Title: Normalization of auditory physiology by cigarette smoking in schizophrenic patients
Abstract: Back to table of contents Previous article Next article No AccessNormalization of auditory physiology by cigarette smoking in schizophrenic patientsPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.150.12.1856AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: Because many schizophrenic patients are heavy smokers, it has been suggested that nicotine normalizes some neuronal deficit involved in their illness. Schizophrenic subjects have various difficulties with maintenance of attention and selective processing of sensory information. One defect in sensory gating in schizophrenia has been characterized by recording auditory evoked potentials. Most normal subjects have a decrease in the evoked response to the second of two closely paired stimuli, whereas most schizophrenic subjects do not. The aim of this study was to determine whether smoking normalizes this deficit in auditory sensory gating in schizophrenia. METHOD: Changes in auditory sensory gating in response to smoking cigarettes were studied in 10 smokers without psychiatric illness and 10 schizophrenic smokers. Both groups were asked to abstain from smoking from 11:00 p.m. until 8:00 a.m. the next morning, when their auditory evoked responses to pairs of clicks were recorded. The ability to gate sensory information is reflected in a decrease in the P50 wave amplitude in response to the second of the two stimuli. After baseline recordings, the subjects smoked as much as they wished, and then two postsmoking recordings were performed. RESULTS: The schizophrenic patients had a marked but brief improvement in P50 auditory gating immediately after smoking, whereas P50 gating for the normal smokers was slightly impaired. CONCLUSIONS: This study suggests that cigarette smoking can transiently normalize the impairment of auditory sensory gating in schizophrenic patients. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development. Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.). FiguresReferencesCited byDetailsCited byCigarette Smoking, Cognitive Performance, and Severe Mental Illness: Quitting Smoking Really Does Seem to MatterPhilip D. Harvey, Ph.D.1 November 2018 | American Journal of Psychiatry, Vol. 175, No. 11Clinical and Cognitive Significance of Auditory Sensory Processing Deficits in SchizophreniaHolly K. Hamilton, Ph.D., Terrance J. Williams, Ph.D., Joseph Ventura, Ph.D., Leland J. Jasperse, B.A., Emily M. Owens, M.A., Gregory A. Miller, Ph.D., Kenneth L. Subotnik, Ph.D., Keith H. Nuechterlein, Ph.D., Cindy M. Yee, Ph.D.5 December 2017 | American Journal of Psychiatry, Vol. 175, No. 3Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of SchizophreniaDaniel C. Javitt, M.D., Ph.D., and Robert Freedman, M.D.1 January 2015 | American Journal of Psychiatry, Vol. 172, No. 1Cognitive Abilities and 50- and 100-msec Paired-Click Processes in SchizophreniaAshley K. Smith, B.S., J. Christopher Edgar, Ph.D., Mingxiong Huang, Ph.D., Brett Y. Lu, M.D., Ph.D., Robert J. Thoma, Ph.D., Faith M. Hanlon, Ph.D., Greg McHaffie, B.S., Aaron P. Jones, B.A., Rodrigo D. Paz, M.D., Gregory A. Miller, Ph.D., and José M. Cañive, M.D.1 October 2010 | American Journal of Psychiatry, Vol. 167, No. 10Suppression of the P50 Evoked Response and Neuregulin 1-Induced AKT Phosphorylation in First-Episode SchizophreniaSzabolcs Kéri, M.D., Ph.D., D.Sc., Sándor Beniczky, M.D., Ph.D., and Oguz Kelemen, M.D., Ph.D.1 April 2010 | American Journal of Psychiatry, Vol. 167, No. 4Successful Tobacco Dependence Treatment in SchizophreniaJill M. Williams, M.D.Jonathan Foulds, Ph.D.1 February 2007 | American Journal of Psychiatry, Vol. 164, No. 2Co-Occurring Mental and Substance Use Disorders: The Neurobiological Effects of Chronic StressKathleen T. Brady, M.D., Ph.D., and Rajita Sinha, Ph.D.1 August 2005 | American Journal of Psychiatry, Vol. 162, No. 8Improved P50 Auditory Gating With Ondansetron in Medicated Schizophrenia PatientsLawrence E. Adler, M.D., Ellen M. Cawthra, R.N., Kara A. Donovan, M.P.H., Josette G. Harris, Ph.D., Herbert T. Nagamoto, M.D., Ann Olincy, M.D., and Merilyne C. Waldo, Ph.D.1 February 2005 | American Journal of Psychiatry, Vol. 162, No. 2fMRI of Response to Nicotine During a Smooth Pursuit Eye Movement Task in SchizophreniaJason R. Tregellas, Ph.D., Jody L. Tanabe, M.D., Laura F. Martin, M.D., and Robert Freedman, M.D.1 February 2005 | American Journal of Psychiatry, Vol. 162, No. 2Diminished Suppression of the P50 Auditory Evoked Potential in Bipolar Disorder Subjects With a History of PsychosisAnn Olincy, M.D., and Laura Martin, M.D.1 January 2005 | American Journal of Psychiatry, Vol. 162, No. 1Varied Effects of Atypical Neuroleptics on P50 Auditory Gating in Schizophrenia PatientsLawrence E. Adler, Ann Olincy, Ellen M. Cawthra, Kara A. McRae, Josette G. Harris, Herbert T. Nagamoto, Merilyne C. Waldo, Mei-Hua Hall, Amanda Bowles, Laurie Woodward, Randal G. Ross, and Robert Freedman22 December 2014 | American Journal of Psychiatry, Vol. 161, No. 10Higher Rates of Cigarette Smoking in Male Adolescents Before the Onset of Schizophrenia: A Historical-Prospective Cohort StudyMark Weiser, M.D., Abraham Reichenberg, Ph.D., Itamar Grotto, M.D., Ross Yasvitzky, B.Sc., Jonathan Rabinowitz, Ph.D., Gad Lubin, M.D., Daniella Nahon, M.A., Haim Y. Knobler, M.D., and Michael Davidson, M.D.1 July 2004 | American Journal of Psychiatry, Vol. 161, No. 7Investigating the Association Between Cigarette Smoking and Schizophrenia in a Cohort StudyStanley Zammit, M.R.C.Psych., Peter Allebeck, M.D., Christina Dalman, M.D., Ingvar Lundberg, M.D., Tomas Hemmingsson, Ph.D., and Glyn Lewis, Ph.D.1 December 2003 | American Journal of Psychiatry, Vol. 160, No. 12Normal P50 Gating in Unmedicated Schizophrenia OutpatientsSidse M. Arnfred, M.D., Ph.D., Andrew C.N. Chen, Ph.D., Birte Y. Glenthøj, M.D., M.Sc., and Ralf P. Hemmingsen, M.D., M.Sc.1 December 2003 | American Journal of Psychiatry, Vol. 160, No. 12Olanzapine Effects on Auditory Sensory Gating in SchizophreniaCelso Arango, M.D., Ann Summerfelt, B.A., and Robert W. Buchanan, M.D.1 November 2003 | American Journal of Psychiatry, Vol. 160, No. 11P50 Sensory Gating in Multiplex Schizophrenia Families From a Pacific Island IsolateMarina Myles-Worsley, Ph.D.1 December 2002 | American Journal of Psychiatry, Vol. 159, No. 12Public Health and Therapeutic Aspects of Smoking Bans in Mental Health and Addiction SettingsNady el-Guebaly, M.D., Janice Cathcart, B.S.N., M.Ed., Shawn Currie, Ph.D., Diane Brown, R.N., and Susan Gloster, R.N., B.N.1 December 2002 | Psychiatric Services, Vol. 53, No. 12A Review of the Effects of Nicotine on Schizophrenia and Antipsychotic MedicationsEdward R. Lyon, M.S., Ed.D.1 October 1999 | Psychiatric Services, Vol. 50, No. 10Nicotine Dependence in Schizophrenia: Clinical Phenomena and Laboratory FindingsGregory W. Dalack, M.D., Daniel J. Healy, M.D., and James H. Meador-Woodruff, M.D.1 November 1998 | American Journal of Psychiatry, Vol. 155, No. 11 Volume 150Issue 12 December 1993Pages 1856-1861 Metrics PDF download History Published online 1 April 2006 Published in print 1 December 1993
Publication Year: 1993
Publication Date: 1993-12-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 685
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot