Publication Information

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1627, 1646, 1654, 1664, 1706, 1728, 1753, 1777, 1781, 1792, 1805, 1834, 1924, 1932, 1941, 1947, 1953, 1958, 1961, 1968, 1982, 1991, 2025, 2038, 2053, 2085, 2094, 2108, 2124, 2129, 2138, 2177, 2197, 2200, 2215, 2221, 2236, 2250, 2264, 2268, 2281, 2293, 2296, 2309, 2312, 2318, 2329, 2361, 2375, 2396, 2428, 2446, 2473, 2507, 2511, 2522, 2527, 2558, 2565, 2569, 2579, 2582, 2608, 2611, 2618, 2621, 2637, 2657, 2664, 2673, 2693, 2727, 2754, 2784, 2787, 2792, 2800, 2822, 2842, 2855, 2881, 2884, 2896, 2900, 2906, 2921, 2948, 2966, 2971, 2976, 3001, 3005, 3039, 3060, 3090, 3121, 3126, 3130, 3147, 3151, 3154, 3189, 3194, 3210, 3213, 3231, 3240, 3251, 3261, 3277, 3283, 3301, 3314, 3319, 3330, 3370, 3377, 3401, 3441, 3466, 3469, 3473, 3482, 3488, 3518, 3538, 3547, 3551, 3607, 3616, 3675, 3679, 3685, 3707, 3720, 3731, 3739, 3781, 3794, 3815, 3822, 3825, 3834, 3842, 3850, 3860, 3922, 3927, 3952, 3962, 3966, 3988, 4001, 4066, 4196, 4201, 4218, 4299, 4306, 4334, 4337, 4347, 4389, 4397, 4413, 4416, 4468, 4477, 4503], 'first': [42, 2907, 3556], 'sponsored': [44], 'Deutsche': [47], 'Forschungsgemeinschaft': [48], '(DFG)': [49], 'as': [50, 79, 81, 758, 1044, 1546, 1548, 1559, 1858, 2476, 2478, 2546, 2562, 2761, 2965, 2992, 2994, 3140, 3168, 3170, 3207, 3588, 3590, 3744, 3982, 3984, 3998, 4221, 4223, 4393, 4528], 'part': [51, 2729, 3605], 'of': [52, 71, 87, 94, 100, 119, 125, 148, 271, 370, 426, 441, 444, 457, 509, 520, 534, 552, 560, 569, 645, 660, 705, 734, 746, 773, 788, 800, 811, 841, 875, 879, 921, 956, 966, 979, 993, 1056, 1077, 1091, 1137, 1143, 1148, 1175, 1202, 1217, 1220, 1232, 1244, 1261, 1270, 1279, 1304, 1320, 1339, 1375, 1390, 1399, 1475, 1484, 1534, 1543, 1551, 1603, 1608, 1619, 1631, 1636, 1666, 1708, 1756, 1769, 1774, 1791, 1809, 1837, 1880, 1931, 1946, 2016, 2027, 2079, 2107, 2199, 2259, 2267, 2283, 2295, 2311, 2320, 2328, 2332, 2348, 2380, 2395, 2416, 2421, 2441, 2445, 2449, 2472, 2514, 2568, 2571, 2581, 2610, 2620, 2677, 2695, 2706, 2730, 2758, 2772, 2786, 2797, 2844, 2847, 2858, 2873, 2880, 2883, 2909, 2936, 2939, 2947, 2968, 2973, 2978, 3000, 3007, 3025, 3043, 3076, 3086, 3125, 3133, 3157, 3243, 3258, 3303, 3329, 3452, 3468, 3475, 3484, 3487, 3505, 3520, 3540, 3592, 3606, 3700, 3712, 3784, 3824, 3827, 3833, 3841, 3857, 3862, 3903, 3921, 3954, 3965, 3973, 3979, 3990, 4014, 4070, 4195, 4238, 4242, 4256, 4259, 4273, 4308, 4336, 4340, 4346, 4360, 4364, 4396, 4400, 4415, 4462, 4500, 4508, 4519], '6': [54], 'year': [55], 'priority': [56], 'programme': [57, 66], 'to': [58, 90, 164, 309, 387, 416, 422, 611, 641, 754, 785, 819, 826, 939, 1018, 1074, 1094, 1128, 1471, 1503, 1657, 1813, 1821, 1869, 1887, 2014, 2064, 2070, 2173, 2182, 2227, 2299, 2305, 2590, 2734, 2834, 3222, 3317, 3336, 3386, 3398, 3434, 3446, 3496, 3508, 3536, 3550, 3585, 3657, 3768, 3792, 3801, 3814, 3894, 3948, 4028, 4045, 4107, 4113, 4144, 4208, 4251, 4283, 4354, 4422, 4436, 4524], 'support': [59], 'research': [60, 241], 'this': [62, 91, 886, 919, 1498, 2410, 2773, 3244, 4365], 'field.': [63], 'The': [64, 132, 264, 490, 1039, 1062, 1135, 1199, 1214, 1442, 1571, 1634, 1735, 2041, 2104, 2325, 2378, 2469, 2496, 2575, 2851, 2930, 2997, 3022, 3073, 3095, 3109, 3216, 3270, 3392, 3450, 3555, 3602, 3627, 3831, 4022, 4192, 4253], 'scientific': [65], 'covered': [67, 109], 'molecular': [69, 82, 1501], 'mechanisms': [70, 519], 'proteolytic': [72, 101, 215, 279, 710, 3096, 4244, 4424], 'systems,': [73, 247], 'including': [74], 'protease': [75, 257, 933, 1051, 1778, 2475, 3050, 3061, 3155, 3195, 3214, 3217, 3278, 3403, 4301, 4391], 'chaperone': [77, 203, 1008, 1371, 1807, 3048, 3152, 3262, 3817, 3924], 'structures': [78], 'well': [80, 1547, 2477, 2993, 3169, 3589, 3983, 4222], 'recognition,': [83], 'unfolding': [84, 210, 835, 1099, 1925, 1992, 2006, 2054], 'processing': [86], 'substrates.': [88, 1124, 2850], 'Complementary': [89], 'biochemical': [92, 3710], 'view': [93], 'proteolysis,': [95, 3587], 'physiology': [97], 'biodiversity': [99], 'processes': [102], 'prokaryotes,': [104], 'mitochondria': [105], 'chloroplasts': [107, 2977], 'were': [108, 465, 1698, 1811, 1900, 1963, 2142, 2225, 2486, 4302, 4328], 'particular': [112], 'focus': [113], 'on': [114, 244, 394, 402, 1600, 1705, 1967, 2196, 3418, 3672, 4163], 'recently': [116, 1404, 3409], 'emerging': [117], 'roles': [118, 1602], 'proteolysis': [120, 613, 1055, 1790, 2831, 2843, 3298, 3858, 4006, 4016, 4148], 'complex': [123, 714, 854, 934, 1146, 1394, 1434, 1536, 1773, 1883, 2133, 2218, 2550, 3190, 3629, 4019, 4220], 'regulation': [124, 144, 3832], 'stress': [126, 506, 663, 680, 1767, 2585, 2624, 3844, 3863, 4132, 4153], 'responses,': [127], 'cell': [128, 3040, 3315, 4381], 'cycle': [129], 'development.': [131], 'cellular': [133, 442], 'proteases': [134, 268, 1885, 2092, 3614], 'major': [137, 1806, 1891, 3294], 'function': [138, 1688, 2379, 3296, 3504], 'protein': [140, 311, 345, 602, 608, 1041, 1112, 1179, 1204, 1343, 1494, 1643, 1660, 1681, 1738, 1763, 1783, 1825, 1847, 1908, 2483, 2517, 2825, 2924, 3036, 3734, 3797, 4104], 'quality': [141, 2484], 'control': [142, 2485, 2580, 3861, 3953, 4355, 4425, 4446], 'have': [145, 448, 556, 1886, 2099, 3947], 'number': [147, 2846], 'features': [149], 'common:': [151], '(i)': [152, 3959], 'they': [153, 187, 586, 2118, 3879], 'recognize': [154], 'many': [155], 'different': [156, 2289], 'substrate': [157, 174, 222, 312, 335, 521, 576, 1138, 1158, 1440, 1510, 1881, 1893, 2017, 2140, 3166, 3227, 4121, 4212, 4410], 'proteins': [158, 167, 336, 492, 499, 528, 577, 998, 1057, 1159, 1359, 1377, 1610, 1640, 1842, 1856, 2122, 2210, 2230, 2242, 2682, 2708, 2937, 3395, 3420, 3522, 3593, 3660, 3917, 4327], 'that': [159, 276, 291, 342, 430, 544, 574, 604, 643, 813, 867, 888, 895, 897, 912, 929, 981, 1070, 1187, 1372, 1419, 1854, 1975, 2405, 2518, 2692, 2722, 2753, 2778, 2827, 2864, 2912, 2916, 3029, 3104, 3138, 3205, 3239, 3412, 3501, 3646, 3807, 4042, 4105, 4188, 4280, 4359, 4373, 4404, 4412, 4487], 'range': [160], 'denatured': [162, 1376, 3309, 3916, 4509], 'polypeptides': [163, 1078, 2426, 3145, 3359, 3387], 'key': [165, 2670, 3033, 3855, 3928], 'regulatory': [166, 1871, 2795, 4198, 4254, 4449], 'fully': [170], 'native': [171, 1846, 1954], 'state,': [172, 3163], 'i.e.': [173, 226, 248, 3323, 3760, 3912, 4511], 'recognition': [175, 363, 562, 596, 624, 1001, 1374, 3967], 'is': [176, 224, 414, 676, 712, 742, 767, 782, 824, 850, 857, 937, 1065, 1071, 1113, 1191, 1205, 1222, 1236, 1253, 1364, 1760, 2059, 2365, 2391, 2453, 2577, 3004, 3031, 3105, 3299, 3334, 3499, 3507, 3572, 3580, 3609, 3688, 3926, 4003, 4031, 4118, 4128, 4137, 4149, 4160, 4177, 4200, 4233, 4261, 4343, 4368, 4458, 4473, 4485, 4495], 'at': [177, 288, 315, 353, 649, 717, 872, 1180, 1317, 1691, 1943, 2084, 2212, 2409, 2783, 2920, 3066, 3512, 3596, 3719], 'same': [179], 'time': [180, 652], 'highly': [181, 184, 4179, 4470], 'flexible': [182], 'specific;': [185], '(ii)': [186, 3970], 'form': [188, 277, 2340, 3218], 'multisubunit': [189], 'barrel-like': [190], 'complexes,': [191], 'active': [194, 2028, 3828], 'sites': [195, 314, 399, 1121, 2020, 3097, 3142], 'sequestered': [196, 990], 'inside': [197, 2037], 'entry': [199], 'tightly': [200], 'controlled': [201, 4130, 4496], 'subunits;': [204], '(iii)': [205, 3985], 'cytosolic': [208, 250], 'proteases,': [209, 252, 2599], 'translocation': [212, 1895, 2186, 2284], 'into': [213, 517, 844, 1314, 1642, 2123, 2345, 2521, 4065], 'chamber': [216, 280], 'requires': [217, 682, 923, 3637], 'ATP': [218], 'hydrolysis;': [219], '(iv)': [221], 'degradation': [223, 644, 787, 943, 1104, 1836, 1959, 1994, 2042, 2286, 2323, 2528, 2609, 2702, 2804, 2814, 3328, 3399, 3611, 3783, 3810, 4127, 4499], 'processive,': [225], 'complete': [227], '(for': [228, 4453], 'recent': [229], 'reviews,': [230], 'see': [231, 1037, 2650, 3347], 'Dougan': [232, 1526], 'et': [233, 297, 301, 487, 565, 620, 656, 693, 697, 701, 1085, 1108, 1161, 1381, 1407, 1411, 1586, 1732, 1797, 1801, 1828, 2357, 2627, 2631, 2927, 3019, 3070, 3081, 3405, 3422, 3576, 3934, 4123, 4214, 4385, 4427], 'al.,': [234, 298, 302, 488, 566, 621, 657, 694, 698, 702, 1086, 1109, 1162, 1382, 1408, 1412, 1587, 1733, 1798, 1802, 1829, 2358, 2628, 2632, 2928, 3020, 3071, 3082, 3406, 3423, 3577, 3935, 4124, 4215, 4386, 4428], '2002a;': [235, 299], 'Jenal': [236], 'Hengge-Aronis,': [238, 4011], '2003).': [239, 489, 567, 622, 1734, 1830, 2539, 4125, 4429], 'Recent': [240], 'has': [242, 306, 1081, 1284, 1512, 1715, 2603, 3046, 3316, 3567, 4205], 'focussed': [243], 'three': [245, 540, 1890], 'model': [246, 1550, 1573, 1907, 3584], 'Clp': [251, 2091, 4504], 'membrane-bound': [254], 'FtsH': [255, 2333, 2386, 2474, 2501, 2543, 2555, 2572, 2654, 2833, 2849, 3883, 4300, 4351, 4390, 4409], '(HflB)': [256, 2334], 'periplasmic': [260], 'DegP': [261, 2933, 3030, 3042, 3077, 3091, 3158, 3192, 3259], '(HtrA)': [262, 2934], 'protease.': [263, 592, 4338, 4505], 'ClpXP': [265, 321, 445, 462, 513, 846, 1050, 1106, 3690, 4120, 4211], 'ClpAP': [267, 323, 447, 464], 'each': [269, 403, 774, 1218, 1233, 2394], 'consist': [270], 'two': [272, 535, 600, 719, 1118, 1156, 1211, 1225, 1248, 1288, 1349, 1420, 1983, 2597, 2780, 3713], 'seven-subunit': [273], 'ClpP': [274, 458, 1779, 2039], 'rings': [275, 286, 3088], 'six-subunit': [282], 'ClpX': [283, 349, 362, 429, 925, 1007, 1095, 1101, 1129, 1150, 3714, 3774, 3816], 'or': [284, 350, 361, 375, 397, 558, 625, 637, 667, 790, 836, 871, 1360, 1839, 2157, 2168, 2257, 2316, 2509, 2776, 2794, 3013, 3327, 3345, 3364, 3779, 3787, 3942, 4115, 4240], 'ClpA': [285, 351, 360, 427, 1370, 1379, 1400, 1466, 1479, 1485, 1509, 1544, 1553, 2031, 2071], 'attached': [287, 1557, 2164], 'both': [289, 924, 1718, 2246, 2919, 3047, 3717, 3808, 4475], 'ends': [290, 1231, 1319, 1945], 'bind': [292, 366], 'unfold': [294, 2119, 2300], 'substrates': [295, 413, 443, 460, 514, 555, 647, 1093, 1745, 1909, 2290, 2655, 3027, 4297], '(Guo': [296, 1406], 'Wang': [300], '1997).': [303], 'Electron': [304], 'microscopy': [305], 'been': [307, 449, 1082, 1285, 1513, 2605], 'used': [308], 'locate': [310], 'binding': [313, 331, 390, 398, 434, 525, 685, 745, 760, 779, 1090, 1120, 2350, 3132, 3167, 3800, 3813], 'outer': [317], 'ring': [318, 352, 2202], 'surface': [319, 2198], 'complexes': [324], '(Mike': [325], 'Maurizi,': [326], 'NIH,': [327], 'Bethesda,': [328], 'USA).': [329, 2154], 'Direct': [330], 'measurements': [332], 'several': [334, 4361], '(λO': [337], 'protein,': [338, 2809, 4450], 'RepA,': [339], 'GFP-SsrA)': [340], 'indicate': [341, 796], 'only': [343, 438, 584, 1431, 2234, 3107, 3620, 4248], 'one': [344, 371, 557, 1243, 3012], 'molecule': [346, 3608], 'binds': [347, 1127, 3776], 'per': [348, 373], 'time.': [355, 2080], 'Surprisingly,': [356, 918, 2248], 'peptides': [358], 'containing': [359], 'tags': [364, 2159], 'also': [365, 572, 982, 1042, 1437, 2220, 2292, 2604, 2840, 3247, 3416, 3669], 'stoichiometry': [369], 'peptide': [372, 412, 1069, 1312], 'ClpA6': [374, 1572], 'ClpX6.': [376, 763, 771], 'Two': [377], 'models': [378, 420], 'can': [379, 632, 1354, 2502, 2531, 2683, 3246, 3307, 3415, 3533, 3818, 3888], 'explain': [380, 1504], 'these': [381, 419, 1670, 3904], 'data:': [382], 'all': [383, 551], 'six': [384, 2112], 'subunits': [385, 1556], 'contribute': [386], 'single': [389, 3909], 'site': [391, 761, 780, 817, 986], 'centrally': [392], 'located': [393, 401, 3099], 'hexamer,': [396, 1151, 1480], 'are': [400, 582, 587, 1337, 1346, 1428, 1445, 1866, 2412, 2459, 2656, 2698, 2952, 2958, 2982, 3054, 3098, 3113, 3172, 3273, 3357, 3374, 3396, 3749, 3763, 3849, 3869, 3872, 3880, 4052, 4226], 'subunit': [404], 'but': [405, 675, 916, 936, 1436, 1950, 1971, 2190, 2799, 2944, 3871], 'display': [406, 4276], 'high': [407, 1462], 'negative': [408], 'cooperativity.': [409], 'Cross-linking': [410], 'underway': [415], 'distinguish': [417], 'between': [418, 1210, 1465, 1537, 2596, 2709, 3191, 3321, 3341], 'identify': [423], 'regions': [425, 721, 1024, 2315], 'make': [431, 3318], 'up': [432, 4044], 'sites.': [435], 'To': [436, 1922, 1956, 2115], 'date,': [437], 'handful': [440], 'identified.': [450], 'Using': [451, 1414, 2155], 'tagged': [453, 1092], 'inactive': [455, 2033, 3162], 'variant': [456, 2717, 3775], '(ClpPtrap),': [459], 'trapped': [466, 491, 554], 'vivo,': [468, 908, 3759], 'purified': [469], 'identified': [471, 512, 4303, 4323], 'mass': [473], 'spectrometry': [474], '(reported': [475], 'Briana': [477], 'Burton,': [478], 'Tania': [480], "Baker's": [481], 'laboratory,': [482, 2149, 3528, 4078, 4170], 'MIT,': [483], 'Cambridge,': [484, 1170], 'USA;': [485], 'Flynn': [486], 'include': [493], 'transcription': [494, 4357], 'factors,': [495, 627], 'metabolic': [496], 'enzymes': [497], 'involved': [500, 1254, 1764, 2983, 4376], 'starvation': [503, 4114, 4140], 'oxidative': [505, 4116, 4152], 'responses.': [507, 3864], 'Analysis': [508, 2705], 'newly': [511], 'provided': [515, 2751], 'insight': [516], 'recognition.': [522, 1033], 'Sequence': [523], 'analysis,': [524], 'studies,': [526], 'fusion': [527, 2269, 3394], 'mutagenesis': [530], 'revealed': [531, 573, 2721], 'presence': [533, 3474], 'related': [536, 541, 1580, 2083], 'C-terminal': [537, 2512, 2756, 2856, 3015], 'motifs': [538, 543], 'N-terminal': [542, 1029, 1397, 1482, 1541, 1933, 2728, 3271], 'may': [545, 4514], 'be': [546, 633, 1997, 2022, 2306, 2503, 2532, 2684, 2735, 3199, 3220, 3248, 3308, 3534, 3819, 3889, 3949, 4209, 4407, 4420, 4437, 4525], 'recognized': [547, 583], 'ClpX.': [549], 'Nearly': [550], 'more': [559, 3014], 'signals': [563, 597, 3938, 4187], '(Flynn': [564, 4122], 'Use': [568], 'ClpPtrap': [571], 'some': [575], '(e.g.': [578, 2231, 2243, 3343, 3352], 'SOS-regulator': [580], 'LexA)': [581], 'after': [585], 'initially': [588, 803], 'cleaved': [589], 'another': [591], 'RecA-induced': [593], 'autocleavage': [594], 'uncovers': [595], 'separated': [601], 'domains': [603, 3017, 3272, 3279, 3287], 'render': [605], 'LexA': [607], 'fragments': [609], 'susceptible': [610], 'ClpXP-dependent': [612, 3782], 'vivo': [615, 3730, 3771], 'vitro': [618, 1651, 2819], '(Neher': [619], 'Additional': [623], 'targeting': [626], 'whose': [628, 1079], 'expression': [629, 4414, 4491], 'and/or': [630], 'activity': [631, 922, 1725, 2796, 3062, 3539, 3737, 3757], 'regulated': [634, 1789, 4180], 'intra-': [636], 'extracellular': [638], 'signals,': [639], 'help': [640], 'ensure': [642], 'specific': [646, 1357, 1870, 2322], 'occurs': [648, 670, 1977, 2195, 3649, 3958], 'right': [651], 'place': [654], '(Dougan': [655, 1380], '2002a).': [658], 'Proteolysis': [659, 3532], 'general': [662, 1766, 3843], 'sigma': [664, 1026, 2660, 3837, 3846, 3905, 4371], 'factor': [665, 775, 1002, 1047, 1367, 2613, 2661, 3034, 3838, 3847, 3968, 4372], 'σS': [666, 706, 723, 789, 806, 823, 843, 856, 891, 913, 941, 959, 969, 3848, 3868, 3955, 3980, 3991, 3999, 4015, 4025, 4145], 'RpoS': [668], '(which': [669], 'rapidly': [672], 'growing': [673], 'cells': [674, 3748, 3762, 4111, 4314], 'inhibited': [677, 1752, 4150], 'various': [679, 2209, 3895], 'conditions)': [681], 'initial': [683, 3131, 4083], 'direct': [684], 'phosphorylated': [688, 747], 'response': [689, 2586, 2625, 3845, 3893], 'regulator': [690, 1794, 4194], 'RssB': [691, 802, 828, 880, 957, 967, 980, 1003, 3974, 4040, 4050, 4059, 4164], '(Becker': [692], '1999;': [695], 'Klauck': [696], '2001;': [699], 'Zhou': [700], '2001).': [703, 2206], 'Recognition': [704], 'RssB/ClpXP': [709, 3885], 'machinery': [711], 'process': [715, 887, 1649], 'involving': [716], 'least': [718, 4321], 'distinct': [720], '(Fig.': [724, 1184, 1401, 1495, 2354, 2494, 3093], '1;': [725], 'R': [726], 'Hengge,': [727, 1012], 'Freie': [728, 1013, 4079, 4171], 'Universität,': [729, 1014], 'Berlin,': [730, 4081, 4173], 'Germany).': [731, 1532, 1877, 3186, 4098, 4174, 4319, 4444], 'Region': [732], '2.5': [733, 1385], 'σS,': [735, 765, 4135], 'which': [736, 1345, 2194, 2373, 2389, 2530, 2588, 2615, 2667, 3119, 3165, 3381, 3683, 4056, 4182, 4204, 4457], 'forms': [737, 935, 3089, 3257], 'long': [739], 'α': [740], 'helix,': [741], 'sufficient': [743, 784, 2765], 'RssB.': [748], 'In': [749, 1469, 1816, 2360, 2540, 3150, 3187, 3367, 3674, 3692, 3729, 3752, 3766, 4430], 'addition,': [750, 3188], 'region': [752, 869, 2725, 2852, 2915], 'close': [753, 818, 1951, 1965], 'N-terminus': [756], 'acts': [757, 2760, 4392], 'Native': [764], 'however,': [766], 'not': [768, 783, 1430, 1849, 1867, 2082, 2188, 2271, 2699, 2790, 2945, 3750, 4053, 4155, 4161, 4262], 'bound': [769, 825, 2069, 2457, 4250], 'Interaction': [772, 992], 'respective': [778], 'alone': [781, 4225, 4232], 'trigger': [786], 'σS-derived': [791], 'reporter': [792], 'proteins.': [793, 1633, 2594, 2956, 3305], 'These': [794, 1352, 1898, 2903, 3052, 3306, 3804], 'data': [795, 3203], 'following': [798], 'sequence': [799, 2088, 3439, 3471], 'events:': [801], 'interacts': [804], 'triggers': [808], 'change': [810, 3430], 'conformation': [812, 2075, 3263], 'exposes': [814], 'ClpX6-binding': [816], 'N-terminus.': [821], 'Once': [822], 'ClpX6,': [827], 'plays': [829, 2668], 'second': [831], 'role': [832, 884, 950, 2480, 2671, 3856, 4255], '(either': [833], 'during': [837, 3389], 'beginning': [839], 'transfer': [840, 1914], 'unfolded': [842, 1838, 2060, 2074, 2425, 3144], 'protease),': [847], 'before': [848], 'it': [849, 1416, 3643, 4484], 'released': [851, 2275, 3375], 'completely': [858], 'degraded.': [859, 1850], 'Experiments': [860], 'reported': [861, 894, 1165, 1597, 1704, 3238, 3694], 'Susan': [863], 'Gottesmann': [864], '(NIH)': [865], 'suggest': [866, 3204], 'near': [870, 2065, 2165], 'C-terminus': [874, 904, 1076, 1260, 2785], 'output': [877], 'domain': [878, 1216, 1398, 1483, 1542, 1935, 2253, 2303, 2331, 2448, 3010, 3156], 'might': [881, 4406], 'play': [882], 'goes': [889], 'beyond': [890], 'binding.': [892], 'She': [893], 'deletions': [896], 'remove': [898], '25–100': [899], 'amino': [900, 2086, 2400, 3603], 'acids': [901], 'apparently': [905], 'sequester': [906], 'σSin': [907], 'consequence': [911], 'becomes': [914, 3618], 'stable': [915, 931, 1115, 1742, 2715, 3619, 3799, 4071], 'inactive.': [917], 'inhibition': [920], 'ClpP,': [927, 2034], 'suggesting': [928, 2418, 4403], 'σS–RssB–ClpXP': [932], 'unable': [938], 'release': [940, 2015], 'ClpXP.': [945], 'Consistent': [946, 1668], 'critical': [949], 'phosphorylation': [952, 985, 3963], 'interaction': [955, 965, 1283, 1296], 'physiologically': [963], 'relevant': [964], 'C-terminally': [972, 976], 'deleted': [973, 977], 'mutants,': [974, 3652], 'derivative': [978], 'lacks': [983], '(D58P)': [987], 'no': [988, 3736], 'longer': [989, 2048], 'σS.': [991], 'σS(RpoS)': [994], 'RpoS::LacZ': [996], 'hybrid': [997, 2707], 'hexameric': [1006, 1552, 1582, 2362], '(provided': [1009, 1323, 1565, 2463, 2642, 3264], 'R.': [1011, 1327, 4076, 4168], 'Berlin).': [1015], 'Numbers': [1016], 'refer': [1017], 'common': [1020, 2399], 'nomenclature': [1021], 'functional': [1023], 'factors.': [1027, 1362, 3906], 'NTE:': [1028], 'element': [1030], 'ClpX6': [1032], 'For': [1034], 'other': [1035, 2241, 2398, 2848, 3658, 4362], 'details,': [1036, 2649], 'text.': [1038], 'SspB': [1040, 1088, 1111, 1125, 1153, 1178, 1189, 1221, 1264, 1306], 'serves': [1043], 'specificity': [1046, 1361, 1456, 1511, 3228], 'specifically': [1053], 'stimulating': [1054], 'bearing': [1058], 'an': [1059, 1066, 1295, 1747, 1761, 2073, 2419, 2547, 2723, 3161, 3502, 3541, 3899, 3913, 4369], 'SsrA': [1060, 1063, 1310, 3378, 3413], 'tag.': [1061], 'tag': [1064, 1311, 2775, 2788, 3385], '11': [1067], 'residue': [1068], 'added': [1072], 'co-translationally': [1073, 3382], 'biosynthesis': [1080, 3560, 4176, 4383], 'stalled': [1083], '(Karzai': [1084, 3404], '2000).': [1087, 1110, 3407], 'enhances': [1089], 'stimulates': [1097, 1131, 2526], 'their': [1098, 1103, 1862, 3390, 3769], '(Levchenko': [1107], 'homodimer': [1116], 'independent': [1119, 1289], 'SsrA-tagged': [1123, 1157], 'itself': [1126], 'ATPase': [1133, 1350, 1724, 2113, 2132, 2178, 2201, 2298, 2330, 2447], 'activity.': [1134, 3234], 'mechanism': [1136, 1502, 4037, 4522], 'delivery': [1139], 'involves': [1140, 4447], 'formation': [1142, 1435, 3519], 'tertiary': [1145], 'consisting': [1147, 1618], 'dimer': [1154, 1190, 1234, 1307, 1322], '(Wah': [1160], '2002).': [1163, 1413, 2359, 2633, 2929, 3021, 3083, 3428, 3578, 4012, 4216, 4387], 'As': [1164, 4467], 'Igor': [1167], 'Levchenko': [1168], '(MIT,': [1169], 'USA),': [1171], 'crystal': [1173, 1290, 1388, 2326, 3074], 'structure': [1174, 1389, 1730, 2101, 2327, 2793, 3075], 'Haemophilus': [1176], 'influenzae': [1177], '1.8': [1181], 'Å': [1182, 1193, 1386], 'resolution': [1183, 1387], '2)': [1185], 'reveals': [1186], '65': [1192], 'wide': [1194], 'maximal': [1197], 'dimension.': [1198], 'dimerization': [1200], 'interface': [1201], 'formed': [1206, 1223, 1241, 3114], 'hydrophobic': [1208, 1239, 1315, 3136], 'contacts': [1209], 'amino-terminal': [1212], 'α-helices.': [1213], 'core': [1215, 3996], 'monomer': [1219], 'four-stranded': [1226], 'β-sheets.': [1227], 'At': [1228, 4320], 'extreme': [1230], 'there': [1235, 2364], 'well-defined': [1238], "'cleft'": [1240], 'β-strands': [1246], 'loop': [1249], 'structures.': [1250], 'This': [1251, 1281, 1713, 1851, 3333, 3897, 3957, 4445, 4521], 'cleft': [1252, 1274], 'crystallographic': [1256], 'contact': [1257, 1421], 'neighbouring': [1263], 'dimer,': [1265], 'where': [1266, 3313, 4049], 'backbone': [1268], 'atoms': [1269], 'Asn53': [1271], 'interact': [1275], 'side-chain': [1278], 'Gln120.': [1280], 'cleft–peptide': [1282], 'observed': [1286, 2606, 3249, 4435], 'forms,': [1291], 'probably': [1293, 3129], 'reflects': [1294], 'important': [1297, 3535, 3820], 'forming': [1299, 1987], 'SspB–SsrA': [1301], 'complex.': [1302], 'Structure': [1303, 1533], 'modelled': [1313, 1487, 2443], 'clefts': [1316], 'opposite': [1318, 1944], 'I.': [1325], 'Levchenko,': [1326], 'Grant': [1328], 'T.': [1330, 3266], 'Baker;': [1331], 'MIT).': [1332], 'ClpA,': [1333], 'ClpB': [1334, 1620, 1710, 1736], 'ClpC': [1336, 1759, 1775, 1810, 1820], 'representatives': [1338], 'typical': [1341], 'HSP100': [1342, 1762], 'family,': [1344], 'chaperones': [1347, 1353, 1604, 3342, 3595], 'domains.': [1351], 'cooperate': [1355], 'adaptor': [1358, 1782, 1855], 'ClpS': [1363, 1391, 1459, 1476, 1538, 1555], 'such': [1365, 1857, 2964, 