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1276, 1352, 1369, 1380, 1462, 1569, 1576, 1613, 1637, 1663, 1668, 1795, 2200, 2223, 2268, 2497, 2518, 2535, 2562, 2567, 2655, 2861, 2979], 'method': [101, 347, 766, 1356, 1373], 'for': [102, 116, 128, 204, 226, 371, 509, 568, 575, 695, 745, 1019, 1357, 1522, 1554, 1684, 1932, 2172, 2179, 2233, 2281, 2286, 2369, 2628, 2640, 2663, 2675, 2710, 2752, 2891, 2949, 2953, 3002, 3017, 3040, 3063, 3070, 3133, 3159], 'base': [107, 1886, 1891, 2998], 'substitutions,': [108], 'insertions,': [109], 'deletions': [111, 1361], '(1,2),': [112], 'well': [114], 'producing': [117], 'chimeric': [118, 230, 310, 432, 731, 806, 904, 1293], 'genes': [119, 1408], 'combining': [121], 'two': [122, 250, 266, 285, 414, 553, 654, 689, 737, 805, 889, 893, 984, 1292, 1325], 'DNA': [123, 532, 1079, 1370, 1470, 1819, 2371, 2729, 3105, 3109, 3136], 'fragments': [124, 268, 416, 422, 496, 656, 987, 3019], 'without': [125, 1466], 'the': [126, 142, 146, 152, 155, 175, 237, 245, 289, 300, 306, 369, 380, 385, 393, 399, 420, 456, 467, 498, 507, 510, 515, 518, 522, 538, 546, 552, 620, 629, 640, 667, 670, 674, 704, 714, 718, 734, 743, 751, 761, 799, 823, 847, 888, 913, 941, 958, 1026, 1034, 1063, 1083, 1087, 1093, 1107, 1113, 1117, 1122, 1127, 1149, 1199, 1204, 1224, 1237, 1241, 1303, 1310, 1314, 1318, 1324, 1335, 1343, 1384, 1410, 1467, 1516, 1633, 1680, 1685, 1751, 1816, 1840, 1889, 1949, 2019, 2056, 2067, 2093, 2097, 2105, 2153, 2159, 2175, 2207, 2219, 2234, 2358, 2437, 2443, 2453, 2539, 2617, 2641, 2645, 2685, 2701, 2711, 2717, 2798, 2801, 2865, 2884, 2926, 2956, 3031, 3139, 3160], 'need': [127], 'restriction': [129, 686], 'sites': [130, 687, 1075], '(3).': [131], 'For': [132, 1289], 'mutagenesis,': [134, 1291], 'mutagenic': [135, 156], 'primers': [136, 231, 311, 408, 447, 556, 807, 1028, 1294, 2285], 'are': [137, 233, 257, 312, 317, 366, 423, 448, 501, 504, 587, 599, 609, 703, 723, 740, 817, 851, 945, 962, 1295, 2389], 'typically': [138], 'designed': [139, 313, 449, 810, 897], 'harbor': [141], 'inserted': [143, 241, 1061, 1108, 1128], 'sequence;': [144], 'thus,': [145], 'insert': [147, 220, 263, 274, 468, 487, 770], 'size': [148], 'limited': [150], 'length': [153, 197, 1364], 'primer': [157, 271, 302, 429, 434, 439, 617, 631, 753, 829, 838, 894, 905, 919, 933, 950, 967, 1337], '(4).': [158], 'Therefore,': [159], 'insertions': [160, 1359], 'larger': [161], 'than': [162], '30': [163], 'nucleotides': [164, 453, 465, 483, 1012, 1042, 1049, 1308], 'difficult': [167], 'traditional': [171], 'methods': [172], 'owing': [173, 525], 'limitations': [176], 'oligonucleotide': [178], 'synthesis.': [179], 'Here': [180], 'we': [181, 757, 1104, 1348], 'describe': [182, 1349], 'PCR-based': [184, 3010], 'procedure': [185], 'that': [186, 232, 315, 365, 409, 749, 816, 1106, 1126, 1515], 'can': [187, 678, 2070], 'be': [188, 240, 679, 721], 'generate': [191, 361, 1281], 'precisely': [192], 'located': [193], 'mutants': [194, 2330], 'with': [195, 407, 551, 615, 628, 1025, 1096, 1334, 1640, 1667, 1802, 1965, 2222, 2472, 2749, 2779, 2984], 'any': [196, 223, 1363, 1366], 'deletion.': [201], 'The': [202, 273, 346, 353, 474, 493, 582, 853, 1191, 1211, 1730, 2651], 'strategy': [203, 1278, 1347], 'employs': [207, 348], 'an': [208, 219, 292, 321, 389, 486, 530, 771, 860, 1152, 1331, 2307, 2993], 'established': [209], 'protocol,': [213], 'but': [214, 2833, 3068], 'involves': [215, 356], 'three': [216, 307, 357, 362, 494, 519, 641, 1002, 1162], 'templates': [217, 1018], 'including': [218, 261], 'fragment': [221, 264, 275, 1037], 'length.The': [224], 'protocol': [225, 567, 574, 694], 'requires': [228, 2018], 'four': [229, 309], 'derived': [234, 334, 454, 484, 818, 911, 1202, 1301], 'partly': [235, 243], 'from': [236, 244, 335, 379, 455, 466, 485, 497, 521, 819, 912, 1013, 1203, 1302, 1309, 2066, 2647], 'sequence': [238, 719, 773, 910, 1201, 1207, 1219], 'template,': [246, 1175], 'addition': [248], 'outermost': [251, 301, 554, 630, 752, 917, 965, 1027, 1336], 'flanking': [252, 386, 415, 421, 597, 690, 715, 890, 985, 1100, 1304, 1311, 1326], 'primers.': [253], 'Three': [254, 606], 'products': [256, 364, 