Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1566478885', 'doi': 'https://doi.org/10.18632/oncotarget.3156', 'title': 'Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia', 'display_name': 'Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia', 'publication_year': 2015, 'publication_date': '2015-02-10', 'ids': {'openalex': 'https://openalex.org/W1566478885', 'doi': 'https://doi.org/10.18632/oncotarget.3156', 'mag': '1566478885', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25762638', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4466645'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3156', 'pdf_url': 'https://www.oncotarget.com/article/3156/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/3156/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5072015194', 'display_name': 'Alisa B. Lee‐Sherick', 'orcid': 'https://orcid.org/0000-0002-1177-7208'}, 'institutions': [{'id': 'https://openalex.org/I188538660', 'display_name': 'University of Colorado Boulder', 'ror': 'https://ror.org/02ttsq026', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I188538660']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alisa B. Lee-Sherick', 'raw_affiliation_strings': ['University of Colorado, Department of Pediatrics, Aurora, CO, USA.'], 'affiliations': [{'raw_affiliation_string': 'University of Colorado, Department of Pediatrics, Aurora, CO, USA.', 'institution_ids': ['https://openalex.org/I188538660']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021975754', 'display_name': 'Weihe Zhang', 'orcid': 'https://orcid.org/0000-0003-2923-9130'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Weihe Zhang', 'raw_affiliation_strings': ['University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, NC, USA'], 'affiliations': [{'raw_affiliation_string': 'University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, NC, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091205764', 'display_name': 'Kelly Menachof', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I188538660', 'display_name': 'University of Colorado Boulder', 'ror': 'https://ror.org/02ttsq026', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I188538660']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kelly K. Menachof', 'raw_affiliation_strings': ['University of Colorado, Department of Pediatrics, Aurora, CO, USA.'], 'affiliations': [{'raw_affiliation_string': 'University of Colorado, Department of Pediatrics, Aurora, CO, USA.', 'institution_ids': ['https://openalex.org/I188538660']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076866502', 'display_name': 'Amanda A. Hill', 'orcid': 'https://orcid.org/0009-0009-9392-1717'}, 'institutions': [{'id': 'https://openalex.org/I188538660', 'display_name': 'University of Colorado Boulder', 'ror': 'https://ror.org/02ttsq026', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I188538660']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amanda A. Hill', 'raw_affiliation_strings': ['University of Colorado, Department of Pediatrics, Aurora, CO, USA.'], 'affiliations': [{'raw_affiliation_string': 'University of Colorado, Department of Pediatrics, Aurora, CO, USA.', 'institution_ids': ['https://openalex.org/I188538660']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035467220', 'display_name': 'Sean Rinella', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I188538660', 'display_name': 'University of Colorado Boulder', 'ror': 'https://ror.org/02ttsq026', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I188538660']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sean Rinella', 'raw_affiliation_strings': ['University of Colorado, Department of Pediatrics, Aurora, CO, USA.'], 'affiliations': [{'raw_affiliation_string': 'University of Colorado, Department of Pediatrics, Aurora, CO, USA.', 'institution_ids': ['https://openalex.org/I188538660']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112310704', 'display_name': 'Gregory Kirkpatrick', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I188538660', 'display_name': 'University of Colorado Boulder', 'ror': 'https://ror.org/02ttsq026', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I188538660']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gregory Kirkpatrick', 'raw_affiliation_strings': ['University of Colorado, Department of Pediatrics, Aurora, CO, USA.'], 'affiliations': [{'raw_affiliation_string': 'University of Colorado, Department of Pediatrics, Aurora, CO, USA.', 'institution_ids': ['https://openalex.org/I188538660']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007470904', 'display_name': 'Lauren S. Page', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I188538660', 'display_name': 'University of Colorado Boulder', 'ror': 'https://ror.org/02ttsq026', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I188538660']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lauren S. Page', 'raw_affiliation_strings': ['University of Colorado, Department of Pediatrics, Aurora, CO, USA.'], 'affiliations': [{'raw_affiliation_string': 'University of Colorado, Department of Pediatrics, Aurora, CO, USA.', 'institution_ids': ['https://openalex.org/I188538660']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052113856', 