalex': 'https://openalex.org/W1589760452', 'doi': 'https://doi.org/10.1111/j.1365-2567.2012.03552.x', 'mag': '1589760452', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22236141', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3372755'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2567.2012.03552.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S89865888', 'display_name': 'Immunology', 'issn_l': '0019-2805', 'issn': ['0019-2805', '1365-2567'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1111/j.1365-2567.2012.03552.x', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5060771562', 'display_name': 'Jean‐Philip Truman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I153297377', 'display_name': 'Medical University of South Carolina', 'ror': 'https://ror.org/012jban78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I153297377']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jean‐Philip Truman', 'raw_affiliation_strings': ['Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, 29425, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, 29425, USA.', 'institution_ids': ['https://openalex.org/I153297377']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000320018', 'display_name': 'Mohammed M. Al Gadban', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Mohammed M. Al Gadban', 'raw_affiliation_strings': ['Department of Regenerative Medicine and Cell Biology'], 'affiliations': [{'raw_affiliation_string': 'Department of Regenerative Medicine and Cell Biology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054626121', 'display_name': 'Kent J. Smith', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kent J. Smith', 'raw_affiliation_strings': ['Department of Regenerative Medicine and Cell Biology'], 'affiliations': [{'raw_affiliation_string': 'Department of Regenerative Medicine and Cell Biology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033056679', 'display_name': 'Russell W. Jenkins', 'orcid': 'https://orcid.org/0000-0001-6110-2148'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Russell W. Jenkins', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028479249', 'display_name': 'Nalini Mayroo', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Nalini Mayroo', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110448097', 'display_name': 'Gabriel Virella', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Gabriel Virella', 'raw_affiliation_strings': ['Department of Microbiology and Immunology'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046063952', 'display_name': 'Maria F. Lopes‐Virella', 'orcid': 'https://orcid.org/0000-0001-5572-1700'}, 'institutions': [{'id': 'https://openalex.org/I153297377', 'display_name': 'Medical University of South Carolina', 'ror': 'https://ror.org/012jban78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I153297377']}, {'id': 'https://openalex.org/I4210132004', 'display_name': 'Ralph H. Johnson VA Medical Center', 'ror': 'https://ror.org/030ma0n95', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210131075', 'https://openalex.org/I4210132004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Maria F. Lopes‐Virella', 'raw_affiliation_strings': ['Division of Endocrinology, Medical University of South Carolina, Charleston, SC', 'Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Endocrinology, Medical University of South Carolina, Charleston, SC', 'institution_ids': ['https://openalex.org/I153297377']}, {'raw_affiliation_string': 'Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC, USA', 'institution_ids': ['https://openalex.org/I4210132004']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076524129', 'display_name': 'Alicja Bielawska', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Alicja Bielawska', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090422329', 'display_name': 'Yusuf A. Hannun', 'orcid': 'https://orcid.org/0000-0003-3349-3369'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yusuf A. Hannun', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010539637', 'display_name': 'Samar M. Hammad', 'orcid': 'https://orcid.org/0000-0002-1313-2542'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Samar M. Hammad', 'raw_affiliation_strings': ['Department of Regenerative Medicine and Cell Biology'], 'affiliations': [{'raw_affiliation_string': 'Department of Regenerative Medicine and Cell Biology', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.912, 'has_fulltext': False, 'cited_by_count': 46, 'citation_normalized_percentile': {'value': 0.893545, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '136', 'issue': '1', 'first_page': '30', 'last_page': '45'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Metabolism and Signaling', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Metabolism and Signaling', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12672', 'display_name': 'Phagocytosis