378, 477, 520, 608, 712, 739, 1167, 1193], 'first': [258, 354, 381, 499, 523, 611, 854, 1159], 'prepared': [259, 406, 610, 724], 'separately,': [260], 'one': [262, 427, 431, 489, 727, 730, 900, 1209], 'adjacent': [267, 286, 337, 655], 'using': [269, 299, 426, 636, 726, 865, 988, 1171, 1182, 1409, 3103], 'appropriate': [270, 616, 685], 'pairs.': [272, 618], 'thus': [276], 'generated': [277, 1169, 1180, 1236], 'contains': [278, 750, 1215], 'terminal': [279, 411, 527, 1917, 2588, 2618], 'complementarities': [280, 412], 'at': [281, 488, 782, 1092, 1121, 1156, 1208, 1220, 1365, 2436], 'ends': [283, 1222], 'fragments.': [287], 'In': [288, 514, 619, 733, 1230, 1757, 2141], 'second': [290, 373, 511, 516, 539, 621, 671, 735, 1232], 'step,': [291, 517, 524, 622, 736, 1233], 'carried': [297, 1111], 'out,': [298], 'pair,': [303], 'recombine': [305], 'fragments.First,': [308], 'such': [314], 'they': [316], 'all': [318], 'consist': [319], '18-nucleotide': [322, 650, 1299], 'annealing': [323, 651], 'segment': [324, 332, 652], '9-nucleotide': [327, 813, 908, 1200, 1217], 'anchor': [328, 331, 814, 909, 1218], 'segment.': [329], 'An': [330, 402], 'sequences': [336, 458, 469, 586, 815, 850, 944, 961, 1300, 2778, 3015], 'regions': [338, 387, 598, 716, 1327], 'final': [341, 1021], 'product': [343, 396, 533, 548, 677, 1178, 1213, 1239, 2932], '(Figure': [344, 417, 444, 491, 881, 993, 1029, 1284], '1).': [345, 418, 445, 473, 492], 'two-step': [350, 763], 'strategy.': [352], 'step': [355, 382, 500, 2440], 'independent': [358], 'PCRs': [359, 979], 'template': [370, 457, 508, 744, 992, 2995], 'ligation': [374, 624, 747, 1022, 1234], 'PCR.': [375, 540, 581, 672, 701], 'Two': [376, 710, 977], 'correspond': [383], 'site,': [391, 1124], 'whereas': [392, 594, 1176], 'third': [394], 'corresponds': [397], 'cassette.': [401], 'cassette': [404, 803, 864, 1091], 'Briefly,': [419], 'created': [424], 'nonchimeric': [428, 728], 'primer:': [433], 'b': [437, 935], 'e': [440, 952], 'f,': [442], 'respectively': [443], 'Chimeric': [446], 'contain': [451, 481, 812, 1198, 1298], '18': [452, 1009], '(triangles': [459], 'Figure': [461, 472, 561, 833, 842, 923, 937, 954, 971], '1)': [462], '9': [464, 482, 1307], '(squares': [470], 'resulting': [475, 1035], 'AB': [478, 658, 1164, 1194, 1226], 'EF': [480, 1166, 1196, 1228], 'end': [490], 'gel-purified': [502], 'step.': [513], 'complementarity,': [528], 'form': [529], 'extended': [531, 1036], 'forming': [535], 'duplexes': [536], 'during': [537], 'During': [541], 'this': [542, 755], 'so-called': [543], 'extension,': [545], 'recombined': [547, 675], 'amplified': [550], 'primers:': [555], 'f': [559, 969], '(see': [560], '1).Figure': [562], '1.': [563], 'Overlap': [564, 1772, 2815], 'mutagenesis.(A)': [572], 'A': [573, 648, 693, 999, 2278, 2333, 2340], 'features': [583], 'denoted': [588, 600], 'squares': [590], '(open': [591, 603], 'closed),': [593], 'those': [595], 'triangles': [602], 'closed).': [605], 'separate': [613, 978], 'reactions': [614], 'performed': [627, 857, 981, 1024, 1329], 'pair': [632, 1338, 1892], '(a': [633, 871], 'f)': [635], 'mixture': [638, 1000], 'fragments:': [643], 'AB,': [644, 1252], 'CD,': [645, 1255], 'EF.': [647], 'new': [649, 1796], 'between': [653, 662, 1062, 2380, 2700, 2928], '(between': [657], 'CD': [660, 663, 1177, 1214], 'EF)': [665], 'facilitates': [666], 'Finally,': [673, 1033], 'recloned': [680], 'making': [682], 'use': [683, 1468], 'regions.': [691], '(B)': [692], 'Symbols': [702], 'same': [705], 'panel': [708], 'A.': [709], 'representing': [713], 'deleted': [722], 'primer.': [732], 'pair.In': [754], 'study,': [756], 'successfully': [759, 1280], 'novel': [762], 'above': [768], '87-nucleotide': [772, 1088, 1153], 'encoding': [774], 'hepatitis': [776, 787, 1265, 1269, 1525, 1545, 2592, 2622, 2718, 2857], 'delta': [777, 1266, 1546], 'virus': [778, 789, 1527, 1547, 2594, 2624, 2859, 2971], '(HDV)': [779], 'antigenomic': [780], 'ribozyme': [781, 801, 849, 862, 943, 960, 1046, 1090, 1110, 1129, 1155, 1206], 'various': [783], 'positions': [784], 'within': [785, 1888], 'B': [788, 1270, 1526, 1913, 1934, 1982, 2364, 2593, 2623, 2719, 2739, 2858, 2886, 2906, 2970, 3141], '(HBV)': [790], 'genomic': [791, 869, 1186], 'construct,': [792], 'pCMV': [793], '(cytomegalovirus)-HBV/30': [794], '(5).': [795, 1078], 'First,': [796], 'HDV': [800, 848, 861, 868, 914, 942, 959, 1045, 1089, 1109, 1154, 1185, 1205], 'fragment,': [804], '(27-mer)': [808], 'were': [809, 896, 980, 1168, 1245], 'each': [820, 1014, 1197], 'side': [821, 1316], 'site': [825, 928, 975, 1095], 'HBV:': [827], 'forward': [828, 918, 949], '(primer': [830, 839, 920, 934, 951, 968], 'c': [831], '1),': [834, 843, 924, 938, 955, 972], '5′-CACCTCTGCGGGTCGGCATGGCATCTC-3′': [835], 'reverse': [837, 932, 966, 3004], 'd': [840], '5′-GATGATTAGCTCTCCCTTAGCCATCCG-3′,': [844], 'which': [846, 899, 1006, 1297], 'underlined.': [852], 'was': [856, 1053, 1179, 1328], 'produce': [859, 983], 'dimeric': [867, 1184], 'clone': [870, 1187], 'gift': [872], 'John': [874], 'Taylor,': [875], 'Fox': [876], 'Chase': [877], 'Cancer': [878, 2422], 'Center)': [879], '(6)': [880], '2,': [882, 994, 1030], 'lane': [883, 1031], '2).': [884], 'Second,': [885], 'prepare': [887], 'HBV': [891, 986, 991, 1101], 'fragments,': [892], 'pairs': [895, 1887], 'member': [901], 'containing': [906], 'ribozyme:': [915], '(i)': [916], '5′-CATCAGCGCATGCGTGGAAC-3′': [925], '(the': [926], 'SphI': [927, 1056, 1064], 'underlined)': [930], '5′-TGCCGACCCGCAGAGGTGAAAAAGTTG-3′,': [939], 'where': [940, 957], 'underlined;': [946], '(ii)': [948], '5′-AAGGGAGAGCTAATCATCTCTTGTTCA-3′,': [956], 'underlined': [963], '5′-TAGAATAGGGCCCTCTAGAA-3′': [973], '(ApaI': [974], 'underlined).': [976], 'wild-type': [990], 'lanes': [995], '1': [996, 2384, 2764], '3).': [998], 'purified': [1003], 'products,': [1005], 'overlapped': [1007], 'bp': [1010], '(9': [1011], 'fragment),': [1015], 'served': [1016], '4).': [1032], '[nucleotides': [1038], '1238–1914': [1039], 'HBV,': [1041, 1268], '900–815': [1043], '(6),': [1047], '1915–1992': [1050], 'HBV]': [1052], 'digested': [1054], 'ApaI': [1058, 1070], 'then': [1060], '(nucleotide': [1065, 1071], '1238': [1066], 'HBV)': [1068], '3069': [1072], 'pcDNA1/amp)': [1074], 'pCMV-HBV/30': [1077, 1172], 'sequencing': [1080], 'analysis': [1081], 'confirmed': [1082], 'precise': [1084], 'no': [1097], 'change': [1098], 'sequences.': [1102], 'Moreover,': [1103], 'found': [1105], 'out': [1112], 'specific': [1114, 1157], 'cleavage': [1115], 'viral': [1118, 2601, 2720], 'pregenomic': [1119, 1528, 2976], 'RNA': [1120, 1548, 1558, 2139, 2629, 2892, 2902, 2977, 2994], 'indicating': [1125], 'catalytically': [1131], 'active': [1132], '(H.-J.': [1133], 'J.': [1135, 1530, 1560, 3113], 'W.-S.': [1138], 'unpublished': [1140], 'data).Figure': [1141], '2.': [1142], 'Application': [1143, 2726], 'position.The': [1158], 'yields': [1161], 'products:': [1163], 'template.': [1190], 'end.': [1210], 'products.': [1229], 'AF': [1238], 'bearing': [1240], 'ribozyme-encoding': [1242], 'insertion.': [1243], 'Samples': [1244], 'analyzed': [1246], '5%': [1248], 'polyacrylamide': [1249], 'gel': [1250], 'electrophoresis.': [1251], '676': [1253], 'bp;': [1254, 1257, 1260, 1263], '85': [1256], 'EF,': [1258], '93': [1259], 'AF,': [1261], '820': [1262], 'HDV,': [1264], 'virus;': [1267, 1271], 'CMV,': [1272], 'cytomegalovirus.We': [1273], 'similar': [1277], 'mutations': [1283, 2855], '1B;': [1285], 'data': [1286], 'not': [1287, 1340, 2507], 'shown).': [1288], 'used,': [1296], 'region': [1305, 1312, 1895, 2022, 2095], 'on': [1313, 2031, 3156], 'other': [1315], 'region.': [1320], 'Subsequent': [1321], 'recombination': [1322], '(data': [1339], 'shown).In': [1341], 'summary,': [1342], 'here': [1350], 'rapid': [1353], 'efficient': [1355, 1490], 'creating': [1358], 'position': [1367], 'molecule.': [1371], 'This': [1372], 'generally': [1375], 'applicable': [1376], 'and,': [1377], 'therefore,': [1378], 'represents': [1379], 'significant': [1381], 'improvement': [1382], 'now': [1385], 'method.References1.': [1391], 'Horton,': [1392, 1419], 'R.M.,': [1393, 1420], 'Z.L.': [1394], 'Cai,': [1395, 1428], 'S.N.': [1396, 1421], 'Ho,': [1397, 1422], 'L.R.': [1399, 1430], 'Pease.': [1400, 1431], '1990.': [1401], 'Gene': [1402, 1433, 1574, 1635, 1682, 1689, 2177], 'splicing': [1403, 