3368], 'improves': [1373], '2002b).': [1383], '3A)': [1402], 'determined': [1405, 2307, 2336], '2002b;': [1409], 'Zeth': [1410], 'mutagenesis,': [1415], 'demonstrated': [1418, 2826], 'residues': [1422, 1444, 2408, 2782], '(Glu': [1423], '79': [1424], 'Lys': [1426], '84)': [1427], 'essential': [1429, 1690, 2413, 2700, 3542], 'ClpAS': [1433], 'ClpAPS-mediated': [1439], 'degradation.': [1441, 1897, 2838], 'corresponding': [1443], 'absent': [1446], 'ClpB,': [1448], 'providing': [1449, 2343], 'structural': [1451, 3202, 3224], 'rationale': [1452], 'unique': [1455], 'exhibited': [1457, 1679], 'despite': [1460], 'overall': [1463, 1729, 3552], 'similarity': [1464], 'ClpB.': [1468, 1667, 3641], 'order': [1470], 'elucidate': [1472], 'location': [1474, 2319], 'within': [1477, 4000], 'onto': [1488, 1578], 'structurally': [1490], 'defined,': [1491], 'homologous,': [1492], 'AAA+': [1493], '3B).': [1496], 'From': [1497], 'model,': [1499], 'ClpS-mediated': [1506], 'switch': [1507, 3232, 3245, 4020, 4064], 'suggested': [1514, 2563], '(Kornelius': [1515], 'Zeth,': [1516, 1568], 'Max': [1517, 3182, 4094], 'Planck': [1518, 3183, 4095], 'Institute,': [1519, 3184], 'Martinsried,': [1520, 3185], 'Germany,': [1521], 'collaboration': [1523], 'David': [1525], 'Bukau,': [1529], 'ZMBH,': [1530, 1875], 'Heidelberg,': [1531, 1595, 1876], '(A)': [1545], 'shown': [1558, 2460, 3274, 3645], 'side': [1560, 2439, 3111], 'top': [1562], 'views': [1563, 2440], '(B)': [1564], 'K.': [1567, 2644], 'MPI': [1569, 3268], 'Martinsried).': [1570, 3269], 'generated': [1575, 3360], 'superposition': [1577], 'AAA-protein': [1581], 'NSF': [1583], 'protein;': [1584], 'Yu': [1585], '1998).': [1588], 'Axel': [1589], 'Mogk': [1590, 1700], '(ZMBH,': [1594], 'Germany)': [1596], 'novel': [1598], 'results': [1599, 2616, 3805, 4057], 'removal': [1607], 'heat-aggregated': [1609, 1841], 'Escherichia': [1613], 'coli': [1614, 2639, 3045, 3563], 'cytosol.': [1615, 2523], "'bi-chaperone',": [1617], 'DnaK': [1623, 1655, 1696, 3628, 3923], 'system': [1624, 1656, 3742], '(KJE),': [1625], 'mediates': [1626], 'solubilization': [1628], 'refolding': [1630, 2011], 'aggregated': [1632, 3311, 3647, 3659], 'intercalation': [1635], 'heat': [1638, 2658, 2954, 3835, 4286], 'shock': [1639, 2659, 2955, 3836], '(sHSPs)': [1641], 'aggregates': [1644, 1661, 1826, 3636], 'accelerated': [1645], 'ClpB/KJE-mediated': [1647], 'resolubilization': [1648], 'enabled': [1653, 1819, 1833], 'disaggregate': [1658, 1822], 'even': [1662], 'absence': [1665, 2026, 4335], 'findings,': [1671], 'E.': [1672, 2638, 2710, 3044, 3562], 'coliΔibpAB': [1673], 'mutant': [1674, 1714, 1737, 1930, 3715, 3733, 3796], 'strains,': [1675], 'lacking': [1676], 'sHSP': [1677, 1687], 'function,': [1678], 'delayed': [1680], 'disaggregation': [1682, 3324], 'reduced': [1684], 'thermotolerance,': [1685], 'became': [1689, 3410], 'higher': [1692], 'growth': [1693, 3548, 3598], 'temperatures': [1694, 3068, 3599], 'when': [1695, 2249, 4249], 'levels': [1697, 2925, 3826, 4026, 4051, 4069, 4109, 4507], 'low.': [1699], 'furthermore': [1703], 'identification': [1707], 'trap': [1711], 'mutant.': [1712], 'alterations': [1716], 'Walker': [1719], 'B': [1720], 'motifs,': [1721], 'thereby': [1722, 3516, 3546], 'abolishing': [1723], 'without': [1726], 'affecting': [1727, 3987], '(Mogk': [1731], 'interacted': [1739], 'manner': [1743], 'ATP-dependent': [1748, 1884, 2192], 'way': [1749], 'strongly': [1751], 'KJE-dependent': [1754], 'dissociation': [1755], 'sHSP/substrate': [1757], 'complexes.': [1758], 'survival': [1768], 'Bacillus': [1770], 'subtilis.': [1771], 'MecA': [1784, 1818, 1832], 'controls': [1785, 4039, 4374], 'competence': [1786, 4292], 'development': [1787], 'master': [1793, 4193], 'ComK': [1795], '(Turgay': [1796], '1998;': [1799], 'Persuh': [1800], '1999).': [1803, 3072], 'Also': [1804], 'activities': [1808, 1899], 'found': [1812, 2172, 2226, 2287, 2733, 4353], 'require': [1814, 2174], 'MecA.': [1815], 'particular,': [1817], 'refold': [1824], '(Schlothauer': [1827], 'Finally,': [1831], 'subsequent': [1835], 'previously': [1840], 'ClpCP': [1844, 4433, 4512], 'while': [1845, 2456], 'study': [1852, 3586], 'demonstrates': [1853], 'MecA,': [1859], 'interacting': [1860], 'cognate': [1863], 'HSP100/Clp': [1864], 'proteins,': [1865, 1882, 3716, 4510], 'restricted': [1868], 'tasks': [1872], '(Kürsad': [1873], 'Turgay,': [1874], 'After': [1878], 'capture': [1879], 'carry': [1888], 'out': [1889, 4207], 'tasks:': [1892], 'unfolding,': [1894, 2193], 'studied': [1901, 2143], 'real-time': [1903], 'using': [1904, 2208], 'ClpAP,': [1905], 'fluorescent': [1906], 'fluorescence': [1911], 'resonance': [1912], 'energy': [1913], '(FRET)': [1915], 'technology': [1916], '(Eilika': [1917], 'Weber-Ban,': [1918], 'ETH,': [1919, 2742], 'Zürich,': [1920, 2743], 'Switzerland).': [1921, 2744], 'probe': [1923], 'reaction,': [1926, 1960], 'double': [1928], 'cysteine': [1929], 'λ-repressor': [1934], '(in': [1936], 'λR-SsrA)': [1937], 'made': [1939], 'cysteines': [1942, 1962, 1984], 'primary': [1948, 1969], 'structure,': [1949, 1970], 'structure.': [1955], 'follow': [1957], 'placed': [1964], 'together': [1966], 'far': [1972], 'enough': [1973], 'apart': [1974], 'cleavage': [1976], 'between.': [1979], 'By': [1980], 'labelling': [1981], 'fluorophores': [1986], 'FRET': [1989, 2003], 'pair,': [1990], 'reaction': [1995, 2043, 2499], 'could': [1996, 2021, 2887, 3198, 4419], 'followed': [1998], 'via': [1999, 4497], 'decrease': [2001], 'efficiency.': [2004], 'An': [2005, 2817], 'phase': [2007, 2012, 2050], 'slow': [2010], 'due': [2013, 4027], 'ClpA-binding': [2019], 