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'during': [28], 'adoptive': [31], 'immune': [32], 'responses.': [33], 'Failure': [34], 'terminate': [36], 'such': [37], 'inflammatory': [38, 74, 194], 'reactions': [39, 75], 'may': [40], 'lead': [41], 'detrimental': [43], 'systemic': [44, 100, 109], 'effects,': [45], 'septic': [47], 'shock': [48], 'autoimmunity.': [50], 'In': [51], 'this': [52, 200], 'study,': [53], 'we': [54, 169], 'provide': [55], 'genetic': [56], 'evidence': [57], 'a': [59, 119], 'critical': [60], 'nonredundant': [62], 'role': [63], 'phosphatase': [66], '(MKP)-1': [67], 'in': [68, 76, 118, 191], 'negative': [70], 'control': [71], 'MAPK-regulated': [73], 'vivo.': [77], 'MKP-1-/-': [78, 136], 'mice': [79], 'hyperresponsive': [81], 'low-dose': [83], 'LPS-induced': [84], 'toxicity': [85], 'exhibit': [87, 138], 'significantly': [88], 'increased': [89, 139], 'serum': [90], 'TNF-alpha,': [91], 'IL-6,': [92], 'IL-12,': [93], 'MCP-1,': [94], 'IFN-gamma,': [95], 'IL-10': [97], 'levels': [98, 110], 'after': [99], 'administration': [101], 'LPS.': [103], 'Furthermore,': [104], 'absence': [105], 'MKP-1': [107, 172], 'increases': [108], 'proinflammatory': [112], 'cytokines': [113], 'exacerbates': [115], 'disease': [116], 'development': [117], 'mouse': [120], 'model': [121], 'rheumatoid': [123], 'arthritis.': [124], 'When': [125], 'activated': [126], 'through': [127], 'TLR2,': [128], 'TLR3,': [129], 'TLR4,': [130], 'TLR5,': [131], 'TLR9,': [133], 'bone': [134], 'marrow-derived': [135], 'macrophages': [137, 154], 'production': [141], 'elevated': [143], 'expression': [144], 'differentiation': [147], 'markers': [148], 'B7.2': [149], '(CD86)': [150], 'CD40.': [152], 'MKP-1-deficient': [153], 'also': [155], 'show': [156], 'enhanced': [157], 'constitutive': [158], 'MAPK.': [164], 'Based': [165], 'on': [166], 'these': [167], 'findings,': [168], 'propose': [170], 'that': [171, 181], 'is': [173], 'an': [174], 'essential': [175], 'component': [176], 'intracellular': [179], 'homeostasis': [180], 'threshold': 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