1434, 2776], 'extension:': [1406], 'tailor-made': [1407], 'polymerase': [1411, 2595, 2625, 2972, 3106], 'chain': [1412], 'reaction.': [1413], 'BioTechniques': [1414], '8:528–535.Medline,': [1415], 'CAS,': [1416, 1442, 1503, 1534, 1564], 'Google': [1417, 1443, 1480, 1504, 1535, 1565], 'Scholar2.': [1418], 'J.K.': [1423], 'Pullen,': [1424], 'H.D.': [1425], 'Hunt,': [1426], 'Z.': [1427], '1993.': [1432], 'extension.': [1437], 'Methods': [1438], 'Enzymol.': [1439], '217:270–279.Crossref,': [1440], 'Medline,': [1441, 1479, 1502, 1533, 1563], 'Scholar3.': [1444], 'Kuwayama,': [1445], 'H.,': [1446], 'S.': [1447], 'Obara,': [1448], 'T.': [1449], 'Morio,': [1450], 'M.': [1451, 2290], 'Katoh,': [1452], 'H.': [1453], 'Urushihara,': [1454], 'Y.': [1456], 'Tanaka.': [1457], '2002.': [1458], 'generation': [1460], 'gene': [1463, 2100, 2771], 'disruption': [1464], 'construct': [1465], 'ligase': [1471], 'plasmid': [1473], 'vectors.': [1474], 'Nucleic': [1475, 1498], 'Acids': [1476, 1499], 'Res.': [1477, 1500], '30:e2.Crossref,': [1478], 'Scholar4.': [1481], 'Ke,': [1482], 'S.H.': [1483], 'E.L.': [1485], 'Madison.': [1486], '1997.': [1487], 'Rapid': [1488], 'singletube': [1494], "'megaprimer'": [1495], 'method.': [1497], '25:3371–3372.Crossref,': [1501], 'Scholar5.': [1505], 'Jeong,': [1506], 'J.K.,': [1507], 'G.S.': [1508], 'Yoon,': [1509], 'W.S.': [1511], 'Ryu.': [1512], '2000.': [1513], 'Evidence': [1514], '5′-end': [1517], 'cap': [1518, 2702], 'structure': [1519, 2707, 2930], 'essential': [1521], 'encapsidation': [1523], 'RNA.': [1529], 'Virol.': [1531, 1561], '74:5502–5508.Crossref,': [1532], 'Scholar6.': [1536], 'Lazinski,': [1537], 'D.W.': [1538], 'J.M.': [1540], 'Taylor.': [1541], '1994.': [1542], 'Expression': [1543, 2180], 'deletions:': [1549], 'cis': [1550, 3129], 'trans': [1552], 'requirements': [1553], 'self-cleavage,': [1555], 'ligation,': [1556], 'packaging.': [1559], '68:2879–2888.Crossref,': [1562], 'ScholarFiguresReferencesRelatedDetailsCited': [1566], 'ByXAC4296': [1567], 'Is': [1568, 2661, 2947, 3061], 'Multifunctional': [1570], 'Exclusive': [1572], 'Xanthomonadaceae': [1573], 'Containing': [1575], 'Fusion': [1577, 1835], 'Lytic': [1579], 'Transglycosylase': [1580], 'Epimerase': [1582], 'Domains11': [1583], 'May': [1584, 1899, 2526, 2680, 2869, 3120], '2022': [1585, 1602], '|': [1586, 1603, 1709, 1729, 1781, 1877, 1901, 1923, 1946, 1970, 2010, 2036, 2085, 2111, 2145, 2258, 2274, 2294, 2319, 2347, 2396, 2426, 2460, 2528, 2552, 2579, 2606, 2668, 2693, 2757, 2871, 3078, 3122], 'Microorganisms,': [1587], 'Vol.': [1588, 1606, 1624, 1647, 1675, 1713, 1733, 1743, 1764, 1786, 1809, 1828, 1849, 1879, 1904, 1926, 1954, 1973, 1989, 2014, 2040, 2062, 2088, 2115, 2128, 2148, 2166, 2190, 2214, 2247, 2261, 2276, 2296, 2323, 2349, 2375, 2399, 2429, 2462, 2489, 2511, 2531, 2557, 2582, 2609, 2635, 2671, 2696, 2722, 2760, 2789, 2807, 2844, 2876, 2897, 2916, 2939, 2966, 2988, 3006, 3024, 3049, 3080, 3098, 3124, 3146, 3150], '10,': [1589, 2262], '5High-light-inducible': [1591], 'proteins': [1592], 'HliA': [1593], 'HliB:': [1595], 'pigment': [1596], 'binding': [1597], 'protein–protein': [1599], 'interactions26': [1600], 'February': [1601, 2345, 2577], 'Photosynthesis': [1604], 'Research,': [1605], '13VirB4-': [1607], 'VirD4-Like': [1609], 'ATPases,': [1610], 'Components': [1611], 'Putative': [1614, 2568], 'Type': [1615], '4C': [1616], 'Secretion': [1617], 'System': [1618, 2571], 'Clostridioides': [1620], 'difficileJournal': [1621], 'Bacteriology,': [1623, 2965], '203,': [1625], '21A': [1627], 'Novel': [1628, 3128], 'Intronic': [1629], 'Splicing': [1630, 2408, 2519], 'Mutation': [1631], 'EXT2': [1634], 'Chinese': [1638], 'Family': [1639], 'Multiple': [1641], 'OsteochondromaGenetic': [1642], 'Testing': [1643], 'Molecular': [1645, 2038, 2154, 2321, 2554, 2935], 'Biomarkers,': [1646], '25,': [1648, 1765, 2041], '7Structural,': [1650], 'Genetic,': [1651], 'Serological': [1653], 'Elucidation': [1654], 'Streptococcus': [1656, 2381, 2575], 'pneumoniae': [1657], 'Serogroup': [1658], '24': [1659], 'Serotypes:': [1660], 'Discovery': [1661], 'New': [1664, 1701], 'Serotype,': [1665], '24C,': [1666], 