'detected': [2023], 'ClpP.': [2029], 'With': [2030, 2056], 'λR-SsrA': [2035, 2058], 'refolds': [2036], 'cavity.': [2040, 3149], 'proceeds': [2044], 'fourfold': [2047], 'lag': [2049], 'compared': [2051], 'reaction.': [2055], 'ATPγS,': [2057], 'very': [2061], 'slowly': [2062], 'completion': [2066], 'stays': [2068], 'over': [2076], 'extended': [2077, 3521, 3656], 'periods': [2078], 'Although': [2081], 'acid': [2087], 'level,': [2089], 'bacterial': [2090], 'eukaryotic': [2095], 'archaeal': [2097], 'proteasome': [2098, 2110, 2126, 2224], 'analogous': [2100], 'function.': [2103], '19S': [2105], 'component': [2106], '26S': [2109, 2223], 'contains': [2111], 'subunits.': [2114], 'clarify': [2116], 'how': [2117], 'translocate': [2121], '20S': [2125, 2217], 'degradation,': [2128, 4146], 'homologous': [2130], 'proteasome-regulatory': [2131], 'archaea,': [2135], 'PAN,': [2136], 'globular': [2139, 2251, 2302], 'GFP-SsrA': [2141, 2170], '(Ami': [2144], 'Navon': [2145], 'A.': [2147], "Goldberg's": [2148], 'Harvard': [2150], 'Medical': [2151], 'School,': [2152], 'Boston,': [2153], 'large': [2158, 2549, 3023], '(Biotin': [2160], 'Biotin-Avidin': [2162], 'respectively)': [2163], 'N-': [2167, 2508], 'C-termini,': [2169], 'threading': [2175, 2424], 'through': [2176, 2427], 'C': [2181, 4529], 'N': [2183, 2237], 'direction.': [2184], 'Moreover,': [2185], 'does': [2187], 'cause': [2189], 'follows': [2191], '(Navon': [2203], 'Goldberg,': [2205], 'However,': [2207, 3642, 3789], 'blocked': [2211], 'either': [2213, 2505, 2687, 3785], 'end,': [2214, 2688], 'PAN': [2216], 'mammalian': [2222], 'degrade': [2228], 'certain': [2229, 2240, 4047], 'casein)': [2232], 'starting': [2233], 'terminus,': [2238], 'calmodulin)': [2244], 'directions.': [2247], 'GFP': [2252, 2265], 'fused': [2255], 'upstream': [2256], 'downstream': [2258], 'readily': [2261], 'degradable': [2262], 'polypeptide,': [2263], 'portion': [2266], 'degraded': [2272, 2685, 3363, 3881, 4227], 'folded': [2278], 'form.': [2279], 'Thus,': [2280], 'direction': [2282], 'capacity': [2294], 'proteasomal': [2297], 'appears': [2304], 'properties': [2310], "protein's": [2313], 'terminal': [2314, 3604], 'signal.': [2324], 'hexamer': [2339, 2444, 3092], 'modelled,': [2342], 'insights': [2344], 'possible': [2346], 'modes': [2347], 'nucleotide': [2349], 'intersubunit': [2352], 'catalysis': [2353, 3171], '4;': [2355], 'Krzywda': [2356], 'ring,': [2363], 'conserved': [2367, 2755, 2774, 2932], 'aromatic': [2368], 'residue,': [2369], 'Phe228': [2370, 2381, 2390, 2422], 'FtsH,': [2372], 'lines': [2374], 'central': [2376, 2430, 3102], 'pore.': [2377], 'probed': [2383], 'constructing': [2385], 'mutants': [2387], 'replaced': [2392], '19': [2397], 'acids.': [2401], 'Functional': [2402], 'assays': [2403], 'indicated': [2404], 'bulkier': [2406], 'uncharged/non-polar': [2407], 'position': [2411], 'retention': [2415], 'activity,': [2417, 4402], 'involvement': [2420], "enzyme's": [2429], 'pore': [2431], '(Teru': [2432], 'Ogura,': [2433, 2466], 'Kumamoto': [2434, 2467], 'University,': [2435, 2492, 2748, 3177, 3664, 4268], 'Japan).': [2436, 4269], 'Top': [2437], 'FtsH.': [2450, 2704, 2806], 'Each': [2451], 'protomer': [2452], 'coloured': [2454], 'differently,': [2455], 'ATPs': [2458], 'red': [2462, 3289], 'Teru': [2465], 'University).': [2468], 'mechanistic': [2470], 'functions': [2471, 3053], 'membrane': [2482, 2516, 2593, 2641, 2681], 'summarized': [2487], 'Koreaki': [2489], 'Ito': [2490], '(Kyoto': [2491], 'Japan)': [2493], '5).': [2495], 'processive': [2497], 'dislocation/proteolysis': [2498], 'initiated': [2504], 'tail': [2513], 'protrudes': [2519], 'sufficiently': [2520], 'Proton-motive': [2524], 'force': [2525], 'process,': [2529, 4181], 'reconstituted': [2533], 'proteoliposomes': [2535], '(Akiyama': [2536], 'Ito,': [2538, 2645], 'wild-type': [2541, 3756, 4310], 'cells,': [2542], 'exists': [2544, 3159], 'exclusively': [2545], 'exceptionally': [2548], 'HflKC,': [2552], 'termed': [2553], "'holo-enzyme'.": [2554], 'cooperates': [2556], 'membrane-integrated': [2559], 'metallo-protease': [2560], 'HtpX,': [2561], 'synthetic': [2566], 'lethality': [2567], 'loss': [2570], 'HtpX.': [2574], 'latter': [2576], 'under': [2578, 3875], 'Cpx': [2583], 'extracytoplasmic': [2584, 2623, 2962], 'pathway,': [2587, 3544], 'responds': [2589], 'abnormal': [2591], 'cytoplasmic': [2592], 'Cooperation': [2595], 'membrane-associated': [2598], 'DegS': [2600], 'YaeL,': [2602], 'anti-σE': [2612], 'RseA,': [2614], 'activation': [2619, 4461], 'σE-dependent': [2622], '(Alba': [2626], '2002;': [2629, 3424, 4008], 'Kanehara': [2630], 'Proteolytic': [2634], 'systems': [2635, 3351, 3668], 'plasma': [2640], 'Kyoto': [2646], 'University;': [2647], 'text).': [2651], 'Classic': [2652], 'soluble': [2653], 'σ32': [2662, 2696, 2716, 3839, 3866, 3931], 'CII': [2665, 2759, 2798, 2803, 2812, 2836, 2859, 2876, 2897], 'regulator,': [2666], 'phage': [2674, 2678], 'lysis-lysogeny': [2675], 'decision': [2676, 3320], 'lambda.': [2679], 'While': [2680], 'truncation': [2689], 'analyses': [2690], 'showed': [2691], 'termini': [2694], '(RpoH)': [2697], 'coliσ32': [2711], 'comparatively': [2714], 'Bradyrhizobium': [2719], 'japonicum': [2720], 'internal': [2724], 'RpoH': [2731], 'required': [2736, 4459], 'rapid': [2738, 2769, 3901, 4029], 'turnover': [2739, 4258], '(Franz': [2740], 'Narberhaus,': [2741], 'Amos': [2745], 'Oppenheim': [2746], '(Hebrew': [2747], 'Jerusalem,': [2749], 'Israel)': [2750], 'evidence': [2752], 'end': [2757, 2857, 2882], 'necessary': [2763], 'cis-acting': [2766], 'target': [2767], 'proteolysis.': [2770, 