Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1586673220', 'doi': 'https://doi.org/10.1111/j.1432-1033.1970.tb00285.x', 'title': 'Regulation of Pyruvate Dehydrogenase Complex Synthesis in Escherichia coli K12. Identification of the Inducing Metabolite', 'display_name': 'Regulation of Pyruvate Dehydrogenase Complex Synthesis in Escherichia coli K12. Identification of the Inducing Metabolite', 'publication_year': 1970, 'publication_date': '1970-06-01', 'ids': {'openalex': 'https://openalex.org/W1586673220', 'doi': 'https://doi.org/10.1111/j.1432-1033.1970.tb00285.x', 'mag': '1586673220', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/4918556'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1432-1033.1970.tb00285.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210214924', 'display_name': 'European Journal of Biochemistry', 'issn_l': '0014-2956', 'issn': ['0014-2956', '0945-5795', '1432-1033'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086035806', 'display_name': 'Jurgen Dietrich', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149899117', 'display_name': 'Max Planck Society', 'ror': 'https://ror.org/01hhn8329', 'country_code': 'DE', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I149899117']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jurgen Dietrich', 'raw_affiliation_strings': ['Max‐Planck‐Institut für BiologieBRD‐7400 Tübingen, Corrensstraße 38, Germany'], 'affiliations': [{'raw_affiliation_string': 'Max‐Planck‐Institut für BiologieBRD‐7400 Tübingen, Corrensstraße 38, Germany', 'institution_ids': ['https://openalex.org/I149899117']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109056979', 'display_name': 'Ulf Henning', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149899117', 'display_name': 'Max Planck Society', 'ror': 'https://ror.org/01hhn8329', 'country_code': 'DE', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I149899117']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ulf Henning', 'raw_affiliation_strings': ['Max‐Planck‐Institut für BiologieBRD‐7400 Tübingen, Corrensstraße 38, Germany'], 'affiliations': [{'raw_affiliation_string': 'Max‐Planck‐Institut für BiologieBRD‐7400 Tübingen, Corrensstraße 38, Germany', 'institution_ids': ['https://openalex.org/I149899117']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.043, 'has_fulltext': False, 'cited_by_count': 69, 'citation_normalized_percentile': {'value': 0.949715, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '14', 'issue': '2', 'first_page': '258', 'last_page': '269'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12915', 'display_name': 'Biochemical Acid Research Studies', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12915', 'display_name': 'Biochemical Acid Research Studies', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11027', 'display_name': 'Metabolism and Genetic Disorders', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Enzymes and Metabolism', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dihydrolipoyl-transacetylase', 'display_name': 'Dihydrolipoyl transacetylase', 'score': 0.8793332}, {'id': 'https://openalex.org/keywords/oxoglutarate-dehydrogenase-complex', 'display_name': 'Oxoglutarate dehydrogenase complex', 'score': 0.66495323}, {'id': 'https://openalex.org/keywords/pyruvate-decarboxylase', 'display_name': 'Pyruvate decarboxylase', 'score': 0.51620656}], 'concepts': [{'id': 'https://openalex.org/C190098323', 'wikidata': 'https://www.wikidata.org/wiki/Q14912712', 'display_name': 'Pyruvate dehydrogenase phosphatase', 'level': 4, 'score': 0.91305286}, {'id': 'https://openalex.org/C88099638', 'wikidata': 'https://www.wikidata.org/wiki/Q412856', 'display_name': 'Pyruvate dehydrogenase complex', 'level': 3, 'score': 0.9076394}, {'id': 'https://openalex.org/C80097345', 'wikidata': 'https://www.wikidata.org/wiki/Q419036', 'display_name': 'Dihydrolipoyl transacetylase', 'level': 5, 'score': 0.8793332}, {'id': 'https://openalex.org/C101972281', 'wikidata': 'https://www.wikidata.org/wiki/Q899965', 'display_name': 'Pyruvate decarboxylation', 'level': 4, 'score': 0.8729837}, {'id': 'https://openalex.org/C9506865', 'wikidata': 'https://www.wikidata.org/wiki/Q6321025', 'display_name': 'Pyruvate dehydrogenase kinase', 'level': 4, 'score': 0.8243309}, {'id': 'https://openalex.org/C151325109', 'wikidata': 'https://www.wikidata.org/wiki/Q22327132', 'display_name': 'Branched-chain alpha-keto acid dehydrogenase complex', 'level': 4, 'score': 0.7392874}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.7086475}, {'id': 'https://openalex.org/C126093377', 