'display_name': 'Michael A. Stashko', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael A. Stashko', 'raw_affiliation_strings': ['University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, NC, USA'], 'affiliations': [{'raw_affiliation_string': 'University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, NC, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038867429', 'display_name': 'Craig T. Jordan', 'orcid': 'https://orcid.org/0000-0003-0869-3465'}, 'institutions': [{'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Craig T. Jordan', 'raw_affiliation_strings': ['University of Colorado, Department of Medicine, Aurora, CO, USA'], 'affiliations': [{'raw_affiliation_string': 'University of Colorado, Department of Medicine, Aurora, CO, USA', 'institution_ids': ['https://openalex.org/I921990950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046136400', 'display_name': 'Qi Wei', 'orcid': 'https://orcid.org/0000-0002-1481-2304'}, 'institutions': [{'id': 'https://openalex.org/I4210096275', 'display_name': "Children's Hospital Colorado", 'ror': 'https://ror.org/00mj9k629', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210096275']}, {'id': 'https://openalex.org/I921990950', 'display_name': 'University of Colorado Denver', 'ror': 'https://ror.org/02hh7en24', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I921990950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Qi Wei', 'raw_affiliation_strings': ["Children's Hospital Colorado, Department of Pathology, Aurora, CO, USA"], 'affiliations': [{'raw_affiliation_string': "Children's Hospital Colorado, Department of Pathology, Aurora, CO, USA", 'institution_ids': ['https://openalex.org/I4210096275', 'https://openalex.org/I921990950']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026080428', 'display_name': 'Jing Liu', 'orcid': 'https://orcid.org/0000-0003-4740-243X'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jing Liu', 'raw_affiliation_strings': ['University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, NC, USA'], 'affiliations': [{'raw_affiliation_string': 'University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, NC, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110301017', 'display_name': 'Dehui� Zhang', 'orcid': 'https://orcid.org/0009-0004-9804-696X'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dehui Zhang', 'raw_affiliation_strings': ['University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, NC, USA'], 'affiliations': [{'raw_affiliation_string': 'University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, NC, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085390573', 'display_name': 'Deborah DeRyckere', 'orcid': 'https://orcid.org/0000-0002-7457-9006'}, 'institutions': [{'id': 'https://openalex.org/I188538660', 'display_name': 'University of Colorado Boulder', 'ror': 'https://ror.org/02ttsq026', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I188538660']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Deborah DeRyckere', 'raw_affiliation_strings': ['University of Colorado, Department of Pediatrics, Aurora, CO, USA.'], 'affiliations': [{'raw_affiliation_string': 'University of Colorado, Department of Pediatrics, Aurora, CO, USA.', 'institution_ids': ['https://openalex.org/I188538660']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100382709', 'display_name': 'Xiaodong Wang', 'orcid': 'https://orcid.org/0000-0003-3293-7538'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiaodong Wang', 'raw_affiliation_strings': ['University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, NC, USA'], 'affiliations': [{'raw_affiliation_string': 'University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, NC, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033923298', 'display_name': 'Stephen V. Frye', 'orcid': 'https://orcid.org/0000-0002-2415-2215'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephen Frye', 'raw_affiliation_strings': ['University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, NC, USA'], 'affiliations': [{'raw_affiliation_string': 'University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, NC, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026053999', 'display_name': 'H. Shelton Earp', 'orcid': 'https://orcid.org/0000-0003-1229-4619'}, 'institutions': [{'id': 'https://openalex.org/I114027177', 'display_name': 'University of North Carolina at Chapel Hill', 'ror': 'https://ror.org/0130frc33', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I114027177']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'H. Shelton Earp', 'raw_affiliation_strings': ['University of North Carolina, Department of Medicine, Chapel Hill, NC, USA'], 'affiliations': [{'raw_affiliation_string': 'University of North Carolina, Department of Medicine, Chapel Hill, NC, USA', 'institution_ids': ['https://openalex.org/I114027177']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5025126021', 'display_name': 'Douglas K. Graham', 'orcid': 'https://orcid.org/0000-0002-6201-6900'}, 'institutions': [{'id': 'https://openalex.org/I188538660', 'display_name': 'University of Colorado Boulder', 'ror': 'https://ror.org/02ttsq026', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I188538660']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Douglas