'Variable': [1669], 'Capsule': [1670], 'StructureJournal': [1671], 'Clinical': [1673], 'Microbiology,': [1674, 2189, 2695], '59,': [1676], '7Identification': [1678], 'Biosynthetic': [1681, 2209], 'Cluster': [1683, 1690, 2178], 'anti-MRSA': [1686], 'Lysocins': [1687], 'through': [1688, 2206, 2267], 'Activation': [1691], 'Using': [1692, 1771], 'Strong': [1693], 'Promoters': [1694], 'Housekeeping': [1696], 'Genes': [1697], 'Production': [1699], 'Analogs': [1702], 'Lysobacter': [1704], 'sp.': [1705], '36551': [1706], 'July': [1707, 2034, 2550, 2755], '2020': [1708], 'ACS': [1710], 'Synthetic': [1711], 'Biology,': [1712, 3023], '9,': [1714], '8JAZ4': [1716], 'involved': [1718], 'plant': [1720, 2498], 'defense,': [1721], 'growth,': [1722], 'development': [1724], 'Arabidopsis6': [1726], 'November': [1727, 2604, 2666, 3170], '2019': [1728], 'Plant': [1731, 2048, 2086, 2553, 2669], 'Journal,': [1732, 1972], '101,': [1734], '2Astroprincin': [1736], '(FAM171A1,': [1737], 'C10orf38)The': [1738], 'American': [1739], 'Journal': [1740, 2112, 2872], 'Pathology,': [1742, 2087], '189,': [1744], '1A': [1746], 'CEP290': [1747, 1753], 'C-Terminal': [1748, 2943], 'Domain': [1749, 2361, 2475, 2653, 3054, 3056], 'Complements': [1750], 'Mutant': [1752], 'Rd16': [1755], 'Mice': [1756], 'Trans': [1758], 'Rescues': [1760], 'Retinal': [1761], 'DegenerationCell': [1762], 'Reports,': [1763, 1903], '3Creating': [1767], 'Insertions': [1768], 'Deletions': [1770], 'Extension': [1773, 2816, 2944], 'Polymerase': [1774, 2366, 2741, 2888], 'Chain': [1775], 'Reaction': [1776], '(PCR)': [1777], 'Mutagenesis1': [1778], 'August': [1779, 1921, 2256], '2018': [1780, 1876, 2293, 3121, 3180], 'Cold': [1782], 'Spring': [1783], 'Harbor': [1784], 'Protocols,': [1785], '2018,': [1787], '8The': [1789], 'cyanobacterial': [1790], 'protoporphyrinogen': [1791], 'oxidase': [1792], 'HemJ': [1793], 'b-type': [1797], 'heme': [1798], 'protein': [1799, 2589, 2619, 2770, 2929], 'functionally': [1800], 'coupled': [1801], 'coproporphyrinogen': [1803], 'III': [1804], 'oxidaseJournal': [1805], 'Biological': [1807, 2060, 2212, 2487, 2842, 3047, 3096], 'Chemistry,': [1808, 2061, 2213, 2488, 2843, 3048, 3097], '293,': [1810], '32The': [1812], 'Circadian': [1813], 'Clock': [1814], 'Sets': [1815], 'Time': [1817], 'Replication': [1820], 'Licensing': [1821], 'Regulate': [1823, 2406], 'Growth': [1824, 2544], 'ArabidopsisDevelopmental': [1826], 'Cell,': [1827], '45,': [1829], '1Utilization': [1831], 'Variant': [1833], 'Proteins': [1836, 2471, 2478, 2828], 'To': [1837], 'Functionally': [1838], 'Map': [1839], 'Aggregatibacter': [1841, 1897], 'actinomycetemcomitans': [1842], 'Trimeric': [1843], 'Autotransporter': [1844], 'Protein': [1845, 2119, 3092], 'ApiAInfection': [1846], 'Immunity,': [1848], '86,': [1850], '3Transposons': [1852], 'pathogenicity': [1854], 'Xanthomonas': [1856, 1867, 2075], ':': [1857], 'acquisition': [1858], 'murein': [1860], 'lytic': [1861], 'transglycosylases': [1862], 'Tn': [1864], 'Xax1': [1865], 'enhances': [1866], 'citri': [1868, 1870, 2076], 'subsp.': [1869], '306': [1871], 'virulence': [1872], 'fitness19': [1874], 'December': [1875, 2109, 3174], 'PeerJ,': [1878], '6Increased': [1880], 'leukotoxin': [1881, 1893], 'production:': [1882], 'Characterization': [1883, 2044], '100': [1885], '530': [1890], 'promoter': [1894, 2854], 'actinomycetemcomitans15': [1898], '2017': [1900, 1922, 1945], 'Scientific': [1902], '7,': [1905, 2532, 2583], '1Murine': [1907], 'gammaherpesvirus': [1908], 'M2': [1909], 'antigen': [1910], 'modulates': [1911], 'splenic': [1912], 'cell': [1914], 'activation': [1915], 'differentiation': [1918], 'vivo2': [1920], 'PLOS': [1924, 2146, 2259], 'Pathogens,': [1925, 2759], '13,': [1927], '8Elucidation': [1929], 'roles': [1931], 'vitamin': [1933], '12': [1935], 'regulation': [1937, 2766, 2799], 'folate,': [1939], 'ubiquinone,': [1940], 'methionine': [1942], 'metabolism30': [1943], 'January': [1944, 2143], 'Proceedings': [1947], 'National': [1950], 'Academy': [1951], 'Sciences,': [1953], '114,': [1955], '7Generation': [1957], 'Plasmodium': [1959], 'falciparum': [1960], 'parasite-inhibitory': [1961], 'antibodies': [1962], 