'wikidata': 'https://www.wikidata.org/wiki/Q309518', 'display_name': 'Oxoglutarate dehydrogenase complex', 'level': 5, 'score': 0.66495323}, {'id': 'https://openalex.org/C165135838', 'wikidata': 'https://www.wikidata.org/wiki/Q133895', 'display_name': 'Citric acid cycle', 'level': 3, 'score': 0.6554745}, {'id': 'https://openalex.org/C179402230', 'wikidata': 'https://www.wikidata.org/wiki/Q14865383', 'display_name': 'Pyruvate dehydrogenase lipoamide kinase isozyme 1', 'level': 5, 'score': 0.5971193}, {'id': 'https://openalex.org/C2777477808', 'wikidata': 'https://www.wikidata.org/wiki/Q407595', 'display_name': 'Metabolite', 'level': 2, 'score': 0.5305904}, {'id': 'https://openalex.org/C2781281423', 'wikidata': 'https://www.wikidata.org/wiki/Q268414', 'display_name': 'Pyruvate decarboxylase', 'level': 4, 'score': 0.51620656}, {'id': 'https://openalex.org/C140137476', 'wikidata': 'https://www.wikidata.org/wiki/Q21114968', 'display_name': 'Pyruvate carboxylase', 'level': 3, 'score': 0.44526947}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39601663}, {'id': 'https://openalex.org/C2776317432', 'wikidata': 'https://www.wikidata.org/wiki/Q412547', 'display_name': 'Dehydrogenase', 'level': 3, 'score': 0.38523892}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38220158}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.2333704}, {'id': 'https://openalex.org/C2777344606', 'wikidata': 'https://www.wikidata.org/wiki/Q410754', 'display_name': 'Alcohol dehydrogenase', 'level': 3, 'score': 0.15511236}], 'mesh': [{'descriptor_ui': 'D000217', 'descriptor_name': 'Acyltransferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D010088', 'descriptor_name': 'Oxidoreductases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000217', 'descriptor_name': 'Acyltransferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002087', 'descriptor_name': 'Butyrates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002951', 'descriptor_name': 'Citrates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003470', 'descriptor_name': 'Culture Media', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008058', 'descriptor_name': 'Dihydrolipoamide Dehydrogenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008058', 'descriptor_name': 'Dihydrolipoamide Dehydrogenase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004790', 'descriptor_name': 'Enzyme Induction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007651', 'descriptor_name': 'Keto Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008190', 'descriptor_name': 'Lyases', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D008190', 'descriptor_name': 'Lyases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009876', 'descriptor_name': 'Operon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010088', 'descriptor_name': 'Oxidoreductases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011771', 'descriptor_name': 'Pyruvate Oxidase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011771', 'descriptor_name': 'Pyruvate Oxidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011773', 'descriptor_name': 'Pyruvates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013831', 'descriptor_name': 'Thiamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1432-1033.1970.tb00285.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210214924', 'display_name': 'European Journal of Biochemistry', 'issn_l': '0014-2956', 'issn': ['0014-2956', '0945-5795', '1432-1033'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/4918556', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1496569297', 'https://openalex.org/W1518644765', 'https://openalex.org/W1555898673', 'https://openalex.org/W1914017094', 'https://openalex.org/W1973468502', 'https://openalex.org/W1989860121', 'https://openalex.org/W2001851939', 'https://openalex.org/W2003672638', 'https://openalex.org/W2008986243', 'https://openalex.org/W2020584576', 'https://openalex.org/W2025511156', 'https://openalex.org/W2037280307', 'https://openalex.org/W2042478578', 'https://openalex.org/W2046244942', 'https://openalex.org/W2050067531', 'https://openalex.org/W2050599642', 'https://openalex.org/W2061202598', 'https://openalex.org/W2065447455', 'https://openalex.org/W2070308347', 'https://openalex.org/W2071590831', 'https://openalex.org/W2077416701', 'https://openalex.org/W2081617813', 'https://openalex.org/W2086282504', 'https://openalex.org/W2091068486', 'https://openalex.org/W2140275799', 'https://openalex.org/W2143154843', 'https://openalex.org/W2143940022', 'https://openalex.org/W2145239230', 'https://openalex.org/W2169776114', 