and Immune Regulation', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11313', 'display_name': 'Immune cells in cancer', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/acid-sphingomyelinase', 'display_name': 'Acid sphingomyelinase', 'score': 0.95689356}, {'id': 'https://openalex.org/keywords/sphingomyelin-phosphodiesterase', 'display_name': 'Sphingomyelin phosphodiesterase', 'score': 0.43134558}], 'concepts': [{'id': 'https://openalex.org/C2781457462', 'wikidata': 'https://www.wikidata.org/wiki/Q16245045', 'display_name': 'Acid sphingomyelinase', 'level': 4, 'score': 0.95689356}, {'id': 'https://openalex.org/C61322309', 'wikidata': 'https://www.wikidata.org/wiki/Q423143', 'display_name': 'Sphingomyelin', 'level': 3, 'score': 0.69522387}, {'id': 'https://openalex.org/C2777851122', 'wikidata': 'https://www.wikidata.org/wiki/Q424213', 'display_name': 'Ceramide', 'level': 3, 'score': 0.6106335}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.54243296}, {'id': 'https://openalex.org/C160448771', 'wikidata': 'https://www.wikidata.org/wiki/Q184726', 'display_name': 'Phagocytosis', 'level': 2, 'score': 0.5391498}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5286598}, {'id': 'https://openalex.org/C180899940', 'wikidata': 'https://www.wikidata.org/wiki/Q117982', 'display_name': 'Lipid signaling', 'level': 3, 'score': 0.44191903}, {'id': 'https://openalex.org/C2781070647', 'wikidata': 'https://www.wikidata.org/wiki/Q413230', 'display_name': 'Sphingomyelin phosphodiesterase', 'level': 4, 'score': 0.43134558}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.4164768}, {'id': 'https://openalex.org/C2780216420', 'wikidata': 'https://www.wikidata.org/wiki/Q83330', 'display_name': 'Lysosome', 'level': 3, 'score': 0.4104544}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.37012157}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.31926793}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23493093}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.18419692}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.10723409}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.10646495}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008077', 'descriptor_name': 'Lipoproteins, LDL', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D010587', 'descriptor_name': 'Phagocytosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013108', 'descriptor_name': 'Sphingomyelin Phosphodiesterase', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008077', 'descriptor_name': 'Lipoproteins, LDL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013108', 'descriptor_name': 'Sphingomyelin Phosphodiesterase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013108', 'descriptor_name': 'Sphingomyelin Phosphodiesterase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2567.2012.03552.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S89865888', 'display_name': 'Immunology', 'issn_l': '0019-2805', 'issn': ['0019-2805', '1365-2567'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372755', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22236141', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2567.2012.03552.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S89865888', 'display_name': 'Immunology', 'issn_l': '0019-2805', 'issn': ['0019-2805', '1365-2567'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 69, 'referenced_works': ['https://openalex.org/W1523513367', 'https://openalex.org/W1523941043', 'https://openalex.org/W1577572535', 'https://openalex.org/W1607948351', 'https://openalex.org/W1678039705', 'https://openalex.org/W1945253873', 'https://openalex.org/W1966824900', 'https://openalex.org/W1968330432', 'https://openalex.org/W1984512960', 'https://openalex.org/W1984745753', 'https://openalex.org/W1986321004', 'https://openalex.org/W1992958840', 'https://openalex.org/W1996514696', 'https://openalex.org/W1998949162', 'https://openalex.org/W2000404485', 'https://openalex.org/W2004142844', 'https://openalex.org/W2006223811', 'https://openalex.org/W2006960442', 'https://openalex.org/W2010709348', 'https://openalex.org/W2010955453', 'https://openalex.org/W2020153835', 'https://openalex.org/W2020466852', 'https://openalex.org/W2022222076', 'https://openalex.org/W2027544313', 'https://openalex.org/W2030410023', 'https://openalex.org/W2041391144', 'https://openalex.org/W2041890590', 'https://openalex.org/W2041922728', 'https://openalex.org/W2046116704', 'https://openalex.org/W2048343908', 'https://openalex.org/W2052017158', 'https://openalex.org/W2053204073', 'https://openalex.org/W2065330071', 'https://openalex.org/W2065844931', 'https://openalex.org/W2065886456', 'https://openalex.org/W2070307875', 'https://openalex.org/W2075463253', 'https://openalex.org/W2076131647', 'https://openalex.org/W2081578928', 'https://openalex.org/W2084672400', 'https://openalex.org/W2087928272', 'https://openalex.org/W2088707556', 