'immunization': [1964], 'recombinantly-expressed': [1966], 'CyRPA15': [1967], 'March': [1968, 2394, 2818, 3184], '2016': [1969, 2009, 2035, 2144], 'Malaria': [1971], '15,': [1974], '1DDB1': [1976], 'Stimulates': [1977], 'Viral': [1978, 2370], 'Transcription': [1979, 2909], 'Hepatitis': [1981, 2363, 2885, 2905, 3140], 'Virus': [1983, 2365, 2740, 2887, 2907, 3142], 'via': [1984, 2747, 2978, 2996], 'HBx-Independent': [1985], 'MechanismsJournal': [1986], 'Virology,': [1988, 2165, 2374, 2634, 2875, 2896, 2915, 3145], '90,': [1990, 2167, 2877], '21TRPA1': [1992], 'Channels': [1993], 'Drosophila': [1995], 'Honey': [1997], 'Bee': [1998], 'Ectoparasitic': [1999], 'Mites': [2000], 'Share': [2001], 'Heat': [2002], 'Sensitivity': [2003], 'Temperature-Related': [2005], 'Physiological': [2006], 'Functions5': [2007], 'October': [2008, 2083], 'Frontiers': [2011], 'Physiology,': [2013, 2670], '7SHOC2': [2015], 'subcellular': [2016], 'shuttling': [2017], 'KEKE': [2020], 'motif-rich': [2021], 'N': [2024], '-terminal': [2025], 'leucine-rich': [2026], 'repeat': [2027], 'domain': [2028, 2590, 2620], 'impacts': [2030], 'ERK': [2032], 'signalling27': [2033], 'Human': [2037, 2320, 2418], 'Genetics,': [2039, 2322, 3079], '17Functional': [2043], 'Propeptides': [2046], 'Subtilases': [2049], 'Intramolecular': [2051], 'Chaperones': [2052, 3089], 'Inhibitors': [2054], 'Mature': [2057], 'ProteaseJournal': [2058], '291,': [2063], '37Bacteria': [2065], 'citrus': [2068, 2079], 'phylloplane': [2069], 'disrupt': [2071], 'cell-cell': [2072], 'signalling': [2073], 'reduce': [2078], 'canker': [2080], 'disease': [2081, 2300, 2310], 'severity23': [2082], '2015': [2084, 2110, 2257, 2273], '65,': [2089], '5Characterization': [2091], "5'-flanking": [2094], 'human': [2098], 'TP53': [2099], 'its': [2102, 2982], 'response': [2103], 'natural': [2106], 'compound,': [2107], 'Resveratrol17': [2108], '159,': [2116], '4Ribosomal': [2118], 'Rps26': [2120], 'Influences': [2121], '80S': [2122], 'Ribosome': [2123], 'Assembly': [2124], 'Saccharomyces': [2126], 'cerevisiaemSphere,': [2127], '1,': [2129], '1Recombinant': [2131], 'hTRBP': [2132], 'hPACT': [2134], 'Modulate': [2135], 'hAgo2-Catalyzed': [2136], 'siRNA-Mediated': [2137], 'Target': [2138], 'Cleavage': [2140], 'Vitro19': [2142], 'ONE,': [2147, 2260, 2428, 2530, 2581], '11,': [2149, 2512], '1Elucidation': [2151], 'Mechanism': [2155], 'Driving': [2156], 'Duplication': [2157], 'HIV-1': [2160], 'PTAP': [2161], 'Late': [2162], 'DomainJournal': [2163], '2Multiplexed': [2169], 'Integrating': [2170], 'Plasmids': [2171], 'Engineering': [2173], 'Erythromycin': [2176], 'Streptomyces': [2182], 'spp.': [2183], 'Combinatorial': [2185], 'BiosynthesisApplied': [2186], 'Environmental': [2188], '81,': [2191], '24Porphyrin': [2193], 'Binding': [2194], 'Gun4': [2196], 'Protein,': [2197], 'Facilitated': [2198], 'Flexible': [2201], 'Loop,': [2202], 'Controls': [2203, 2542], 'Metabolite': [2204], 'Flow': [2205], 'Chlorophyll': [2208], 'PathwayJournal': [2210], '290,': [2215], '47Interaction': [2217], 'PsbH': [2220], 'subunit': [2221], 'chlorophyll': [2224, 2434], 'bound': [2225], 'histidine': [2227], '114': [2228], 'CP47': [2230], 'responsible': [2232], 'red': [2235], '77K': [2236], 'fluorescence': [2237], 'Photosystem': [2239, 2447, 2450], 'IIBiochimica': [2240], 'et': [2241], 'Biophysica': [2242], 'Acta': [2243], '(BBA)': [2244], '-': [2245], 'Bioenergetics,': [2246], '1847,': [2248], '10Distinct': [2250], 'OGT-Binding': [2251], 'Sites': [2252], 'Promote': [2253], 'HCF-1': [2254], 'Cleavage25': [2255], '8MAF1': [2264], 'represses': [2265], 'CDKN1A': [2266], 'Pol': [2269], 'III-dependent': [2270], 'mechanism12': [2271], 'June': [2272, 2317, 2691, 3076, 3179], 'eLife,': [2275], '4STITCHER:': [2277], 'web': [2279], 'resource': [2280], 'high-throughput': [2282], 'design': [2283], 'overlapping': [2287, 2866], 'applicationsDamien': [2289], "O'Halloran3": [2291], 'April': [2292, 2424], 'BioTechniques,': [2295, 3123], '58,': [2297], '6Gaucher': [2299], 'due': [2301], 'saposin': [2303], 'C': [2304], 'deficiency': [2305], 'inherited': [2308], 'lysosomal': [2309], 'caused': [2311], 'rapidly': [2313], 'degraded': [2314], 