'https://openalex.org/W2170004862', 'https://openalex.org/W2240641831', 'https://openalex.org/W2316838174', 'https://openalex.org/W2376788889', 'https://openalex.org/W4214835933', 'https://openalex.org/W4246503454', 'https://openalex.org/W73923369', 'https://openalex.org/W79141321'], 'related_works': ['https://openalex.org/W2460573764', 'https://openalex.org/W2369281961', 'https://openalex.org/W2086930068', 'https://openalex.org/W204747089', 'https://openalex.org/W2015269539', 'https://openalex.org/W2015093830', 'https://openalex.org/W1975622822', 'https://openalex.org/W1779131763', 'https://openalex.org/W1661091665', 'https://openalex.org/W1586673220'], 'abstract_inverted_index': {'1': [0], 'The': [1], 'synthesis': [2, 122, 170, 239, 248], 'of': [3, 27, 36, 75, 91, 123, 199, 215, 271, 281], 'the': [4, 17, 25, 37, 89, 95, 121, 138, 166, 204, 220, 272, 279, 282, 305], 'pyruvate': [5, 15, 29, 38, 41, 55, 61, 96, 107, 111, 126, 162, 191, 228, 236, 263, 273, 298], 'dehydrogenase': [6, 39, 62, 79, 97, 108, 127, 163, 237, 274, 299], 'complex': [7, 98, 128, 164, 238], 'in': [8, 88, 133], 'Escherichia': [9], 'coli': [10], 'K12': [11], 'is': [12, 16, 42, 80, 100, 154, 219, 225, 284], 'inducible,': [13], 'and': [14, 31, 259], 'metabolite': [18, 217, 234, 244], 'causing': [19, 211], 'induction.': [20], 'In': [21, 51], 'a': [22, 53, 143, 251], 'mutant': [23, 54], 'lacking': [24], 'activities': [26], 'phosphoenol': [28], 'synthase': [30], 'dihydrolipoamide': [32], 'transacetylase': [33], '(a': [34], 'component': [35], 'complex)': [40], 'no': [43], 'longer': [44], 'significantly': [45], 'metabolized': [46], 'under': [47], 'certain': [48], 'growth': [49, 177], 'conditions.': [50, 178], 'such': [52], 'as': [56, 58, 232, 242], 'well': [57], 'α-ketobutyrate': [59], 'induces': [60], 'synthesis.': [63], 'Decreasing': [64], 'inducing': [65, 168, 233], 'activity': [66, 280], 'was': [67, 147, 181], 'found': [68, 148, 182], 'with': [69, 117], 'increasing': [70], 'chain': [71], 'length': [72], '(or': [73, 249], 'branching)': [74], 'homologous': [76], 'α-ketoacids.': [77], 'Apo-pyruvate': [78], 'produced': [81, 296], 'when': [82, 112], 'thiamine': [83, 118, 151], 'requiring': [84], 'strains': [85, 135], 'are': [86], 'grown': [87], 'absence': [90], 'thiamine,': [92], 'i.': [93, 189], 'e.,': [94, 190], 'formed': [99], 'inactive.': [101], 'Such': [102], 'strains,': [103], 'possessing': [104], 'wild': [105, 124, 139, 260], 'type': [106, 125, 140, 261], 'complex,': [109], 'accumulate': [110], 'growing': [113], 'without': [114], 'thiamine.': [115], 'Only': [116], 'starvation': [119], 'could': [120], 'be': [129], 'fully': [130], 'induced.': [131], 'Also,': [132], 'merodiploid': [134], 'homogenotic': [136], 'for': [137, 183, 235, 245, 250, 304], 'ace': [141, 257], 'locus': [142], 'gene': [144], 'dosage': [145], 'effect': [146], 'only': [149, 231], 'upon': [150], 'deprivation.': [152], 'Inducibility': [153], 'thus': [155, 171], 'separable': [156], 'from': [157], 'enzymatic': [158], 'activity;': [159], 'enzymatically': [160], 'active': [161], 'removes': [165], 'effector': [167], 'its': [169], 'preventing': [172], 'full': [173], 'induction': [174], 'during': [175], 'normal': [176], 'No': [179], 'evidence': [180], 'an': [184, 212, 265], 'indirect': [185], 'action': [186], 'by': [187, 195], 'pyruvate,': [188], 'does': [192], 'not': [193, 230, 308], 'induce': [194], 'inhibition': [196], 'or': [197, 208], 'activation': [198], 'some': [200], 'other': [201], 'reaction': [202], '(in': [203], 'citric': [205], 'acid': [206], 'cycle': [207, 253], 'glycolysis),': [209], 'thereby': [210], 'increased': [213], 'concentration': [214], 'another': [216], 'which': [218, 291], 'true': [221], 'inducer.': [222], '2': [223], 'It': [224, 276], 'possible': [226], 'that': [227, 278, 294], 'serves': [229], 'but': [240], 'also': [241], 'repressing': [243], 'isocitric': [246], 'lyase': [247], 'glyoxylate': [252], 'operon).': [254], '3': [255], 'Both': [256], 'mutants': [258], 'possess': [262], 'oxidase,': [264], 'acetate': [266, 290], 'producing': [267], 'enzyme': [268], 'system': [269], 'independent': [270], 'complex.': [275, 300], 'appears': [277], 'oxidase': [283, 306], 'too': [285], 'low': [286], 'to': [287], 'provide': [288], 'enough': [289], 'can': [292], 'replace': [293], 'normally': [295], 'via': [297], 'A': [301], 'physiological': [302], 'role': [303], 'has': [307], 'been': [309], 'found.': [310]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1586673220', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-12-14T10:28:36.800909', 'created_date': '2016-06-24'}