K. Graham', 'raw_affiliation_strings': ['University of Colorado, Department of Pediatrics, Aurora, CO, USA.'], 'affiliations': [{'raw_affiliation_string': 'University of Colorado, Department of Pediatrics, Aurora, CO, USA.', 'institution_ids': ['https://openalex.org/I188538660']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.759, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 40, 'citation_normalized_percentile': {'value': 0.999923, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '6', 'issue': '9', 'first_page': '6722', 'last_page': '6736'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12672', 'display_name': 'Phagocytosis and Immune Regulation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12672', 'display_name': 'Phagocytosis and Immune Regulation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11215', 'display_name': 'Chronic Myeloid Leukemia Treatments', 'score': 0.9776, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9758, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2778729363', 'wikidata': 'https://www.wikidata.org/wiki/Q11688946', 'display_name': 'Myeloid leukemia', 'level': 2, 'score': 0.67554265}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.64756554}, {'id': 'https://openalex.org/C2910954276', 'wikidata': 'https://www.wikidata.org/wiki/Q14912399', 'display_name': 'Fms-Like Tyrosine Kinase 3', 'level': 4, 'score': 0.6115426}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.60027736}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.5711288}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.5604749}, {'id': 'https://openalex.org/C2778820342', 'wikidata': 'https://www.wikidata.org/wiki/Q906415', 'display_name': 'Tyrosine-kinase inhibitor', 'level': 3, 'score': 0.5551717}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.5064784}, {'id': 'https://openalex.org/C2779282312', 'wikidata': 'https://www.wikidata.org/wiki/Q1956561', 'display_name': 'Myeloid', 'level': 2, 'score': 0.4738163}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.43734118}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.43385872}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42521244}, {'id': 'https://openalex.org/C2778461978', 'wikidata': 'https://www.wikidata.org/wiki/Q29496', 'display_name': 'Leukemia', 'level': 2, 'score': 0.41404414}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.35076728}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.34685433}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.33053643}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3264465}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.2398729}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.13351563}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11860511}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.068684906}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015470', 'descriptor_name': 'Leukemia, Myeloid, Acute', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011758', 'descriptor_name': 'Pyrroles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D051941', 'descriptor_name': 'fms-Like Tyrosine Kinase 3', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042381', 'descriptor_name': 'Granulocyte Precursor Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000076202', 'descriptor_name': 'c-Mer Tyrosine Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3156', 'pdf_url': 'https://www.oncotarget.com/article/3156/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4466645', 'pdf_url': 'https://europepmc.org/articles/pmc4466645?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466645', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.17615/97th-6a10', 'pdf_url': 'https://cdr.lib.unc.edu/downloads/rb68xk82t', 'source': {'id': 'https://openalex.org/S4306401075', 'display_name': 'Carolina Digital Repository (University of North Carolina at Chapel Hill)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I114027177', 'host_organization_name': 'University of North Carolina at Chapel Hill', 'host_organization_lineage': ['https://openalex.org/I114027177'], 'host_organization_lineage_names': ['University of North Carolina at Chapel Hill'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25762638', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.3156', 'pdf_url': 'https://www.oncotarget.com/article/3156/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.69, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1571940374', 'https://openalex.org/W1941509421', 'https://openalex.org/W1968306285', 'https://openalex.org/W1969485126', 'https://openalex.org/W1976711842', 'https://openalex.org/W1985590863', 'https://openalex.org/W1996840524', 'https://openalex.org/W2002625908', 'https://openalex.org/W2015036977', 'https://openalex.org/W2016490796', 'https://openalex.org/W2019347872', 'https://openalex.org/W2022307983', 'https://openalex.org/W2022540314', 'https://openalex.org/W2037709544', 'https://openalex.org/W2057314625', 'https://openalex.org/W2069411231', 'https://openalex.org/W2080732293', 'https://openalex.org/W2086404440', 'https://openalex.org/W2097035477', 'https://openalex.org/W2106011543', 'https://openalex.org/W2113230030', 