'mutant': [2315], 'proteins12': [2316], '2014': [2318, 2346], '23,': [2324], '21Nuclear': [2326], 'localization': [2327], 'signal': [2328], 'lamin': [2332, 2339], 'progerin': [2335], 'reveal': [2336, 2501], 'insights': [2337], 'into': [2338, 2912], 'processing': [2341], 'emerin': [2343], 'targeting4': [2344], 'Nucleus,': [2348], '5,': [2350], '1Residues': [2352], 'Arg703,': [2353], 'Asp777,': [2354], 'Arg781': [2356], 'RNase': [2359], 'H': [2360], 'Are': [2367, 2834, 2889], 'Critical': [2368, 2890, 2948], 'SynthesisJournal': [2372], '88,': [2376], '1Functional': [2378], 'differences': [2379], 'pyogenes': [2382], 'cluster': [2383, 2386], '2b': [2387], 'streptokinases': [2388], 'determined': [2390], 'their': [2392], 'β‐domains7': [2393], '2013': [2395, 2425], 'FEBS': [2397, 2607], 'Letters,': [2398, 2608], '587,': [2400], '9HnRNP': [2402], 'A1/A2': [2403], 'SF2/ASF': [2405], 'Alternative': [2407], 'Interferon': [2410], 'Regulatory': [2411, 2520, 2656, 2827], 'Factor-3': [2412], 'Affect': [2414], 'Immunomodulatory': [2415], 'Functions': [2416], 'Non-Small': [2419], 'Cell': [2420], 'Lung': [2421], 'Cells29': [2423], 'PLoS': [2427, 2529, 2580, 2758], '8,': [2430], '4Inhibition': [2432], 'biosynthesis': [2435], 'protochlorophyllide': [2438], 'reduction': [2439], 'results': [2441], 'parallel': [2444], 'depletion': [2445], 'I': [2448], 'II': [2451, 2660], 'cyanobacterium': [2454], 'Synechocystis': [2455, 2648, 2960], 'PCC': [2456, 2649, 2962], '680326': [2457], 'September': [2458, 2737], '2012': [2459, 2527, 2578], 'Planta,': [2461], '237,': [2463], '2Direct': [2465], 'Interaction': [2466, 2748], 'Bax': [2468], 'Bak': [2470], 'Bcl-2': [2473], 'Homology': [2474], '(BH3)-only': [2477], 'Living': [2480], 'Cells': [2481], 'Revealed': [2482], 'Fluorescence': [2484], 'ComplementationJournal': [2485], '288,': [2490], '7Structural': [2492], 'biochemical': [2494], 'studies': [2495, 2796], 'formamidopyrimidine-DNA': [2499], 'glycosylase': [2500], 'why': [2502], 'eukaryotic': [2503], 'Fpg': [2504], 'glycosylases': [2505], 'do': [2506], 'excise': [2508], '8-oxoguanineDNA': [2509], 'Repair,': [2510], '9Evolutionary': [2514], 'Constraint': [2515], 'Helps': [2516], 'Unmask': [2517], 'Region': [2521, 2565, 2659], 'BRCA1': [2523], 'Exon': [2524], '1116': [2525], '5AtRabD2b,': [2534], 'Functional': [2536], 'Ortholog': [2537], 'Yeast': [2540, 3058], 'Ypt1,': [2541], 'Developmental': [2546], 'Processes': [2547], 'Arabidopsis15': [2549], '2011': [2551, 2605], 'Biology': [2555], 'Reporter,': [2556], '30,': [2558], '2Contribution': [2560], 'Genomic': [2563], 'Accessory': [2564], 'Encoding': [2566], 'Cellobiose': [2569], 'Phosphotransferase': [2570], 'Virulence': [2573], 'pneumoniae21': [2576], '2Hydrophobic': [2585], 'residues': [2586], 'contribute': [2596], 'distinct': [2598], 'steps': [2599], 'genome': [2602], 'replication10': [2603], '585,': [2610], '24A': [2612], 'conserved': [2613], 'arginine': [2614], 'residue': [2615], 'critical': [2627, 2709, 3001], 'pre-genome': [2630], 'encapsidationJournal': [2631], 'General': [2633, 2874], '92,': [2636], '8Functional': [2638], 'Assignments': [2639], 'Carboxyl-Terminal': [2642], 'Domains': [2643, 2820], 'Ferrochelatase': [2646, 2946], '6803:': [2650], 'CAB': [2652], 'Plays': [2654], 'Role,': [2657], 'Essential': [2662], 'Catalysis': [2664, 2936], '16': [2665], '2010': [2667, 2692, 2756], '155,': [2672], '4Tools': [2674], 'Genetic': [2676], 'Manipulation': [2677], 'Cyanobacteria26': [2679], '2011Role': [2681], 'Lys281': [2683], 'Dunaliella': [2686], 'salina': [2687], '(6-4)': [2688], 'Photolyase': [2689], 'Reaction9': [2690], 'Current': [2694], '62,': [2697], '1Proximity': [2699], '5′': [2704, 2985], 'ε': [2705], 'stem–loop': [2706, 2986], 'suppression': [2712], 'pgRNA': [2714], 'translation': [2715, 2974], 'polymeraseVirology,': [2721], '406,': [2723], '1The': [2725], 'Recombinant': [2728], 'Technology': [2730], 'Medicinal': [2732], 'Chemistry': [2733], 'Drug': [2735], 'Discovery15': [2736], '2010Hepatitis': [2738], 'Blocks': [2742], 'Pattern': [2743], 'Recognition': [2744], 'Receptor': [2745, 2826, 2839, 3033], 'Signaling': [2746], 'DDX3:': [2750], 