3673, 3956], 'Deletions': [2771], 'mutations': [2777, 2801], 'add': [2779], 'aspartate': [2781], 'do': [2789], 'affect': [2791], 'abrogate': [2802], 'Another': [2807], 'λ': [2808], 'CIII,': [2810], 'protects': [2811], 'vivo.': [2816], 'assay': [2820], 'lambda': [2823], 'CIII': [2824, 2828, 2839], 'directly': [2829], 'inhibits': [2830, 2841], 'protect': [2835], 'coding': [2853], 'overlaps': [2860], 'gene': [2863, 2886, 2911, 4455], 'encodes': [2865], 'antisense': [2868], 'RNA': [2869, 2890], 'called': [2870], 'OOP.': [2871], 'Expression': [2872], 'OOP': [2874, 2889], 'decreases': [2875], 'mRNA': [2877, 2922, 3442], 'stability.': [2878], 'Deletion': [2879], 'cII': [2885], 'prevent': [2888, 3509], '(supplied': [2891], 'trans)': [2893], 'interference': [2894], 'requirement': [2898], 'lysogenic': [2901], 'pathway.': [2902], 'findings': [2904], 'provide': [2905], 'example': [2908], 'carries': [2913], 'modulates': [2917], 'stability': [2918], '(Kobiler': [2926], 'widely': [2931, 4526], 'family': [2935, 2950, 3003], 'consists': [2938], 'ATP-independent': [2940], 'serine': [2941], 'proteases.': [2942], 'Some,': [2943], 'all,': [2946], '180': [2949], 'members': [2951], 'classic': [2953], 'They': [2957], 'typically': [2959], 'localized': [2960], 'compartments': [2963], 'periplasm': [2967], 'Gram-negative': [2969], 'bacteria,': [2970], 'ER': [2972], 'eukaryotes': [2974], 'plants.': [2979], 'Prokaryotic': [2980], 'DegPs': [2981], 'thermal,': [2985], 'osmotic,': [2986], 'hydrogen': [2987], 'peroxide': [2988], 'pH': [2990, 3945], 'tolerance,': [2991], 'virulence.': [2996], 'defining': [2998], 'feature': [2999], 'HtrA': [3002], 'combination': [3006], 'catalytic': [3009], 'PDZ': [3016, 3117], '(Clausen': [3018], 'variety': [3024], 'known': [3026], 'indicates': [3028], 'controlling': [3035, 3961], 'metabolism': [3037], 'envelope.': [3041], 'activities.': [3051], 'switching': [3055], 'temperature-dependent': [3058], 'manner,': [3059], 'being': [3063], 'most': [3064], 'apparent': [3065], 'elevated': [3067], '(Spiess': [3069], 'solved': [3079], '(Krojer': [3080], 'Staggered': [3084], 'association': [3085], 'trimeric': [3087], '6).': [3094], 'cavity': [3103], 'accessible': [3106], 'laterally.': [3108], 'mobile': [3110], 'walls': [3112], '12': [3116], 'domains,': [3118], 'mediate': [3120], 'opening': [3122], 'closing': [3124], 'particle': [3127], 'substrate.': [3134, 3691], 'Several': [3135], 'patches': [3137], 'act': [3139], 'docking': [3141], 'line': [3146], 'inner': [3148], 'conformation,': [3153], 'abolished': [3173], '(Michael': [3174], 'Ehrmann,': [3175], 'Cardiff': [3176], 'UK,': [3178], 'Tim': [3180, 3236], 'Clausen,': [3181, 3267], 'inhibitor': [3196], 'DFP': [3197], 'crystallized.': [3200], 'Preliminary': [3201], 'DegP,': [3206], 'present': [3208, 4329], 'complex,': [3211, 4203], 'represents': [3212, 4017], 'state.': [3215, 3253], 'should': [3219], 'helpful': [3221], 'deduce': [3223], 'determinants': [3225], 'Remarkably,': [3235], 'Clausen': [3237], 'temperature': [3241, 3943], 'dependence': [3242], 'crystalline': [3252], 'Open': [3254], 'closed': [3256], 'blue,': [3276], 'green': [3281], 'PDZ1': [3284], 'PDZ2': [3286], 'yellow': [3291], 'respectively.': [3292], 'housekeeping': [3295, 3355], 'obviously': [3300], 'disposal': [3302], 'non-functional': [3304], 'polypeptides,': [3312], "'repair',": [3322], 'refolding,': [3326], "'hopeless'": [3331], 'cases.': [3332], 'believed': [3335], 'occur': [3337, 3417], 'kinetic': [3339], 'partitioning': [3340], 'GroEL/ES': [3344], 'ClpB/DnaK,': [3346], 'above)': [3348], 'chaperone/protease': [3350], 'ClpAP).': [3353], 'Other': [3354], 'problems': [3356], 'incomplete': [3358], 'partially': [3362], 'damaged': [3365], 'mRNAs.': [3366], 'cases,': [3369], 'ribosomes': [3371], 'stall': [3372], 'tagging': [3379, 3414, 3453], 'system,': [3380, 3678, 3925], 'adds': [3383], 'arrested': [3388], 'biosynthesis.': [3391], 'resulting': [3393], 'directed': [3397], 'SspB/ClpXP': [3402], 'clear': [3411, 4264], 'full-length': [3419], '(Collier': [3421], 'Roche': [3425], 'Sauer,': [3427], 'weak': [3433], 'strong': [3436], 'translational': [3437, 3458, 3485, 3510], 'stop': [3438, 3470], 'ribokinase': [3444, 3489], '(UGAc': [3445], 'UAAu)': [3447], 'annihilated': [3448], 'SsrA-tagging.': [3449], 'efficiency': [3451, 3483], 'inversely': [3455], 'correlated': [3456], 'termination': [3459, 3486, 3514], 'efficiency,': [3460], 'revealing': [3461], 'dynamic': [3463], 'competition.': [3464], 'Both': [3465, 3865], 'nature': [3467], 'rare': [3476], 'codons': [3477], 'vicinity': [3480], 'diminished': [3481], 'messenger,': [3490], 'allowing': [3491], 'readthrough': [3492], 'frameshifting': [3494], 'events': [3495], 'occur.': [3497], 'proposed': [3500, 4486], 'additional': [3503], 'SsrA-tagging': [3506], 'recoding': [3511], 'inefficient': [3513], 'sites,': [3515], 'avoiding': [3517], '(Justine': [3523], 'Collier': [3524], 'Philippe': [3526], "Bouloc's": [3527], 'Université': [3529], 'Paris-Sud,': [3530], 'France).': [3531], 'adjust': [3537], 'biosynthetic': [3543], 'rate,': [3549], 'physiological': [3553, 3597], 'situation.': [3554], 'enzyme': [3557, 3617], 'methionine': [3559], '(homoserine': [3564], 'transsuccinylase,': [3565], 'HTS)': [3566], 'short': [3569], 'half-life': [3570], 'thermally': [3573], 'unstable': [3574, 3680, 3874, 4471], '(Gur': [3575], 'therefore': [3581, 3919, 4062], 'useful': [3583], 'stabilization': [3591, 3932], '(above': [3600], '37°C).': [3601], 'signal': [3612], 'triple': [3622], 'lon,': [3623], 'clpP,': [3624], 'hslVU': [3625], 'mutants.': [3626], 'prevents': [3630], 