'https://openalex.org/W2114242622', 'https://openalex.org/W2122222663', 'https://openalex.org/W2123727748', 'https://openalex.org/W2124110638', 'https://openalex.org/W2125676392', 'https://openalex.org/W2129615499', 'https://openalex.org/W2132912591', 'https://openalex.org/W2136565061', 'https://openalex.org/W2141838614', 'https://openalex.org/W2141869972', 'https://openalex.org/W2147109509', 'https://openalex.org/W2151258061', 'https://openalex.org/W2162009827', 'https://openalex.org/W2164496417', 'https://openalex.org/W2164886552', 'https://openalex.org/W2321946412', 'https://openalex.org/W2415870562'], 'related_works': ['https://openalex.org/W4386496024', 'https://openalex.org/W284991352', 'https://openalex.org/W2321063763', 'https://openalex.org/W2320148073', 'https://openalex.org/W2160930114', 'https://openalex.org/W2150814991', 'https://openalex.org/W2075312788', 'https://openalex.org/W2029323837', 'https://openalex.org/W2027911638', 'https://openalex.org/W1491304291'], 'abstract_inverted_index': {'//': [0], 'Alisa': [1], 'B.': [2], 'Lee-Sherick': [3], '1': [4, 13, 18, 22, 26, 31, 57, 75, 76], ',': [5, 9, 14, 19, 23, 27, 32, 37, 42, 46, 50, 54, 58, 62, 66, 71], 'Weihe': [6], 'Zhang': [7, 52], '2': [8, 36, 49, 53, 61, 65, 86], 'Kelly': [10], 'K.': [11, 73, 134], 'Menachof': [12], 'Amanda': [15], 'A.': [16, 34], 'Hill': [17], 'Sean': [20], 'Rinella': [21], 'Gregory': [24], 'Kirkpatrick': [25], 'Lauren': [28], 'S.': [29], 'Page': [30], 'Michael': [33], 'Stashko': [35], 'Craig': [38], 'T.': [39], 'Jordan': [40], '3': [41, 99], 'Qi': [43], 'Wei': [44], '4': [45, 109], 'Jing': [47], 'Liu': [48], 'Dehui': [51], 'Deborah': [55], 'DeRyckere': [56], 'Xiaodong': [59], 'Wang': [60], 'Stephen': [63], 'Frye': [64], 'H.': [67], 'Shelton': [68], 'Earp': [69], '5': [70, 119], 'Douglas': [72, 133], 'Graham': [74], 'University': [77, 87, 100, 120], 'of': [78, 81, 88, 93, 101, 104, 114, 121, 125, 223, 234, 240, 244, 262, 272, 279], 'Colorado,': [79, 102, 112], 'Department': [80, 103, 113, 124], 'Pediatrics,': [82], 'Aurora,': [83, 106, 116], 'CO,': [84, 107, 117], 'USA': [85, 98, 108, 118, 130], 'North': [89, 122], 'Carolina,': [90, 123], 'Eshelman': [91], 'School': [92], 'Pharmacy,': [94], 'Chapel': [95, 127], 'Hill,': [96, 128], 'NC,': [97, 129], 'Medicine,': [105, 126], "Children's": [110], 'Hospital': [111], 'Pathology,': [115], 'Correspondence': [131], 'to:': [132], 'Graham,': [135], 'e-mail:': [136], '[email protected]': [137], 'Keywords:': [138], 'Tyrosine': [139], 'kinase': [140, 189, 276, 313], 'inhibitor,': [141, 190], 'acute': [142, 173], 'myeloid': [143, 174], 'leukemia,': [144], 'TAM': [145], 'receptors': [146], 'Received:': [147], 'October': [148], '24,': [149], '2014': [150], 'Accepted:': [151], 'January': [152], '15,': [153], '2015': [154, 158], 'Published:': [155], 'February': [156], '10,': [157], 'ABSTRACT': [159], 'Mer': [160, 194, 213, 273, 285, 292], 'and': [161, 195, 205, 226, 231, 242, 265, 293, 299, 319], 'Flt3': [162, 196, 215, 225, 275, 294], 'receptor': [163], 'tyrosine': [164, 188, 312], 'kinases': [165], 'have': [166], 'been': [167], 'implicated': [168], 'as': [169, 327], 'therapeutic': [170], 'targets': [171], 'in': [172, 198, 208, 236], 'leukemia': [175], '(AML).': [176], 'In': [177, 303], 'this': [178], 'manuscript': [179], 'we': [180], 'describe': [181], 'UNC1666,': [182], 'a': [183, 307], 'novel': [184, 308], 'ATP-competitive': [185], 'small': [186, 310], 'molecule': [187, 311], 'which': [191], 'potently': [192], 'diminishes': [193], 'phosphorylation': [197, 222], 'AML.': [199, 333], 'Treatment': [200, 278], 'with': [201, 254, 260, 269, 288], 'UNC1666': [202, 289, 305], 'mediated': [203], 'biochemical': [204], 'functional': [206, 266], 'effects': [207, 257, 267], 'AML': [209, 281], 'cell': [210], 'lines': [211], 'expressing': [212, 284], 'or': [214, 274], 'internal': [216], 'tandem': [217], 'duplication': [218], '(ITD),': [219], 'including': [220], 'decreased': [221], 'Mer,': [224], 'downstream': [227, 263], 'effectors': [228], 'Stat,': [229], 'Akt': [230], 'Erk,': [232], 'induction': [233], 'apoptosis': [235], 'up': [237], 'to': [238, 252], '98%': [239], 'cells,': [241], 'reduction': [243], 'colony': [245, 301], 'formation': [246], 'by': [247], 'greater': [248], 'than': [249], '90%,': [250], 'compared': [251], 'treatment': [253, 330], 'vehicle.': [255], 'These': [256], 'were': [258], 'dose-dependent,': [259], 'inhibition': [261, 326], 'signaling': [264, 318], 'correlating': [268], 'the': [270], 'degree': [271], 'inhibition.': [277], 'primary': [280], 'patient': [282], 'samples': [283], 'and/or': [286], 'Flt3-ITD': [287], 'also': [290], 'inhibited': [291, 300], 'intracellular': [295], 'signaling,': [296], 'induced': [297], 'apoptosis,': [298], 'formation.': [302], 'summary,': [304], 'is': [306], 'potent': [309], 'inhibitor': [314], 'that': [315], 'decreases': [316], 'oncogenic': [317], 'myeloblast': [320], 'survival,': [321], 'thereby': [322], 'validating': [323], 'dual': [324], 'Mer/Flt3': [325], 'an': [328], 'attractive': [329], 'strategy': [331], 'for': [332]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1566478885', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 3}], 'updated_date': '2024-12-28T12:23:45.291929', 'created_date': '2016-06-24'}