'Implications': [2751], 'Immune': [2753], 'Evasion15': [2754], '6,': [2761], '7Intron': [2763], 'mediated': [2765], 'bovine': [2768], 'prion': [2769], 'expression:': [2772], 'Role': [2773], 'donor': [2775], 'sites,': [2777], 'potential': [2780], 'enhancer': [2781], 'suppressor': [2783], 'activitiesBiochemical': [2784], 'Biophysical': [2786], 'Research': [2787], 'Communications,': [2788], '397,': [2790], '4In': [2792], 'silico': [2793], 'functional': [2795], 'glucocerebrosidase': [2802], 'geneMolecular': [2803], 'Genetics': [2804], 'Metabolism,': [2806], '99,': [2808], '3Insertion': [2810], 'Deletion': [2812], 'PCR19': [2817], '2010C-terminal': [2819], 'Transmembrane': [2822], 'α-Amino-3-hydroxy-5-methyl-4-isoxazole': [2823], 'Propionate': [2824], '(AMPA)': [2825], 'Not': [2829], 'Only': [2830], 'Facilitate': [2831], 'Trafficking': [2832], 'Major': [2835], 'Modulators': [2836], 'AMPA': [2838], 'FunctionJournal': [2840], '284,': [2845], '47Genetic': [2847], 'dissection': [2848], 'naturally': [2850], 'occurring': [2851], 'basal': [2852], 'core': [2853], 'reveals': [2860], 'silent': [2862], 'phenotype': [2863], 'X': [2867], 'gene13': [2868], '2009': [2870], '9Four': [2879], 'Conserved': [2880], 'Cysteine': [2881], 'Residues': [2882], 'Pregenome': [2893], 'EncapsidationJournal': [2894], '83,': [2898, 2917], '16DDX3': [2900], 'DEAD-Box': [2901], 'Helicase': [2903], 'Inhibits': [2904], 'Reverse': [2908], 'Incorporation': [2911], 'NucleocapsidsJournal': [2913], '11A': [2919], 'predominant': [2920], 'β-CGTase': [2921], 'G1': [2922], 'engineered': [2923], 'elucidate': [2925], 'relationship': [2927], 'specificityJournal': [2933], 'B:': [2937], 'Enzymatic,': [2938], '57,': [2940], '1-4The': [2942], 'Enzyme': [2950], 'Activity': [2951], 'Functioning': [2954], 'Tetrapyrrole': [2957], 'Pathway': [2958], 'Strain': [2961], '6803Journal': [2963], '190,': [2967], '6Hepatitis': [2969], 'suppresses': [2973], 'mechanism': [2980], 'involving': [2981], 'interaction': [2983], 'structureVirology,': [2987], '373,': [2989], '1Circularization': [2991], 'long-range': [2997], 'pairing': [2999], 'hepadnaviral': [3003], 'transcriptionVirology,': [3005], '371,': [3007], '2Inverse': [3009], 'nucleotide': [3014], 'coding': [3016], 'carbohydrate-binding': [3018], 'legume': [3021], 'lectinsMolecular': [3022], '41,': [3025], '5The': [3027], 'Hop': [3028], 'Cassette': [3029], 'PAC1': [3032], 'Confers': [3034], 'Coupling': [3035], 'Ca2+': [3037], 'Elevation': [3038], 'Required': [3039, 3132], 'Pituitary': [3041], 'Adenylate': [3042], 'Cyclase-activating': [3043], 'Polypeptide-evoked': [3044], 'NeurosecretionJournal': [3045], '282,': [3050], '11TonB/TolA': [3052], 'Amino‐Terminal': [3053], 'ModelingN-Terminal': [3055], 'Hsp104': [3059, 3074], 'Chaperone': [3060], 'Dispensable': [3062], 'Thermotolerance': [3064], 'Prion': [3066], 'Propagation': [3067], 'Necessary': [3069], 'Curing': [3071], 'Prions': [3072], 'Overexpression1': [3075], '2006': [3077], '173,': [3081], '2Independent': [3083], 'Regulation': [3084], 'Hsp70': [3086], 'Hsp90': [3088], 'Hsp70/Hsp90-organizing': [3091], 'Sti1': [3093], '(Hop1)Journal': [3094], '280,': [3099], '40Site-directed': [3101], 'Pfu': [3104], 'T4': [3108], 'ligaseYair': [3110], 'Adereth,': [3111], 'Kristen': [3112], 'Champion,': [3114], 'Tien': [3115], 'Hsu': [3116], 'Vincent': [3118], 'Dammai30': [3119], '38,': [3125], '6Three': [3127], '-Acting': [3130], 'Elements': [3131], 'Efficient': [3134], 'Plus-Strand': [3135], 'Synthesis': [3137], 'GenomeJournal': [3143], '78,': [3147], '14': [3149], 'Follow': [3154], 'us': [3155], 'social': [3157], 'media': [3158], 'latest': [3161], 'updates': [3162], 'Metrics': [3163], 'Downloaded': [3164], '2,716': [3165], 'times': [3166], 'History': [3167], 'Received': [3168], '4': [3169], '2003': [3171, 3175], 'Accepted': [3172], '8': [3173], 'Published': [3176, 3181], 'online': [3177], '6': [3178], 'print': [3183], '2004': [3185, 3187], 'Information©': [3186], 'Author(s)PDF': [3188], 'download': [3189]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1557175253', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-08T22:15:11.758891', 'created_date': '2016-06-24'}