'https://openalex.org/W2090387937', 'https://openalex.org/W2092137773', 'https://openalex.org/W2093782393', 'https://openalex.org/W2095421021', 'https://openalex.org/W2104911178', 'https://openalex.org/W2109070574', 'https://openalex.org/W2110184627', 'https://openalex.org/W2111128412', 'https://openalex.org/W2118323715', 'https://openalex.org/W2118662136', 'https://openalex.org/W2118877270', 'https://openalex.org/W2119750530', 'https://openalex.org/W2120651556', 'https://openalex.org/W2121390857', 'https://openalex.org/W2134173538', 'https://openalex.org/W2140162407', 'https://openalex.org/W2146156622', 'https://openalex.org/W2148670577', 'https://openalex.org/W2153531028', 'https://openalex.org/W2165741917', 'https://openalex.org/W2167783807', 'https://openalex.org/W2172232070', 'https://openalex.org/W2177288739', 'https://openalex.org/W2183454150', 'https://openalex.org/W2286810390', 'https://openalex.org/W2321616228', 'https://openalex.org/W2339096213'], 'related_works': ['https://openalex.org/W3022403817', 'https://openalex.org/W3005620600', 'https://openalex.org/W2946793880', 'https://openalex.org/W2119623639', 'https://openalex.org/W2102853734', 'https://openalex.org/W2088001693', 'https://openalex.org/W2041922728', 'https://openalex.org/W2022248964', 'https://openalex.org/W2005434082', 'https://openalex.org/W1967950972'], 'abstract_inverted_index': {'Oxidized': [0], 'low-density': [1], 'lipoprotein': [2, 54], '(oxLDL)': [3], 'and': [4, 41, 53, 56, 75, 85, 90, 96, 106, 175, 193, 197, 211, 217], 'oxLDL-containing': [5], 'immune': [6], 'complexes': [7], '(oxLDL-IC)': [8], 'contribute': [9, 233], 'to': [10, 62, 138, 167, 221, 234], 'the': [11, 64, 159, 162, 181, 185, 191, 206, 218], 'formation': [12, 192], 'of': [13, 22, 50, 109, 161, 195, 228, 237], 'lipid-laden': [14], 'macrophages': [15, 40], '(foam': [16], 'cells).': [17], 'Fcγ': [18], 'receptors': [19, 26], 'mediate': [20], 'uptake': [21], 'oxLDL-IC,': [23, 34, 100, 168], 'whereas': [24, 120], 'scavenger': [25], 'internalize': [27], 'oxLDL.': [28], 'We': [29], 'have': [30], 'previously': [31], 'reported': [32], 'that': [33, 149, 209], 'but': [35, 101], 'not': [36, 102], 'free': [37], 'oxLDL,': [38, 103], 'activate': [39], 'prolong': [42], 'their': [43], 'survival.': [44], 'Sphingomyelin': [45], 'is': [46], 'a': [47, 123], 'major': [48], 'constituent': [49], 'cell': [51], 'membranes': [52], 'particles': [55], 'acid': [57], 'sphingomyelinase': [58], '(ASMase)': [59], 'hydrolyses': [60], 'sphingomyelin': [61], 'generate': [63], 'bioactive': [65], 'lipid': [66], 'ceramide.': [67], 'ASMase': [68, 88, 92, 179, 215], 'exists': [69], 'in': [70, 127, 180, 242], 'two': [71], 'forms:': [72], 'lysosomal': [73], '(L-ASMase)': [74], 'secretory': [76], '(S-ASMase).': [77], 'In': [78, 165], 'this': [79], 'study': [80], 'we': [81], 'examined': [82], 'whether': [83, 91], 'oxLDL': [84, 121, 139, 210], 'oxLDL-IC': [86, 114, 189, 212, 222], 'regulate': [87, 214], 'differently,': [89], 'mediates': [93], 'monocyte/macrophage': [94], 'activation': [95, 227], 'cytokine': [97], 'release.': [98], 'The': [99, 113], 'induced': [104, 122, 150, 190], 'early': [105], 'consistent': [107], 'release': [108, 194], 'catalytically': [110], 'active': [111], 'S-ASMase.': [112], 'also': [115], 'consistently': [116], 'stimulated': [117], 'L-ASMase': [118, 128, 141], 'activity,': [119, 216], 'rapid': [124], 'transient': [125], 'increase': [126], 'activity': [129, 144], 'before': [130], 'it': [131], 'steadily': [132], 'declined': [133], 'below': [134], 'baseline.': [135], 'Prolonged': [136], 'exposure': [137], 'increased': [140, 235], 'activity;': [142], 'however,': [143], 'remained': [145], 'significantly': [146], 'lower': [147], 'than': [148], 'by': [151, 225], 'oxLDL-IC.': [152], 'Further': [153], 'studies': [154], 'were': [155], 'aimed': [156], 'at': [157], 'defining': [158], 'function': [160], 'activated': [163], 'ASMase.': [164, 229], 'response': [166], 'heat-shock': [169], 'protein': [170], "70B'": [171], "(HSP70B')": [172], 'was': [173], 'up-regulated': [174], 'localized': [176], 'with': [177, 188], 'redistributed': [178], 'endosomal': [182], 'compartment': [183], 'outside': [184], 'lysosome.': [186], 'Treatment': [187], 'HSP70-containing': [196], 'IL-1β-containing': [198], 'exosomes': [199], 'via': [200], 'an': [201], 'ASMase-dependent': [202], 'mechanism.': [203], 'Taken': [204], 'together,': [205], 'results': [207], 'suggest': [208], 'differentially': [213], 'pro-inflammatory': [219], 'responses': [220], 'are': [223], 'mediated': [224], 'prolonged': [226], 'These': [230], 'findings': [231], 'may': [232], 'understanding': [236], 'mechanisms': [238], 'mediating': [239], 'macrophage': [240], 'involvement': [241], 'atherosclerosis.': [243]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1589760452', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2025-01-12T22:07:39.180827', 'created_date': '2016-06-24'}