'inactivation': [3631], 'aggregation.': [3633], 'Rescue': [3634], 'DnaK,': [3638], 'GrpE': [3639], 'HTS': [3648], 'dnaJ': [3651], 'finding': [3654], 'subsequently': [3655], '(Eliora': [3661], 'Ron,': [3662], 'Tel.:Aviv': [3663], 'Israel).': [3665], 'Plasmid': [3666], 'maintenance': [3667], 'often': [3670], 'depend': [3671], 'P1': [3676, 3740], 'plasmid': [3677, 3741], 'antitoxin,': [3681], 'Phd,': [3682], 'antagonizes': [3684], 'toxin': [3686], 'Doc,': [3687], 'experiments': [3693], 'Maciej': [3696], 'Zylicz': [3697], '(International': [3698], 'Institute': [3699, 4096], 'Molecular': [3701], 'Cell': [3703], 'Biology,': [3704], 'Warsaw,': [3705], 'Poland),': [3706], 'genetic': [3708], 'behaviour': [3711], 'mutated': [3718], 'ATP-binding': [3721], 'site,': [3722], 'namely': [3723], 'K125T': [3724], 'T126A,': [3726], 'investigated.': [3728], 'ClpX(T126A)': [3732], 'exhibits': [3735, 3755, 3798], 'and,': [3743], 'consequence,': [3746], 'cured': [3747, 3761], 'killed.': [3751, 3765], 'contrast,': [3753], 'ClpX(K125T)': [3754, 3795], 'selectively': [3764], 'contrast': [3767, 3791, 4143], 'behaviour,': [3772], 'neither': [3773], 'ATP,': [3777], 'hexamerizes': [3778], 'promotes': [3780], 'Phd': [3786, 3802, 3809], 'λO.': [3788], 'ClpX(T126A),': [3793], 'protein.': [3803], 'show': [3806], 'modulation': [3823], 'Doc': [3829], 'toxin.': [3830], 'best-studied': [3851], 'examples': [3852], 'synthesized': [3870], 'extremely': [3873], 'non-stress': [3876], 'conditions': [3877], '(because': [3878], 'respectively),': [3886], 'stabilized': [3890, 4032, 4138, 4474], 'instantaneously': [3891], 'stresses.': [3896], 'allows': [3898], 'extraordinarily': [3900], 'upregulation': [3902, 4518], 'Whereas': [3907], 'intracellular': [3910], 'signal,': [3911], 'increase': [3914], 'titration': [3920, 3972, 4060], 'event': [3929], '(Tomoyasu': [3933, 4213], '1998),': [3936], 'multiple': [3937], '(i.e.': [3939], 'starvation,': [3940], 'osmotic': [3941], 'upshift,': [3944], 'downshift)': [3946], 'integrated': [3950], 'state': [3964], 'RssB,': [3969], 'suddenly': [3976], 'increased': [3977, 4331], 'rates': [3978], 'synthesis,': [3981], 'competition': [3989], 'σ70': [3993], 'RNAP': [3995], 'enzyme,': [3997], 'holoenzyme': [4002], 'protected': [4004], 'against': [4005], '(Hengge-Aronis,': [4007], 'Pruteanu': [4009, 4074], 'mechanism.': [4021], 'off-state': [4023], '(low': [4024], 'degradation)': [4030], 'homeostatic': [4035], 'feedback': [4036], '(σS': [4038], 'expression)': [4041], 'operates': [4043], 'threshold,': [4048], 'further': [4054], 'increased,': [4055], 'on-state': [4067], '(high': [4068], 'σS)': [4072], '(Mihaela': [4073], "Hengge's": [4077, 4169], 'Universität': [4080, 4172, 4317], 'Germany;': [4082], 'mathematical': [4084], 'modelling': [4085], 'presented': [4086], 'Tobias': [4088], 'Backfisch': [4089], 'E.D.': [4091], "Gilles'": [4092], 'group,': [4093], 'Magdeburg,': [4097], 'Dps,': [4099], 'σS-regulated': [4101], 'nucleoid-associated': [4102], 'DNA-protective': [4103], 'accumulates': [4106], 'substantial': [4108], 'exposed': [4112], 'stress,': [4117, 4287], 'Dps': [4126, 4136, 4147], 'differentially': [4129], 'signals.': [4133], 'Like': [4134], 'but,': [4141], '(but': [4154], 'hyperosmotic': [4157], 'shift),': [4158], 'dependent': [4162], '(Kunigunde': [4165], 'Stephani': [4166], 'Flagellum': [4175], 'enteric': [4184], 'bacteria': [4185], 'integrates': [4186], 'reflect': [4189], 'nutritional': [4190], 'conditions.': [4191], 'flagellar': [4197], 'cascade': [4199], 'FlhC/D': [4202, 4219, 4260], 'turned': [4206], 'Interestingly,': [4217], 'FlhD': [4224], 'ClpXP,': [4229], 'whereas': [4230], 'FlhC': [4231, 4247], 'stable,': [4234], 'indicating': [4235], 'case': [4237], "'trans'-recognition": [4239], 'exposure': [4241], 'determinant': [4245], 'FlhD.': [4252], 'ClpXP-mediated': [4257], 'yet': [4263], '(Toshifumi': [4265], 'Tomoyasu,': [4266], 'Chiba': [4267], 'ftsH': [4270, 4309, 4312], 'knockout': [4271, 4313], 'strains': [4272], 'B.': [4274], 'subtilis': [4275], 'pleiotropic': [4278], 'phenotype': [4279], 'includes': [4281], 'sensitivity': [4282], 'salt': [4284], 'defects': [4288], 'sporulation': [4290], 'filamentous': [4294], 'growth.': [4295], 'Potential': [4296], 'comparing': [4305], 'proteomes': [4307], '(Wolfgang': [4315], 'Schumann,': [4316], 'Bayreuth,': [4318], 'four': [4322], 'five': [4325], 'unidentified': [4326], 'amounts': [4332], 'One': [4339], 'them,': [4341], 'Pbp4*,': [4342], 'member': [4345], 'σW': [4348, 4367, 4401, 4405, 4417], 'regulon': [4349, 4418], '(and': [4358], 'genes': [4363, 4375], 'regulon).': [4366], 'ECF': [4370], 'coping': [4378], 'disturbed': [4380], 'wall': [4382], '(Cao': [4384], 'Formally,': [4388], 'repressor': [4395], 'basal': [4398], 'level': [4399], 'subject': [4421], 'differential': [4423], '(Zellmeier': [4426], 'Corynebacterium': [4431], 'glutamicum,': [4432], 'indirectly': [4438], 'autoregulated': [4439], '(Steffen': [4440], 'Schaffer,': [4441], 'Forschungszentrum': [4442], 'Jülich,': [4443], 'designated': [4451], 'ClgR': [4452, 4472, 4501], 'clp': [4454], 'regulator),': [4456], 'clpC': [4463, 4478, 4488], 'clpP1P2': [4465, 4482], 'transcription.': [4466], 'otherwise': [4469], 'conditional': [4481, 4498], 'mutant,': [4483], 'clpP': [4490], 'C.': [4493], 'glutamicum': [4494], 'Increased': [4506], 'substrates,': [4513], 'thus': [4515], 'result': [4516], 'ClpCP.': [4520], 'seems': [4523], 'conserved,': [4527]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1569886462', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-08T11:19:07.516492', 'created_date': '2016-06-24'}